Ferulic acid_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ferulic acid perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ferulic acid_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.107023
MKI67 marker of proliferation Ki-67 0.0778385
CENPF centromere protein F, 350/400kDa 0.0755272
TMSB4X thymosin beta 4, X-linked 0.0731051
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0658316
EEF2 eukaryotic translation elongation factor 2 0.0640704
EGR1 early growth response 1 0.0503852
YBX1 Y box binding protein 1 0.048905
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0487471
PLEC plectin 0.0485172
RACK1 receptor for activated C kinase 1 0.0475006
LOXL2 lysyl oxidase-like 2 0.0464563
ERRFI1 ERBB receptor feedback inhibitor 1 0.0461852
MYH9 myosin, heavy chain 9, non-muscle 0.0446413
LOC112694756 uncharaterized LOC112694756 0.043664
RPS10 ribosomal protein S10 0.0414533
RPS19 ribosomal protein S19 0.041209
VEGFA vascular endothelial growth factor A 0.0407193
P4HB prolyl 4-hydroxylase, beta polypeptide 0.039524
NDRG1 N-myc downstream regulated 1 0.038201
ACTG1 actin gamma 1 0.0376694
HOOK2 hook microtubule-tethering protein 2 0.0362438
MSN moesin 0.0357339
MED15 mediator complex subunit 15 0.0348435
RPL3 ribosomal protein L3 0.034555
RPS8 ribosomal protein S8 0.0324214
YEATS2 YEATS domain containing 2 0.0321528
FOSL1 FOS-like antigen 1 0.0319006
PRRC2A proline-rich coiled-coil 2A 0.0318377
SRRM2 serine/arginine repetitive matrix 2 0.0317164
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0310832
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.030407
WSB1 WD repeat and SOCS box containing 1 0.0301802
NONO non-POU domain containing, octamer-binding 0.030109
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.029901
RPL35A ribosomal protein L35a 0.0298799
ESYT2 extended synaptotagmin-like protein 2 0.0296009
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0294562
KRT18 keratin 18, type I 0.0288419
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0287931
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.028442
CDK19 cyclin-dependent kinase 19 0.0282652
GOLGA4 golgin A4 0.0279071
MINK1 misshapen-like kinase 1 0.0277567
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0271757
DDIT4 DNA-damage-inducible transcript 4 0.0271061
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0270977
BHLHE40 basic helix-loop-helix family, member e40 0.0269871
TRA2B transformer 2 beta homolog (Drosophila) 0.0268028
ANLN anillin, actin binding protein 0.0266514
CAMTA1 calmodulin binding transcription activator 1 0.0265731
FLNB filamin B, beta 0.0262918
ARRDC3 arrestin domain containing 3 0.0261891
LENG8 leukocyte receptor cluster (LRC) member 8 0.0252726
FTL ferritin, light polypeptide 0.0249937
PRPF8 pre-mRNA processing factor 8 0.0249747
RPL37A ribosomal protein L37a 0.0246376
UBA1 ubiquitin-like modifier activating enzyme 1 0.0245769
ANKRD11 ankyrin repeat domain 11 0.0244613
GARS1 glycyl-tRNA synthetase 1 0.0244338
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0243376
KIF14 kinesin family member 14 0.0242639
CSNK1A1 casein kinase 1, alpha 1 0.0240844
ZNF292 zinc finger protein 292 0.0239834
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0238525
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.023568
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0234667
EIF1 eukaryotic translation initiation factor 1 0.0234052
TMED2 transmembrane emp24 domain trafficking protein 2 0.0232789
PRRC2B proline-rich coiled-coil 2B 0.0228709
RAD23B RAD23 homolog B (S. cerevisiae) 0.0228159
LGALS3 lectin, galactoside-binding, soluble, 3 0.0225828
RPL36 ribosomal protein L36 0.022337
TCOF1 Treacher Collins-Franceschetti syndrome 1 0.0222673
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 0.0221487
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0217763
SLK STE20-like kinase 0.0215769
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0212631
EZR ezrin 0.0212567
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0211566
MIDEAS mitotic deacetylase associated SANT domain protein 0.0211364
FUS FUS RNA binding protein 0.0210674
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0209982
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.0207047
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.020653
BEGAIN brain-enriched guanylate kinase-associated 0.0205554
RREB1 ras responsive element binding protein 1 0.0204946
CEP250 centrosomal protein 250kDa 0.0203634
TUBB tubulin, beta class I 0.0201631
UBAP2L ubiquitin associated protein 2-like 0.0201303
SEPTIN2 septin 2 0.0201088
TOP2A topoisomerase (DNA) II alpha 170kDa 0.020104
TRERF1 transcriptional regulating factor 1 0.0200624
PODXL podocalyxin-like 0.0199324
EP300 E1A binding protein p300 0.0197957
EIF4H eukaryotic translation initiation factor 4H 0.0197638
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0197163
USP36 ubiquitin specific peptidase 36 0.0197038
TRIO trio Rho guanine nucleotide exchange factor 0.0196797
SRSF4 serine/arginine-rich splicing factor 4 0.0196713

