Ferulic acid_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ferulic acid perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ferulic acid_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PODXL podocalyxin-like 0.190091
TRIO trio Rho guanine nucleotide exchange factor 0.183013
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.161803
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.158426
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0947913
FLNB filamin B, beta 0.0918398
MYH9 myosin, heavy chain 9, non-muscle 0.0876394
NAV1 neuron navigator 1 0.0857311
SEPTIN9 septin 9 0.0762415
AKAP12 A kinase (PRKA) anchor protein 12 0.0742381
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0729306
NAV2 neuron navigator 2 0.0700703
FLNA filamin A, alpha 0.0673602
NDRG1 N-myc downstream regulated 1 0.0663903
FBN1 fibrillin 1 0.0660624
BHLHE40 basic helix-loop-helix family, member e40 0.0658783
THBS2 thrombospondin 2 0.0653126
DST dystonin 0.0638007
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0629971
COL5A1 collagen, type V, alpha 1 0.0591466
LOXL2 lysyl oxidase-like 2 0.0582803
TNIP1 TNFAIP3 interacting protein 1 0.0571673
AUTS2 autism susceptibility candidate 2 0.0563787
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0554746
PLEC plectin 0.051932
ELL2 elongation factor, RNA polymerase II, 2 0.048747
RUNX1 runt-related transcription factor 1 0.0472756
MSI2 musashi RNA-binding protein 2 0.0470194
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0455087
APP amyloid beta (A4) precursor protein 0.0443193
SOD2 superoxide dismutase 2, mitochondrial 0.0442148
ZMIZ1 zinc finger, MIZ-type containing 1 0.0416497
DLG1 discs, large homolog 1 (Drosophila) 0.0404899
OGA O-GlcNAcase 0.0403696
ATP13A3 ATPase type 13A3 0.0400048
PSD3 pleckstrin and Sec7 domain containing 3 0.0388026
ZEB1 zinc finger E-box binding homeobox 1 0.0387036
CD109 CD109 molecule 0.0377941
VEGFA vascular endothelial growth factor A 0.0377429
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0374834
C1D C1D nuclear receptor corepressor 0.0373801
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0370162
AHNAK2 AHNAK nucleoprotein 2 0.0366335
NCOR2 nuclear receptor corepressor 2 0.0361103
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0359372
CD44 CD44 molecule (Indian blood group) 0.0359233
NFE2L1 nuclear factor, erythroid 2-like 1 0.0357464
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0354535
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0352492
SLC39A11 solute carrier family 39, member 11 0.034782
HDAC9 histone deacetylase 9 0.034387
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0339596
SLC22A23 solute carrier family 22, member 23 0.0338322
MACF1 microtubule-actin crosslinking factor 1 0.0336223
FBXL7 F-box and leucine-rich repeat protein 7 0.0333725
FNDC3B fibronectin type III domain containing 3B 0.0326943
FRMD4A FERM domain containing 4A 0.0325823
PRELID2 PRELI domain containing 2 0.0320521
MYOF myoferlin 0.0311
GPC6 glypican 6 0.030257
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0300645
SBF2 SET binding factor 2 0.0295626
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0290859
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0290122
WDFY1 WD repeat and FYVE domain containing 1 0.0289624
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0286276
FNIP1 folliculin interacting protein 1 0.0285007
ERRFI1 ERBB receptor feedback inhibitor 1 0.0280885
SHB Src homology 2 domain containing adaptor protein B 0.0279384
AFDN afadin, adherens junction formation factor 0.0279084
SDK1 sidekick cell adhesion molecule 1 0.0274461
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0271408
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0270937
TMOD1 tropomodulin 1 0.0269552
IQSEC1 IQ motif and Sec7 domain 1 0.0268431
RASA3 RAS p21 protein activator 3 0.0266524
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0266078
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0264078
DPYSL3 dihydropyrimidinase-like 3 0.0263202
SQSTM1 sequestosome 1 0.0260867
STK10 serine/threonine kinase 10 0.0258824
ANXA6 annexin A6 0.0248215
MINK1 misshapen-like kinase 1 0.0246899
YEATS2 YEATS domain containing 2 0.0243818
LENG8 leukocyte receptor cluster (LRC) member 8 0.024112
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0238226
STEAP3 STEAP family member 3, metalloreductase 0.0235853
COL18A1 collagen, type XVIII, alpha 1 0.0232432
ANKRD36 ankyrin repeat domain 36 0.0231117
TRAM2 translocation associated membrane protein 2 0.022963
BACE2 beta-site APP-cleaving enzyme 2 0.0229304
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0227331
PFKP phosphofructokinase, platelet 0.0226867
ARRDC3 arrestin domain containing 3 0.0225462
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0225384
ANO6 anoctamin 6 0.0223605
MSN moesin 0.0222694
ANKRD10 ankyrin repeat domain 10 0.0221896
IGF2R insulin-like growth factor 2 receptor 0.0218247
