Ferulic acid_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ferulic acid perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ferulic acid_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.130851
EEF2 eukaryotic translation elongation factor 2 0.113608
NDRG1 N-myc downstream regulated 1 0.1011
FAM13A family with sequence similarity 13, member A 0.0925879
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0878005
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0839181
KRT8 keratin 8, type II 0.0803432
DSCAM Down syndrome cell adhesion molecule 0.0789331
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0771292
FAT1 FAT atypical cadherin 1 0.0770581
FLNB filamin B, beta 0.075569
TXNIP thioredoxin interacting protein 0.0697606
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0656365
KRT18 keratin 18, type I 0.064682
MYH9 myosin, heavy chain 9, non-muscle 0.057811
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0576916
ANXA2 annexin A2 0.0543929
DSPP dentin sialophosphoprotein 0.0541598
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0540947
EREG epiregulin 0.0539654
TNS4 tensin 4 0.0538436
RPL3 ribosomal protein L3 0.0531761
RNF43 ring finger protein 43 0.0526159
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0513641
DDIT4 DNA-damage-inducible transcript 4 0.0510795
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0493404
CALR calreticulin 0.0492448
PLEC plectin 0.0472133
MACF1 microtubule-actin crosslinking factor 1 0.0457105
LOC112694756 uncharaterized LOC112694756 0.045071
GOLGA4 golgin A4 0.0447816
CEMIP cell migration inducing protein, hyaluronan binding 0.044743
CSNK1A1 casein kinase 1, alpha 1 0.0433986
ZNF292 zinc finger protein 292 0.0412896
OGA O-GlcNAcase 0.0401268
H1-0 H1.0 linker histone 0.0398222
COPA coatomer protein complex, subunit alpha 0.0397345
KDM3A lysine (K)-specific demethylase 3A 0.0391058
CCNY cyclin Y 0.038553
MED13L mediator complex subunit 13-like 0.0380393
CANX calnexin 0.037992
SREBF2 sterol regulatory element binding transcription factor 2 0.0369755
UBA6 ubiquitin-like modifier activating enzyme 6 0.0365222
ZFAND3 zinc finger, AN1-type domain 3 0.0363002
ESYT2 extended synaptotagmin-like protein 2 0.0354059
ATXN1 ataxin 1 0.0346677
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0345888
RBM39 RNA binding motif protein 39 0.03444
WDR45B WD repeat domain 45B 0.0340695
TMSB4X thymosin beta 4, X-linked 0.033249
BHLHE40 basic helix-loop-helix family, member e40 0.0330059
SHROOM3 shroom family member 3 0.0329766
EPHA2 EPH receptor A2 0.0328776
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0326373
MINK1 misshapen-like kinase 1 0.0323404
PRELID2 PRELI domain containing 2 0.0320353
HSPA8 heat shock 70kDa protein 8 0.0319768
RNF145 ring finger protein 145 0.0318886
HDLBP high density lipoprotein binding protein 0.0317856
RREB1 ras responsive element binding protein 1 0.0316468
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0314742
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0312507
EZR ezrin 0.031065
EIF4B eukaryotic translation initiation factor 4B 0.0309343
LMO7 LIM domain 7 0.0306884
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.030669
NUMA1 nuclear mitotic apparatus protein 1 0.0301617
PRRC2C proline-rich coiled-coil 2C 0.0299612
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0298329
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0297165
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0296197
RPS3 ribosomal protein S3 0.029573
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0290709
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0289444
APP amyloid beta (A4) precursor protein 0.0282741
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0282432
PNN pinin, desmosome associated protein 0.0279327
WAC WW domain containing adaptor with coiled-coil 0.0278924
ONECUT3 one cut homeobox 3 0.0276341
YBX1 Y box binding protein 1 0.0275491
KDM4B lysine (K)-specific demethylase 4B 0.0273554
NUP58 nucleoporin 58 0.0273157
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0272461
ANKRD11 ankyrin repeat domain 11 0.0270896
PGK1 phosphoglycerate kinase 1 0.0262973
MXI1 MAX interactor 1, dimerization protein 0.0262224
ERRFI1 ERBB receptor feedback inhibitor 1 0.0261211
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0260225
EIF1 eukaryotic translation initiation factor 1 0.0260118
MBNL2 muscleblind-like splicing regulator 2 0.0259043
DERA deoxyribose-phosphate aldolase (putative) 0.0256627
AFDN afadin, adherens junction formation factor 0.0251825
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0251084
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0250648
PTPRR protein tyrosine phosphatase, receptor type, R 0.0250369
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.025024
EXOC1 exocyst complex component 1 0.0250195
SEC31A SEC31 homolog A (S. cerevisiae) 0.0243885
SRRM2 serine/arginine repetitive matrix 2 0.0243074
