Fenofibrate_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fenofibrate perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fenofibrate_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.177237
MYH9 myosin, heavy chain 9, non-muscle 0.175448
TRIO trio Rho guanine nucleotide exchange factor 0.15638
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.132645
FNDC3B fibronectin type III domain containing 3B 0.112178
NAMPT nicotinamide phosphoribosyltransferase 0.102607
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.101371
NAV2 neuron navigator 2 0.0975561
FN1 fibronectin 1 0.0902089
ZNF292 zinc finger protein 292 0.0817826
OGA O-GlcNAcase 0.0803847
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0696879
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0664968
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0650024
VEGFA vascular endothelial growth factor A 0.064925
RB1CC1 RB1-inducible coiled-coil 1 0.062647
MYOF myoferlin 0.0625621
ELL2 elongation factor, RNA polymerase II, 2 0.0609436
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0605949
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0605909
MSN moesin 0.0598475
PDE10A phosphodiesterase 10A 0.0598002
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.059644
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0594176
ANLN anillin, actin binding protein 0.0543695
ARRDC3 arrestin domain containing 3 0.0527244
SPAG9 sperm associated antigen 9 0.0519347
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.051266
TENT5A terminal nucleotidyltransferase 5A 0.050558
CENPF centromere protein F, 350/400kDa 0.0493985
TNIP1 TNFAIP3 interacting protein 1 0.0487188
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0487186
DST dystonin 0.0481866
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0467012
RTN4 reticulon 4 0.0466385
USP9X ubiquitin specific peptidase 9, X-linked 0.0465297
UBC ubiquitin C 0.0457444
PRELID2 PRELI domain containing 2 0.0455602
MKI67 marker of proliferation Ki-67 0.0454254
FNIP1 folliculin interacting protein 1 0.044405
MXI1 MAX interactor 1, dimerization protein 0.0440835
HELZ helicase with zinc finger 0.042279
CADM1 cell adhesion molecule 1 0.0420741
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0420598
APLP2 amyloid beta (A4) precursor-like protein 2 0.0416597
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0412761
JMJD1C jumonji domain containing 1C 0.0405176
GOLGA4 golgin A4 0.0395715
UBA6 ubiquitin-like modifier activating enzyme 6 0.0395602
EEF2 eukaryotic translation elongation factor 2 0.039469
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0385764
LDHA lactate dehydrogenase A 0.0385143
RBM39 RNA binding motif protein 39 0.0380476
APP amyloid beta (A4) precursor protein 0.038041
DIAPH3 diaphanous-related formin 3 0.0361548
SDC4 syndecan 4 0.0358282
CSDE1 cold shock domain containing E1, RNA-binding 0.0346697
SBF2 SET binding factor 2 0.034492
PGK1 phosphoglycerate kinase 1 0.0344133
B2M beta-2-microglobulin 0.0338642
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0335753
KIF4A kinesin family member 4A 0.0334943
CCNL1 cyclin L1 0.0331124
CKAP5 cytoskeleton associated protein 5 0.0330485
ENO1 enolase 1, (alpha) 0.0330281
LCORL ligand dependent nuclear receptor corepressor-like 0.0325035
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0323831
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0323325
TUBB tubulin, beta class I 0.0323141
QKI QKI, KH domain containing, RNA binding 0.0322789
CEP250 centrosomal protein 250kDa 0.0317509
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0316566
NT5C2 5'-nucleotidase, cytosolic II 0.0310317
LAMP2 lysosomal-associated membrane protein 2 0.0309341
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0309053
RPS4X ribosomal protein S4, X-linked 0.030902
FLNB filamin B, beta 0.0308508
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0303325
PCBP2 poly(rC) binding protein 2 0.0301944
CDK19 cyclin-dependent kinase 19 0.0299493
RPL3 ribosomal protein L3 0.029385
UGCG UDP-glucose ceramide glucosyltransferase 0.0291764
KDM3A lysine (K)-specific demethylase 3A 0.028951
FLNA filamin A, alpha 0.0288318
ICAM1 intercellular adhesion molecule 1 0.0288224
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0288086
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0285449
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0280479
DSCAM Down syndrome cell adhesion molecule 0.0278878
TPX2 TPX2, microtubule-associated 0.0276756
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0272202
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0271732
FOXO3 forkhead box O3 0.026655
BCLAF1 BCL2-associated transcription factor 1 0.0262943
NEK7 NIMA-related kinase 7 0.0254725
YBX1 Y box binding protein 1 0.0253508
CORO1C coronin, actin binding protein, 1C 0.0253211
FRMD5 FERM domain containing 5 0.0252228
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0252004
DENND5A DENN/MADD domain containing 5A 0.0251545

