Fenofibrate_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fenofibrate perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fenofibrate_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.334216
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.22428
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.167959
UBC ubiquitin C 0.154527
FN1 fibronectin 1 0.150569
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.127415
ASPH aspartate beta-hydroxylase 0.115388
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.113639
MYH9 myosin, heavy chain 9, non-muscle 0.111749
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.105036
CALR calreticulin 0.102556
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0927077
ENO1 enolase 1, (alpha) 0.0925583
APLP2 amyloid beta (A4) precursor-like protein 2 0.0905141
LAMC2 laminin, gamma 2 0.0860633
DSPP dentin sialophosphoprotein 0.0818115
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.081612
LDHA lactate dehydrogenase A 0.0769225
CANX calnexin 0.0765278
HMGB2 high mobility group box 2 0.0763642
FNDC3B fibronectin type III domain containing 3B 0.0728613
VEGFA vascular endothelial growth factor A 0.0726423
AHNAK AHNAK nucleoprotein 0.0677531
NAV2 neuron navigator 2 0.0662503
HSPA8 heat shock 70kDa protein 8 0.0655448
RPL4 ribosomal protein L4 0.0654213
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0637724
RPS3 ribosomal protein S3 0.0627481
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0617443
TMSB4X thymosin beta 4, X-linked 0.0615653
MSN moesin 0.0607257
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0606741
RACK1 receptor for activated C kinase 1 0.0588824
TPM3 tropomyosin 3 0.0554515
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0544848
KRT7 keratin 7, type II 0.0523307
SQSTM1 sequestosome 1 0.0522984
NAMPT nicotinamide phosphoribosyltransferase 0.0514946
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0497603
RPL23 ribosomal protein L23 0.0495372
RPL3 ribosomal protein L3 0.0488847
POTEF POTE ankyrin domain family, member F 0.0482656
G0S2 G0/G1 switch 2 0.0480885
CSDE1 cold shock domain containing E1, RNA-binding 0.0473563
ARRDC3 arrestin domain containing 3 0.0463552
EEF2 eukaryotic translation elongation factor 2 0.0462521
TPT1 tumor protein, translationally-controlled 1 0.0451923
EEF1G eukaryotic translation elongation factor 1 gamma 0.0448745
TRIO trio Rho guanine nucleotide exchange factor 0.0448346
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0443135
FHIT fragile histidine triad 0.0441866
PDIA6 protein disulfide isomerase family A, member 6 0.043972
RPL37 ribosomal protein L37 0.0439423
DSCAM Down syndrome cell adhesion molecule 0.0439211
LAMB3 laminin, beta 3 0.0438179
LPP LIM domain containing preferred translocation partner in lipoma 0.0434645
PTK2 protein tyrosine kinase 2 0.0434496
EXT1 exostosin glycosyltransferase 1 0.0433486
PKM pyruvate kinase, muscle 0.0429469
RPL14 ribosomal protein L14 0.0428827
SAMD4A sterile alpha motif domain containing 4A 0.0417594
SET SET nuclear proto-oncogene 0.0414573
IQGAP1 IQ motif containing GTPase activating protein 1 0.0411668
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0411561
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0410121
RPS17 ribosomal protein S17 0.0389898
RPS12 ribosomal protein S12 0.0388841
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0386442
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0385307
SDC4 syndecan 4 0.0380036
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0373905
ELL2 elongation factor, RNA polymerase II, 2 0.0372015
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0370103
APP amyloid beta (A4) precursor protein 0.0369918
RPLP1 ribosomal protein, large, P1 0.0364322
RPLP2 ribosomal protein, large, P2 0.0353193
UPP1 uridine phosphorylase 1 0.0353116
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0350238
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0349462
EIF4A2 eukaryotic translation initiation factor 4A2 0.0347678
ACTG1 actin gamma 1 0.0347512
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0345766
RPS8 ribosomal protein S8 0.0336625
BHLHE40 basic helix-loop-helix family, member e40 0.0333336
STEAP4 STEAP family member 4 0.0333241
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0332183
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0331777
MKI67 marker of proliferation Ki-67 0.0320883
YBX1 Y box binding protein 1 0.0320694
DST dystonin 0.0320139
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0315504
PLEC plectin 0.031523
RPL19 ribosomal protein L19 0.0313562
CTTN cortactin 0.0312333
IRF6 interferon regulatory factor 6 0.031181
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.031172
MYO5B myosin VB 0.0311055
FXR1 fragile X mental retardation, autosomal homolog 1 0.0310896
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0310264
PDIA4 protein disulfide isomerase family A, member 4 0.0310132

decreased expression

Symbol Name Standardized Value
TSC22D2 TSC22 domain family, member 2 -0.0844496
IGFBP3 insulin-like growth factor binding protein 3 -0.07035
