Fenofibrate_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fenofibrate perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fenofibrate_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.243025
AKAP12 A kinase (PRKA) anchor protein 12 0.184777
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.14039
ERRFI1 ERBB receptor feedback inhibitor 1 0.127384
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.111253
RAD51B RAD51 paralog B 0.105156
GRAMD1B GRAM domain containing 1B 0.102703
TPM3 tropomyosin 3 0.0977368
CSDE1 cold shock domain containing E1, RNA-binding 0.0969683
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0929376
TRIO trio Rho guanine nucleotide exchange factor 0.0806441
THSD4 thrombospondin, type I, domain containing 4 0.0795278
UBC ubiquitin C 0.0741056
EXOC4 exocyst complex component 4 0.0730204
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0716917
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0713485
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0693156
ENO1 enolase 1, (alpha) 0.0654501
MACF1 microtubule-actin crosslinking factor 1 0.0648553
TXNRD1 thioredoxin reductase 1 0.0637933
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0606319
PDE4D phosphodiesterase 4D, cAMP-specific 0.0604479
PTK2 protein tyrosine kinase 2 0.0589212
FMNL2 formin-like 2 0.0569794
ANKRD36 ankyrin repeat domain 36 0.056
RPL3 ribosomal protein L3 0.0545754
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0545544
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0531909
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0505285
PRELID2 PRELI domain containing 2 0.0504206
MYH9 myosin, heavy chain 9, non-muscle 0.049317
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0484056
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0483642
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0482208
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0479231
BBX bobby sox homolog (Drosophila) 0.0477247
STAT1 signal transducer and activator of transcription 1, 91kDa 0.046679
EIF4B eukaryotic translation initiation factor 4B 0.0466753
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0452343
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0439427
TM4SF1 transmembrane 4 L six family member 1 0.0436736
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0429618
DOCK5 dedicator of cytokinesis 5 0.0427933
SET SET nuclear proto-oncogene 0.0426799
HSPA8 heat shock 70kDa protein 8 0.0425802
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0403177
OGA O-GlcNAcase 0.0403075
PGK1 phosphoglycerate kinase 1 0.0400831
SMYD3 SET and MYND domain containing 3 0.039939
ZNF292 zinc finger protein 292 0.039774
TBC1D5 TBC1 domain family, member 5 0.0397316
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0395244
NF1 neurofibromin 1 0.039216
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0392079
CTTN cortactin 0.0389866
ZFAND3 zinc finger, AN1-type domain 3 0.0389088
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0381731
XPO1 exportin 1 0.0378122
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0377468
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0368316
AFF3 AF4/FMR2 family, member 3 0.0366664
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0363354
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0360903
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0360729
CAMTA1 calmodulin binding transcription activator 1 0.0358599
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0355832
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0352957
WWOX WW domain containing oxidoreductase 0.0352112
CEP250 centrosomal protein 250kDa 0.03512
RBM39 RNA binding motif protein 39 0.0350203
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0349997
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0347869
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0345552
PRKCE protein kinase C, epsilon 0.0345333
ZNF638 zinc finger protein 638 0.0339584
SMAD3 SMAD family member 3 0.0337634
IGF1R insulin-like growth factor 1 receptor 0.0335511
PDIA6 protein disulfide isomerase family A, member 6 0.0334366
MCL1 myeloid cell leukemia 1 0.0333831
PDE10A phosphodiesterase 10A 0.0333282
KTN1 kinectin 1 (kinesin receptor) 0.033034
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0329236
BABAM2 BRISC and BRCA1 A complex member 2 0.0327842
LDHA lactate dehydrogenase A 0.0322103
CAND1 cullin-associated and neddylation-dissociated 1 0.0320795
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0319302
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0311839
TLK1 tousled-like kinase 1 0.0308351
MSH6 mutS homolog 6 0.030617
TRIP12 thyroid hormone receptor interactor 12 0.0306002
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0305616
CANX calnexin 0.0304799
PPME1 protein phosphatase methylesterase 1 0.0304695
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0303489
ANO6 anoctamin 6 0.0302605
