Ferulic acid_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ferulic acid perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ferulic acid_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.167635
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.115673
TXNRD1 thioredoxin reductase 1 0.0883694
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0831752
VEGFA vascular endothelial growth factor A 0.0792133
KRT8 keratin 8, type II 0.0711416
EEF2 eukaryotic translation elongation factor 2 0.0695991
KMT2C lysine (K)-specific methyltransferase 2C 0.0690532
PLEC plectin 0.0681571
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0655956
DSCAM Down syndrome cell adhesion molecule 0.0648373
GOLGA4 golgin A4 0.0519045
MBNL2 muscleblind-like splicing regulator 2 0.0518367
RAD21 RAD21 homolog (S. pombe) 0.0512948
BIRC6 baculoviral IAP repeat containing 6 0.0486035
HYOU1 hypoxia up-regulated 1 0.0482249
OGA O-GlcNAcase 0.047746
PDIA3 protein disulfide isomerase family A, member 3 0.0472945
PTK2 protein tyrosine kinase 2 0.0469003
ATXN1 ataxin 1 0.0458577
MYH9 myosin, heavy chain 9, non-muscle 0.0458429
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0456501
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0433903
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0431492
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0426934
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0424736
KDM6A lysine (K)-specific demethylase 6A 0.0410158
MACF1 microtubule-actin crosslinking factor 1 0.040729
GCLC glutamate-cysteine ligase, catalytic subunit 0.0395955
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0394722
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0392913
RPL23 ribosomal protein L23 0.0384571
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0371653
RPL3 ribosomal protein L3 0.0358296
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0353915
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0352797
KRT18 keratin 18, type I 0.0352302
HELZ helicase with zinc finger 0.0350982
YBX1 Y box binding protein 1 0.0346578
PRRC2C proline-rich coiled-coil 2C 0.0345069
CNOT12 CCR4-NOT transcription complex subunit 12 0.0343812
ADAM17 ADAM metallopeptidase domain 17 0.0343517
CSNK1A1 casein kinase 1, alpha 1 0.0343315
NUMA1 nuclear mitotic apparatus protein 1 0.0342544
TNIP1 TNFAIP3 interacting protein 1 0.0339621
ANKRD11 ankyrin repeat domain 11 0.0339331
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0338719
CALR calreticulin 0.033837
SBF2 SET binding factor 2 0.0334986
FNDC3B fibronectin type III domain containing 3B 0.0334199
RBM39 RNA binding motif protein 39 0.0329823
NUP58 nucleoporin 58 0.0328362
MKI67 marker of proliferation Ki-67 0.032671
COG5 component of oligomeric golgi complex 5 0.0322635
ZFAND3 zinc finger, AN1-type domain 3 0.0321007
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0319887
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.031964
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0313955
RB1CC1 RB1-inducible coiled-coil 1 0.0310749
RBM33 RNA binding motif protein 33 0.0310456
EXT1 exostosin glycosyltransferase 1 0.030661
ZMYM2 zinc finger, MYM-type 2 0.0306509
PTEN phosphatase and tensin homolog 0.0305214
FAM13A family with sequence similarity 13, member A 0.0305139
SRRM2 serine/arginine repetitive matrix 2 0.0300954
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0293221
LOC112694756 uncharaterized LOC112694756 0.0292153
ADARB1 adenosine deaminase, RNA-specific, B1 0.0291684
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0291088
ZNF292 zinc finger protein 292 0.0290548
EIF4B eukaryotic translation initiation factor 4B 0.0286652
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0284996
RICTOR RPTOR independent companion of MTOR, complex 2 0.0284784
SMAD3 SMAD family member 3 0.0280696
SND1 staphylococcal nuclease and tudor domain containing 1 0.0278707
USP9X ubiquitin specific peptidase 9, X-linked 0.0277463
MSN moesin 0.0276813
RPS12 ribosomal protein S12 0.0270301
ANKRD12 ankyrin repeat domain 12 0.0269607
BTBD9 BTB (POZ) domain containing 9 0.0269474
MYO18A myosin XVIIIA 0.0269317
CTNND1 catenin (cadherin-associated protein), delta 1 0.0268558
ESRP1 epithelial splicing regulatory protein 1 0.0267559
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0267445
GARS1 glycyl-tRNA synthetase 1 0.026638
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0264801
WNK1 WNK lysine deficient protein kinase 1 0.0264073
WAC WW domain containing adaptor with coiled-coil 0.0263313
NCOR2 nuclear receptor corepressor 2 0.0262901
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0262603
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.026088
GSK3B glycogen synthase kinase 3 beta 0.0259908
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0259147
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0256845
NCKAP1 NCK-associated protein 1 0.0256211
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0252708
FNIP1 folliculin interacting protein 1 0.0251665
LENG8 leukocyte receptor cluster (LRC) member 8 0.0249818
