Ferulic acid_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ferulic acid perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ferulic acid_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.230349
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.19948
P4HB prolyl 4-hydroxylase, beta polypeptide 0.181561
EEF2 eukaryotic translation elongation factor 2 0.14159
MYH9 myosin, heavy chain 9, non-muscle 0.120684
NDRG1 N-myc downstream regulated 1 0.104139
LOC112694756 uncharaterized LOC112694756 0.102868
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.101884
GOLGA4 golgin A4 0.0899042
ZNF292 zinc finger protein 292 0.0726867
PRELID2 PRELI domain containing 2 0.0708971
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0693365
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0688006
CANX calnexin 0.0638772
TXNRD1 thioredoxin reductase 1 0.0600189
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0582973
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0579702
DDIT4 DNA-damage-inducible transcript 4 0.0574821
HDLBP high density lipoprotein binding protein 0.0568384
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0564026
VEGFA vascular endothelial growth factor A 0.0554836
HELZ helicase with zinc finger 0.0521883
NUP58 nucleoporin 58 0.0519373
KRT18 keratin 18, type I 0.0510818
PLEC plectin 0.0508629
RPL3 ribosomal protein L3 0.0503597
TBC1D22A TBC1 domain family, member 22A 0.0499933
YEATS2 YEATS domain containing 2 0.0497219
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.046956
SEC31A SEC31 homolog A (S. cerevisiae) 0.0468731
FTL ferritin, light polypeptide 0.0456819
ANKRD12 ankyrin repeat domain 12 0.0455011
CDK19 cyclin-dependent kinase 19 0.0450796
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0438764
ARL5B ADP-ribosylation factor-like 5B 0.0436815
ACBD3 acyl-CoA binding domain containing 3 0.04344
KRT8 keratin 8, type II 0.0433417
OGA O-GlcNAcase 0.0430499
ERRFI1 ERBB receptor feedback inhibitor 1 0.0429341
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0419027
CSNK1A1 casein kinase 1, alpha 1 0.0413474
GOLGA2 golgin A2 0.0410177
COPA coatomer protein complex, subunit alpha 0.0402595
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0401097
ANKRD11 ankyrin repeat domain 11 0.0397125
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0395702
TTC3 tetratricopeptide repeat domain 3 0.0391377
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.038883
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0387571
MKI67 marker of proliferation Ki-67 0.0385464
SUCO SUN domain containing ossification factor 0.0380839
SRRM2 serine/arginine repetitive matrix 2 0.0377807
KDM4C lysine (K)-specific demethylase 4C 0.0377413
GOLGB1 golgin B1 0.0374009
MATR3 matrin 3 0.0372924
TMF1 TATA element modulatory factor 1 0.0372363
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.037182
NBAS neuroblastoma amplified sequence 0.036923
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0366593
BRD2 bromodomain containing 2 0.0365593
WSB1 WD repeat and SOCS box containing 1 0.0364418
EIF1 eukaryotic translation initiation factor 1 0.0362158
PGK1 phosphoglycerate kinase 1 0.0350808
KMT2C lysine (K)-specific methyltransferase 2C 0.0347538
GARS1 glycyl-tRNA synthetase 1 0.0344567
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0343795
AKAP9 A kinase (PRKA) anchor protein 9 0.0343361
PDIA3 protein disulfide isomerase family A, member 3 0.0342721
DSCAM Down syndrome cell adhesion molecule 0.0340342
WDR45B WD repeat domain 45B 0.033921
RAD23B RAD23 homolog B (S. cerevisiae) 0.033829
MED15 mediator complex subunit 15 0.0335392
RAB1A RAB1A, member RAS oncogene family 0.0332947
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0332611
INSIG2 insulin induced gene 2 0.0328057
UBA6 ubiquitin-like modifier activating enzyme 6 0.0327812
SEPTIN2 septin 2 0.0326667
WDR26 WD repeat domain 26 0.0324369
SON SON DNA binding protein 0.0322945
TMEM41B transmembrane protein 41B 0.0322582
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0321483
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0319217
SREBF2 sterol regulatory element binding transcription factor 2 0.0317344
TMED2 transmembrane emp24 domain trafficking protein 2 0.0315398
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0312497
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0311841
TOR1AIP2 torsin A interacting protein 2 0.0311836
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0309985
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0309736
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0305937
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.0304261
COPB1 coatomer protein complex, subunit beta 1 0.030368
ZNF638 zinc finger protein 638 0.0303314
PLAUR plasminogen activator, urokinase receptor 0.0301699
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0301348
PGM3 phosphoglucomutase 3 0.0299487
SRP54 signal recognition particle 54kDa 0.0297825
