Fenofibrate_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fenofibrate perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fenofibrate_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.179308
NAMPT nicotinamide phosphoribosyltransferase 0.171049
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.163653
FNDC3B fibronectin type III domain containing 3B 0.135404
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.133518
CANX calnexin 0.113975
CXCL8 chemokine (C-X-C motif) ligand 8 0.112125
TRIO trio Rho guanine nucleotide exchange factor 0.108899
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.104105
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.093078
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0887385
VEGFA vascular endothelial growth factor A 0.0769593
SUCO SUN domain containing ossification factor 0.0719233
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0676002
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0667928
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0665322
CD109 CD109 molecule 0.066525
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0664501
AHR aryl hydrocarbon receptor 0.06574
SOD2 superoxide dismutase 2, mitochondrial 0.0652354
ZNF292 zinc finger protein 292 0.0648392
RICTOR RPTOR independent companion of MTOR, complex 2 0.0638106
FAM13A family with sequence similarity 13, member A 0.0635035
OGA O-GlcNAcase 0.0614546
CENPF centromere protein F, 350/400kDa 0.0596027
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0590726
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0586086
PTK2 protein tyrosine kinase 2 0.0582504
RBM39 RNA binding motif protein 39 0.0576046
APLP2 amyloid beta (A4) precursor-like protein 2 0.0575237
HELZ helicase with zinc finger 0.0571173
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0560977
RNF145 ring finger protein 145 0.0560472
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0545963
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0543785
UBC ubiquitin C 0.0540574
COPA coatomer protein complex, subunit alpha 0.0539614
TPR translocated promoter region, nuclear basket protein 0.0531235
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0524549
KMT2C lysine (K)-specific methyltransferase 2C 0.0523075
WAC WW domain containing adaptor with coiled-coil 0.0519523
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0508254
GOLGA4 golgin A4 0.0496964
ITGA1 integrin, alpha 1 0.0493915
EPS8 epidermal growth factor receptor pathway substrate 8 0.0484056
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0483202
MYH9 myosin, heavy chain 9, non-muscle 0.0483133
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0480371
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0475247
RAB1A RAB1A, member RAS oncogene family 0.0474989
HDGF hepatoma-derived growth factor 0.0456295
CALR calreticulin 0.0453446
NEK7 NIMA-related kinase 7 0.0452282
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0448645
TPM3 tropomyosin 3 0.0447546
SEC23A Sec23 homolog A (S. cerevisiae) 0.044658
TM9SF3 transmembrane 9 superfamily member 3 0.0446018
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0444438
TFG TRK-fused gene 0.0443068
DST dystonin 0.0440595
KDM5B lysine (K)-specific demethylase 5B 0.0422536
NAP1L1 nucleosome assembly protein 1-like 1 0.0418652
CALU calumenin 0.041655
RAD21 RAD21 homolog (S. pombe) 0.0413407
ZC3H11A zinc finger CCCH-type containing 11A 0.0412836
SPAG9 sperm associated antigen 9 0.041269
TENT2 terminal nucleotidyltransferase 2 0.0411318
UBA6 ubiquitin-like modifier activating enzyme 6 0.0410418
CSDE1 cold shock domain containing E1, RNA-binding 0.0406053
LCORL ligand dependent nuclear receptor corepressor-like 0.0404837
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0402403
CADM1 cell adhesion molecule 1 0.040051
WDR45B WD repeat domain 45B 0.0399926
ANKRD11 ankyrin repeat domain 11 0.0396376
MCTP2 multiple C2 domains, transmembrane 2 0.03844
RB1CC1 RB1-inducible coiled-coil 1 0.0383372
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0380035
FAT1 FAT atypical cadherin 1 0.0376302
HILPDA hypoxia inducible lipid droplet-associated 0.0375928
NUP58 nucleoporin 58 0.0375193
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0372241
PRRC2C proline-rich coiled-coil 2C 0.0371725
SEC31A SEC31 homolog A (S. cerevisiae) 0.0371575
ACBD3 acyl-CoA binding domain containing 3 0.0371176
ENO1 enolase 1, (alpha) 0.0371112
ANLN anillin, actin binding protein 0.0370929
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.036538
CDC73 cell division cycle 73 0.0363047
BIRC6 baculoviral IAP repeat containing 6 0.0358195
NRIP1 nuclear receptor interacting protein 1 0.0357378
YME1L1 YME1-like 1 ATPase 0.0356065
KMT2E lysine (K)-specific methyltransferase 2E 0.0353923
ETNK1 ethanolamine kinase 1 0.0351375
IRAK3 interleukin-1 receptor-associated kinase 3 0.0345988
