Ferulic acid_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ferulic acid perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ferulic acid_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PM20D1 peptidase M20 domain containing 1 0.15626
PABPC1 poly(A) binding protein, cytoplasmic 1 0.123994
EEF2 eukaryotic translation elongation factor 2 0.116016
GRAMD1B GRAM domain containing 1B 0.114558
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.10219
TPM3 tropomyosin 3 0.0810577
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0778151
AKAP12 A kinase (PRKA) anchor protein 12 0.0763591
HSPA8 heat shock 70kDa protein 8 0.0736874
RPL3 ribosomal protein L3 0.0699314
PDE4D phosphodiesterase 4D, cAMP-specific 0.0674889
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0673336
MYH9 myosin, heavy chain 9, non-muscle 0.0650726
APP amyloid beta (A4) precursor protein 0.0649398
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0640671
ERRFI1 ERBB receptor feedback inhibitor 1 0.0607177
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.060291
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0601926
TFPI2 tissue factor pathway inhibitor 2 0.0591867
TXNRD1 thioredoxin reductase 1 0.0574129
MCL1 myeloid cell leukemia 1 0.0571921
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0562283
TM4SF1 transmembrane 4 L six family member 1 0.0560083
MKI67 marker of proliferation Ki-67 0.054658
YBX1 Y box binding protein 1 0.0544969
MACF1 microtubule-actin crosslinking factor 1 0.054389
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0541745
WDR43 WD repeat domain 43 0.0537685
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0531758
IGF2 insulin-like growth factor 2 0.0523732
FGB fibrinogen beta chain 0.0493711
EGR1 early growth response 1 0.0486659
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0483693
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0473832
PLEC plectin 0.0473767
FLNA filamin A, alpha 0.0458939
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0458199
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0456773
UBASH3B ubiquitin associated and SH3 domain containing B 0.0437453
PKM pyruvate kinase, muscle 0.0433145
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0420642
RPS10 ribosomal protein S10 0.0410644
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0408906
ASPH aspartate beta-hydroxylase 0.04067
SPAG5 sperm associated antigen 5 0.0401034
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0394326
RPS12 ribosomal protein S12 0.0391918
PRRC2A proline-rich coiled-coil 2A 0.0391791
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0389234
PDLIM5 PDZ and LIM domain 5 0.0388679
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.038739
PFDN2 prefoldin subunit 2 0.0382638
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0381775
NUP58 nucleoporin 58 0.0377386
ECT2 epithelial cell transforming 2 0.0362812
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0360863
ARL5B ADP-ribosylation factor-like 5B 0.0356938
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0356471
MSN moesin 0.0353272
CAMTA1 calmodulin binding transcription activator 1 0.035254
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 0.0351906
EIF4A1 eukaryotic translation initiation factor 4A1 0.0349615
DGKD diacylglycerol kinase, delta 130kDa 0.0349133
SLC38A2 solute carrier family 38, member 2 0.0347185
ANLN anillin, actin binding protein 0.0340954
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0340733
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0337542
YBX3 Y box binding protein 3 0.0334086
SRRM2 serine/arginine repetitive matrix 2 0.0331634
TRA2B transformer 2 beta homolog (Drosophila) 0.0330692
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0328057
ACTN1 actinin, alpha 1 0.0325534
BMP6 bone morphogenetic protein 6 0.0324543
HDGF hepatoma-derived growth factor 0.0323706
NUMA1 nuclear mitotic apparatus protein 1 0.0322745
CENPF centromere protein F, 350/400kDa 0.0321236
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.03183
UBAP2L ubiquitin associated protein 2-like 0.0317421
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0317066
PDIA6 protein disulfide isomerase family A, member 6 0.0315393
HYOU1 hypoxia up-regulated 1 0.0313892
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0313774
CCL5 chemokine (C-C motif) ligand 5 0.0305525
WWOX WW domain containing oxidoreductase 0.0297831
USP3 ubiquitin specific peptidase 3 0.0297662
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0296613
SFTPA2 surfactant protein A2 0.0295599
FAM168A family with sequence similarity 168, member A 0.029522
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0295049
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0294471
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0294376
POTEF POTE ankyrin domain family, member F 0.0294282
RPS17 ribosomal protein S17 0.0290893
TNIP1 TNFAIP3 interacting protein 1 0.0290747
RAD21 RAD21 homolog (S. pombe) 0.0290464
KIF23 kinesin family member 23 0.0287518
MEF2D myocyte enhancer factor 2D 0.0287058
FAT1 FAT atypical cadherin 1 0.0286285
