Fenofibrate_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fenofibrate perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fenofibrate_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LDHA lactate dehydrogenase A 0.126522
DSCAM Down syndrome cell adhesion molecule 0.0982204
PTMA prothymosin, alpha 0.096994
CANX calnexin 0.0892551
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0872101
RBM39 RNA binding motif protein 39 0.0831281
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0786282
WAC WW domain containing adaptor with coiled-coil 0.0770186
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.075796
TRIO trio Rho guanine nucleotide exchange factor 0.0729011
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0720979
ZNF292 zinc finger protein 292 0.0691235
BIRC3 baculoviral IAP repeat containing 3 0.0647252
HOOK2 hook microtubule-tethering protein 2 0.0642556
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.062207
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0597484
GOLGA4 golgin A4 0.0588375
ENO1 enolase 1, (alpha) 0.0576801
HILPDA hypoxia inducible lipid droplet-associated 0.0562509
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0561831
FXR1 fragile X mental retardation, autosomal homolog 1 0.0557332
NUP58 nucleoporin 58 0.0553773
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0515899
ANKRD28 ankyrin repeat domain 28 0.0511997
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.05084
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.050797
ANXA1 annexin A1 0.0501341
KIAA1328 KIAA1328 0.0482252
SMYD3 SET and MYND domain containing 3 0.0478648
MYH9 myosin, heavy chain 9, non-muscle 0.0470327
PICALM phosphatidylinositol binding clathrin assembly protein 0.0467115
SPAG9 sperm associated antigen 9 0.0447801
MBNL1 muscleblind-like splicing regulator 1 0.0443128
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0439843
HELZ helicase with zinc finger 0.0438381
RPL4 ribosomal protein L4 0.0437035
ECT2 epithelial cell transforming 2 0.0435045
RSRC2 arginine/serine-rich coiled-coil 2 0.0432409
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0431516
TPR translocated promoter region, nuclear basket protein 0.0426854
SEPTIN2 septin 2 0.0423679
ZFAND3 zinc finger, AN1-type domain 3 0.0420698
ZC3H11A zinc finger CCCH-type containing 11A 0.04163
PUM2 pumilio RNA-binding family member 2 0.041621
FNIP1 folliculin interacting protein 1 0.0412307
LCORL ligand dependent nuclear receptor corepressor-like 0.0410153
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0410038
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0404003
ANLN anillin, actin binding protein 0.0402425
NIPBL Nipped-B homolog (Drosophila) 0.0397722
NGLY1 N-glycanase 1 0.0395487
CD44 CD44 molecule (Indian blood group) 0.0389761
RSRC1 arginine/serine-rich coiled-coil 1 0.0388647
ZNF638 zinc finger protein 638 0.0387522
UBC ubiquitin C 0.0386511
BIRC6 baculoviral IAP repeat containing 6 0.0385791
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0383299
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0380177
LPP LIM domain containing preferred translocation partner in lipoma 0.0373741
DERA deoxyribose-phosphate aldolase (putative) 0.0373525
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 0.0370281
RAD21 RAD21 homolog (S. pombe) 0.0366851
SEC24A SEC24 family member A 0.0364481
YBX3 Y box binding protein 3 0.036182
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0360257
SET SET nuclear proto-oncogene 0.0354864
KIF5B kinesin family member 5B 0.0353999
MYO9A myosin IXA 0.0351056
CKAP5 cytoskeleton associated protein 5 0.034922
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0348071
IQGAP1 IQ motif containing GTPase activating protein 1 0.0347784
MACF1 microtubule-actin crosslinking factor 1 0.0346768
OGA O-GlcNAcase 0.0346281
TPX2 TPX2, microtubule-associated 0.0342032
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0341537
NAMPT nicotinamide phosphoribosyltransferase 0.0340155
TOP2B topoisomerase (DNA) II beta 180kDa 0.0340036
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.0340022
PKM pyruvate kinase, muscle 0.0339005
PDE8A phosphodiesterase 8A 0.0339001
ATP13A3 ATPase type 13A3 0.0337388
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0336895
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0332795
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0331055
FMNL2 formin-like 2 0.0330891
BZW1 basic leucine zipper and W2 domains 1 0.0330669
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0329961
JMJD1C jumonji domain containing 1C 0.0328477
NAP1L1 nucleosome assembly protein 1-like 1 0.0328337
ZFR zinc finger RNA binding protein 0.032619
PRRC2B proline-rich coiled-coil 2B 0.032442
SEPTIN7 septin 7 0.0319002
TM4SF1 transmembrane 4 L six family member 1 0.0317956
CALR calreticulin 0.0315913
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0314201
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.0314181
MATR3 matrin 3 0.0312118
ANKRD36 ankyrin repeat domain 36 0.0311249
NSD2 nuclear receptor binding SET domain protein 2 0.031064
