Ferulic acid_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ferulic acid perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ferulic acid_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.132035
NDRG1 N-myc downstream regulated 1 0.128974
MYH9 myosin, heavy chain 9, non-muscle 0.127565
FLNB filamin B, beta 0.110797
SMAD3 SMAD family member 3 0.109141
TNIP1 TNFAIP3 interacting protein 1 0.0997877
EEF2 eukaryotic translation elongation factor 2 0.097844
PLEC plectin 0.0973194
ANKRD11 ankyrin repeat domain 11 0.0968542
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0877873
PABPC1 poly(A) binding protein, cytoplasmic 1 0.082334
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0773717
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0754318
GRB10 growth factor receptor-bound protein 10 0.0739423
MSN moesin 0.0735405
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0637383
FLNA filamin A, alpha 0.061035
SHB Src homology 2 domain containing adaptor protein B 0.0575062
PKM pyruvate kinase, muscle 0.0570523
BHLHE40 basic helix-loop-helix family, member e40 0.0556394
NAV2 neuron navigator 2 0.0537985
MCL1 myeloid cell leukemia 1 0.0518097
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0510689
RPL3 ribosomal protein L3 0.0499193
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0498884
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0496949
EGR1 early growth response 1 0.0495265
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0493971
SEPTIN9 septin 9 0.0486524
FMNL2 formin-like 2 0.0474783
TNS1 tensin 1 0.046599
MACF1 microtubule-actin crosslinking factor 1 0.0452041
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0451751
AUTS2 autism susceptibility candidate 2 0.0447561
ADAM17 ADAM metallopeptidase domain 17 0.0443966
NUP58 nucleoporin 58 0.0435665
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0428724
POTEF POTE ankyrin domain family, member F 0.0425634
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0423935
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0412059
VEGFA vascular endothelial growth factor A 0.0409959
PTK2 protein tyrosine kinase 2 0.0406328
HELZ helicase with zinc finger 0.0402188
SPAG9 sperm associated antigen 9 0.0400309
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0396446
UBA6 ubiquitin-like modifier activating enzyme 6 0.0378774
C1D C1D nuclear receptor corepressor 0.0372654
COPA coatomer protein complex, subunit alpha 0.0369338
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0368582
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0363978
LENG8 leukocyte receptor cluster (LRC) member 8 0.0357836
EPAS1 endothelial PAS domain protein 1 0.0349058
NONO non-POU domain containing, octamer-binding 0.0347082
CTBP2 C-terminal binding protein 2 0.0345683
KRT18 keratin 18, type I 0.0343276
WAC WW domain containing adaptor with coiled-coil 0.0336901
ARL5B ADP-ribosylation factor-like 5B 0.0334154
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0333653
MKI67 marker of proliferation Ki-67 0.0333216
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0327278
RPS3 ribosomal protein S3 0.0325201
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0324398
AXL AXL receptor tyrosine kinase 0.032331
BCL2L1 BCL2-like 1 0.0320645
MINK1 misshapen-like kinase 1 0.0316617
SAMD4A sterile alpha motif domain containing 4A 0.0316346
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0315916
STC1 stanniocalcin 1 0.0314479
PFN1 profilin 1 0.0309011
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0304077
TPM3 tropomyosin 3 0.0301847
DDIT4 DNA-damage-inducible transcript 4 0.0301314
ACTN1 actinin, alpha 1 0.0300999
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0300472
MED15 mediator complex subunit 15 0.0298902
CD44 CD44 molecule (Indian blood group) 0.0295883
LTBP4 latent transforming growth factor beta binding protein 4 0.0293665
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.029337
TBC1D22A TBC1 domain family, member 22A 0.0288962
ZMIZ1 zinc finger, MIZ-type containing 1 0.0287963
FAM13A family with sequence similarity 13, member A 0.0285896
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0285253
KDM6A lysine (K)-specific demethylase 6A 0.0285157
FOSL1 FOS-like antigen 1 0.0279906
MT2A metallothionein 2A 0.0279588
PARD3 par-3 family cell polarity regulator 0.0279414
FNDC3B fibronectin type III domain containing 3B 0.0277975
PTPRF protein tyrosine phosphatase, receptor type, F 0.0277586
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0277253
MYO10 myosin X 0.0272776
PCBP2 poly(rC) binding protein 2 0.0271964
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.027111
HDGF hepatoma-derived growth factor 0.0269646
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0269463
PRPF8 pre-mRNA processing factor 8 0.0268917
USP3 ubiquitin specific peptidase 3 0.0267203
KCTD9 potassium channel tetramerization domain containing 9 0.0266311
RAD23B RAD23 homolog B (S. cerevisiae) 0.0265708
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0264193
DUSP5 dual specificity phosphatase 5 0.0260519

