Ferulic acid_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ferulic acid perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ferulic acid_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRB10 growth factor receptor-bound protein 10 0.0983978
SMAD3 SMAD family member 3 0.0850312
TRIO trio Rho guanine nucleotide exchange factor 0.0848933
NAV2 neuron navigator 2 0.0786713
FAM20C family with sequence similarity 20, member C 0.0736816
VEGFA vascular endothelial growth factor A 0.0695623
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0673584
PDE4D phosphodiesterase 4D, cAMP-specific 0.0656478
SDK1 sidekick cell adhesion molecule 1 0.0631648
MYH9 myosin, heavy chain 9, non-muscle 0.0610378
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0602462
PRELID2 PRELI domain containing 2 0.053715
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0524156
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0499361
FAM13A family with sequence similarity 13, member A 0.0499169
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0493171
CDH13 cadherin 13 0.0486527
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0483655
EEF2 eukaryotic translation elongation factor 2 0.0482712
DOCK5 dedicator of cytokinesis 5 0.0472176
FNDC3B fibronectin type III domain containing 3B 0.0465774
EFNA5 ephrin-A5 0.0462997
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0460129
ANKRD11 ankyrin repeat domain 11 0.0451919
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0443941
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0414746
MACF1 microtubule-actin crosslinking factor 1 0.0402705
FLNB filamin B, beta 0.0371638
NDRG1 N-myc downstream regulated 1 0.0356766
ATXN1 ataxin 1 0.0356764
RICTOR RPTOR independent companion of MTOR, complex 2 0.0350932
CEP250 centrosomal protein 250kDa 0.0346307
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0344293
SEPTIN9 septin 9 0.0340677
APP amyloid beta (A4) precursor protein 0.033949
RUNX1 runt-related transcription factor 1 0.0334209
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0330724
NAMPT nicotinamide phosphoribosyltransferase 0.0324609
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.032457
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0322043
BHLHE40 basic helix-loop-helix family, member e40 0.0316386
ZFAND3 zinc finger, AN1-type domain 3 0.031344
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0312502
ATP13A3 ATPase type 13A3 0.0311986
PSD3 pleckstrin and Sec7 domain containing 3 0.0306968
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0305111
TNIP1 TNFAIP3 interacting protein 1 0.0299309
DSCAM Down syndrome cell adhesion molecule 0.0295396
CNOT12 CCR4-NOT transcription complex subunit 12 0.0294801
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0292696
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0285492
NPC1 Niemann-Pick disease, type C1 0.0280394
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0276561
PFKP phosphofructokinase, platelet 0.0270409
TGM2 transglutaminase 2 0.0270085
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0268776
USP34 ubiquitin specific peptidase 34 0.0265358
NGLY1 N-glycanase 1 0.0265058
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0264059
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0259701
EGFR epidermal growth factor receptor 0.025799
NPAS2 neuronal PAS domain protein 2 0.0251289
IGF1R insulin-like growth factor 1 receptor 0.0250583
RPL3 ribosomal protein L3 0.0245502
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0245096
NBAS neuroblastoma amplified sequence 0.0244307
YEATS2 YEATS domain containing 2 0.0241955
RBM39 RNA binding motif protein 39 0.0240906
LIMCH1 LIM and calponin homology domains 1 0.0240188
EXT1 exostosin glycosyltransferase 1 0.0238717
SHB Src homology 2 domain containing adaptor protein B 0.0238202
CCNY cyclin Y 0.0232792
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0231805
FLNA filamin A, alpha 0.0231758
OGA O-GlcNAcase 0.0229365
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0229232
JARID2 jumonji, AT rich interactive domain 2 0.0227179
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.022603
AKAP13 A kinase (PRKA) anchor protein 13 0.0225702
LRMDA leucine rich melanocyte differentiation associated 0.0224076
MLPH melanophilin 0.0223977
DST dystonin 0.0223797
CTNNBL1 catenin, beta like 1 0.0223152
TBC1D22A TBC1 domain family, member 22A 0.0221079
RAD51B RAD51 paralog B 0.0220647
SAMD4A sterile alpha motif domain containing 4A 0.0218803
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0217059
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0216743
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0215798
SUN1 Sad1 and UNC84 domain containing 1 0.0213597
MYO1B myosin IB 0.0212266
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0207327
LOXL2 lysyl oxidase-like 2 0.0204999
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0204854
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0203257
AMPD3 adenosine monophosphate deaminase 3 0.0200699
