Ferulic acid_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ferulic acid perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ferulic acid_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CEP250 centrosomal protein 250kDa 0.0845672
NCOA3 nuclear receptor coactivator 3 0.0807795
VMP1 vacuole membrane protein 1 0.0708964
ERBB2 erb-b2 receptor tyrosine kinase 2 0.0635708
MYH9 myosin, heavy chain 9, non-muscle 0.0635046
GRB10 growth factor receptor-bound protein 10 0.0609643
CLTC clathrin, heavy chain (Hc) 0.0592562
DTNA dystrobrevin, alpha 0.0500717
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0477972
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0466188
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0457425
TRIO trio Rho guanine nucleotide exchange factor 0.0453997
NDRG1 N-myc downstream regulated 1 0.0441909
MSI2 musashi RNA-binding protein 2 0.042477
PRRC2B proline-rich coiled-coil 2B 0.0422994
PLEC plectin 0.0420148
SRCIN1 SRC kinase signaling inhibitor 1 0.0411721
ITCH itchy E3 ubiquitin protein ligase 0.0410622
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0408888
THSD4 thrombospondin, type I, domain containing 4 0.0408005
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0393462
KIAA1217 KIAA1217 0.0393321
LASP1 LIM and SH3 protein 1 0.0391043
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.038757
SHROOM3 shroom family member 3 0.0382401
FBXL20 F-box and leucine-rich repeat protein 20 0.0371175
VEGFA vascular endothelial growth factor A 0.0360552
GSE1 Gse1 coiled-coil protein 0.0356577
LPP LIM domain containing preferred translocation partner in lipoma 0.03558
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0351189
KIF16B kinesin family member 16B 0.0337359
ELOVL5 ELOVL fatty acid elongase 5 0.0310425
KMT2C lysine (K)-specific methyltransferase 2C 0.0306077
YAP1 Yes-associated protein 1 0.0305389
IGFBP5 insulin-like growth factor binding protein 5 0.0300612
PBX1 pre-B-cell leukemia homeobox 1 0.0297695
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0296747
HSPA8 heat shock 70kDa protein 8 0.0284977
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.02831
MCL1 myeloid cell leukemia 1 0.027601
ACTN4 actinin, alpha 4 0.0275663
KIF1A kinesin family member 1A 0.0271326
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0265238
WAC WW domain containing adaptor with coiled-coil 0.0264358
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.026405
MLPH melanophilin 0.0262241
PDLIM5 PDZ and LIM domain 5 0.0261357
VCP valosin containing protein 0.0260602
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0253865
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0251201
SLC22A23 solute carrier family 22, member 23 0.0246408
FAM168A family with sequence similarity 168, member A 0.0245972
PTPRK protein tyrosine phosphatase, receptor type, K 0.0245601
CSNK1A1 casein kinase 1, alpha 1 0.0242317
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0242186
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.023794
MYO5B myosin VB 0.0231267
UNC13B unc-13 homolog B (C. elegans) 0.0229063
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0228345
CCNY cyclin Y 0.0224177
ACACA acetyl-CoA carboxylase alpha 0.022361
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0221451
ZMIZ1 zinc finger, MIZ-type containing 1 0.0219007
KRT8 keratin 8, type II 0.0218018
FLNA filamin A, alpha 0.0217032
SREBF2 sterol regulatory element binding transcription factor 2 0.0215849
NCOR2 nuclear receptor corepressor 2 0.0213437
LRRC59 leucine rich repeat containing 59 0.0213087
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.020918
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0206226
SHB Src homology 2 domain containing adaptor protein B 0.0202002
NCOA6 nuclear receptor coactivator 6 0.0200391
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.0199777
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0198936
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0198248
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0198117
KAT7 K(lysine) acetyltransferase 7 0.019679
RCOR1 REST corepressor 1 0.0194944
USP9X ubiquitin specific peptidase 9, X-linked 0.0194067
CEMIP cell migration inducing protein, hyaluronan binding 0.0193905
CTNND1 catenin (cadherin-associated protein), delta 1 0.0191904
PTK2 protein tyrosine kinase 2 0.0191828
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0187854
WDR1 WD repeat domain 1 0.0183604
ZFAND3 zinc finger, AN1-type domain 3 0.0182378
ACTN1 actinin, alpha 1 0.0180193
FAM219A family with sequence similarity 219, member A 0.0180038
ENAH enabled homolog (Drosophila) 0.0180001
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 0.0179707
SGMS1 sphingomyelin synthase 1 0.0177804
DENND5A DENN/MADD domain containing 5A 0.0177073
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0176789
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) 0.0176525
COPA coatomer protein complex, subunit alpha 0.0175365
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0174933
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0174771
