Ferulic acid_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ferulic acid perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ferulic acid_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.263354
PDE4D phosphodiesterase 4D, cAMP-specific 0.156126
PDE10A phosphodiesterase 10A 0.14254
RORA RAR-related orphan receptor A 0.106334
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.100199
FAM13A family with sequence similarity 13, member A 0.0987827
MT2A metallothionein 2A 0.0884902
ELL2 elongation factor, RNA polymerase II, 2 0.0861076
NALF1 NALCN channel auxiliary factor 1 0.0809621
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0739279
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0675439
GRB10 growth factor receptor-bound protein 10 0.0673974
APP amyloid beta (A4) precursor protein 0.0667669
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0656619
LIMCH1 LIM and calponin homology domains 1 0.06499
SMOC1 SPARC related modular calcium binding 1 0.0639463
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.060396
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0595036
PRELID2 PRELI domain containing 2 0.0589686
FNDC3B fibronectin type III domain containing 3B 0.0563231
RAB40C RAB40C, member RAS oncogene family 0.0553713
EXT1 exostosin glycosyltransferase 1 0.0541344
PTMA prothymosin, alpha 0.0536562
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0529339
ERRFI1 ERBB receptor feedback inhibitor 1 0.0519828
RTN4 reticulon 4 0.0505903
EEF2 eukaryotic translation elongation factor 2 0.0505757
PDLIM5 PDZ and LIM domain 5 0.0504207
TENT5A terminal nucleotidyltransferase 5A 0.0498695
ASPH aspartate beta-hydroxylase 0.0492003
CCNY cyclin Y 0.0476876
ESYT2 extended synaptotagmin-like protein 2 0.0473596
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0472169
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0464595
HSPA8 heat shock 70kDa protein 8 0.0464033
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0463372
LOC112694756 uncharaterized LOC112694756 0.0463272
MYH9 myosin, heavy chain 9, non-muscle 0.0461951
RICTOR RPTOR independent companion of MTOR, complex 2 0.0459584
RPL37 ribosomal protein L37 0.0451061
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0440463
MXI1 MAX interactor 1, dimerization protein 0.0431934
FLNB filamin B, beta 0.0424952
VEGFA vascular endothelial growth factor A 0.0410728
ANKRD11 ankyrin repeat domain 11 0.0409522
RIOK3 RIO kinase 3 0.0408219
EFNA5 ephrin-A5 0.0407055
ACBD6 acyl-CoA binding domain containing 6 0.0406021
NCKAP1 NCK-associated protein 1 0.0405832
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0402977
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0399188
RACK1 receptor for activated C kinase 1 0.039786
AHR aryl hydrocarbon receptor 0.0395482
MCTP1 multiple C2 domains, transmembrane 1 0.0392676
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0391534
DOCK5 dedicator of cytokinesis 5 0.0383867
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0383699
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0382017
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0378018
HOOK2 hook microtubule-tethering protein 2 0.0376567
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0372971
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0361341
FUS FUS RNA binding protein 0.0358445
ANKHD1 ankyrin repeat and KH domain containing 1 0.0355672
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0353811
ENO1 enolase 1, (alpha) 0.0352668
FNBP1L formin binding protein 1-like 0.0352127
IGFBP5 insulin-like growth factor binding protein 5 0.0340844
ABLIM1 actin binding LIM protein 1 0.034024
RPS23 ribosomal protein S23 0.0335901
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0330344
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0330324
KMT2E lysine (K)-specific methyltransferase 2E 0.0330076
UBAP2L ubiquitin associated protein 2-like 0.0324074
ACTG1 actin gamma 1 0.0317977
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0315165
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0312872
RIGI RNA sensor RIG-I 0.0308718
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.030731
DDB1 damage-specific DNA binding protein 1, 127kDa 0.0305086
TMEM87A transmembrane protein 87A 0.030487
LMTK2 lemur tyrosine kinase 2 0.030441
MATR3 matrin 3 0.0302489
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0301032
CCDC88A coiled-coil domain containing 88A 0.0298928
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0293868
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0291962
PEAK1 pseudopodium-enriched atypical kinase 1 0.0289039
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0288594
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0288586
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.02845
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0284409
CSDE1 cold shock domain containing E1, RNA-binding 0.0282526
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0282201
MON2 MON2 homolog (S. cerevisiae) 0.0275618
TOP1 topoisomerase (DNA) I 0.0273312
ARHGAP21 Rho GTPase activating protein 21 0.0270579
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0268728
