Ferulic acid_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ferulic acid perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ferulic acid_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.0992398
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.099092
EEF2 eukaryotic translation elongation factor 2 0.087681
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0595492
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0593513
ANXA1 annexin A1 0.0555201
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0505109
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0472371
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0469459
TRIO trio Rho guanine nucleotide exchange factor 0.0462107
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0457456
ATP11A ATPase, class VI, type 11A 0.0454311
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0453763
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0450968
MED13L mediator complex subunit 13-like 0.0446848
FAT1 FAT atypical cadherin 1 0.0436474
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0434944
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0434148
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0422565
GASK1B golgi associated kinase 1B 0.0416101
WNK1 WNK lysine deficient protein kinase 1 0.0415095
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0413664
TXNRD1 thioredoxin reductase 1 0.0399091
DST dystonin 0.0387763
YEATS2 YEATS domain containing 2 0.0381861
MYH9 myosin, heavy chain 9, non-muscle 0.0380602
ZNF217 zinc finger protein 217 0.0376845
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.0367376
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0357332
TPM3 tropomyosin 3 0.0356713
XPO1 exportin 1 0.0351594
SRRM2 serine/arginine repetitive matrix 2 0.0345544
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0344945
MACF1 microtubule-actin crosslinking factor 1 0.0342966
HSPA8 heat shock 70kDa protein 8 0.0339258
CSNK1A1 casein kinase 1, alpha 1 0.0333452
NONO non-POU domain containing, octamer-binding 0.0332235
MKI67 marker of proliferation Ki-67 0.0331779
RPL3 ribosomal protein L3 0.0331518
PLEC plectin 0.033127
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0330369
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0326151
TENM3 teneurin transmembrane protein 3 0.032398
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0322668
AXIN2 axin 2 0.0321851
NCAPD2 non-SMC condensin I complex, subunit D2 0.0321738
APP amyloid beta (A4) precursor protein 0.031213
USP9X ubiquitin specific peptidase 9, X-linked 0.0303947
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0301413
LOC112694756 uncharaterized LOC112694756 0.0297988
NEBL nebulette 0.0296643
KMT2D lysine (K)-specific methyltransferase 2D 0.0293318
YAP1 Yes-associated protein 1 0.0293024
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0292504
PDE4B phosphodiesterase 4B, cAMP-specific 0.0290799
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.028979
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0289756
ASPH aspartate beta-hydroxylase 0.0287705
CAMTA1 calmodulin binding transcription activator 1 0.0279271
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0278348
PDGFC platelet derived growth factor C 0.0277697
NUMA1 nuclear mitotic apparatus protein 1 0.0276931
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.027632
EIF4B eukaryotic translation initiation factor 4B 0.0270855
RRM2 ribonucleotide reductase M2 0.0265516
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0262916
CPOX coproporphyrinogen oxidase 0.0262542
FLNA filamin A, alpha 0.026066
TMEM41B transmembrane protein 41B 0.0260373
MMP12 matrix metallopeptidase 12 0.0257926
SMYD3 SET and MYND domain containing 3 0.0257509
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0255434
TBC1D5 TBC1 domain family, member 5 0.0253875
WWOX WW domain containing oxidoreductase 0.0252104
EIF4A2 eukaryotic translation initiation factor 4A2 0.02452
MTCL1 microtubule crosslinking factor 1 0.0244777
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 0.0240174
NPC1 Niemann-Pick disease, type C1 0.0238857
ANKRD36 ankyrin repeat domain 36 0.0238845
ZNF292 zinc finger protein 292 0.0237026
NHSL1 NHS-like 1 0.0236341
PRELID2 PRELI domain containing 2 0.0234848
SET SET nuclear proto-oncogene 0.0233466
CLTC clathrin, heavy chain (Hc) 0.0232086
ZBTB20 zinc finger and BTB domain containing 20 0.0229889
ARRDC3 arrestin domain containing 3 0.02298
MSI2 musashi RNA-binding protein 2 0.0229367
PNN pinin, desmosome associated protein 0.0228968
KLC1 kinesin light chain 1 0.0227809
HSPA4 heat shock 70kDa protein 4 0.02273
FUS FUS RNA binding protein 0.0225911
DSPP dentin sialophosphoprotein 0.0223022
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.022301
KCMF1 potassium channel modulatory factor 1 0.0222673
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0219664
KDM3A lysine (K)-specific demethylase 3A 0.0219137
YBX1 Y box binding protein 1 0.0216602
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.0216055