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.175333
IGFBP3 insulin-like growth factor binding protein 3 -0.150606
GLIS3 GLIS family zinc finger 3 -0.0916842
AKAP12 A kinase (PRKA) anchor protein 12 -0.0915228
HMGA2 high mobility group AT-hook 2 -0.0684249
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0648971
IER3 immediate early response 3 -0.0550781
HLA-B major histocompatibility complex, class I, B -0.0469651
ZMYND8 zinc finger, MYND-type containing 8 -0.0446531
FTH1 ferritin, heavy polypeptide 1 -0.0435388
BICC1 BicC family RNA binding protein 1 -0.0415102
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0376231
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0371721
EGR1 early growth response 1 -0.0360992
FTL ferritin, light polypeptide -0.035785
EGFR epidermal growth factor receptor -0.0347568
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0347419
BTG1 B-cell translocation gene 1, anti-proliferative -0.0345177
HLA-A major histocompatibility complex, class I, A -0.0316155
TPT1 tumor protein, translationally-controlled 1 -0.0303847
CTSD cathepsin D -0.0303479
RAI14 retinoic acid induced 14 -0.0301369
CDH13 cadherin 13 -0.0295765
LOX lysyl oxidase -0.0293546
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0279544
CLMP CXADR-like membrane protein -0.0277609
SAMD3 sterile alpha motif domain containing 3 -0.0271551
PLIN2 perilipin 2 -0.0250281
SLC38A1 solute carrier family 38, member 1 -0.0238411
INHBA inhibin, beta A -0.0236337
NDRG1 N-myc downstream regulated 1 -0.0229459
ARL4C ADP-ribosylation factor-like 4C -0.0225293
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0221835
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0219541
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0216275
SOX5 SRY (sex determining region Y)-box 5 -0.0212802
STC1 stanniocalcin 1 -0.0209757
TMEM132D transmembrane protein 132D -0.0208508
RND3 Rho family GTPase 3 -0.0203006
SFRP1 secreted frizzled-related protein 1 -0.0195084
TGFBI transforming growth factor, beta-induced, 68kDa -0.0192836
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0188578
INTS6 integrator complex subunit 6 -0.0187703
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0187474
RPL35A ribosomal protein L35a -0.0185642
SOX4 SRY (sex determining region Y)-box 4 -0.0184588
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0182722
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0179006
ADAM12 ADAM metallopeptidase domain 12 -0.0177488
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0176865
TCEAL9 transcription elongation factor A like 9 -0.0175236
FRMD4A FERM domain containing 4A -0.0173527
IFITM3 interferon induced transmembrane protein 3 -0.0172326
COL6A3 collagen, type VI, alpha 3 -0.0171825
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0171783
CTSB cathepsin B -0.0170576
CP ceruloplasmin (ferroxidase) -0.0168253
CAVIN1 caveolae associated protein 1 -0.0165221
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0164489
VDAC1 voltage-dependent anion channel 1 -0.0161299
ZBTB38 zinc finger and BTB domain containing 38 -0.0159886
TBCA tubulin folding cofactor A -0.0158638
DIAPH2 diaphanous-related formin 2 -0.0156685
COL6A1 collagen, type VI, alpha 1 -0.0155312
GPC6 glypican 6 -0.0154135
PRKG1 protein kinase, cGMP-dependent, type I -0.0153645
GDF15 growth differentiation factor 15 -0.0153558
GNAS GNAS complex locus -0.0152018
EFNA5 ephrin-A5 -0.0149591
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0148773
PALLD palladin, cytoskeletal associated protein -0.0145191
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0143232
ARHGAP22 Rho GTPase activating protein 22 -0.0143109
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0142755
VCAN versican -0.0141954
LOC102724023 ES1 protein homolog, mitochondrial -0.0141568
TENM2 teneurin transmembrane protein 2 -0.0140812
SCARB1 scavenger receptor class B, member 1 -0.0138824
LHFPL2 lipoma HMGIC fusion partner-like 2 -0.0137645
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.013719
NTN4 netrin 4 -0.0136754
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0136259
ASPH aspartate beta-hydroxylase -0.0135974
TMSB10 thymosin beta 10 -0.0135613
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0134948
FOXP1 forkhead box P1 -0.0133783
LSAMP limbic system-associated membrane protein -0.013353
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0133508
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0131952
NRN1 neuritin 1 -0.0130907
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0128461
WFDC10B WAP four-disulfide core domain 10B -0.0128172
FRMPD4 FERM and PDZ domain containing 4 -0.012727
TCEAL4 transcription elongation factor A (SII)-like 4 -0.0127148
NT5E 5'-nucleotidase, ecto (CD73) -0.0126843
DNER delta/notch-like EGF repeat containing -0.0126313
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0125976
ZFHX3 zinc finger homeobox 3 -0.0124583
HLA-E major histocompatibility complex, class I, E -0.0122357
DENND2A DENN/MADD domain containing 2A -0.0122235