Ferulic acid_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ferulic acid perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ferulic acid_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.212085
PABPC1 poly(A) binding protein, cytoplasmic 1 0.16535
RPS12 ribosomal protein S12 0.128081
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.115138
TMSB10 thymosin beta 10 0.104189
RPS8 ribosomal protein S8 0.102421
PTMA prothymosin, alpha 0.0971139
RPL23 ribosomal protein L23 0.0942107
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0880599
RPLP0 ribosomal protein, large, P0 0.0873158
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.085131
RPL3 ribosomal protein L3 0.0835253
RACK1 receptor for activated C kinase 1 0.0775309
RPS19 ribosomal protein S19 0.0772278
RPS3 ribosomal protein S3 0.0764767
RPL37A ribosomal protein L37a 0.0754586
RPS17 ribosomal protein S17 0.0743299
KRT8 keratin 8, type II 0.074199
MYH9 myosin, heavy chain 9, non-muscle 0.0719357
RPS23 ribosomal protein S23 0.0637321
RPLP1 ribosomal protein, large, P1 0.0633739
FAT1 FAT atypical cadherin 1 0.0620029
RPS6 ribosomal protein S6 0.0616591
FLNB filamin B, beta 0.0614034
KRT18 keratin 18, type I 0.0606088
RPL35A ribosomal protein L35a 0.0588973
EPHA2 EPH receptor A2 0.0569522
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0538564
RPS10 ribosomal protein S10 0.0534349
PRELID2 PRELI domain containing 2 0.0529219
CALB1 calbindin 1, 28kDa 0.0514105
LOC112694756 uncharaterized LOC112694756 0.0508923
RPS27 ribosomal protein S27 0.0501251
PKM pyruvate kinase, muscle 0.0490245
RPS13 ribosomal protein S13 0.0485506
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0466029
EIF4B eukaryotic translation initiation factor 4B 0.0465928
RPL36 ribosomal protein L36 0.0463707
ESYT2 extended synaptotagmin-like protein 2 0.0462017
SRRM2 serine/arginine repetitive matrix 2 0.0458248
NCOR2 nuclear receptor corepressor 2 0.0455516
TNIP1 TNFAIP3 interacting protein 1 0.0453766
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0451695
RPL31 ribosomal protein L31 0.0449968
VEGFA vascular endothelial growth factor A 0.04492
RPL11 ribosomal protein L11 0.0425793
RPL19 ribosomal protein L19 0.0422721
RPL26 ribosomal protein L26 0.0419155
NDRG1 N-myc downstream regulated 1 0.0416531
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0410406
RPS27A ribosomal protein S27a 0.0406602
RPL30 ribosomal protein L30 0.0401558
RPL13A ribosomal protein L13a 0.0398554
CALR calreticulin 0.038952
PDIA3 protein disulfide isomerase family A, member 3 0.0388746
RPS29 ribosomal protein S29 0.0388678
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0388004
RPL12 ribosomal protein L12 0.0386976
RPL34 ribosomal protein L34 0.0386533
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0372568
ANXA11 annexin A11 0.0371329
YBX1 Y box binding protein 1 0.0370703
ACTG1 actin gamma 1 0.0369855
PLEC plectin 0.0366507
GOLGA4 golgin A4 0.035911
ITGB4 integrin, beta 4 0.0356924
RPL9 ribosomal protein L9 0.0349155
MLEC malectin 0.0344465
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0339778
RPLP2 ribosomal protein, large, P2 0.0332941
MPRIP myosin phosphatase Rho interacting protein 0.0328342
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.032322
RPS11 ribosomal protein S11 0.032185
MKI67 marker of proliferation Ki-67 0.0321404
RPL37 ribosomal protein L37 0.0319443
RPL8 ribosomal protein L8 0.0319348
KMT2D lysine (K)-specific methyltransferase 2D 0.0318434
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0314184
SREBF2 sterol regulatory element binding transcription factor 2 0.0313927
ENO1 enolase 1, (alpha) 0.0310933
KCMF1 potassium channel modulatory factor 1 0.0310925
KMT2C lysine (K)-specific methyltransferase 2C 0.0308684
TMED2 transmembrane emp24 domain trafficking protein 2 0.0306665
EGR1 early growth response 1 0.0306553
RPL5 ribosomal protein L5 0.0303328
DDIT4 DNA-damage-inducible transcript 4 0.0302457
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0301693
UBA6 ubiquitin-like modifier activating enzyme 6 0.0296989
RPL18 ribosomal protein L18 0.0296602
GMDS GDP-mannose 4,6-dehydratase 0.0282839
CDK19 cyclin-dependent kinase 19 0.0282443
BHLHE40 basic helix-loop-helix family, member e40 0.0278959
RPL35 ribosomal protein L35 0.0278743
COPA coatomer protein complex, subunit alpha 0.0278328
TPI1 triosephosphate isomerase 1 0.0277839
DNM2 dynamin 2 0.0277299
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0276067
PGK1 phosphoglycerate kinase 1 0.0272233
SET SET nuclear proto-oncogene 0.0269366
RPL7 ribosomal protein L7 0.0268962

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.127849
LMO7 LIM domain 7 -0.115143
MYO1E myosin IE -0.100213
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0865318
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0805784