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0345961
AFDN afadin, adherens junction formation factor 0.0344798
PDIA6 protein disulfide isomerase family A, member 6 0.0344299
KDM3A lysine (K)-specific demethylase 3A 0.0342277
PRELID2 PRELI domain containing 2 0.0341684
PCBP2 poly(rC) binding protein 2 0.0341506

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.25
FN1 fibronectin 1 -0.120848
NRG1 neuregulin 1 -0.0856591
MT2A metallothionein 2A -0.0717865
TMSB10 thymosin beta 10 -0.0651834
HLA-B major histocompatibility complex, class I, B -0.0634878
FTL ferritin, light polypeptide -0.0588438
NTN4 netrin 4 -0.0421462
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0389037
SOX4 SRY (sex determining region Y)-box 4 -0.0386411
HMGA2 high mobility group AT-hook 2 -0.0385867
RPL35A ribosomal protein L35a -0.0384194
VCL vinculin -0.0369125
TMEM156 transmembrane protein 156 -0.0346472
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0341684
LOC102724023 ES1 protein homolog, mitochondrial -0.0338075
IFI27 interferon, alpha-inducible protein 27 -0.03293
EGR1 early growth response 1 -0.0315299
NDRG1 N-myc downstream regulated 1 -0.0297405
SYT1 synaptotagmin I -0.028236
S100A6 S100 calcium binding protein A6 -0.0277048
PALLD palladin, cytoskeletal associated protein -0.0275182
RPL36 ribosomal protein L36 -0.0265666
TPT1 tumor protein, translationally-controlled 1 -0.0264493
RPS21 ribosomal protein S21 -0.0261073
RPS19 ribosomal protein S19 -0.0260398
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.024876
IFI6 interferon, alpha-inducible protein 6 -0.0229271
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0227056
ACTG1 actin gamma 1 -0.0226822
CTSD cathepsin D -0.0208645
EXT1 exostosin glycosyltransferase 1 -0.020809
RPLP1 ribosomal protein, large, P1 -0.0205715
GLIS3 GLIS family zinc finger 3 -0.0203347
FHL2 four and a half LIM domains 2 -0.0198584
RPLP2 ribosomal protein, large, P2 -0.0192808
VIM vimentin -0.0192191
TSHZ2 teashirt zinc finger homeobox 2 -0.0187725
RPL34 ribosomal protein L34 -0.0186312
TENM4 teneurin transmembrane protein 4 -0.0185722
RPS29 ribosomal protein S29 -0.0182156
RPL28 ribosomal protein L28 -0.017651
RPL31 ribosomal protein L31 -0.0176295
MX2 MX dynamin-like GTPase 2 -0.0174637
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0173801
CLIP2 CAP-GLY domain containing linker protein 2 -0.0164969
ASTN2 astrotactin 2 -0.01602
RASAL2 RAS protein activator like 2 -0.0159609
RPL36A ribosomal protein L36a -0.0158303
RPL11 ribosomal protein L11 -0.015759
IGFBP5 insulin-like growth factor binding protein 5 -0.0155414
RPL37A ribosomal protein L37a -0.0153462
DNAH5 dynein, axonemal, heavy chain 5 -0.0151327
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0150296
LMNA lamin A/C -0.0150271
HMGA1 high mobility group AT-hook 1 -0.0147488
RPS6 ribosomal protein S6 -0.0147075
SFRP1 secreted frizzled-related protein 1 -0.0146045
CTSB cathepsin B -0.0144218
S100A9 S100 calcium binding protein A9 -0.0142851
RPL38 ribosomal protein L38 -0.0141176
RPL36AL ribosomal protein L36a-like -0.0137227
RPS28 ribosomal protein S28 -0.0137212
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0135669
AHNAK2 AHNAK nucleoprotein 2 -0.0134626
RPS20 ribosomal protein S20 -0.0133803
RPL9 ribosomal protein L9 -0.0133606
RPS23 ribosomal protein S23 -0.0131995
PDLIM5 PDZ and LIM domain 5 -0.0130119
IFITM1 interferon induced transmembrane protein 1 -0.0127492
RAB31 RAB31, member RAS oncogene family -0.0127396
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0127144
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0126645
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0125036
ADAM8 ADAM metallopeptidase domain 8 -0.0121772
TNS3 tensin 3 -0.0121359
SLIT2 slit homolog 2 (Drosophila) -0.0121015
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.0119917
TRIM56 tripartite motif containing 56 -0.01193
RPL19 ribosomal protein L19 -0.0118705
RPL12 ribosomal protein L12 -0.0118238
DNAH14 dynein, axonemal, heavy chain 14 -0.011796
S100A10 S100 calcium binding protein A10 -0.0117887
IGFBP3 insulin-like growth factor binding protein 3 -0.0115189
GLCCI1 glucocorticoid induced 1 -0.0114896
PRH1 proline-rich protein HaeIII subfamily 1 -0.0114807
GUK1 guanylate kinase 1 -0.011362
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0112334
RPL23 ribosomal protein L23 -0.0111721
CD63 CD63 molecule -0.0111647
IGF2 insulin-like growth factor 2 -0.0111505
RPLP0 ribosomal protein, large, P0 -0.0110973
RPS27 ribosomal protein S27 -0.0110418
RPL8 ribosomal protein L8 -0.0110394
ETV1 ets variant 1 -0.0110096
TPM4 tropomyosin 4 -0.0109995
UBL5 ubiquitin-like 5 -0.0107166
LTBP1 latent transforming growth factor beta binding protein 1 -0.0106607
TGFB1 transforming growth factor, beta 1 -0.0105219
ATP5MK ATP synthase membrane subunit k -0.0105113