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.306706
TP63 tumor protein p63 -0.209305
CD44 CD44 molecule (Indian blood group) -0.165092
TM4SF1 transmembrane 4 L six family member 1 -0.156201
UBC ubiquitin C -0.1514
PSD3 pleckstrin and Sec7 domain containing 3 -0.146847
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.128651
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.126119
AHNAK AHNAK nucleoprotein -0.107742
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.1052
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0930204
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0833267
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0764267
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0757699
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0756119
RPS27A ribosomal protein S27a -0.0720866
BIRC3 baculoviral IAP repeat containing 3 -0.0680585
RIGI RNA sensor RIG-I -0.067495
CADM2 cell adhesion molecule 2 -0.0669238
SP100 SP100 nuclear antigen -0.0650036
ENO1 enolase 1, (alpha) -0.0623195
MT2A metallothionein 2A -0.0614184
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0603224
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0588693
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0587776
BCAR3 breast cancer anti-estrogen resistance 3 -0.0579812
DST dystonin -0.0575258
DNER delta/notch-like EGF repeat containing -0.0573902
JUN jun proto-oncogene -0.0553834
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0552755
TPT1 tumor protein, translationally-controlled 1 -0.0550496
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0548784
EREG epiregulin -0.0540608
ARHGAP5 Rho GTPase activating protein 5 -0.0540192
MT1X metallothionein 1X -0.0536002
VMP1 vacuole membrane protein 1 -0.0527941
EHBP1 EH domain binding protein 1 -0.0507053
CFLAR CASP8 and FADD-like apoptosis regulator -0.0498824
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0491285
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0490469
DPYD dihydropyrimidine dehydrogenase -0.0486518
HDAC9 histone deacetylase 9 -0.0477585
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0477359
PLSCR1 phospholipid scramblase 1 -0.0473049
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0464027
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.044876
IFIH1 interferon induced with helicase C domain 1 -0.0440534
CAPRIN2 caprin family member 2 -0.0438078
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0417112
VCL vinculin -0.0416171
ZBTB38 zinc finger and BTB domain containing 38 -0.0406548
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0406056
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0403946
CMIP c-Maf inducing protein -0.0403494
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0400485
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0396781
APP amyloid beta (A4) precursor protein -0.0387748
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0385855
BICD1 bicaudal D homolog 1 (Drosophila) -0.0382678
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0380941
EMP1 epithelial membrane protein 1 -0.0378012
SDC4 syndecan 4 -0.0365866
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0364642
CSMD3 CUB and Sushi multiple domains 3 -0.0361413
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0360014
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0359347
WARS1 tryptophanyl-tRNA synthetase 1 -0.0356994
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -0.0356324
PCBP2 poly(rC) binding protein 2 -0.0349937
RPS24 ribosomal protein S24 -0.0345074
SOD2 superoxide dismutase 2, mitochondrial -0.0339137
TGM2 transglutaminase 2 -0.0332737
SDCCAG8 serologically defined colon cancer antigen 8 -0.0330512
DNAH14 dynein, axonemal, heavy chain 14 -0.0329102
GCLM glutamate-cysteine ligase, modifier subunit -0.0325039
MT1E metallothionein 1E -0.0323335
DLG1 discs, large homolog 1 (Drosophila) -0.0319316
USP34 ubiquitin specific peptidase 34 -0.0318363
TSC22D1 TSC22 domain family, member 1 -0.0315579
MCTP1 multiple C2 domains, transmembrane 1 -0.0315334
NEK10 NIMA-related kinase 10 -0.0308256
LDHA lactate dehydrogenase A -0.0307829
FBXO11 F-box protein 11 -0.0302723
SPIDR scaffolding protein involved in DNA repair -0.0302311
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0295209
S100A6 S100 calcium binding protein A6 -0.0287221
FMNL2 formin-like 2 -0.0285683
CFAP299 cilia and flagella associated protein 299 -0.0285233
NAP1L1 nucleosome assembly protein 1-like 1 -0.0280504
COL5A2 collagen, type V, alpha 2 -0.0274472
INTS6 integrator complex subunit 6 -0.0272166
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.0271986
POTEF POTE ankyrin domain family, member F -0.0265827
SPDYA speedy/RINGO cell cycle regulator family member A -0.0264244
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0260171
TRIM56 tripartite motif containing 56 -0.0257979
KMT2E lysine (K)-specific methyltransferase 2E -0.0255412
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0251447
SCGB1D1 secretoglobin, family 1D, member 1 -0.0249822
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0247856