Ferulic acid_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ferulic acid perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ferulic acid_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.190676
PLEC plectin 0.128629
FLNA filamin A, alpha 0.118266
APP amyloid beta (A4) precursor protein 0.107576
EEF2 eukaryotic translation elongation factor 2 0.102824
SMAD3 SMAD family member 3 0.0963362
FNDC3B fibronectin type III domain containing 3B 0.0820817
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0746349
ANKRD10 ankyrin repeat domain 10 0.0720403
FLNB filamin B, beta 0.0686351
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0654742
LPP LIM domain containing preferred translocation partner in lipoma 0.0620462
ANKRD11 ankyrin repeat domain 11 0.0557696
TNIP1 TNFAIP3 interacting protein 1 0.0552989
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0550723
SEPTIN9 septin 9 0.0519773
BHLHE40 basic helix-loop-helix family, member e40 0.0494581
PAX8 paired box 8 0.0488481
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0475548
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0472871
MACF1 microtubule-actin crosslinking factor 1 0.0470825
AFDN afadin, adherens junction formation factor 0.0465206
VEGFA vascular endothelial growth factor A 0.0464195
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0455682
RPL3 ribosomal protein L3 0.0455328
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0445886
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0440311
CTBP2 C-terminal binding protein 2 0.0438083
PRELID2 PRELI domain containing 2 0.0432261
USP9X ubiquitin specific peptidase 9, X-linked 0.0430716
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0422939
KDM6A lysine (K)-specific demethylase 6A 0.0421319
PARD3 par-3 family cell polarity regulator 0.0407607
WAC WW domain containing adaptor with coiled-coil 0.0404726
TMSB4X thymosin beta 4, X-linked 0.0401617
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0397688
MPRIP myosin phosphatase Rho interacting protein 0.0397342
MED15 mediator complex subunit 15 0.0391029
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.039019
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0387202
RAD23B RAD23 homolog B (S. cerevisiae) 0.0369383
TRIO trio Rho guanine nucleotide exchange factor 0.0365933
ZFAND3 zinc finger, AN1-type domain 3 0.0361482
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0356797
HELZ helicase with zinc finger 0.0352375
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0347737
ANXA11 annexin A11 0.0345654
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0342561
PRRC2B proline-rich coiled-coil 2B 0.0340076
ACTN4 actinin, alpha 4 0.0332254
EWSR1 EWS RNA-binding protein 1 0.0322144
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.03209
WDR43 WD repeat domain 43 0.0316154
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0311969
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0309219
COL18A1 collagen, type XVIII, alpha 1 0.0306535
HSPA8 heat shock 70kDa protein 8 0.0306482
PSD3 pleckstrin and Sec7 domain containing 3 0.0306471
NCKAP1 NCK-associated protein 1 0.0303598
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0302586
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0301025
CAMTA1 calmodulin binding transcription activator 1 0.030031
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0297726
FUBP1 far upstream element (FUSE) binding protein 1 0.0296549
PUM1 pumilio RNA-binding family member 1 0.0295116
SHB Src homology 2 domain containing adaptor protein B 0.0293313
TOP2B topoisomerase (DNA) II beta 180kDa 0.0289309
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0280323
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0280152
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0277906
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0276115
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0275833
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0274862
NONO non-POU domain containing, octamer-binding 0.0274809
CSNK1A1 casein kinase 1, alpha 1 0.0272666
UPP1 uridine phosphorylase 1 0.0272042
ZNF292 zinc finger protein 292 0.0271358
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0270134
ICAM1 intercellular adhesion molecule 1 0.0269409
SRRM2 serine/arginine repetitive matrix 2 0.026855
MINK1 misshapen-like kinase 1 0.0267371
DSCAM Down syndrome cell adhesion molecule 0.0263374
OSBPL10 oxysterol binding protein-like 10 0.026293
TRA2B transformer 2 beta homolog (Drosophila) 0.0260717
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0260155
NUMA1 nuclear mitotic apparatus protein 1 0.0258907
NCOR2 nuclear receptor corepressor 2 0.0258258
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.025769
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0256985
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0256646
GLS2 glutaminase 2 (liver, mitochondrial) 0.0254382
CCNY cyclin Y 0.0254159
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0253584
