Fenofibrate_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fenofibrate perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fenofibrate_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.22517
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.168002
CALR calreticulin 0.113692
UBC ubiquitin C 0.107293
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.088848
MYH9 myosin, heavy chain 9, non-muscle 0.0869277
NAMPT nicotinamide phosphoribosyltransferase 0.0790448
CANX calnexin 0.0751449
TRIO trio Rho guanine nucleotide exchange factor 0.0669231
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0642446
RBM39 RNA binding motif protein 39 0.0638656
ELL2 elongation factor, RNA polymerase II, 2 0.0625125
B2M beta-2-microglobulin 0.0623667
TENT5A terminal nucleotidyltransferase 5A 0.0603998
ARRDC3 arrestin domain containing 3 0.0599914
COL6A3 collagen, type VI, alpha 3 0.0585629
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0583099
FNDC3B fibronectin type III domain containing 3B 0.0568584
FTL ferritin, light polypeptide 0.0540975
HOOK2 hook microtubule-tethering protein 2 0.0529322
SOD2 superoxide dismutase 2, mitochondrial 0.0515575
ENO1 enolase 1, (alpha) 0.0515157
NDRG1 N-myc downstream regulated 1 0.0498572
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0497282
FAM13A family with sequence similarity 13, member A 0.0495362
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0482254
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0471608
PRELID2 PRELI domain containing 2 0.0468458
PDIA4 protein disulfide isomerase family A, member 4 0.0464958
SKIC3 SKI3 subunit of superkiller complex 0.0460487
PKM pyruvate kinase, muscle 0.0440844
UBA6 ubiquitin-like modifier activating enzyme 6 0.044027
TTC3 tetratricopeptide repeat domain 3 0.0436399
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0429334
SEC24D SEC24 family member D 0.0428
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0425124
HMGB2 high mobility group box 2 0.0423948
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0414834
HDLBP high density lipoprotein binding protein 0.0413204
PDIA6 protein disulfide isomerase family A, member 6 0.0412615
RAB1A RAB1A, member RAS oncogene family 0.0411321
COPB1 coatomer protein complex, subunit beta 1 0.0409483
PDE4D phosphodiesterase 4D, cAMP-specific 0.0408171
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.040559
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0401579
ZNF292 zinc finger protein 292 0.0397366
CD109 CD109 molecule 0.0395826
INSIG2 insulin induced gene 2 0.0394126
PDIA3 protein disulfide isomerase family A, member 3 0.0393768
TRA2A transformer 2 alpha homolog (Drosophila) 0.0384372
VEGFA vascular endothelial growth factor A 0.0375594
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.037217
FNIP1 folliculin interacting protein 1 0.0368739
FMNL2 formin-like 2 0.036253
SETD5 SET domain containing 5 0.0362351
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0359555
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0359079
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0353289
ATP13A3 ATPase type 13A3 0.0350773
ARHGAP35 Rho GTPase activating protein 35 0.0349084
COPA coatomer protein complex, subunit alpha 0.0344276
ANKRD11 ankyrin repeat domain 11 0.0337541
PTMA prothymosin, alpha 0.0330312
LMAN1 lectin, mannose-binding, 1 0.0327586
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0315383
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0314054
SDCBP syndecan binding protein (syntenin) 0.0311159
LIMS1 LIM and senescent cell antigen-like domains 1 0.030822
SHB Src homology 2 domain containing adaptor protein B 0.0307905
RAB8B RAB8B, member RAS oncogene family 0.030766
RYBP RING1 and YY1 binding protein 0.0305647
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0304818
BTBD9 BTB (POZ) domain containing 9 0.0302894
OGA O-GlcNAcase 0.0300378
SRP54 signal recognition particle 54kDa 0.0299866
DDIT4 DNA-damage-inducible transcript 4 0.0299457
PDIA5 protein disulfide isomerase family A, member 5 0.0297756
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0292734
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0285984
RAD51B RAD51 paralog B 0.0285663
DPYSL2 dihydropyrimidinase-like 2 0.0284956
SPAG9 sperm associated antigen 9 0.0283673
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0282408
ANXA1 annexin A1 0.027606
SEPTIN2 septin 2 0.0274409
AKAP13 A kinase (PRKA) anchor protein 13 0.0274344
SNX3 sorting nexin 3 0.0273959
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0273371
POM121 POM121 transmembrane nucleoporin 0.0272809
KDM3A lysine (K)-specific demethylase 3A 0.0271745
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 0.0271159
YBX1 Y box binding protein 1 0.0270961
RLF rearranged L-myc fusion 0.0270744
RNF145 ring finger protein 145 0.0270101
GOLGA4 golgin A4 0.0269646
NBAS neuroblastoma amplified sequence 0.0269556
ZCCHC7 zinc finger, CCHC domain containing 7 0.0268034
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0265809
ZNF395 zinc finger protein 395 0.0265795
SFXN1 sideroflexin 1 0.0264771

