Fenofibrate_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fenofibrate perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fenofibrate_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 0.258882
ASPH aspartate beta-hydroxylase 0.177081
NAMPT nicotinamide phosphoribosyltransferase 0.170082
TRIO trio Rho guanine nucleotide exchange factor 0.135369
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.128898
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.122311
LIMCH1 LIM and calponin homology domains 1 0.118611
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.109633
TXNRD1 thioredoxin reductase 1 0.102844
MYOF myoferlin 0.0957321
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0931016
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0873747
PSD3 pleckstrin and Sec7 domain containing 3 0.0810075
GDA guanine deaminase 0.079859
PDE10A phosphodiesterase 10A 0.0758032
FNDC3B fibronectin type III domain containing 3B 0.0749037
RTN4 reticulon 4 0.074423
NEK7 NIMA-related kinase 7 0.0680319
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0678055
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0651631
CXCL8 chemokine (C-X-C motif) ligand 8 0.0630246
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0626321
OGA O-GlcNAcase 0.0623542
NRCAM neuronal cell adhesion molecule 0.0616746
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0605336
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0605319
GRAMD1B GRAM domain containing 1B 0.0593751
COL5A2 collagen, type V, alpha 2 0.058736
MCL1 myeloid cell leukemia 1 0.0563103
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0552077
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.054786
SAMD4A sterile alpha motif domain containing 4A 0.0546297
TM4SF1 transmembrane 4 L six family member 1 0.0544953
PGK1 phosphoglycerate kinase 1 0.0535148
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0530247
UBC ubiquitin C 0.051176
LDHA lactate dehydrogenase A 0.050542
CANX calnexin 0.0504812
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0504313
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0487239
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0478556
ESYT2 extended synaptotagmin-like protein 2 0.0462764
ENO1 enolase 1, (alpha) 0.0461474
COL4A6 collagen, type IV, alpha 6 0.0447035
RBM39 RNA binding motif protein 39 0.0446972
FLNB filamin B, beta 0.0436156
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0423835
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0422253
DST dystonin 0.0417694
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0411838
PRRC2C proline-rich coiled-coil 2C 0.0410911
MFF mitochondrial fission factor 0.0410256
TNPO1 transportin 1 0.0407997
AGFG1 ArfGAP with FG repeats 1 0.0404339
ELL2 elongation factor, RNA polymerase II, 2 0.0396325
ANXA1 annexin A1 0.0394836
CARD16 caspase recruitment domain family, member 16 0.0390602
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.038572
RPL3 ribosomal protein L3 0.0376439
NBAS neuroblastoma amplified sequence 0.0373737
MSN moesin 0.0370982
BIRC6 baculoviral IAP repeat containing 6 0.0367466
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0363866
ZNF292 zinc finger protein 292 0.0362997
CTSC cathepsin C 0.0359816
FAM13A family with sequence similarity 13, member A 0.0358707
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0357088
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0355235
TGFBR1 transforming growth factor, beta receptor 1 0.0352694
PTGR1 prostaglandin reductase 1 0.0350717
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.034892
CD109 CD109 molecule 0.0346899
USP9X ubiquitin specific peptidase 9, X-linked 0.0346233
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0345587
KMT2C lysine (K)-specific methyltransferase 2C 0.0344998
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.034385
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0332598
RAI1 retinoic acid induced 1 0.0325015
BRWD3 bromodomain and WD repeat domain containing 3 0.0320532
ANKRD28 ankyrin repeat domain 28 0.0319999
PTK2 protein tyrosine kinase 2 0.0318619
CENPF centromere protein F, 350/400kDa 0.0317315
CSNK1A1 casein kinase 1, alpha 1 0.0316437
ANKRD11 ankyrin repeat domain 11 0.0316414
TPM3 tropomyosin 3 0.0313934
AVL9 AVL9 homolog (S. cerevisiase) 0.0311801
USP34 ubiquitin specific peptidase 34 0.0309847
ATP13A3 ATPase type 13A3 0.0308989
EZR ezrin 0.0308173
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0307868
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0306923
PDIA6 protein disulfide isomerase family A, member 6 0.0306276
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0305924
RPL4 ribosomal protein L4 0.0302385
ENAH enabled homolog (Drosophila) 0.030095
MKI67 marker of proliferation Ki-67 0.0300608