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0252318
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0251924
BCAR3 breast cancer anti-estrogen resistance 3 0.0250044
CCNT2 cyclin T2 0.0249575
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0248426
MIDEAS mitotic deacetylase associated SANT domain protein 0.0244801
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0244376

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.214537
FTL ferritin, light polypeptide -0.145552
MT2A metallothionein 2A -0.135253
TMSB10 thymosin beta 10 -0.121492
TPT1 tumor protein, translationally-controlled 1 -0.111276
RPS6 ribosomal protein S6 -0.0911178
RPL35A ribosomal protein L35a -0.0803239
PTMA prothymosin, alpha -0.0794653
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0793673
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0786881
CCND1 cyclin D1 -0.0755303
RPS19 ribosomal protein S19 -0.0670706
RPL12 ribosomal protein L12 -0.0644435
ALCAM activated leukocyte cell adhesion molecule -0.0626531
RPLP1 ribosomal protein, large, P1 -0.0615483
TOP2A topoisomerase (DNA) II alpha 170kDa -0.060903
RPL19 ribosomal protein L19 -0.0590441
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0585794
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0579317
RPS8 ribosomal protein S8 -0.0548538
ACTG1 actin gamma 1 -0.0512714
SMC4 structural maintenance of chromosomes 4 -0.0508894
S100A9 S100 calcium binding protein A9 -0.0505943
RPL32 ribosomal protein L32 -0.0469825
S100A6 S100 calcium binding protein A6 -0.046619
RPL31 ribosomal protein L31 -0.045775
RPLP2 ribosomal protein, large, P2 -0.0441079
RPL34 ribosomal protein L34 -0.0437863
VDAC1 voltage-dependent anion channel 1 -0.0429033
RPL28 ribosomal protein L28 -0.0414755
S100A10 S100 calcium binding protein A10 -0.0395423
HMGA1 high mobility group AT-hook 1 -0.0394628
RPS24 ribosomal protein S24 -0.0390982
ENO1 enolase 1, (alpha) -0.0383701
RPS14 ribosomal protein S14 -0.0381354
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0379728
RPS11 ribosomal protein S11 -0.0378066
LDHA lactate dehydrogenase A -0.0364855
RPS5 ribosomal protein S5 -0.0363825
EIF1 eukaryotic translation initiation factor 1 -0.0359254
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0352372
RPL9 ribosomal protein L9 -0.0350376
EIF5B eukaryotic translation initiation factor 5B -0.034816
RPS27A ribosomal protein S27a -0.0344923
MT1X metallothionein 1X -0.0343757
GNAS GNAS complex locus -0.0342259
TUBA1B tubulin, alpha 1b -0.0333978
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0330026
DEK DEK proto-oncogene -0.0329599
RPL23 ribosomal protein L23 -0.0328804
BPTF bromodomain PHD finger transcription factor -0.0322945
RPS16 ribosomal protein S16 -0.0317028
SEPTIN7 septin 7 -0.0313567
RPLP0 ribosomal protein, large, P0 -0.0302787
RPS29 ribosomal protein S29 -0.0297919
HMGB1 high mobility group box 1 -0.0292477
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0289619
DSG2 desmoglein 2 -0.0287629
RHEX regulator of hemoglobinization and erythroid cell expansion -0.0285465
RPL7A ribosomal protein L7a -0.0278212
RPL35 ribosomal protein L35 -0.0277624
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0274327
POTEF POTE ankyrin domain family, member F -0.0272197
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0271724
MYL12B myosin, light chain 12B, regulatory -0.0271273
RPS13 ribosomal protein S13 -0.026937
AHNAK AHNAK nucleoprotein -0.0265715
TPM4 tropomyosin 4 -0.0265711
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0261357
TPI1 triosephosphate isomerase 1 -0.0256943
DCAF7 DDB1 and CUL4 associated factor 7 -0.0256137
RPS20 ribosomal protein S20 -0.0255904
CBX3 chromobox homolog 3 -0.0251347
RPS25 ribosomal protein S25 -0.025032
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0249082
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0247163
RPL27A ribosomal protein L27a -0.0244983
RPL36 ribosomal protein L36 -0.0244931
IER3 immediate early response 3 -0.0244194
RPL18 ribosomal protein L18 -0.0242747
CCNI cyclin I -0.0241862
VIM vimentin -0.024133
B2M beta-2-microglobulin -0.0236577
RPL26 ribosomal protein L26 -0.023646
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0234543
RPL8 ribosomal protein L8 -0.0234044
DLG1 discs, large homolog 1 (Drosophila) -0.023207
RPS23 ribosomal protein S23 -0.0229831
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0229222
TUBB4B tubulin, beta 4B class IVb -0.0226189
RPL11 ribosomal protein L11 -0.0224553
RPS15 ribosomal protein S15 -0.0217169
ZBTB20 zinc finger and BTB domain containing 20 -0.021349
GCC2 GRIP and coiled-coil domain containing 2 -0.0213425
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0213419
GSTP1 glutathione S-transferase pi 1 -0.0213014
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0211488
SKAP2 src kinase associated phosphoprotein 2 -0.0209716
DSTN destrin (actin depolymerizing factor) -0.0205732
RPS3 ribosomal protein S3 -0.0204241