Ferulic acid_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ferulic acid perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ferulic acid_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.128804
FAM13A family with sequence similarity 13, member A 0.0929027
NAMPT nicotinamide phosphoribosyltransferase 0.0731189
TBC1D22A TBC1 domain family, member 22A 0.0677163
EGFR epidermal growth factor receptor 0.0650493
PLEC plectin 0.0610779
MKI67 marker of proliferation Ki-67 0.0583649
ARRDC3 arrestin domain containing 3 0.0583198
CAMTA1 calmodulin binding transcription activator 1 0.0571266
NGLY1 N-glycanase 1 0.057081
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0566696
CES1 carboxylesterase 1 0.0566458
MYH9 myosin, heavy chain 9, non-muscle 0.0552731
RUNX1 runt-related transcription factor 1 0.0548151
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0547075
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0537122
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0512393
PABPC1 poly(A) binding protein, cytoplasmic 1 0.050783
AGO2 argonaute RISC catalytic component 2 0.0490851
PRRC2C proline-rich coiled-coil 2C 0.0488824
TOP1 topoisomerase (DNA) I 0.0454468
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0443456
EEF2 eukaryotic translation elongation factor 2 0.0424146
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0420122
ADAM17 ADAM metallopeptidase domain 17 0.041656
SPAG9 sperm associated antigen 9 0.0411422
ELL2 elongation factor, RNA polymerase II, 2 0.0409065
RICTOR RPTOR independent companion of MTOR, complex 2 0.0408163
KMT2E lysine (K)-specific methyltransferase 2E 0.0401441
HELZ helicase with zinc finger 0.0386457
WDR45B WD repeat domain 45B 0.0360952
CSNK1A1 casein kinase 1, alpha 1 0.0356174
KCMF1 potassium channel modulatory factor 1 0.0355461
TMEM165 transmembrane protein 165 0.0354853
UBA6 ubiquitin-like modifier activating enzyme 6 0.0349664
GSK3B glycogen synthase kinase 3 beta 0.0348089
HOOK2 hook microtubule-tethering protein 2 0.0347604
ANKRD10 ankyrin repeat domain 10 0.0341271
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0333615
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0333281
FTH1 ferritin, heavy polypeptide 1 0.0331544
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0328818
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0328305
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0325607
UVRAG UV radiation resistance associated 0.0323579
H1-0 H1.0 linker histone 0.032199
KDM6A lysine (K)-specific demethylase 6A 0.0321219
RNF145 ring finger protein 145 0.031745
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0317176
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0312404
ANKRD11 ankyrin repeat domain 11 0.0312351
LOC112694756 uncharaterized LOC112694756 0.0312276
ZNF292 zinc finger protein 292 0.0308761
SMAD3 SMAD family member 3 0.0307902
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0307034
TXNRD1 thioredoxin reductase 1 0.0306871
TNIP1 TNFAIP3 interacting protein 1 0.0306823
MT2A metallothionein 2A 0.0304465
HYOU1 hypoxia up-regulated 1 0.0301942
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0301498
NPTN neuroplastin 0.0300404
SOD2 superoxide dismutase 2, mitochondrial 0.0299104
TSC22D2 TSC22 domain family, member 2 0.0298012
PGK1 phosphoglycerate kinase 1 0.0294988
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.029387
USP9X ubiquitin specific peptidase 9, X-linked 0.02905
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0289653
TFG TRK-fused gene 0.0289141
RPS3 ribosomal protein S3 0.0288128
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0287428
SRRM2 serine/arginine repetitive matrix 2 0.0285118
OGA O-GlcNAcase 0.0284039
ATP13A3 ATPase type 13A3 0.028093
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0279883
GCLC glutamate-cysteine ligase, catalytic subunit 0.0278392
MCL1 myeloid cell leukemia 1 0.0276769
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0276401
PUM2 pumilio RNA-binding family member 2 0.0274687
RNMT RNA (guanine-7-) methyltransferase 0.0274323
DTNA dystrobrevin, alpha 0.0272608
ZC3H11A zinc finger CCCH-type containing 11A 0.0271543
YEATS2 YEATS domain containing 2 0.0271254
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0266545
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0266474
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0266128
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0261522
UBE2O ubiquitin-conjugating enzyme E2O 0.0261321
EP300 E1A binding protein p300 0.0259547
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0254295
CEMIP cell migration inducing protein, hyaluronan binding 0.0254172
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0253241
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.025312
BHLHE40 basic helix-loop-helix family, member e40 0.0241516
ARGLU1 arginine and glutamate rich 1 0.0241173
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0241156
SEPTIN2 septin 2 0.0241011
ANO6 anoctamin 6 0.023828
PKM pyruvate kinase, muscle 0.0238113