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0791109
RIGI RNA sensor RIG-I -0.0509861
VCL vinculin -0.0506149
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0504925
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0482915
SP100 SP100 nuclear antigen -0.0476154
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0464774
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0443652
RIMKLB ribosomal modification protein rimK-like family member B -0.0439872
RPS2 ribosomal protein S2 -0.0412644
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0408833
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.040116
PRSS3 protease, serine, 3 -0.0378081
TC2N tandem C2 domains, nuclear -0.0370901
PTPRB protein tyrosine phosphatase, receptor type, B -0.0353705
MX1 MX dynamin-like GTPase 1 -0.0347419
PLSCR1 phospholipid scramblase 1 -0.0337928
NCOA7 nuclear receptor coactivator 7 -0.0337568
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0332796
SERINC5 serine incorporator 5 -0.032976
SLC38A2 solute carrier family 38, member 2 -0.0329631
CCND2 cyclin D2 -0.0329484
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0325673
PDE4D phosphodiesterase 4D, cAMP-specific -0.0325
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0324891
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0319525
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0313736
IARS1 isoleucyl-tRNA synthetase 1 -0.0306636
MX2 MX dynamin-like GTPase 2 -0.0303955
PALLD palladin, cytoskeletal associated protein -0.0302706
CYSTM1 cysteine-rich transmembrane module containing 1 -0.0299261
TMEM45B transmembrane protein 45B -0.0294351
TXNRD1 thioredoxin reductase 1 -0.0293443
MYOF myoferlin -0.02882
RPL4 ribosomal protein L4 -0.0287689
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 -0.028295
P3H2 prolyl 3-hydroxylase 2 -0.0279832
CCSER1 coiled-coil serine-rich protein 1 -0.027226
IFIH1 interferon induced with helicase C domain 1 -0.0260482
RAP1B RAP1B, member of RAS oncogene family -0.0254484
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0252138
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0249402
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0248146
TJP1 tight junction protein 1 -0.0244855
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0240255
XAF1 XIAP associated factor 1 -0.0240175
CATSPERB catsper channel auxiliary subunit beta -0.0238744
PTPRG protein tyrosine phosphatase, receptor type, G -0.0236933
CCNG1 cyclin G1 -0.0234216
AHCYL2 adenosylhomocysteinase-like 2 -0.0233139
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0231404
PDLIM5 PDZ and LIM domain 5 -0.0230868
PTPRK protein tyrosine phosphatase, receptor type, K -0.022327
FOXP1 forkhead box P1 -0.0220667
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0220086
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) -0.0218906
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0217301
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0217046
RNF213 ring finger protein 213 -0.0216546
WWC1 WW and C2 domain containing 1 -0.0215449
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0214819
SEPTIN10 septin 10 -0.0214516
MYO9A myosin IXA -0.0208307
OXSR1 oxidative stress responsive 1 -0.0205318
LAMA4 laminin, alpha 4 -0.0204251
NT5C2 5'-nucleotidase, cytosolic II -0.0203961
PHF14 PHD finger protein 14 -0.0203673
UBR1 ubiquitin protein ligase E3 component n-recognin 1 -0.0202809
PCDHB16 protocadherin beta 16 -0.0201977
SCLT1 sodium channel and clathrin linker 1 -0.0200879
MTAP methylthioadenosine phosphorylase -0.019934
FBXO11 F-box protein 11 -0.0197888
ARL15 ADP-ribosylation factor-like 15 -0.0196415
KLF3 Kruppel-like factor 3 (basic) -0.0193284
RBBP6 retinoblastoma binding protein 6 -0.0192784
DSG2 desmoglein 2 -0.0188907
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0188328
FHL2 four and a half LIM domains 2 -0.0188109
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.018804
EXT1 exostosin glycosyltransferase 1 -0.0187494
SCAPER S-phase cyclin A-associated protein in the ER -0.0187163
PKP2 plakophilin 2 -0.0186166
USP15 ubiquitin specific peptidase 15 -0.0185081
RANBP17 RAN binding protein 17 -0.0180004
PARD3B par-3 family cell polarity regulator beta -0.0179162
TDRD7 tudor domain containing 7 -0.0178636
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0176326
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0174738
POF1B premature ovarian failure, 1B -0.016781
FBXL17 F-box and leucine-rich repeat protein 17 -0.0165268
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0165132
RBM25 RNA binding motif protein 25 -0.0163804
ATP10B ATPase, class V, type 10B -0.0163481
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0162754
EPSTI1 epithelial stromal interaction 1 (breast) -0.0161405