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0216908

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.190104
TMSB10 thymosin beta 10 -0.124489
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.104423
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0837117
MT2A metallothionein 2A -0.0823612
IGFBP3 insulin-like growth factor binding protein 3 -0.0790755
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0655469
FN1 fibronectin 1 -0.0556209
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0554344
MAP1B microtubule-associated protein 1B -0.0537299
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0460523
SAMD9 sterile alpha motif domain containing 9 -0.0442751
S100A10 S100 calcium binding protein A10 -0.0419807
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0393963
S100A6 S100 calcium binding protein A6 -0.0380989
IFITM1 interferon induced transmembrane protein 1 -0.0370212
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0363234
IFITM3 interferon induced transmembrane protein 3 -0.0341045
LOX lysyl oxidase -0.0331906
ABI3BP ABI family, member 3 (NESH) binding protein -0.0319069
SLC38A1 solute carrier family 38, member 1 -0.0303676
CSTB cystatin B (stefin B) -0.0299327
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0288912
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0276609
SP100 SP100 nuclear antigen -0.0266511
MYADM myeloid-associated differentiation marker -0.0264608
SUCNR1 succinate receptor 1 -0.0260857
IFIH1 interferon induced with helicase C domain 1 -0.0254053
FTL ferritin, light polypeptide -0.0249103
MT1X metallothionein 1X -0.0246544
ALCAM activated leukocyte cell adhesion molecule -0.0244076
IFI16 interferon, gamma-inducible protein 16 -0.0242269
RIGI RNA sensor RIG-I -0.0239493
BSG basigin (Ok blood group) -0.0238431
B2M beta-2-microglobulin -0.0238289
POTEF POTE ankyrin domain family, member F -0.0237159
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0233682
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0226907
S100A11 S100 calcium binding protein A11 -0.0226075
TPT1 tumor protein, translationally-controlled 1 -0.0223952
TPM4 tropomyosin 4 -0.0222634
RTN4 reticulon 4 -0.0220192
GNAS GNAS complex locus -0.0211915
RPLP1 ribosomal protein, large, P1 -0.0209515
FGF13 fibroblast growth factor 13 -0.0201717
MTDH metadherin -0.0201648
RPS6 ribosomal protein S6 -0.0199065
SH3KBP1 SH3-domain kinase binding protein 1 -0.01971
LRRC17 leucine rich repeat containing 17 -0.0195304
RPL28 ribosomal protein L28 -0.0191633
PFN1 profilin 1 -0.019162
RPLP2 ribosomal protein, large, P2 -0.0189368
SMC4 structural maintenance of chromosomes 4 -0.0188496
RPL35A ribosomal protein L35a -0.0188084
PRSS23 protease, serine, 23 -0.0187147
OASL 2'-5'-oligoadenylate synthetase-like -0.0185165
HLA-C major histocompatibility complex, class I, C -0.0183257
SEPTIN7 septin 7 -0.0181347
ISG15 ISG15 ubiquitin-like modifier -0.0181116
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0179711
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0178854
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0177554
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0177327
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.01704
HSPB1 heat shock 27kDa protein 1 -0.01685
SEC61G Sec61 gamma subunit -0.0165696
IL7R interleukin 7 receptor -0.0165258
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0163058
IFI6 interferon, alpha-inducible protein 6 -0.0162061
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -0.0160573
CD81 CD81 molecule -0.0158899
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0158124
LDHA lactate dehydrogenase A -0.0156314
CTSD cathepsin D -0.0156097
RPL34 ribosomal protein L34 -0.0155447
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.015528
IFI27 interferon, alpha-inducible protein 27 -0.0154894
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0154424
RBM25 RNA binding motif protein 25 -0.0154311
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.015367
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0152972
DEK DEK proto-oncogene -0.0151764
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.015121
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0150331
RPS24 ribosomal protein S24 -0.0149399
RPS19 ribosomal protein S19 -0.0148735
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.014664
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0144753
VDAC1 voltage-dependent anion channel 1 -0.0144506
PMP22 peripheral myelin protein 22 -0.0143079
BPTF bromodomain PHD finger transcription factor -0.0142256
SORBS2 sorbin and SH3 domain containing 2 -0.0142113
EIF5B eukaryotic translation initiation factor 5B -0.0141044
DSTN destrin (actin depolymerizing factor) -0.0140583
S100A9 S100 calcium binding protein A9 -0.013872
NUCB2 nucleobindin 2 -0.0136689
PCDH7 protocadherin 7 -0.0136466
CCND1 cyclin D1 -0.0136164
ENO1 enolase 1, (alpha) -0.013567
SLC38A2 solute carrier family 38, member 2 -0.0134589