RAB8B RAB8B, member RAS oncogene family 0.019994
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0199594
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0198484
ESYT2 extended synaptotagmin-like protein 2 0.0193065

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.179138
VIM vimentin -0.134267
FTL ferritin, light polypeptide -0.100803
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.073176
TMSB10 thymosin beta 10 -0.0701963
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0647557
RPLP1 ribosomal protein, large, P1 -0.0534101
MT2A metallothionein 2A -0.047554
LOX lysyl oxidase -0.0413203
C15ORF48 chromosome 15 open reading frame 48 -0.0408563
FTH1 ferritin, heavy polypeptide 1 -0.0402728
IER3 immediate early response 3 -0.0389429
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.037837
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0369534
PTMA prothymosin, alpha -0.0368831
S100A6 S100 calcium binding protein A6 -0.0356092
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0339175
HMGA1 high mobility group AT-hook 1 -0.030967
RPS19 ribosomal protein S19 -0.0302337
RPS6 ribosomal protein S6 -0.0283542
SOS1 son of sevenless homolog 1 (Drosophila) -0.0277131
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0266098
RPL35A ribosomal protein L35a -0.0262386
BASP1 brain abundant, membrane attached signal protein 1 -0.0258022
TPT1 tumor protein, translationally-controlled 1 -0.0257903
PCBP2 poly(rC) binding protein 2 -0.0252191
RPL34 ribosomal protein L34 -0.0251921
EIF1 eukaryotic translation initiation factor 1 -0.0249333
LMAN1 lectin, mannose-binding, 1 -0.0246216
RPS24 ribosomal protein S24 -0.0245488
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0245402
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0241506
MAP1B microtubule-associated protein 1B -0.0238894
DDIT3 DNA-damage-inducible transcript 3 -0.0222479
VDAC1 voltage-dependent anion channel 1 -0.0217435
BTG1 B-cell translocation gene 1, anti-proliferative -0.0216712
LOC102724023 ES1 protein homolog, mitochondrial -0.0216404
S100A10 S100 calcium binding protein A10 -0.0214463
BLZF1 basic leucine zipper nuclear factor 1 -0.0213346
GNAS GNAS complex locus -0.0209268
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0206379
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0204656
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0202019
RPL28 ribosomal protein L28 -0.0200223
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0199223
LDHA lactate dehydrogenase A -0.0199013
ANKRD28 ankyrin repeat domain 28 -0.0198458
RPS21 ribosomal protein S21 -0.0191527
RPLP2 ribosomal protein, large, P2 -0.0191126
RPL32 ribosomal protein L32 -0.0189907
PFN1 profilin 1 -0.0189474
PLIN2 perilipin 2 -0.0187871
MYADM myeloid-associated differentiation marker -0.0187853
EGR1 early growth response 1 -0.0183653
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0180851
UBC ubiquitin C -0.017904
RPS16 ribosomal protein S16 -0.0176914
S100A9 S100 calcium binding protein A9 -0.0174562
CCNI cyclin I -0.0173024
RPL19 ribosomal protein L19 -0.0170838
RPS8 ribosomal protein S8 -0.0170651
SLC38A1 solute carrier family 38, member 1 -0.0168665
RPS25 ribosomal protein S25 -0.016676
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0165463
RPS5 ribosomal protein S5 -0.0165405
TMEM263 transmembrane protein 263 -0.0165351
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0162834
PDIA3 protein disulfide isomerase family A, member 3 -0.016057
RPL12 ribosomal protein L12 -0.0158287
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0157795
IFITM3 interferon induced transmembrane protein 3 -0.0157529
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0156916
TXNIP thioredoxin interacting protein -0.0156072
HILPDA hypoxia inducible lipid droplet-associated -0.0155773
ARF4 ADP-ribosylation factor 4 -0.015545
RPS29 ribosomal protein S29 -0.015521
B2M beta-2-microglobulin -0.0154946
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0153405
RPL27A ribosomal protein L27a -0.0152875
KDM5B lysine (K)-specific demethylase 5B -0.0152208
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0150767
NCOA7 nuclear receptor coactivator 7 -0.0150248
SEC24A SEC24 family member A -0.014743
SYAP1 synapse associated protein 1 -0.0147369
BSG basigin (Ok blood group) -0.0145833
SRGN serglycin -0.0144407
KDM2A lysine (K)-specific demethylase 2A -0.0142676
RIOK3 RIO kinase 3 -0.0142347
GSTP1 glutathione S-transferase pi 1 -0.0142134
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0140728
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0139198
RPS14 ribosomal protein S14 -0.01371
RPS13 ribosomal protein S13 -0.0136436
RPL31 ribosomal protein L31 -0.0136422
POTEF POTE ankyrin domain family, member F -0.0136346
RPL36 ribosomal protein L36 -0.013631
IFI16 interferon, gamma-inducible protein 16 -0.0134038
CLEC1B C-type lectin domain family 1, member B -0.0133981
RNF24 ring finger protein 24 -0.0130656
RPS20 ribosomal protein S20 -0.0130187