CEP192 centrosomal protein 192kDa 0.0215366
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0215022

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.156486
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.130928
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0848522
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0583212
FTL ferritin, light polypeptide -0.0562845
TMSB10 thymosin beta 10 -0.0544315
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0533446
MYL12B myosin, light chain 12B, regulatory -0.0505185
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0470158
NLGN1 neuroligin 1 -0.040225
CCND1 cyclin D1 -0.034262
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0334542
RPLP1 ribosomal protein, large, P1 -0.0331034
TPT1 tumor protein, translationally-controlled 1 -0.0321986
LOC102724023 ES1 protein homolog, mitochondrial -0.0318285
RPS6 ribosomal protein S6 -0.0317679
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0290559
SMC4 structural maintenance of chromosomes 4 -0.0285661
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0282543
ZNF804A zinc finger protein 804A -0.0282239
HSPB1 heat shock 27kDa protein 1 -0.0270821
HMGA2 high mobility group AT-hook 2 -0.0268985
DDIT3 DNA-damage-inducible transcript 3 -0.026126
RPL35A ribosomal protein L35a -0.0260518
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0245192
BIRC3 baculoviral IAP repeat containing 3 -0.024517
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0238215
IFIH1 interferon induced with helicase C domain 1 -0.0235884
AREG amphiregulin -0.0232506
RAB7A RAB7A, member RAS oncogene family -0.0231438
VDAC1 voltage-dependent anion channel 1 -0.0225893
ATP5F1B ATP synthase F1 subunit beta -0.0224283
CLDN1 claudin 1 -0.0220469
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0218712
PHACTR4 phosphatase and actin regulator 4 -0.0207227
RPS24 ribosomal protein S24 -0.0204183
TUBA1B tubulin, alpha 1b -0.0203942
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0201416
SLC38A2 solute carrier family 38, member 2 -0.020032
DPYD dihydropyrimidine dehydrogenase -0.0199553
PTMA prothymosin, alpha -0.0196533
RPLP2 ribosomal protein, large, P2 -0.0193989
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.019318
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0191073
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0190013
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0188916
JMJD1C jumonji domain containing 1C -0.0188372
CCDC88A coiled-coil domain containing 88A -0.0186552
U2SURP U2 snRNP-associated SURP domain containing -0.0186175
RPL34 ribosomal protein L34 -0.0181909
CNRIP1 cannabinoid receptor interacting protein 1 -0.0179596
FBXO11 F-box protein 11 -0.0179135
EIF5B eukaryotic translation initiation factor 5B -0.017856
RPL31 ribosomal protein L31 -0.0177747
INTS6 integrator complex subunit 6 -0.0177061
PFN1 profilin 1 -0.0172578
NABP1 nucleic acid binding protein 1 -0.0168839
MSRB3 methionine sulfoxide reductase B3 -0.0166882
RPL12 ribosomal protein L12 -0.0164058
RPL28 ribosomal protein L28 -0.0162574
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0162469
RTN3 reticulon 3 -0.0157265
LRRC23 leucine rich repeat containing 23 -0.0153498
STAU1 staufen double-stranded RNA binding protein 1 -0.0153262
TSC22D2 TSC22 domain family, member 2 -0.0152906
RPL27A ribosomal protein L27a -0.015217
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -0.0152161
RPS16 ribosomal protein S16 -0.015177
HMGA1 high mobility group AT-hook 1 -0.0150232
RPS19 ribosomal protein S19 -0.0149992
PTMS parathymosin -0.0148391
POTEF POTE ankyrin domain family, member F -0.014766
GNAS GNAS complex locus -0.0147642
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0147361
RPL8 ribosomal protein L8 -0.0146636
RPS20 ribosomal protein S20 -0.0145607
RPS14 ribosomal protein S14 -0.0144347
ADIPOR2 adiponectin receptor 2 -0.0143994
TTC3 tetratricopeptide repeat domain 3 -0.0142873
RPS29 ribosomal protein S29 -0.0139781
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0137168
NBEAL1 neurobeachin-like 1 -0.0136818
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0136102
RPS5 ribosomal protein S5 -0.0135274
CSMD3 CUB and Sushi multiple domains 3 -0.0133777
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0133042
USP15 ubiquitin specific peptidase 15 -0.0132489
BPTF bromodomain PHD finger transcription factor -0.0130461
RPS2 ribosomal protein S2 -0.0129639
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0129435
HMGB1 high mobility group box 1 -0.0127851
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0126682
RPL39 ribosomal protein L39 -0.0126295
RLF rearranged L-myc fusion -0.0125495
RAB10 RAB10, member RAS oncogene family -0.0123462
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0122739
S100A11 S100 calcium binding protein A11 -0.0122711
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0122026
KPNB1 karyopherin (importin) beta 1 -0.0121947
TBCA tubulin folding cofactor A -0.0121545