BMPR1A bone morphogenetic protein receptor, type IA 0.0267302
VEZT vezatin, adherens junctions transmembrane protein 0.0265265

decreased expression

Symbol Name Standardized Value
ATOSA atos homolog A -0.139477
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.113193
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.104398
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0936894
FTL ferritin, light polypeptide -0.0910319
SAMD4A sterile alpha motif domain containing 4A -0.0844841
TPT1 tumor protein, translationally-controlled 1 -0.0830519
LPP LIM domain containing preferred translocation partner in lipoma -0.0777655
LAMC2 laminin, gamma 2 -0.0761104
LMO7 LIM domain 7 -0.0742882
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0734803
ERBIN erbb2 interacting protein -0.0711308
BACE2 beta-site APP-cleaving enzyme 2 -0.067977
RAI14 retinoic acid induced 14 -0.0619268
ANTXR2 anthrax toxin receptor 2 -0.0614013
IGFBP3 insulin-like growth factor binding protein 3 -0.0596911
SVIL supervillin -0.057065
AKAP9 A kinase (PRKA) anchor protein 9 -0.0564362
CD44 CD44 molecule (Indian blood group) -0.0552956
AFF4 AF4/FMR2 family, member 4 -0.0547747
S100A9 S100 calcium binding protein A9 -0.0543156
MYO1E myosin IE -0.0543137
GOLGA4 golgin A4 -0.0543107
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0535044
SBF2 SET binding factor 2 -0.0534065
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0527387
TXNRD1 thioredoxin reductase 1 -0.052504
KDM7A lysine (K)-specific demethylase 7A -0.0523134
MCL1 myeloid cell leukemia 1 -0.0522858
DLG1 discs, large homolog 1 (Drosophila) -0.0504426
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0496796
RREB1 ras responsive element binding protein 1 -0.0496019
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0486481
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.04815
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0466568
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0466315
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0454297
RPS6 ribosomal protein S6 -0.0451264
S100A6 S100 calcium binding protein A6 -0.0449017
ANXA2 annexin A2 -0.0448502
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0444453
ANKRD12 ankyrin repeat domain 12 -0.0442695
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0437226
RAD51B RAD51 paralog B -0.0432393
H3-3B H3.3 histone B -0.0425571
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0421781
PTPRM protein tyrosine phosphatase, receptor type, M -0.0420908
UGCG UDP-glucose ceramide glucosyltransferase -0.0415988
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0413846
MBD5 methyl-CpG binding domain protein 5 -0.0413196
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0412417
GNAS GNAS complex locus -0.0412136
SSH2 slingshot protein phosphatase 2 -0.0408449
FTH1 ferritin, heavy polypeptide 1 -0.0408255
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0401859
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0401636
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0399726
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0398731
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0396679
GCLC glutamate-cysteine ligase, catalytic subunit -0.0381029
KRT17 keratin 17, type I -0.0378783
RBM15 RNA binding motif protein 15 -0.0378202
NHSL1 NHS-like 1 -0.0375075
RPL31 ribosomal protein L31 -0.0374407
RPS24 ribosomal protein S24 -0.0371161
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.037088
STC1 stanniocalcin 1 -0.0369094
DSCAM Down syndrome cell adhesion molecule -0.0368773
ACVR1 activin A receptor, type I -0.0368027
RCOR1 REST corepressor 1 -0.0365199
ZNFX1 zinc finger, NFX1-type containing 1 -0.0364145
CAPN2 calpain 2, (m/II) large subunit -0.0362433
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0360931
CEMIP cell migration inducing protein, hyaluronan binding -0.0360677
ABHD17C abhydrolase domain containing 17C -0.0360508
NPEPPS aminopeptidase puromycin sensitive -0.0356912
RAB1A RAB1A, member RAS oncogene family -0.0349925
RB1CC1 RB1-inducible coiled-coil 1 -0.0347652
RPL11 ribosomal protein L11 -0.0346293
S100A10 S100 calcium binding protein A10 -0.0340238
SRPK2 SRSF protein kinase 2 -0.0339182
WASF2 WAS protein family, member 2 -0.0339168
KTN1 kinectin 1 (kinesin receptor) -0.0330459
STK24 serine/threonine kinase 24 -0.0327892
ZBTB20 zinc finger and BTB domain containing 20 -0.0326998
BBX bobby sox homolog (Drosophila) -0.032685
MED13 mediator complex subunit 13 -0.0326688
OSMR oncostatin M receptor -0.0324823
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.032351
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0323411
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0322637
DENND4C DENN/MADD domain containing 4C -0.0320809
FBXO11 F-box protein 11 -0.031918
ZMYND8 zinc finger, MYND-type containing 8 -0.0319126
SOX4 SRY (sex determining region Y)-box 4 -0.031673
AHNAK AHNAK nucleoprotein -0.0314177
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0313119
RPL12 ribosomal protein L12 -0.0311334
DIAPH1 diaphanous-related formin 1 -0.031018
SQSTM1 sequestosome 1 -0.0307748