Ferulic acid_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ferulic acid perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ferulic acid_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.17309
MYH9 myosin, heavy chain 9, non-muscle 0.156906
PLEC plectin 0.127049
FN1 fibronectin 1 0.118887
GRB10 growth factor receptor-bound protein 10 0.118706
VEGFA vascular endothelial growth factor A 0.114015
FNDC3B fibronectin type III domain containing 3B 0.0945692
EEF2 eukaryotic translation elongation factor 2 0.0757557
MSN moesin 0.069306
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0623053
TRIO trio Rho guanine nucleotide exchange factor 0.0618123
NAV2 neuron navigator 2 0.0533301
UBA6 ubiquitin-like modifier activating enzyme 6 0.051664
BHLHE40 basic helix-loop-helix family, member e40 0.0502054
TPM3 tropomyosin 3 0.0490798
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0490551
APLP2 amyloid beta (A4) precursor-like protein 2 0.047468
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0455679
ARRDC3 arrestin domain containing 3 0.045375
FLNB filamin B, beta 0.0444919
FAM13A family with sequence similarity 13, member A 0.0440596
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0430307
FLNA filamin A, alpha 0.0415036
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0406302
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0403165
RPL3 ribosomal protein L3 0.038801
TNIP1 TNFAIP3 interacting protein 1 0.0384546
PPARD peroxisome proliferator-activated receptor delta 0.0381989
UPP1 uridine phosphorylase 1 0.0377084
DUSP10 dual specificity phosphatase 10 0.0367785
PTK2 protein tyrosine kinase 2 0.0364985
HSPA8 heat shock 70kDa protein 8 0.0356262
LPP LIM domain containing preferred translocation partner in lipoma 0.0351125
DSPP dentin sialophosphoprotein 0.0349277
LAMC2 laminin, gamma 2 0.0349066
ELL2 elongation factor, RNA polymerase II, 2 0.0343638
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.034196
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0338788
MACF1 microtubule-actin crosslinking factor 1 0.0336527
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0330244
IGFBP3 insulin-like growth factor binding protein 3 0.0330237
KRT8 keratin 8, type II 0.0318936
RAD23B RAD23 homolog B (S. cerevisiae) 0.0294743
CALR calreticulin 0.0292579
PKM pyruvate kinase, muscle 0.0288777
USP9X ubiquitin specific peptidase 9, X-linked 0.0283791
COPA coatomer protein complex, subunit alpha 0.0283552
KDM6A lysine (K)-specific demethylase 6A 0.0282809
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0282557
G0S2 G0/G1 switch 2 0.0278205
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0278186
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.027732
AHDC1 AT hook, DNA binding motif, containing 1 0.0275443
NONO non-POU domain containing, octamer-binding 0.0272848
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0271894
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0264701
MYO5B myosin VB 0.0264009
RCOR1 REST corepressor 1 0.0260278
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0257192
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0255986
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0255571
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0250081
KRT18 keratin 18, type I 0.0245462
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0245309
NUP58 nucleoporin 58 0.0242593
MXD1 MAX dimerization protein 1 0.024229
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0240849
FXR1 fragile X mental retardation, autosomal homolog 1 0.0237525
ERRFI1 ERBB receptor feedback inhibitor 1 0.0237476
TRA2B transformer 2 beta homolog (Drosophila) 0.0234896
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0234416
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0233959
PRRC2C proline-rich coiled-coil 2C 0.0229881
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0227362
NUMA1 nuclear mitotic apparatus protein 1 0.0226851
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0224612
SLMAP sarcolemma associated protein 0.0223539
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.02227
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0222428
SEC23A Sec23 homolog A (S. cerevisiae) 0.022152
ADAR adenosine deaminase, RNA-specific 0.0219979
FEM1C fem-1 homolog c (C. elegans) 0.0216207
APP amyloid beta (A4) precursor protein 0.0214411
HDGF hepatoma-derived growth factor 0.0212765
CSNK1A1 casein kinase 1, alpha 1 0.0210806
CCNL1 cyclin L1 0.0205052
MSI2 musashi RNA-binding protein 2 0.020425
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0201201
AFDN afadin, adherens junction formation factor 0.0201121
SET SET nuclear proto-oncogene 0.02001
WNK1 WNK lysine deficient protein kinase 1 0.0197471
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0196928
SMAD3 SMAD family member 3 0.0196861
