Ferulic acid_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ferulic acid perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ferulic acid_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.153992
GRAMD1B GRAM domain containing 1B 0.0933189
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0916057
ERRFI1 ERBB receptor feedback inhibitor 1 0.0904472
TPM3 tropomyosin 3 0.0897429
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.089571
PLEC plectin 0.0830651
MYH9 myosin, heavy chain 9, non-muscle 0.0789776
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.07728
KRT18 keratin 18, type I 0.0755371
MACF1 microtubule-actin crosslinking factor 1 0.0653655
RAD51B RAD51 paralog B 0.0637553
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0621427
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0619943
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0618545
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0598238
RPL3 ribosomal protein L3 0.0593351
TRIO trio Rho guanine nucleotide exchange factor 0.057484
NONO non-POU domain containing, octamer-binding 0.0565714
PRELID2 PRELI domain containing 2 0.055178
ATP11A ATPase, class VI, type 11A 0.053826
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0533075
ADAR adenosine deaminase, RNA-specific 0.0523325
FUS FUS RNA binding protein 0.0508599
RRM2 ribonucleotide reductase M2 0.0507532
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0505841
CAMTA1 calmodulin binding transcription activator 1 0.0500589
CEP250 centrosomal protein 250kDa 0.0499133
HSPA8 heat shock 70kDa protein 8 0.0497193
YBX1 Y box binding protein 1 0.0492877
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.049072
SMAD3 SMAD family member 3 0.04895
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.047371
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0470774
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0465787
H1-0 H1.0 linker histone 0.0463217
PFKP phosphofructokinase, platelet 0.0462567
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0460323
PTPRF protein tyrosine phosphatase, receptor type, F 0.0459455
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0450519
FLNA filamin A, alpha 0.0450305
CEP192 centrosomal protein 192kDa 0.0448164
MKI67 marker of proliferation Ki-67 0.0439461
PKM pyruvate kinase, muscle 0.0436584
CTTN cortactin 0.043581
PRRC2A proline-rich coiled-coil 2A 0.0435352
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0422899
IGF1R insulin-like growth factor 1 receptor 0.0419849
NCAPD2 non-SMC condensin I complex, subunit D2 0.041154
RPL37A ribosomal protein L37a 0.0405049
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0400827
PTMA prothymosin, alpha 0.0400586
FMNL2 formin-like 2 0.0399647
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0394387
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0391166
ENO1 enolase 1, (alpha) 0.038042
MSN moesin 0.0378283
PRPF8 pre-mRNA processing factor 8 0.0373453
LOC112694756 uncharaterized LOC112694756 0.0372683
KMT2D lysine (K)-specific methyltransferase 2D 0.0370166
ACTN1 actinin, alpha 1 0.0368811
ARID1A AT rich interactive domain 1A (SWI-like) 0.03678
RPS10 ribosomal protein S10 0.0366414
ATXN1 ataxin 1 0.0362911
IQGAP3 IQ motif containing GTPase activating protein 3 0.0360429
MCL1 myeloid cell leukemia 1 0.0348899
SET SET nuclear proto-oncogene 0.0348082
THSD4 thrombospondin, type I, domain containing 4 0.0347741
RPS3 ribosomal protein S3 0.0344594
SMYD3 SET and MYND domain containing 3 0.0344412
WWOX WW domain containing oxidoreductase 0.0340857
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0339475
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0339319
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0338986
WNK1 WNK lysine deficient protein kinase 1 0.0333214
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0331009
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0329264
NUMA1 nuclear mitotic apparatus protein 1 0.0328557
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0328397
ANKRD36 ankyrin repeat domain 36 0.0326352
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0322257
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0321807
RBM33 RNA binding motif protein 33 0.0317793
TPI1 triosephosphate isomerase 1 0.0317423
SHB Src homology 2 domain containing adaptor protein B 0.031714
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.030875
PGK1 phosphoglycerate kinase 1 0.0307411
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0303605
MINK1 misshapen-like kinase 1 0.0302848
FAM168A family with sequence similarity 168, member A 0.0302523
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0302284
OGA O-GlcNAcase 0.0301484
EXT1 exostosin glycosyltransferase 1 0.0300745
SND1 staphylococcal nuclease and tudor domain containing 1 0.0296096
UBAP2L ubiquitin associated protein 2-like 0.0294217
UBE2H ubiquitin-conjugating enzyme E2H 0.0292602
NCOR2 nuclear receptor corepressor 2 0.029181
ACTG1 actin gamma 1 0.0290901
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0289839
TLN1 talin 1 0.0289641

decreased expression

