Ferulic acid_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ferulic acid perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ferulic acid_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.175683
LSAMP limbic system-associated membrane protein 0.119608
TMSB10 thymosin beta 10 0.116524
DTNA dystrobrevin, alpha 0.107358
MYH9 myosin, heavy chain 9, non-muscle 0.101035
NUP58 nucleoporin 58 0.0932118
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0915334
TRIO trio Rho guanine nucleotide exchange factor 0.0914931
MMP12 matrix metallopeptidase 12 0.0882555
PLEC plectin 0.0812123
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0796773
FLNA filamin A, alpha 0.0757055
ELL2 elongation factor, RNA polymerase II, 2 0.0728194
EGR1 early growth response 1 0.0705498
RPL23 ribosomal protein L23 0.066104
LOC112694756 uncharaterized LOC112694756 0.0648689
ANXA2 annexin A2 0.0587604
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0560069
NDRG1 N-myc downstream regulated 1 0.0559735
WSB1 WD repeat and SOCS box containing 1 0.0552537
FN1 fibronectin 1 0.0543461
UBA6 ubiquitin-like modifier activating enzyme 6 0.0529402
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0520521
CD109 CD109 molecule 0.051685
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0509748
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0492267
CORO1C coronin, actin binding protein, 1C 0.0476192
JUN jun proto-oncogene 0.0473564
FNDC3B fibronectin type III domain containing 3B 0.0471936
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0471795
RPL3 ribosomal protein L3 0.04614
AKAP12 A kinase (PRKA) anchor protein 12 0.0459877
ADAM9 ADAM metallopeptidase domain 9 0.043502
CXCL8 chemokine (C-X-C motif) ligand 8 0.0398071
GPC6 glypican 6 0.0397314
PHACTR1 phosphatase and actin regulator 1 0.0396269
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0390828
MYO10 myosin X 0.0388489
VEGFA vascular endothelial growth factor A 0.0387106
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0386837
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0381577
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0380889
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0378427
PKM pyruvate kinase, muscle 0.0378159
BHLHE40 basic helix-loop-helix family, member e40 0.0374262
RAD23B RAD23 homolog B (S. cerevisiae) 0.0373061
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.037161
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0370652
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0370359
EIF4B eukaryotic translation initiation factor 4B 0.0370212
PRRC2A proline-rich coiled-coil 2A 0.0370087
PTPRF protein tyrosine phosphatase, receptor type, F 0.0366689
PTMA prothymosin, alpha 0.0365138
ARID1A AT rich interactive domain 1A (SWI-like) 0.036164
FOSL1 FOS-like antigen 1 0.0356772
PBX3 pre-B-cell leukemia homeobox 3 0.0353398
RPS10 ribosomal protein S10 0.035315
PTK2 protein tyrosine kinase 2 0.0353091
DST dystonin 0.0352435
MSN moesin 0.0351124
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0343496
KLF6 Kruppel-like factor 6 0.0332644
NONO non-POU domain containing, octamer-binding 0.0331782
RAB6A RAB6A, member RAS oncogene family 0.0331208
RUNX1 runt-related transcription factor 1 0.0330703
FLNC filamin C, gamma 0.0329753
NCOR2 nuclear receptor corepressor 2 0.0329186
FMNL2 formin-like 2 0.0329147
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0328993
MACF1 microtubule-actin crosslinking factor 1 0.0327328
FUS FUS RNA binding protein 0.0326889
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0325525
HILPDA hypoxia inducible lipid droplet-associated 0.0325402
MED15 mediator complex subunit 15 0.0321562
FGFR1 fibroblast growth factor receptor 1 0.0320039
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0319967
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0316653
RPS3 ribosomal protein S3 0.0316021
DDIT4 DNA-damage-inducible transcript 4 0.0313932
ANKRD11 ankyrin repeat domain 11 0.0311184
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0306879
RPS12 ribosomal protein S12 0.0301378
TPM3 tropomyosin 3 0.0300437
RPLP0 ribosomal protein, large, P0 0.0300256
LIMCH1 LIM and calponin homology domains 1 0.0296887
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0296537
ACTN1 actinin, alpha 1 0.0294214
HAS2 hyaluronan synthase 2 0.0294062
TAC4 tachykinin 4 (hemokinin) 0.0292972
ATP13A3 ATPase type 13A3 0.0292623
SRRM2 serine/arginine repetitive matrix 2 0.0290615
RACK1 receptor for activated C kinase 1 0.0289667
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0289159
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0288141
WDR45B WD repeat domain 45B 0.0287477
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0287315
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0285986
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0285328
LPP LIM domain containing preferred translocation partner in lipoma 0.0282729
RAB8B RAB8B, member RAS oncogene family 0.0278667

decreased expression

Symbol Name Standardized Value
RPS2 ribosomal protein S2 -0.103219