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0247944
TPM3 tropomyosin 3 0.024647

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.120718
KRT20 keratin 20, type I -0.115608
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0983062
LOC102724023 ES1 protein homolog, mitochondrial -0.0937884
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0859534
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0818276
MYH14 myosin, heavy chain 14, non-muscle -0.0650146
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0578851
ITPKC inositol-trisphosphate 3-kinase C -0.0491039
LAMA4 laminin, alpha 4 -0.0461251
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0454384
AHNAK AHNAK nucleoprotein -0.0421982
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0419848
LMO7 LIM domain 7 -0.0418121
MYO1E myosin IE -0.0405067
POF1B premature ovarian failure, 1B -0.0400198
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0394043
EZR ezrin -0.0391054
PTPRK protein tyrosine phosphatase, receptor type, K -0.0384741
TJP1 tight junction protein 1 -0.0378626
KLF3 Kruppel-like factor 3 (basic) -0.0358646
TRIB1 tribbles pseudokinase 1 -0.035289
DIAPH2 diaphanous-related formin 2 -0.0332079
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0328743
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0322998
PDE4D phosphodiesterase 4D, cAMP-specific -0.0310929
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0303715
TMC5 transmembrane channel-like 5 -0.0300888
MMP7 matrix metallopeptidase 7 -0.0298289
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0295194
GCC2 GRIP and coiled-coil domain containing 2 -0.0289195
ZMYND8 zinc finger, MYND-type containing 8 -0.0289039
CCSER1 coiled-coil serine-rich protein 1 -0.0286259
MAML3 mastermind-like 3 (Drosophila) -0.028186
WNT2B wingless-type MMTV integration site family, member 2B -0.0276593
FRY furry homolog (Drosophila) -0.0271949
JUN jun proto-oncogene -0.0271915
NTN4 netrin 4 -0.0261524
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0259894
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.025958
ZBTB20 zinc finger and BTB domain containing 20 -0.025374
FTH1 ferritin, heavy polypeptide 1 -0.0245854
RNF213 ring finger protein 213 -0.0243557
KLK10 kallikrein-related peptidase 10 -0.023937
TMEM123 transmembrane protein 123 -0.0235566
CD2AP CD2-associated protein -0.023451
RPS24 ribosomal protein S24 -0.0230115
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0228129
AREG amphiregulin -0.0227831
KRT19 keratin 19, type I -0.0227718
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0227577
S100A6 S100 calcium binding protein A6 -0.0226183
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -0.0224921
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -0.0218893
SOX4 SRY (sex determining region Y)-box 4 -0.0217514
PPARD peroxisome proliferator-activated receptor delta -0.0214514
MUC13 mucin 13, cell surface associated -0.0214088
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0213075
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0212419
EPB41L5 erythrocyte membrane protein band 4.1 like 5 -0.0210206
RDH13 retinol dehydrogenase 13 (all-trans/9-cis) -0.0207843
GMDS GDP-mannose 4,6-dehydratase -0.0205821
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0203286
NECTIN2 nectin cell adhesion molecule 2 -0.0200659
RPS6 ribosomal protein S6 -0.0197142
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -0.0194347
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0193118
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) -0.0190985
NPC1 Niemann-Pick disease, type C1 -0.018994
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0187975
ITGA1 integrin, alpha 1 -0.0186473
PDLIM5 PDZ and LIM domain 5 -0.0185248
MAML2 mastermind-like 2 (Drosophila) -0.0184198
KLF10 Kruppel-like factor 10 -0.0180269
ETV6 ets variant 6 -0.0179163
MACC1 metastasis associated in colon cancer 1 -0.0178821
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0178632
FOXP1 forkhead box P1 -0.0178467
S100A10 S100 calcium binding protein A10 -0.0178079
CA12 carbonic anhydrase XII -0.0177824
KLF5 Kruppel-like factor 5 (intestinal) -0.0173824
PCED1B PC-esterase domain containing 1B -0.0172921
SLC38A1 solute carrier family 38, member 1 -0.01717
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0170575
DGKH diacylglycerol kinase, eta -0.0168875
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 -0.0168578
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0168279
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.016825
HMGA2 high mobility group AT-hook 2 -0.0167148
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0165187
GSN gelsolin -0.0162951
RRBP1 ribosome binding protein 1 -0.0161804
MECOM MDS1 and EVI1 complex locus -0.0160858
FHL2 four and a half LIM domains 2 -0.0160222
EPS8 epidermal growth factor receptor pathway substrate 8 -0.016014
PRR5L proline rich 5 like -0.0157288
BCAS1 breast carcinoma amplified sequence 1 -0.0155128
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0154168
ACTG1 actin gamma 1 -0.0154167
PAQR5 progestin and adipoQ receptor family member V -0.0154085