Symbol Name Standardized Value
OSMR oncostatin M receptor -0.057923
NABP1 nucleic acid binding protein 1 -0.0563546
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0548864
TXNRD1 thioredoxin reductase 1 -0.0367631
RIMS2 regulating synaptic membrane exocytosis 2 -0.035638
LOC102724023 ES1 protein homolog, mitochondrial -0.0349033
VCL vinculin -0.0339137
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.032452
HMGA2 high mobility group AT-hook 2 -0.0310804
CDK17 cyclin-dependent kinase 17 -0.030094
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0299723
BPTF bromodomain PHD finger transcription factor -0.0297458
WNT2B wingless-type MMTV integration site family, member 2B -0.0296558
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0290926
SLC38A2 solute carrier family 38, member 2 -0.0271994
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0262317
VMP1 vacuole membrane protein 1 -0.0258633
IFIH1 interferon induced with helicase C domain 1 -0.0244964
CCND1 cyclin D1 -0.0240583
RBM25 RNA binding motif protein 25 -0.0238941
ATF6 activating transcription factor 6 -0.0238351
NSUN6 NOP2/Sun domain family, member 6 -0.023832
TFPI2 tissue factor pathway inhibitor 2 -0.0230282
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0227674
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0223843
RIGI RNA sensor RIG-I -0.0223406
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0222768
PHF14 PHD finger protein 14 -0.0221214
PLSCR1 phospholipid scramblase 1 -0.0218168
GOSR1 golgi SNAP receptor complex member 1 -0.0216527
BICD1 bicaudal D homolog 1 (Drosophila) -0.0215518
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0212684
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.021035
SENP6 SUMO1/sentrin specific peptidase 6 -0.0208628
ZNF644 zinc finger protein 644 -0.0200883
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0200752
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0198534
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0196444
DUSP6 dual specificity phosphatase 6 -0.01951
TUT4 terminal uridylyl transferase 4 -0.0193343
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0192698
KLF6 Kruppel-like factor 6 -0.019225
NF1 neurofibromin 1 -0.0191841
CALD1 caldesmon 1 -0.018905
RBBP6 retinoblastoma binding protein 6 -0.0188809
NBEAL1 neurobeachin-like 1 -0.0188735
STC1 stanniocalcin 1 -0.0188183
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0186319
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0181635
JMJD1C jumonji domain containing 1C -0.0180996
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0178197
CLDN1 claudin 1 -0.0175782
SCLT1 sodium channel and clathrin linker 1 -0.0175586
YBX3 Y box binding protein 3 -0.0174114
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0173665
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0172452
DCAF10 DDB1 and CUL4 associated factor 10 -0.0172425
THADA thyroid adenoma associated -0.0172205
MMP12 matrix metallopeptidase 12 -0.0171934
DDIT3 DNA-damage-inducible transcript 3 -0.0171518
NRG1 neuregulin 1 -0.0168505
DNAH14 dynein, axonemal, heavy chain 14 -0.01665
PIBF1 progesterone immunomodulatory binding factor 1 -0.0165012
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0164298
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0163884
GOLM2 golgi membrane protein 2 -0.0163448
NCOA7 nuclear receptor coactivator 7 -0.0163292
TASOR2 transcription activation suppressor family member 2 -0.0162119
FBXL2 F-box and leucine-rich repeat protein 2 -0.0160829
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0160214
DHFR dihydrofolate reductase -0.015915
KDM5A lysine (K)-specific demethylase 5A -0.0158532
REL v-rel avian reticuloendotheliosis viral oncogene homolog -0.0155856
RASAL2 RAS protein activator like 2 -0.0154851
TMEM263 transmembrane protein 263 -0.0153977
EHBP1 EH domain binding protein 1 -0.0149877
PCF11 PCF11 cleavage and polyadenylation factor subunit -0.0149689
GPATCH8 G patch domain containing 8 -0.0147342
ELL2 elongation factor, RNA polymerase II, 2 -0.0146374
MSRB3 methionine sulfoxide reductase B3 -0.0145414
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0144598
RAB7A RAB7A, member RAS oncogene family -0.0144119
NSRP1 nuclear speckle splicing regulatory protein 1 -0.0143418
FAF2 Fas associated factor family member 2 -0.0143358
TMEM87A transmembrane protein 87A -0.0143309
TAPBP TAP binding protein (tapasin) -0.0143183
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0142854
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0142732
TAOK1 TAO kinase 1 -0.0142548
ZMYM4 zinc finger, MYM-type 4 -0.0142505
MYSM1 Myb-like, SWIRM and MPN domains 1 -0.0141274
TUT7 terminal uridylyl transferase 7 -0.0139842
ETV6 ets variant 6 -0.0139674
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0139625
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0138738
PDLIM5 PDZ and LIM domain 5 -0.0137903
SNAP25 synaptosomal-associated protein, 25kDa -0.0137779
TRIM56 tripartite motif containing 56 -0.0137728
LIMA1 LIM domain and actin binding 1 -0.0136323
R3HDM2 R3H domain containing 2 -0.0135501