Fenofibrate_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fenofibrate perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

125 genes differentially expressed following the Fenofibrate_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 0.229437
TRIO trio Rho guanine nucleotide exchange factor 0.181843
FNDC3B fibronectin type III domain containing 3B 0.176919
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.161789
FMN1 formin 1 0.159816
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.145468
VCL vinculin 0.113624
MAML3 mastermind-like 3 (Drosophila) 0.102713
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.101945
IGFBP3 insulin-like growth factor binding protein 3 0.099454
TENM3 teneurin transmembrane protein 3 0.0975713
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0870733
ZFAND3 zinc finger, AN1-type domain 3 0.0853381
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0850246
CANX calnexin 0.084123
FN1 fibronectin 1 0.0820247
POTEF POTE ankyrin domain family, member F 0.0814237
RBM39 RNA binding motif protein 39 0.0789105
RORA RAR-related orphan receptor A 0.0764574
RPS19 ribosomal protein S19 0.0749463
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0747872
FTL ferritin, light polypeptide 0.0741509
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0722033
RPLP1 ribosomal protein, large, P1 0.068708
GRB10 growth factor receptor-bound protein 10 0.0673383
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0637468
LIMCH1 LIM and calponin homology domains 1 0.0631847
NF1 neurofibromin 1 0.0625286
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0613396
JMJD1C jumonji domain containing 1C 0.0609652
DOCK5 dedicator of cytokinesis 5 0.0601076
FTH1 ferritin, heavy polypeptide 1 0.0588018
PRELID2 PRELI domain containing 2 0.0530384
TMSB10 thymosin beta 10 0.0525261
OXSR1 oxidative stress responsive 1 0.0518631
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0514576
RTN4 reticulon 4 0.0502358
KMT2E lysine (K)-specific methyltransferase 2E 0.048852
NAMPT nicotinamide phosphoribosyltransferase 0.0467134
CDH13 cadherin 13 0.0466378
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0360178
BBX bobby sox homolog (Drosophila) 0.0341404
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0311607
KMT2C lysine (K)-specific methyltransferase 2C 0.031157
AKAP13 A kinase (PRKA) anchor protein 13 0.0280012
RBM25 RNA binding motif protein 25 0.0256718
ENO1 enolase 1, (alpha) 0.0243568
NLGN1 neuroligin 1 0.0237852
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0204353
FAT1 FAT atypical cadherin 1 0.0189144
LOC112694756 uncharaterized LOC112694756 0.0185867
PGK1 phosphoglycerate kinase 1 0.0184259
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0182777
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0170643
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0167115
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0161694
TRA2A transformer 2 alpha homolog (Drosophila) 0.0151833
NRG3 neuregulin 3 0.013625
PARD3 par-3 family cell polarity regulator 0.0133557
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0129431
GOLGA4 golgin A4 0.0128724
PDE10A phosphodiesterase 10A 0.0114296
KDM3A lysine (K)-specific demethylase 3A 0.0108855
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0105503
SRPK2 SRSF protein kinase 2 0.00588024
ACTG1 actin gamma 1 0.00515361
SETD5 SET domain containing 5 0.00159604
PABPC1 poly(A) binding protein, cytoplasmic 1 0.00128119
RPL23 ribosomal protein L23 0.00112233
DST dystonin 3.63168E-4

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.363621
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.264808
EGFR epidermal growth factor receptor -0.199182
NDRG1 N-myc downstream regulated 1 -0.180513
PKM pyruvate kinase, muscle -0.143444
GPC6 glypican 6 -0.140519
VIM vimentin -0.135517
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.128004
DSCAM Down syndrome cell adhesion molecule -0.11711
CXCL8 chemokine (C-X-C motif) ligand 8 -0.115887
MT2A metallothionein 2A -0.115253
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.1026
SMYD3 SET and MYND domain containing 3 -0.0922508
USP34 ubiquitin specific peptidase 34 -0.0908733
PTMA prothymosin, alpha -0.0884882
STC1 stanniocalcin 1 -0.0846268
ANXA2 annexin A2 -0.0810024
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0783279
ZNF292 zinc finger protein 292 -0.074528
EEF2 eukaryotic translation elongation factor 2 -0.0694095
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0634672
ADAM10 ADAM metallopeptidase domain 10 -0.0577899
RPS27A ribosomal protein S27a -0.0572236
NUP58 nucleoporin 58 -0.0542554
ACTN4 actinin, alpha 4 -0.0529233
CCNI cyclin I -0.052611
ZBTB20 zinc finger and BTB domain containing 20 -0.0520501
RPS12 ribosomal protein S12 -0.0513857
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0510405
ASPH aspartate beta-hydroxylase -0.0505274
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0429122
LDHA lactate dehydrogenase A -0.0427949
PRRC2C proline-rich coiled-coil 2C -0.0380654
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0347966
WAC WW domain containing adaptor with coiled-coil -0.0344971
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.031065
RPS3 ribosomal protein S3 -0.031039
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0245664
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0245557
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0236654
RLF rearranged L-myc fusion -0.0199587
SLC38A1 solute carrier family 38, member 1 -0.0197754
UBC ubiquitin C -0.0183303
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0141633
LSAMP limbic system-associated membrane protein -0.0125027
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0101711
PDE4D phosphodiesterase 4D, cAMP-specific -0.00917348
ANKRD11 ankyrin repeat domain 11 -0.00852872
MYH9 myosin, heavy chain 9, non-muscle -0.00758597
TPT1 tumor protein, translationally-controlled 1 -0.00722815
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.00451404
RPL31 ribosomal protein L31 -0.0040481
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.00146737
RACK1 receptor for activated C kinase 1 -5.56074E-4
PTK2 protein tyrosine kinase 2 -1.265E-4