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0301906
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0300189
ANLN anillin, actin binding protein 0.0299532
HDGF hepatoma-derived growth factor 0.0296808
UBE2H ubiquitin-conjugating enzyme E2H 0.0292827

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.201762
EGR1 early growth response 1 -0.0696904
TMSB10 thymosin beta 10 -0.0444385
RPL35A ribosomal protein L35a -0.0360214
IGF2 insulin-like growth factor 2 -0.033611
ACTG1 actin gamma 1 -0.0325355
RPS21 ribosomal protein S21 -0.0320448
WNT2B wingless-type MMTV integration site family, member 2B -0.0311005
RAB7A RAB7A, member RAS oncogene family -0.0303236
LOC102724023 ES1 protein homolog, mitochondrial -0.0287852
EIF1 eukaryotic translation initiation factor 1 -0.0282861
PFN1 profilin 1 -0.02623
FTL ferritin, light polypeptide -0.0260673
VIM vimentin -0.0258107
RPLP1 ribosomal protein, large, P1 -0.0256126
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0250638
TFPI2 tissue factor pathway inhibitor 2 -0.0248849
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0245647
NABP1 nucleic acid binding protein 1 -0.0232573
GNAS GNAS complex locus -0.0230955
LRRC23 leucine rich repeat containing 23 -0.022844
INTS6 integrator complex subunit 6 -0.021247
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0211864
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0208129
REL v-rel avian reticuloendotheliosis viral oncogene homolog -0.0203405
RPL37A ribosomal protein L37a -0.0197617
RPL36 ribosomal protein L36 -0.0192977
GSTP1 glutathione S-transferase pi 1 -0.0185324
ASTN2 astrotactin 2 -0.0181271
RPS19 ribosomal protein S19 -0.0175202
RPS15 ribosomal protein S15 -0.0174297
RPL5 ribosomal protein L5 -0.0173658
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0173475
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0169844
ELL2 elongation factor, RNA polymerase II, 2 -0.0162195
RPL34 ribosomal protein L34 -0.016144
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0160897
RPL28 ribosomal protein L28 -0.0158188
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0156931
RPL12 ribosomal protein L12 -0.0156344
LMNA lamin A/C -0.0155815
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0153332
DHFR dihydrofolate reductase -0.015033
BSG basigin (Ok blood group) -0.0149881
UBB ubiquitin B -0.0149429
RPS23 ribosomal protein S23 -0.0145924
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0145445
RPLP0 ribosomal protein, large, P0 -0.0142996
FBXO11 F-box protein 11 -0.0141557
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0141076
RACK1 receptor for activated C kinase 1 -0.0140081
AGO3 argonaute RISC catalytic component 3 -0.0139962
VDAC1 voltage-dependent anion channel 1 -0.0139919
RPS16 ribosomal protein S16 -0.0138126
NBEAL1 neurobeachin-like 1 -0.0137691
PDLIM5 PDZ and LIM domain 5 -0.0136558
PPP4R3B protein phosphatase 4 regulatory subunit 3B -0.0131265
MYPN myopalladin -0.0131043
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0128411
SRP54 signal recognition particle 54kDa -0.0125559
RPL36A ribosomal protein L36a -0.012527
ARMH4 armadillo like helical domain containing 4 -0.0122922
TUBA1B tubulin, alpha 1b -0.0122558
RPS8 ribosomal protein S8 -0.0119681
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0118432
SEC61G Sec61 gamma subunit -0.01171
MLF2 myeloid leukemia factor 2 -0.0116906
AHCYL1 adenosylhomocysteinase-like 1 -0.0116558
RPLP2 ribosomal protein, large, P2 -0.011628
PIBF1 progesterone immunomodulatory binding factor 1 -0.0116074
JUN jun proto-oncogene -0.0115348
VCL vinculin -0.0114892
UBE2B ubiquitin-conjugating enzyme E2B -0.0114658
RPL7L1 ribosomal protein L7-like 1 -0.0114099
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.011371
RPL38 ribosomal protein L38 -0.0113137
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0111458
AFTPH aftiphilin -0.011129
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.011031
DCAF7 DDB1 and CUL4 associated factor 7 -0.0109774
LMAN1 lectin, mannose-binding, 1 -0.0109762
MYOM1 myomesin 1 -0.0109555
FAM177A1 family with sequence similarity 177, member A1 -0.0109318
RPS25 ribosomal protein S25 -0.0109253
UBE2I ubiquitin-conjugating enzyme E2I -0.0107591
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0106794
H3-3B H3.3 histone B -0.010599
CAVIN1 caveolae associated protein 1 -0.0105831
RAB5A RAB5A, member RAS oncogene family -0.0105008
FSCN1 fascin actin-bundling protein 1 -0.01033
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -0.0102668
RPL7A ribosomal protein L7a -0.0101741
LASP1 LIM and SH3 protein 1 -0.0101097
TBCA tubulin folding cofactor A -0.0100388
KANSL1L KAT8 regulatory NSL complex subunit 1-like -0.00997768
RPL23 ribosomal protein L23 -0.00996134
GOLPH3L golgi phosphoprotein 3-like -0.00995282
ZC3H15 zinc finger CCCH-type containing 15 -0.00992837
RPL8 ribosomal protein L8 -0.00973793
PCF11 PCF11 cleavage and polyadenylation factor subunit -0.00972485