ERRFI1 ERBB receptor feedback inhibitor 1 0.0300301
ZFC3H1 zinc finger, C3H1-type containing 0.0299704
HSPA8 heat shock 70kDa protein 8 0.0298459
DOCK4 dedicator of cytokinesis 4 0.0298063

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.258543
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0889208
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0854113
VIM vimentin -0.0694031
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0616411
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0580178
TPT1 tumor protein, translationally-controlled 1 -0.0578344
TMSB10 thymosin beta 10 -0.0492252
RPL35A ribosomal protein L35a -0.0423589
RPLP1 ribosomal protein, large, P1 -0.0410211
FN1 fibronectin 1 -0.0408601
RPS6 ribosomal protein S6 -0.0360449
PDLIM5 PDZ and LIM domain 5 -0.033403
SOX4 SRY (sex determining region Y)-box 4 -0.0315107
RPS19 ribosomal protein S19 -0.0309461
P3H2 prolyl 3-hydroxylase 2 -0.0298843
WARS1 tryptophanyl-tRNA synthetase 1 -0.0282457
FTL ferritin, light polypeptide -0.0282363
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0276709
HLA-B major histocompatibility complex, class I, B -0.0267272
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0263081
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0261586
EGR1 early growth response 1 -0.0251067
RPL31 ribosomal protein L31 -0.024737
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0236087
SMAD2 SMAD family member 2 -0.0225852
RPL37A ribosomal protein L37a -0.022509
RPS8 ribosomal protein S8 -0.0224883
RPL34 ribosomal protein L34 -0.0219622
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0216322
RAB31 RAB31, member RAS oncogene family -0.0208823
RPS21 ribosomal protein S21 -0.0203102
PCDH15 protocadherin-related 15 -0.0200133
RPS28 ribosomal protein S28 -0.0199744
LSAMP limbic system-associated membrane protein -0.0191865
RPL36A ribosomal protein L36a -0.0191082
RPS25 ribosomal protein S25 -0.0189485
ASTN2 astrotactin 2 -0.0187845
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0187786
NTN4 netrin 4 -0.0186576
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0185934
RPL36 ribosomal protein L36 -0.0184885
RPLP0 ribosomal protein, large, P0 -0.0183531
RPS23 ribosomal protein S23 -0.0181239
RPL12 ribosomal protein L12 -0.0179206
MAP7 microtubule-associated protein 7 -0.0177935
FNDC3A fibronectin type III domain containing 3A -0.0176594
RPS12 ribosomal protein S12 -0.0176151
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0174419
LOC102724023 ES1 protein homolog, mitochondrial -0.0171195
ADGRD1 adhesion G protein-coupled receptor D1 -0.0168707
PRSS23 protease, serine, 23 -0.0167784
RPS14 ribosomal protein S14 -0.0167696
LMNA lamin A/C -0.0164281
CDH13 cadherin 13 -0.0164055
XYLT1 xylosyltransferase I -0.016355
CADM2 cell adhesion molecule 2 -0.0162335
GNAS GNAS complex locus -0.0161202
RPS24 ribosomal protein S24 -0.016118
ESM1 endothelial cell-specific molecule 1 -0.0160288
PTMA prothymosin, alpha -0.0156513
PCDH9 protocadherin 9 -0.0153396
RPL11 ribosomal protein L11 -0.0152242
S100A6 S100 calcium binding protein A6 -0.0151561
SOX6 SRY (sex determining region Y)-box 6 -0.0150988
PRKN parkin RBR E3 ubiquitin protein ligase -0.0150421
OASL 2'-5'-oligoadenylate synthetase-like -0.0150001
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0147383
RPL7A ribosomal protein L7a -0.0146373
RPLP2 ribosomal protein, large, P2 -0.0145709
RPS16 ribosomal protein S16 -0.0145192
PRICKLE1 prickle homolog 1 (Drosophila) -0.0144238
IFIH1 interferon induced with helicase C domain 1 -0.0142706
NR4A3 nuclear receptor subfamily 4, group A, member 3 -0.0142355
AEBP2 AE binding protein 2 -0.0138749
CUX1 cut-like homeobox 1 -0.0136139
FOXK1 forkhead box K1 -0.0135211
TBCA tubulin folding cofactor A -0.0134633
EPHA4 EPH receptor A4 -0.0134061
FSTL4 follistatin-like 4 -0.0133453
PGM2L1 phosphoglucomutase 2-like 1 -0.0131539
HLA-A major histocompatibility complex, class I, A -0.0130677
BMP6 bone morphogenetic protein 6 -0.013058
FTH1 ferritin, heavy polypeptide 1 -0.0129983
RPS10 ribosomal protein S10 -0.012964
AADAC arylacetamide deacetylase -0.0128876
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0128301
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 -0.0127182
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0126789
RPL28 ribosomal protein L28 -0.0126264
SMOC1 SPARC related modular calcium binding 1 -0.0125496
CHL1 cell adhesion molecule L1-like -0.0125063
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0124013
RPL19 ribosomal protein L19 -0.0123191
C9ORF153 chromosome 9 open reading frame 153 -0.0123025
ISG15 ISG15 ubiquitin-like modifier -0.0120414
STEAP1B STEAP family member 1B -0.0120271
RPL39 ribosomal protein L39 -0.0119674
VCL vinculin -0.0119523
PDE4D phosphodiesterase 4D, cAMP-specific -0.0118498