NPEPPS aminopeptidase puromycin sensitive -0.0464993
FAM3C family with sequence similarity 3, member C -0.0409413
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0386307
SOX4 SRY (sex determining region Y)-box 4 -0.0335675
KMT2E lysine (K)-specific methyltransferase 2E -0.0292355
STRN3 striatin, calmodulin binding protein 3 -0.0286031
ITCH itchy E3 ubiquitin protein ligase -0.0262242
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0261421
KDM5B lysine (K)-specific demethylase 5B -0.0256935
ARHGAP29 Rho GTPase activating protein 29 -0.0255448
F3 coagulation factor III (thromboplastin, tissue factor) -0.025218
HMGA1 high mobility group AT-hook 1 -0.0240958
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0237991
PRRC1 proline-rich coiled-coil 1 -0.0237422
MXD1 MAX dimerization protein 1 -0.0233521
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -0.0229146
TMSB10 thymosin beta 10 -0.0220599
MARCHF6 membrane associated ring-CH-type finger 6 -0.0216851
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0206351
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0205909
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0205467
TXNIP thioredoxin interacting protein -0.0200255
BASP1 brain abundant, membrane attached signal protein 1 -0.0195283
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0195246
CD2AP CD2-associated protein -0.0193805
JMJD1C jumonji domain containing 1C -0.0192827
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.019261
ACBD3 acyl-CoA binding domain containing 3 -0.0190607
RAB6A RAB6A, member RAS oncogene family -0.018848
IFITM1 interferon induced transmembrane protein 1 -0.0182973
RBM25 RNA binding motif protein 25 -0.017331
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.016911
VDAC1 voltage-dependent anion channel 1 -0.0164978
IFITM3 interferon induced transmembrane protein 3 -0.0163934
FBXO11 F-box protein 11 -0.0161063
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0158919
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.015725
LMNA lamin A/C -0.0154589
GNAS GNAS complex locus -0.0152702
COPA coatomer protein complex, subunit alpha -0.0150552
ZNF207 zinc finger protein 207 -0.0150132
TMEM165 transmembrane protein 165 -0.0149683
SACK1A scaffolding CK1 anchoring protein A -0.0148007
NDRG1 N-myc downstream regulated 1 -0.0147881
UBE2B ubiquitin-conjugating enzyme E2B -0.0146866
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0144462
RASAL2 RAS protein activator like 2 -0.0142765
NDFIP1 Nedd4 family interacting protein 1 -0.0141413
FAM162A family with sequence similarity 162, member A -0.0138397
ARF1 ADP-ribosylation factor 1 -0.0137375
CERT1 ceramide transporter 1 -0.0136594
RPL35A ribosomal protein L35a -0.013628
EGR1 early growth response 1 -0.0135385
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0135266
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.013263
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0128139
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0126662
TP53BP2 tumor protein p53 binding protein 2 -0.0124549
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0123441
CLDN4 claudin 4 -0.0122502
YY1 YY1 transcription factor -0.0122345
WASF2 WAS protein family, member 2 -0.0120592
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0119534
UGCG UDP-glucose ceramide glucosyltransferase -0.0117756
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0115565
DLC1 DLC1 Rho GTPase activating protein -0.011477
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0112775
LIMCH1 LIM and calponin homology domains 1 -0.0112073
CDK17 cyclin-dependent kinase 17 -0.0109368
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0109025
RLF rearranged L-myc fusion -0.0107696
RNF145 ring finger protein 145 -0.0107629
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0107148
RNF11 ring finger protein 11 -0.0107078
UBE2C ubiquitin-conjugating enzyme E2C -0.0107012
JUP junction plakoglobin -0.0106334
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0106302
RAB2A RAB2A, member RAS oncogene family -0.0104418
SOS2 son of sevenless homolog 2 (Drosophila) -0.0103721
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0103269
CSTB cystatin B (stefin B) -0.0103054
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0102814
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -0.0101608
MYADM myeloid-associated differentiation marker -0.0100944
AZIN1 antizyme inhibitor 1 -0.00995919
SETD5 SET domain containing 5 -0.00995321
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.00994731
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.00979897
ABLIM3 actin binding LIM protein family, member 3 -0.00973368
LY6E lymphocyte antigen 6 complex, locus E -0.00960586
PALM2AKAP2 PALM2 and AKAP2 fusion -0.00948022
TRA2A transformer 2 alpha homolog (Drosophila) -0.00944803
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0093513
WAC WW domain containing adaptor with coiled-coil -0.00932176
VIM vimentin -0.00912465
RFX7 regulatory factor X, 7 -0.00911953
PARD6B par-6 family cell polarity regulator beta -0.00911379
CIB1 calcium and integrin binding 1 (calmyrin) -0.00896705