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0196586
MED15 mediator complex subunit 15 0.0196047
HOOK2 hook microtubule-tethering protein 2 0.0195762
CD109 CD109 molecule 0.0195439
CCNY cyclin Y 0.0194654
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0194286
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.019365

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.256675
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.241662
FTL ferritin, light polypeptide -0.225731
TMSB10 thymosin beta 10 -0.1468
TPT1 tumor protein, translationally-controlled 1 -0.137975
S100A6 S100 calcium binding protein A6 -0.136715
PTMA prothymosin, alpha -0.129633
RPLP1 ribosomal protein, large, P1 -0.104567
ACTG1 actin gamma 1 -0.102191
RPL35A ribosomal protein L35a -0.0938494
RPL34 ribosomal protein L34 -0.0789832
ALCAM activated leukocyte cell adhesion molecule -0.0718409
SLC38A1 solute carrier family 38, member 1 -0.0674788
RPLP2 ribosomal protein, large, P2 -0.0650188
S100A10 S100 calcium binding protein A10 -0.0649281
EIF1 eukaryotic translation initiation factor 1 -0.0584332
MT2A metallothionein 2A -0.0571236
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0570106
RPL8 ribosomal protein L8 -0.055585
RPS8 ribosomal protein S8 -0.0524209
HMGA1 high mobility group AT-hook 1 -0.0519819
GNAS GNAS complex locus -0.0511991
CCND1 cyclin D1 -0.051082
RPS19 ribosomal protein S19 -0.0504892
RPS6 ribosomal protein S6 -0.0503954
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0497747
RPS29 ribosomal protein S29 -0.0495202
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0493277
TM4SF1 transmembrane 4 L six family member 1 -0.0492637
RPS24 ribosomal protein S24 -0.0478325
RPL32 ribosomal protein L32 -0.04461
IFITM3 interferon induced transmembrane protein 3 -0.0443953
RPL12 ribosomal protein L12 -0.0439318
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.043525
ISG15 ISG15 ubiquitin-like modifier -0.0434899
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0422679
IFI27 interferon, alpha-inducible protein 27 -0.041687
RPL19 ribosomal protein L19 -0.0412325
VIM vimentin -0.0403086
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0402575
SDC4 syndecan 4 -0.0401268
CSTB cystatin B (stefin B) -0.0396968
IFITM1 interferon induced transmembrane protein 1 -0.0387588
UBC ubiquitin C -0.03857
RPL28 ribosomal protein L28 -0.0379686
RPL27A ribosomal protein L27a -0.0379077
RPS23 ribosomal protein S23 -0.0377071
LMO7 LIM domain 7 -0.0372847
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0364411
RPS13 ribosomal protein S13 -0.0360903
RPLP0 ribosomal protein, large, P0 -0.0359451
S100A9 S100 calcium binding protein A9 -0.0353439
RPL23 ribosomal protein L23 -0.0350775
RPS25 ribosomal protein S25 -0.0347525
RPL37 ribosomal protein L37 -0.0347205
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0346181
C15ORF48 chromosome 15 open reading frame 48 -0.0338967
RPS21 ribosomal protein S21 -0.0337997
SQSTM1 sequestosome 1 -0.0337451
RPS14 ribosomal protein S14 -0.0336392
IFI16 interferon, gamma-inducible protein 16 -0.0335751
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0329753
RPS16 ribosomal protein S16 -0.0328686
RPL31 ribosomal protein L31 -0.0323538
EPCAM epithelial cell adhesion molecule -0.0322104
IFI6 interferon, alpha-inducible protein 6 -0.0321276
NPC2 Niemann-Pick disease, type C2 -0.0315048
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0306918
RPS20 ribosomal protein S20 -0.0305033
RPS5 ribosomal protein S5 -0.0299224
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0284338
CD2AP CD2-associated protein -0.0276709
F11R F11 receptor -0.0275044
RPL36A ribosomal protein L36a -0.0273908
RPS27A ribosomal protein S27a -0.0273467
DEK DEK proto-oncogene -0.0272915
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0272295
POTEF POTE ankyrin domain family, member F -0.0271966
RPL11 ribosomal protein L11 -0.0264806
TMEM263 transmembrane protein 263 -0.0263673
RPL15 ribosomal protein L15 -0.0263501
TPM4 tropomyosin 4 -0.0260125
MYL12B myosin, light chain 12B, regulatory -0.0259411
S100A11 S100 calcium binding protein A11 -0.0256476
IER3 immediate early response 3 -0.0253168
DSG2 desmoglein 2 -0.0252785
CCNI cyclin I -0.0252735
SOX4 SRY (sex determining region Y)-box 4 -0.0250055
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0249557
TACSTD2 tumor-associated calcium signal transducer 2 -0.024214
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0241509
RPS15 ribosomal protein S15 -0.023855
HMGB1 high mobility group box 1 -0.0238461
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0237422
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0236806
VDAC1 voltage-dependent anion channel 1 -0.0235451
RPS3 ribosomal protein S3 -0.0233301
CAVIN1 caveolae associated protein 1 -0.0230637
CTSD cathepsin D -0.0229285
RPL9 ribosomal protein L9 -0.0226964