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.198691
TGFBI transforming growth factor, beta-induced, 68kDa -0.161991
HLA-B major histocompatibility complex, class I, B -0.115958
TMSB10 thymosin beta 10 -0.0842523
FN1 fibronectin 1 -0.0794164
HMGA2 high mobility group AT-hook 2 -0.0599671
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0575358
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0545837
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0490417
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0478603
CDK6 cyclin-dependent kinase 6 -0.0470401
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0465652
LOXL2 lysyl oxidase-like 2 -0.0460892
GLIS3 GLIS family zinc finger 3 -0.0455074
RAB7A RAB7A, member RAS oncogene family -0.0453726
IGFBP7 insulin-like growth factor binding protein 7 -0.0434391
MT1X metallothionein 1X -0.043194
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0426422
VCL vinculin -0.0408044
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0407415
AKAP12 A kinase (PRKA) anchor protein 12 -0.0407234
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0382619
AOPEP aminopeptidase O (putative) -0.0370669
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0370073
PRSS23 protease, serine, 23 -0.0365335
EXOC4 exocyst complex component 4 -0.0358771
TNNC1 troponin C type 1 (slow) -0.0356314
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0355643
USP34 ubiquitin specific peptidase 34 -0.0354678
LOX lysyl oxidase -0.0352579
RPL35A ribosomal protein L35a -0.0349953
NKTR natural killer cell triggering receptor -0.034468
PALLD palladin, cytoskeletal associated protein -0.0344332
CLTC clathrin, heavy chain (Hc) -0.034355
HLA-C major histocompatibility complex, class I, C -0.034079
HIP1 huntingtin interacting protein 1 -0.0340398
RASAL2 RAS protein activator like 2 -0.0337931
COL6A2 collagen, type VI, alpha 2 -0.0329097
EIF5B eukaryotic translation initiation factor 5B -0.0325489
MAP4 microtubule-associated protein 4 -0.0323719
SRPK2 SRSF protein kinase 2 -0.0316914
FKBP10 FK506 binding protein 10, 65 kDa -0.0311968
CAV1 caveolin 1, caveolae protein, 22kDa -0.0309339
ZEB2 zinc finger E-box binding homeobox 2 -0.0309092
DNAH11 dynein, axonemal, heavy chain 11 -0.0305818
COL7A1 collagen, type VII, alpha 1 -0.0300361
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0291591
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0287853
FAF1 Fas (TNFRSF6) associated factor 1 -0.0285297
RAI14 retinoic acid induced 14 -0.0282367
TAGLN2 transgelin 2 -0.0278712
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0274305
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0273822
CAVIN1 caveolae associated protein 1 -0.0272601
MT2A metallothionein 2A -0.0269521
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0268979
F3 coagulation factor III (thromboplastin, tissue factor) -0.0266495
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0265946
TIMP1 TIMP metallopeptidase inhibitor 1 -0.026294
TRIM56 tripartite motif containing 56 -0.0262844
IL6 interleukin 6 -0.0262618
NRP1 neuropilin 1 -0.0261093
RSU1 Ras suppressor protein 1 -0.0260869
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0259259
RAB31 RAB31, member RAS oncogene family -0.0254814
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0253877
MBNL1 muscleblind-like splicing regulator 1 -0.0253397
MAPK8 mitogen-activated protein kinase 8 -0.0249482
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase -0.0249343
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0249136
OSMR oncostatin M receptor -0.0247471
VEGFC vascular endothelial growth factor C -0.0244806
ANTXR2 anthrax toxin receptor 2 -0.0244752
COL1A1 collagen, type I, alpha 1 -0.0244593
PDLIM5 PDZ and LIM domain 5 -0.0239364
TRIM9 tripartite motif containing 9 -0.0238816
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0238344
SH3KBP1 SH3-domain kinase binding protein 1 -0.02364
NABP1 nucleic acid binding protein 1 -0.0235679
IGFBP5 insulin-like growth factor binding protein 5 -0.0234036
ZHX3 zinc fingers and homeoboxes 3 -0.02329
UST uronyl-2-sulfotransferase -0.0232828
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0232053
TACC1 transforming, acidic coiled-coil containing protein 1 -0.0230372
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) -0.0229935
MAP1B microtubule-associated protein 1B -0.0229078
ANKRD28 ankyrin repeat domain 28 -0.0226955
NECTIN3 nectin cell adhesion molecule 3 -0.022652
CDKL5 cyclin-dependent kinase-like 5 -0.022645
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.022451
COL6A1 collagen, type VI, alpha 1 -0.0224293
E2F7 E2F transcription factor 7 -0.0224236
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) -0.0223997
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0222779
CDK13 cyclin-dependent kinase 13 -0.021973
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0219479
TMEM87A transmembrane protein 87A -0.02183
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 -0.0217474
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0214621
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 -0.0214583