RPL3 ribosomal protein L3 0.0235901
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0233428

decreased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase -0.0784208
LMO7 LIM domain 7 -0.0669459
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0651193
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0625917
THSD4 thrombospondin, type I, domain containing 4 -0.0572475
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0502429
PTPRM protein tyrosine phosphatase, receptor type, M -0.0483872
CAV1 caveolin 1, caveolae protein, 22kDa -0.0473086
EFNA5 ephrin-A5 -0.0464128
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0447827
CXCL8 chemokine (C-X-C motif) ligand 8 -0.042993
ACTG1 actin gamma 1 -0.0420515
CCND1 cyclin D1 -0.0399827
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0370139
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0368029
AHNAK AHNAK nucleoprotein -0.0367798
OSMR oncostatin M receptor -0.0346994
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0311684
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0305901
LPP LIM domain containing preferred translocation partner in lipoma -0.02911
BZW1 basic leucine zipper and W2 domains 1 -0.029038
MAML3 mastermind-like 3 (Drosophila) -0.0287894
RNF213 ring finger protein 213 -0.0281586
FOXP1 forkhead box P1 -0.0268797
NCOA7 nuclear receptor coactivator 7 -0.0266612
CCSER1 coiled-coil serine-rich protein 1 -0.0262639
TMSB10 thymosin beta 10 -0.0261972
ZMYND8 zinc finger, MYND-type containing 8 -0.0258617
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0256128
TPM4 tropomyosin 4 -0.0247289
S100A10 S100 calcium binding protein A10 -0.0239959
SP100 SP100 nuclear antigen -0.0238249
TRIM56 tripartite motif containing 56 -0.0235585
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0229919
IGFBP5 insulin-like growth factor binding protein 5 -0.0229773
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0228678
KRT7 keratin 7, type II -0.0224462
IFI6 interferon, alpha-inducible protein 6 -0.0220411
DSG2 desmoglein 2 -0.0215835
RABGAP1L RAB GTPase activating protein 1-like -0.0215432
TPT1 tumor protein, translationally-controlled 1 -0.0214762
LDHA lactate dehydrogenase A -0.0212152
AKAP12 A kinase (PRKA) anchor protein 12 -0.0209186
PDLIM5 PDZ and LIM domain 5 -0.0208926
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0202914
AHNAK2 AHNAK nucleoprotein 2 -0.0195718
TNS3 tensin 3 -0.0191981
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0188968
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0187465
INTS6 integrator complex subunit 6 -0.0184019
HLA-B major histocompatibility complex, class I, B -0.0182041
CUX1 cut-like homeobox 1 -0.0180642
ETV6 ets variant 6 -0.0179882
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0178571
EHBP1 EH domain binding protein 1 -0.0176897
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0175961
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0174718
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0174036
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0173705
SLC38A1 solute carrier family 38, member 1 -0.0173151
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0172114
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0169277
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.016712
RIMS2 regulating synaptic membrane exocytosis 2 -0.0166527
VCL vinculin -0.0165576
SLC38A2 solute carrier family 38, member 2 -0.016511
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.016446
AREG amphiregulin -0.0164338
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0164004
IFI44L interferon-induced protein 44-like -0.0163012
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0162936
SCEL sciellin -0.0162341
NSUN6 NOP2/Sun domain family, member 6 -0.0159186
AKR1C1 aldo-keto reductase family 1, member C1 -0.0158224
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0157999
NTN4 netrin 4 -0.015699
GNAS GNAS complex locus -0.0153892
PARD3 par-3 family cell polarity regulator -0.0151478
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0150795
KLF5 Kruppel-like factor 5 (intestinal) -0.0149969
EGR1 early growth response 1 -0.014901
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0148901
KRT18 keratin 18, type I -0.0148683
RIGI RNA sensor RIG-I -0.0148489
ANXA2 annexin A2 -0.0148044
PATJ PATJ crumbs cell polarity complex component -0.0147624
SMYD3 SET and MYND domain containing 3 -0.0146954
MX1 MX dynamin-like GTPase 1 -0.0146445
RAI14 retinoic acid induced 14 -0.0146042
LOC102724023 ES1 protein homolog, mitochondrial -0.0144864
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0144721
NABP1 nucleic acid binding protein 1 -0.014425
MYOF myoferlin -0.0141819
FAM107B family with sequence similarity 107, member B -0.014051
MYO1E myosin IE -0.0138083
DOCK10 dedicator of cytokinesis 10 -0.0136002
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0135717
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0135458
DOCK9 dedicator of cytokinesis 9 -0.0134522
GM2A GM2 ganglioside activator -0.0134012