MARK2 MAP/microtubule affinity-regulating kinase 2 0.0174104
KDM6A lysine (K)-specific demethylase 6A 0.0173874
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0173409
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0172116

decreased expression

Symbol Name Standardized Value
RPL23 ribosomal protein L23 -0.168813
RPL19 ribosomal protein L19 -0.143494
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0683671
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0647776
PTMA prothymosin, alpha -0.0641483
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0636029
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0633417
ASPH aspartate beta-hydroxylase -0.0624838
RPL35A ribosomal protein L35a -0.0504588
MT2A metallothionein 2A -0.0496936
TPT1 tumor protein, translationally-controlled 1 -0.0492934
FTH1 ferritin, heavy polypeptide 1 -0.0477788
TMSB10 thymosin beta 10 -0.0451868
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0442318
CCNI cyclin I -0.0364177
S100A8 S100 calcium binding protein A8 -0.0340465
RPS19 ribosomal protein S19 -0.0331314
RPL12 ribosomal protein L12 -0.0325305
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0317625
S100A9 S100 calcium binding protein A9 -0.0315221
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0308124
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0305254
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0299011
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0284879
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0277374
RPS8 ribosomal protein S8 -0.0263125
RPLP1 ribosomal protein, large, P1 -0.0256421
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0253412
MYL12B myosin, light chain 12B, regulatory -0.0247691
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0247168
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -0.0241512
RPL8 ribosomal protein L8 -0.0234774
RPL31 ribosomal protein L31 -0.0232309
ARID5B AT rich interactive domain 5B (MRF1-like) -0.022805
NCOA7 nuclear receptor coactivator 7 -0.0227478
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -0.0225383
EIF1 eukaryotic translation initiation factor 1 -0.0225021
VIM vimentin -0.0222634
S100A6 S100 calcium binding protein A6 -0.0222396
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0214491
RPS24 ribosomal protein S24 -0.0213918
PFDN4 prefoldin subunit 4 -0.0213058
AREG amphiregulin -0.0212068
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0210903
AHNAK AHNAK nucleoprotein -0.0207935
NTN4 netrin 4 -0.0207673
RPS6 ribosomal protein S6 -0.0201045
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0198726
IER3 immediate early response 3 -0.0197401
RPL35 ribosomal protein L35 -0.0196735
RPL34 ribosomal protein L34 -0.0195708
PDE4D phosphodiesterase 4D, cAMP-specific -0.0192916
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0192169
DSG2 desmoglein 2 -0.0190177
KIF5B kinesin family member 5B -0.0189208
DYNLRB1 dynein, light chain, roadblock-type 1 -0.0188817
RPS3 ribosomal protein S3 -0.0187787
RAD21 RAD21 homolog (S. pombe) -0.0187734
TUBA1B tubulin, alpha 1b -0.0182602
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0181329
NAMPT nicotinamide phosphoribosyltransferase -0.0180903
GATA3 GATA binding protein 3 -0.0179492
PRR11 proline rich 11 -0.0176574
ALCAM activated leukocyte cell adhesion molecule -0.0175324
PRRC2C proline-rich coiled-coil 2C -0.0175263
HMGB1 high mobility group box 1 -0.017426
RPL7A ribosomal protein L7a -0.0173366
RPS14 ribosomal protein S14 -0.0173026
RPS27A ribosomal protein S27a -0.0173013
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.017296
OSMR oncostatin M receptor -0.0172034
DPYD dihydropyrimidine dehydrogenase -0.0171169
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0170163
CBX3 chromobox homolog 3 -0.0170049
YBX1 Y box binding protein 1 -0.0169595
SPTSSA serine palmitoyltransferase, small subunit A -0.0168145
RIMS2 regulating synaptic membrane exocytosis 2 -0.0167254
TNIK TRAF2 and NCK interacting kinase -0.0166824
SLFN5 schlafen family member 5 -0.0166653
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0164347
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0162253
PERP PERP, TP53 apoptosis effector -0.016205
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0161945
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0161278
NDUFA4 NDUFA4, mitochondrial complex associated -0.0159777
RPL9 ribosomal protein L9 -0.0157508
UBC ubiquitin C -0.0156823
GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 -0.0156136
SMIM14 small integral membrane protein 14 -0.0155017
S100A11 S100 calcium binding protein A11 -0.015483
BPTF bromodomain PHD finger transcription factor -0.0154766
PARP1 poly (ADP-ribose) polymerase 1 -0.0154706
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0153709
RPS27 ribosomal protein S27 -0.0150113
NF1 neurofibromin 1 -0.0150004
SNX6 sorting nexin 6 -0.0149612
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0149363
KLF6 Kruppel-like factor 6 -0.0149153
TUBB tubulin, beta class I -0.014803
MAP4 microtubule-associated protein 4 -0.0147755