ARF4 ADP-ribosylation factor 4 0.0297456
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0294512
BHLHE40 basic helix-loop-helix family, member e40 0.0294383

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.167441
PTMA prothymosin, alpha -0.118374
TPT1 tumor protein, translationally-controlled 1 -0.0946134
FAT1 FAT atypical cadherin 1 -0.0695249
AHNAK AHNAK nucleoprotein -0.0617473
RPL35A ribosomal protein L35a -0.0422585
CCND1 cyclin D1 -0.0416099
INTS6 integrator complex subunit 6 -0.0393586
RPS24 ribosomal protein S24 -0.0377423
TMSB10 thymosin beta 10 -0.0366287
VCL vinculin -0.0360075
SERINC5 serine incorporator 5 -0.0349149
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0326892
CADPS Ca++-dependent secretion activator -0.0324987
LRRC23 leucine rich repeat containing 23 -0.0321393
POTEF POTE ankyrin domain family, member F -0.0313518
HMGA2 high mobility group AT-hook 2 -0.0309357
RPS6 ribosomal protein S6 -0.0305612
FRMD5 FERM domain containing 5 -0.0300538
ACTG1 actin gamma 1 -0.0289735
RPLP1 ribosomal protein, large, P1 -0.0278778
RPLP2 ribosomal protein, large, P2 -0.0267217
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0257053
WWOX WW domain containing oxidoreductase -0.0249087
FHIT fragile histidine triad -0.0247676
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.024576
PKM pyruvate kinase, muscle -0.0241983
ZNRF3 zinc and ring finger 3 -0.0240633
TUBA1B tubulin, alpha 1b -0.0237737
HMGB1 high mobility group box 1 -0.0234074
NOP56 NOP56 ribonucleoprotein -0.023396
PTPRK protein tyrosine phosphatase, receptor type, K -0.0230609
RPS25 ribosomal protein S25 -0.0228596
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0222864
EGR1 early growth response 1 -0.0218674
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0212553
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0211284
LDHB lactate dehydrogenase B -0.0211225
CCDC138 coiled-coil domain containing 138 -0.0211173
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0209446
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0207712
RPL31 ribosomal protein L31 -0.0205511
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0202668
S100A6 S100 calcium binding protein A6 -0.0196025
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0195242
RPL34 ribosomal protein L34 -0.019511
IFITM3 interferon induced transmembrane protein 3 -0.0192075
CUX1 cut-like homeobox 1 -0.0190526
GMDS GDP-mannose 4,6-dehydratase -0.0189557
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0188731
HELLS helicase, lymphoid-specific -0.0188241
FAF1 Fas (TNFRSF6) associated factor 1 -0.0187755
RPL38 ribosomal protein L38 -0.0181535
RPS15 ribosomal protein S15 -0.0181258
FOXP1 forkhead box P1 -0.0180728
RPS16 ribosomal protein S16 -0.0178992
HLA-A major histocompatibility complex, class I, A -0.017611
RPS29 ribosomal protein S29 -0.0172647
PERP PERP, TP53 apoptosis effector -0.0171164
MTAP methylthioadenosine phosphorylase -0.01709
FMNL2 formin-like 2 -0.0169548
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0167453
GPHN gephyrin -0.0167193
UBB ubiquitin B -0.0165663
GPC5 glypican 5 -0.0164739
RANBP17 RAN binding protein 17 -0.0163179
RPL36A ribosomal protein L36a -0.0161299
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0161263
RPS20 ribosomal protein S20 -0.0160574
STMN1 stathmin 1 -0.0160133
MORC4 MORC family CW-type zinc finger 4 -0.0159873
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0158733
TPM4 tropomyosin 4 -0.0158399
NPR2 natriuretic peptide receptor 2 -0.0156506
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0155815
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0154805
EIF5B eukaryotic translation initiation factor 5B -0.0153975
EPCAM epithelial cell adhesion molecule -0.0152502
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0151858
EHBP1 EH domain binding protein 1 -0.0151803
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0151741
MRPS6 mitochondrial ribosomal protein S6 -0.0150942
TGFB1 transforming growth factor, beta 1 -0.0150576
IGFBP4 insulin-like growth factor binding protein 4 -0.0149751
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0148891
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -0.0147446
SLC38A2 solute carrier family 38, member 2 -0.0146502
VDAC1 voltage-dependent anion channel 1 -0.0146359
COMMD10 COMM domain containing 10 -0.0144699
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0144048
PA2G4 proliferation-associated 2G4, 38kDa -0.0142985
RBM25 RNA binding motif protein 25 -0.0142056
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0142051
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.014181
PRDX2 peroxiredoxin 2 -0.0141782
ACACA acetyl-CoA carboxylase alpha -0.0141723
BZW2 basic leucine zipper and W2 domains 2 -0.0141366
HSPE1 heat shock 10kDa protein 1 -0.0139191
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0138479
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0138307