EIF4A3 eukaryotic translation initiation factor 4A3 0.0283631
SET SET nuclear proto-oncogene 0.0283005

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.323756
VIM vimentin -0.130784
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.117838
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0858175
IER3 immediate early response 3 -0.0852448
FTL ferritin, light polypeptide -0.0830219
IGFBP3 insulin-like growth factor binding protein 3 -0.0720055
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0620771
PYGL phosphorylase, glycogen, liver -0.0533509
TPT1 tumor protein, translationally-controlled 1 -0.0504411
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0458612
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0437407
CXCL8 chemokine (C-X-C motif) ligand 8 -0.042998
RPLP1 ribosomal protein, large, P1 -0.0397629
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0392028
RPL31 ribosomal protein L31 -0.0391979
CAVIN1 caveolae associated protein 1 -0.0386396
EGFR epidermal growth factor receptor -0.0367887
USP34 ubiquitin specific peptidase 34 -0.034272
EIF1 eukaryotic translation initiation factor 1 -0.0339924
CDK13 cyclin-dependent kinase 13 -0.0335651
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0326694
C15ORF48 chromosome 15 open reading frame 48 -0.0311718
BICC1 BicC family RNA binding protein 1 -0.0310331
LOC102724023 ES1 protein homolog, mitochondrial -0.0309278
RBM25 RNA binding motif protein 25 -0.0286474
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0280241
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.027664
RPS6 ribosomal protein S6 -0.0265865
OSMR oncostatin M receptor -0.0261027
NEBL nebulette -0.0255029
NEMF nuclear export mediator factor -0.0253447
SOS1 son of sevenless homolog 1 (Drosophila) -0.025089
RPL35A ribosomal protein L35a -0.0249961
NUMB numb homolog (Drosophila) -0.0248627
FBXL2 F-box and leucine-rich repeat protein 2 -0.0248259
HLA-E major histocompatibility complex, class I, E -0.0236283
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0236191
RPS29 ribosomal protein S29 -0.023554
NAV3 neuron navigator 3 -0.0231454
NIPBL Nipped-B homolog (Drosophila) -0.0229867
TPM4 tropomyosin 4 -0.0229295
ERBIN erbb2 interacting protein -0.0227191
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0225652
BICD1 bicaudal D homolog 1 (Drosophila) -0.0224717
KIF13A kinesin family member 13A -0.022364
HDAC9 histone deacetylase 9 -0.0223038
ARB2A ARB2 cotranscriptional regulator A -0.0222324
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0221884
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -0.0220967
ARHGAP26 Rho GTPase activating protein 26 -0.0215258
MSRB3 methionine sulfoxide reductase B3 -0.0214094
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0211602
S100A6 S100 calcium binding protein A6 -0.0211421
HLA-A major histocompatibility complex, class I, A -0.0210989
THSD4 thrombospondin, type I, domain containing 4 -0.0209306
EHBP1 EH domain binding protein 1 -0.0207748
RSPRY1 ring finger and SPRY domain containing 1 -0.0205988
TTC3 tetratricopeptide repeat domain 3 -0.0205134
DHRS7 dehydrogenase/reductase (SDR family) member 7 -0.0199943
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0199658
SENP6 SUMO1/sentrin specific peptidase 6 -0.0199217
NABP1 nucleic acid binding protein 1 -0.0198373
CD99 CD99 molecule -0.0197389
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0196674
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0195789
RPS24 ribosomal protein S24 -0.0195681
RPL28 ribosomal protein L28 -0.0195444
HMGA2 high mobility group AT-hook 2 -0.0194722
DOCK4 dedicator of cytokinesis 4 -0.0192418
SQSTM1 sequestosome 1 -0.0191169
ZBTB20 zinc finger and BTB domain containing 20 -0.0189872
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0189341
HLA-B major histocompatibility complex, class I, B -0.0189226
VDAC1 voltage-dependent anion channel 1 -0.0188902
GNAS GNAS complex locus -0.0186794
MTDH metadherin -0.0186732
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0186301
ZFR zinc finger RNA binding protein -0.0184587
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0184471
FBXO11 F-box protein 11 -0.0183556
WASF2 WAS protein family, member 2 -0.018345
SH3KBP1 SH3-domain kinase binding protein 1 -0.0182354
PCNX4 pecanex 4 -0.0181517
TRIP11 thyroid hormone receptor interactor 11 -0.0181233
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -0.0180568
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -0.0180303
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0180028
SNX6 sorting nexin 6 -0.0179855
WDR70 WD repeat domain 70 -0.017926
EPC1 enhancer of polycomb homolog 1 (Drosophila) -0.0179145
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0176566
ATG7 autophagy related 7 -0.017638
PIBF1 progesterone immunomodulatory binding factor 1 -0.0176279
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0176196
RAI14 retinoic acid induced 14 -0.0175947
SPDYA speedy/RINGO cell cycle regulator family member A -0.0174934
LMAN1 lectin, mannose-binding, 1 -0.0174763
S100A10 S100 calcium binding protein A10 -0.017455
RPS27A ribosomal protein S27a -0.0174057