PLAUR plasminogen activator, urokinase receptor 0.0241731

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.159331
TPT1 tumor protein, translationally-controlled 1 -0.133897
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.111581
ALCAM activated leukocyte cell adhesion molecule -0.102275
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0955332
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0951024
GMDS GDP-mannose 4,6-dehydratase -0.0929777
TMSB10 thymosin beta 10 -0.0903008
NALF1 NALCN channel auxiliary factor 1 -0.0840854
RPS6 ribosomal protein S6 -0.0823557
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0789824
VCL vinculin -0.0752751
MYO1E myosin IE -0.0734839
MUC6 mucin 6, oligomeric mucus/gel-forming -0.072558
GREB1L growth regulation by estrogen in breast cancer-like -0.056421
ACTG1 actin gamma 1 -0.0554849
POTEF POTE ankyrin domain family, member F -0.0542992
RPL35A ribosomal protein L35a -0.0534567
PTPRK protein tyrosine phosphatase, receptor type, K -0.0465165
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0457749
LOC102724023 ES1 protein homolog, mitochondrial -0.0440888
TFF1 trefoil factor 1 -0.0440371
EXT1 exostosin glycosyltransferase 1 -0.0435623
S100A6 S100 calcium binding protein A6 -0.0421841
RPS24 ribosomal protein S24 -0.0419248
PDLIM5 PDZ and LIM domain 5 -0.0418988
ANTXR2 anthrax toxin receptor 2 -0.0398042
RPS25 ribosomal protein S25 -0.0396973
MBNL1 muscleblind-like splicing regulator 1 -0.03852
FHIT fragile histidine triad -0.0383515
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0375018
CCND1 cyclin D1 -0.0374399
FTL ferritin, light polypeptide -0.0367969
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0348056
MT2A metallothionein 2A -0.034424
DEK DEK proto-oncogene -0.0340866
SLC35F3 solute carrier family 35, member F3 -0.0337887
ATP5F1B ATP synthase F1 subunit beta -0.0336186
PSD3 pleckstrin and Sec7 domain containing 3 -0.03359
PDE4D phosphodiesterase 4D, cAMP-specific -0.0331579
KLK10 kallikrein-related peptidase 10 -0.0331366
RAB10 RAB10, member RAS oncogene family -0.0330899
TPM4 tropomyosin 4 -0.0329643
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0327183
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0325448
TUBA1B tubulin, alpha 1b -0.0323764
DIAPH2 diaphanous-related formin 2 -0.0318567
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0317268
GPHN gephyrin -0.031558
IER3 immediate early response 3 -0.0314354
EGFR epidermal growth factor receptor -0.0310282
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0302503
CCSER1 coiled-coil serine-rich protein 1 -0.0299899
DSTN destrin (actin depolymerizing factor) -0.0295884
SOX4 SRY (sex determining region Y)-box 4 -0.0294028
RPL9 ribosomal protein L9 -0.0293572
FBXO11 F-box protein 11 -0.029209
MAML3 mastermind-like 3 (Drosophila) -0.0282889
RPL31 ribosomal protein L31 -0.0275849
ZBTB20 zinc finger and BTB domain containing 20 -0.0273949
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0260704
EIF5B eukaryotic translation initiation factor 5B -0.0258016
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0257837
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0255457
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0251078
RPS8 ribosomal protein S8 -0.0250065
RNF217 ring finger protein 217 -0.0246288
EHBP1 EH domain binding protein 1 -0.0246215
HMGA1 high mobility group AT-hook 1 -0.0246116
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0245684
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0245536
LAMA4 laminin, alpha 4 -0.0243319
TFF3 trefoil factor 3 (intestinal) -0.023797
SAMD5 sterile alpha motif domain containing 5 -0.0232608
RAD51B RAD51 paralog B -0.0230795
RPLP2 ribosomal protein, large, P2 -0.0224556
TUBB4B tubulin, beta 4B class IVb -0.0224053
MUC17 mucin 17, cell surface associated -0.0223892
PPP1R9A protein phosphatase 1, regulatory subunit 9A -0.0223736
FRMD5 FERM domain containing 5 -0.0223035
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0222522
SH3D19 SH3 domain containing 19 -0.0221743
RPS14 ribosomal protein S14 -0.0221411
CATSPERB catsper channel auxiliary subunit beta -0.0221409
SLC38A2 solute carrier family 38, member 2 -0.0220309
PATJ PATJ crumbs cell polarity complex component -0.0218689
PTPRB protein tyrosine phosphatase, receptor type, B -0.0216393
LSAMP limbic system-associated membrane protein -0.0214947
DIAPH1 diaphanous-related formin 1 -0.0212127
JMJD1C jumonji domain containing 1C -0.0211259
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0210538
MTAP methylthioadenosine phosphorylase -0.0207917
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0207599
CCDC91 coiled-coil domain containing 91 -0.020739
RPL27A ribosomal protein L27a -0.0206786
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.020577
HMGB1 high mobility group box 1 -0.0205406
POF1B premature ovarian failure, 1B -0.0201412
MAML2 mastermind-like 2 (Drosophila) -0.0200315
PFN1 profilin 1 -0.0199802