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.100583
PDE4D phosphodiesterase 4D, cAMP-specific -0.0811495
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0789362
KYNU kynureninase -0.077144
AKAP12 A kinase (PRKA) anchor protein 12 -0.0691656
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0680435
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0678226
OSMR oncostatin M receptor -0.0635683
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.062327
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0618475
NCOA7 nuclear receptor coactivator 7 -0.0582545
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0554112
BASP1 brain abundant, membrane attached signal protein 1 -0.0534885
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0517688
IGFBP4 insulin-like growth factor binding protein 4 -0.0503224
TPT1 tumor protein, translationally-controlled 1 -0.048075
FTH1 ferritin, heavy polypeptide 1 -0.046604
RPL4 ribosomal protein L4 -0.0463135
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0455379
TXNRD1 thioredoxin reductase 1 -0.0449818
TM4SF1 transmembrane 4 L six family member 1 -0.0436006
ZBTB20 zinc finger and BTB domain containing 20 -0.0433708
EHBP1 EH domain binding protein 1 -0.0433271
TMSB10 thymosin beta 10 -0.0432739
AHNAK AHNAK nucleoprotein -0.0426035
RPS24 ribosomal protein S24 -0.0419437
RPLP1 ribosomal protein, large, P1 -0.0417252
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0329595
RRBP1 ribosome binding protein 1 -0.0328627
BTG1 B-cell translocation gene 1, anti-proliferative -0.0318686
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0309749
C15ORF48 chromosome 15 open reading frame 48 -0.0308998
GLIS3 GLIS family zinc finger 3 -0.0307494
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0305023
PDE10A phosphodiesterase 10A -0.0296442
EFNA5 ephrin-A5 -0.0295313
RPS16 ribosomal protein S16 -0.0292085
TAS2R14 taste receptor, type 2, member 14 -0.02879
RAI14 retinoic acid induced 14 -0.0282374
RIGI RNA sensor RIG-I -0.0282027
CA12 carbonic anhydrase XII -0.028163
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0278311
S100A6 S100 calcium binding protein A6 -0.0274368
BICC1 BicC family RNA binding protein 1 -0.0273895
NAP1L1 nucleosome assembly protein 1-like 1 -0.0269843
CEP95 centrosomal protein 95kDa -0.0268838
RPL12 ribosomal protein L12 -0.0265386
BMAL2 basic helix-loop-helix ARNT like 2 -0.0262485
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0261435
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0254322
SLC38A1 solute carrier family 38, member 1 -0.0244932
FBXL2 F-box and leucine-rich repeat protein 2 -0.0241697
IGF1R insulin-like growth factor 1 receptor -0.0240235
BZW1 basic leucine zipper and W2 domains 1 -0.0237095
CLDN1 claudin 1 -0.0233114
NRP1 neuropilin 1 -0.0231147
MYO9A myosin IXA -0.0227027
AKR1C2 aldo-keto reductase family 1, member C2 -0.0226985
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0225825
BIRC3 baculoviral IAP repeat containing 3 -0.0221921
LDHA lactate dehydrogenase A -0.0221709
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0220492
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0219861
GCC2 GRIP and coiled-coil domain containing 2 -0.0211821
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0211607
BMERB1 bMERB domain containing 1 -0.0208965
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0206357
PMP22 peripheral myelin protein 22 -0.0205904
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0202332
UBB ubiquitin B -0.0201649
GPRIN3 GPRIN family member 3 -0.0201168
ZC3H12C zinc finger CCCH-type containing 12C -0.0200535
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0198436
RAD21 RAD21 homolog (S. pombe) -0.0196394
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0194342
RBBP6 retinoblastoma binding protein 6 -0.0194156
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0190451
PLSCR1 phospholipid scramblase 1 -0.0188555
NF1 neurofibromin 1 -0.0188535
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 -0.0188322
SBF2 SET binding factor 2 -0.0187318
RPL26 ribosomal protein L26 -0.0186969
RIC8B RIC8 guanine nucleotide exchange factor B -0.0186321
HLA-E major histocompatibility complex, class I, E -0.0185828
GNAS GNAS complex locus -0.0183274
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -0.0182622
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0180954
EXOC6B exocyst complex component 6B -0.0180605
ABLIM1 actin binding LIM protein 1 -0.0180032
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0180008
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0179647
NAMPT nicotinamide phosphoribosyltransferase -0.0171033
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0170125
SAMD9 sterile alpha motif domain containing 9 -0.016903
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0168718
EVA1C eva-1 homolog C (C. elegans) -0.0167323
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0166536
ETV6 ets variant 6 -0.0166417
RSPO3 R-spondin 3 -0.0166333
SCLT1 sodium channel and clathrin linker 1 -0.0164726