TNPO1 transportin 1 0.0309101

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0813035
HMGA2 high mobility group AT-hook 2 -0.0595844
NDRG1 N-myc downstream regulated 1 -0.0506111
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0354639
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0340601
RPL35A ribosomal protein L35a -0.0337731
EGFR epidermal growth factor receptor -0.0337546
FTL ferritin, light polypeptide -0.0312415
EGR1 early growth response 1 -0.0300029
IGFBP3 insulin-like growth factor binding protein 3 -0.0292289
AKAP12 A kinase (PRKA) anchor protein 12 -0.0282854
IGF2 insulin-like growth factor 2 -0.0278158
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0267137
PFN1 profilin 1 -0.0264686
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0263675
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0260821
STXBP1 syntaxin binding protein 1 -0.0251887
INTS6 integrator complex subunit 6 -0.025069
RASAL2 RAS protein activator like 2 -0.0250555
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.0249198
ITGAV integrin, alpha V -0.0236145
MYO9B myosin IXB -0.0232916
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 -0.0228202
PRKCA protein kinase C, alpha -0.0224449
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.022357
COL5A1 collagen, type V, alpha 1 -0.0219742
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0219035
AREG amphiregulin -0.0215407
RHOBTB3 Rho-related BTB domain containing 3 -0.0213869
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0209444
RPL23 ribosomal protein L23 -0.0204943
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0204648
RNASEH2A ribonuclease H2, subunit A -0.0204386
CDK6 cyclin-dependent kinase 6 -0.0201629
POTEF POTE ankyrin domain family, member F -0.0199754
PRKD3 protein kinase D3 -0.0199361
FTH1 ferritin, heavy polypeptide 1 -0.0199196
FN1 fibronectin 1 -0.0198963
MT2A metallothionein 2A -0.019711
GDI1 GDP dissociation inhibitor 1 -0.0197102
STC1 stanniocalcin 1 -0.0196192
EXT1 exostosin glycosyltransferase 1 -0.0194718
IL6ST interleukin 6 signal transducer -0.0194364
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0193809
PMP22 peripheral myelin protein 22 -0.0193757
RPLP2 ribosomal protein, large, P2 -0.019255
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0192072
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0191647
PODXL podocalyxin-like -0.0191573
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0191437
KAZN kazrin, periplakin interacting protein -0.019115
IL1RAP interleukin 1 receptor accessory protein -0.0190666
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.018825
BCAR1 breast cancer anti-estrogen resistance 1 -0.0186592
PRSS23 protease, serine, 23 -0.0186435
BICD1 bicaudal D homolog 1 (Drosophila) -0.0186035
ITGB4 integrin, beta 4 -0.0185318
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0183911
PCED1B PC-esterase domain containing 1B -0.0183804
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0182112
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.018039
NOTCH2 notch 2 -0.0178075
MAP3K11 mitogen-activated protein kinase kinase kinase 11 -0.0177219
NALCN sodium leak channel, non selective -0.0176222
ANGPTL4 angiopoietin-like 4 -0.0175693
CEBPB CCAAT/enhancer binding protein (C/EBP), beta -0.0175643
RAI14 retinoic acid induced 14 -0.0175021
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0174167
NUB1 negative regulator of ubiquitin-like proteins 1 -0.0174032
CTIF CBP80/20-dependent translation initiation factor -0.0173865
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0173844
NALF1 NALCN channel auxiliary factor 1 -0.0173296
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0173234
ANKMY1 ankyrin repeat and MYND domain containing 1 -0.0172854
RPS19 ribosomal protein S19 -0.0172798
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.017209
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) -0.0170728
CC2D1B coiled-coil and C2 domain containing 1B -0.0168691
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 -0.0168565
EPC2 enhancer of polycomb homolog 2 (Drosophila) -0.0167691
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.016737
PTPRK protein tyrosine phosphatase, receptor type, K -0.0165712
SUMF1 sulfatase modifying factor 1 -0.0165553
CSNK1E casein kinase 1, epsilon -0.0165448
NSRP1 nuclear speckle splicing regulatory protein 1 -0.0165256
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0164303
GSN gelsolin -0.0162997
LAMA5 laminin, alpha 5 -0.0162756
PXDN peroxidasin -0.0162386
CREB1 cAMP responsive element binding protein 1 -0.0161798
TPCN1 two pore segment channel 1 -0.0161014
SHISA5 shisa family member 5 -0.015971
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.0159414
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0159288
FANCC Fanconi anemia, complementation group C -0.0159245
MAML2 mastermind-like 2 (Drosophila) -0.0158514
GUK1 guanylate kinase 1 -0.0156402
LYRM4 LYR motif containing 4 -0.0155286
IFITM3 interferon induced transmembrane protein 3 -0.015525
PRR16 proline rich 16 -0.0154896