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0907612
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0899072
RPS6 ribosomal protein S6 -0.0764022
ASPH aspartate beta-hydroxylase -0.0669177
ALCAM activated leukocyte cell adhesion molecule -0.0650177
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0637643
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0635395
OSBPL8 oxysterol binding protein-like 8 -0.0567444
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0537306
FTL ferritin, light polypeptide -0.0509229
PRKG1 protein kinase, cGMP-dependent, type I -0.0484753
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0476745
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0476241
EIF1 eukaryotic translation initiation factor 1 -0.0465714
USP34 ubiquitin specific peptidase 34 -0.045514
RTN4 reticulon 4 -0.0449984
ZNF638 zinc finger protein 638 -0.0444012
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0440301
TPT1 tumor protein, translationally-controlled 1 -0.0437826
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0421986
RPL4 ribosomal protein L4 -0.0413574
DPYD dihydropyrimidine dehydrogenase -0.0412647
MCTP1 multiple C2 domains, transmembrane 1 -0.0409569
TMPRSS15 transmembrane protease, serine 15 -0.0408039
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0400945
LIMA1 LIM domain and actin binding 1 -0.0393693
TLE4 transducin-like enhancer of split 4 -0.0388686
ENKUR enkurin, TRPC channel interacting protein -0.0379405
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0379356
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0378994
ANO6 anoctamin 6 -0.0376348
CDK6 cyclin-dependent kinase 6 -0.0368115
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0359831
JMJD1C jumonji domain containing 1C -0.035958
POTEF POTE ankyrin domain family, member F -0.0355687
KTN1 kinectin 1 (kinesin receptor) -0.0352752
NF1 neurofibromin 1 -0.0350754
MBD5 methyl-CpG binding domain protein 5 -0.0345789
EXOC6B exocyst complex component 6B -0.0342209
NAP1L1 nucleosome assembly protein 1-like 1 -0.0340056
VCL vinculin -0.0337938
LDHA lactate dehydrogenase A -0.0335125
AHNAK AHNAK nucleoprotein -0.0329447
TXNRD1 thioredoxin reductase 1 -0.0323099
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0321099
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0319999
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0316334
SDCCAG8 serologically defined colon cancer antigen 8 -0.0304072
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0302754
CD163L1 CD163 molecule-like 1 -0.0302244
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0299046
RPL7 ribosomal protein L7 -0.0292862
PHF3 PHD finger protein 3 -0.0286558
PHF14 PHD finger protein 14 -0.0285694
PEG10 paternally expressed 10 -0.0284841
MAML2 mastermind-like 2 (Drosophila) -0.0278348
RPL21 ribosomal protein L21 -0.0277362
VIM vimentin -0.0275312
ZBTB20 zinc finger and BTB domain containing 20 -0.02724
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0271687
WDPCP WD repeat containing planar cell polarity effector -0.0271546
NABP1 nucleic acid binding protein 1 -0.0269203
TAS2R14 taste receptor, type 2, member 14 -0.0267139
HMGA1 high mobility group AT-hook 1 -0.0266145
EXT1 exostosin glycosyltransferase 1 -0.0264811
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0261311
ITSN1 intersectin 1 (SH3 domain protein) -0.0261202
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0259027
GOLGB1 golgin B1 -0.0258054
SEPTIN10 septin 10 -0.025801
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0257433
PTPRG protein tyrosine phosphatase, receptor type, G -0.0251788
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0251532
ATM ATM serine/threonine kinase -0.0250907
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0249945
TNPO1 transportin 1 -0.0248153
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0247248
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.024565
CCDC88A coiled-coil domain containing 88A -0.0240628
UBXN4 UBX domain protein 4 -0.0238414
TMF1 TATA element modulatory factor 1 -0.0238286
RFX3 regulatory factor X, 3 (influences HLA class II expression) -0.023802
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0237955
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0236108
NCOA1 nuclear receptor coactivator 1 -0.0235244
TXNIP thioredoxin interacting protein -0.023481
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0232174
ZFC3H1 zinc finger, C3H1-type containing -0.0230882
RO60 Ro60, Y RNA binding protein -0.0227107
GCC2 GRIP and coiled-coil domain containing 2 -0.0226739
MAP4 microtubule-associated protein 4 -0.0226644
ATP5F1B ATP synthase F1 subunit beta -0.0223682
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.0223576
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0222715
MAP1B microtubule-associated protein 1B -0.0222424
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0222189
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0221725
STAU2 staufen double-stranded RNA binding protein 2 -0.022115
MBNL1 muscleblind-like splicing regulator 1 -0.0220666