Ferulic acid_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ferulic acid perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ferulic acid_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase 0.129444
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.120491
EFNA5 ephrin-A5 0.115739
TRIO trio Rho guanine nucleotide exchange factor 0.114874
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.110929
PDE10A phosphodiesterase 10A 0.100271
FNDC3B fibronectin type III domain containing 3B 0.0919498
PSD3 pleckstrin and Sec7 domain containing 3 0.0882597
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0828696
LIMCH1 LIM and calponin homology domains 1 0.0787566
NAMPT nicotinamide phosphoribosyltransferase 0.0771222
MCL1 myeloid cell leukemia 1 0.0740064
NRCAM neuronal cell adhesion molecule 0.0701786
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0682094
FLNB filamin B, beta 0.0681696
EEF2 eukaryotic translation elongation factor 2 0.0672844
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0589397
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0560568
GRAMD1B GRAM domain containing 1B 0.0540741
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0528148
TNIP1 TNFAIP3 interacting protein 1 0.0523888
ESYT2 extended synaptotagmin-like protein 2 0.0511866
PCBP3 poly(rC) binding protein 3 0.0509336
DST dystonin 0.0507827
PDE4D phosphodiesterase 4D, cAMP-specific 0.0495405
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0469955
NEK7 NIMA-related kinase 7 0.046421
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0460002
NDRG1 N-myc downstream regulated 1 0.045062
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0444766
CDH13 cadherin 13 0.044244
DOCK4 dedicator of cytokinesis 4 0.043717
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0423438
MYOF myoferlin 0.0417052
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0415038
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0403146
GDA guanine deaminase 0.0402191
NCOR2 nuclear receptor corepressor 2 0.0401919
FLNA filamin A, alpha 0.0395721
RPL3 ribosomal protein L3 0.0394707
SMOC1 SPARC related modular calcium binding 1 0.0381735
CTIF CBP80/20-dependent translation initiation factor 0.03741
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0364823
AGFG1 ArfGAP with FG repeats 1 0.0361456
ERRFI1 ERBB receptor feedback inhibitor 1 0.0360777
PDLIM5 PDZ and LIM domain 5 0.0355983
COL5A2 collagen, type V, alpha 2 0.0354515
SAMD4A sterile alpha motif domain containing 4A 0.0352501
MSN moesin 0.0341783
TGFBI transforming growth factor, beta-induced, 68kDa 0.0340523
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.033625
TBXT T-box transcription factor T 0.033449
HSPA8 heat shock 70kDa protein 8 0.0333225
KYNU kynureninase 0.0324767
COL4A6 collagen, type IV, alpha 6 0.0314569
ADGRD1 adhesion G protein-coupled receptor D1 0.0313258
NPAS2 neuronal PAS domain protein 2 0.0312401
CTBP2 C-terminal binding protein 2 0.0308095
TPM3 tropomyosin 3 0.0306787
NONO non-POU domain containing, octamer-binding 0.0305054
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0304229
BCAR3 breast cancer anti-estrogen resistance 3 0.0303754
NBAS neuroblastoma amplified sequence 0.0302795
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0300049
SOD2 superoxide dismutase 2, mitochondrial 0.030004
USP9X ubiquitin specific peptidase 9, X-linked 0.0299837
LOC112694756 uncharaterized LOC112694756 0.029498
HELZ helicase with zinc finger 0.0293319
COPA coatomer protein complex, subunit alpha 0.028395
FAM13A family with sequence similarity 13, member A 0.0282358
STC2 stanniocalcin 2 0.027483
BHLHE40 basic helix-loop-helix family, member e40 0.0269867
MYH9 myosin, heavy chain 9, non-muscle 0.0268987
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0267065
PRELID2 PRELI domain containing 2 0.0266576
ITPRID2 ITPR interacting domain containing 2 0.0260854
RAB3B RAB3B, member RAS oncogene family 0.0258704
DGKD diacylglycerol kinase, delta 130kDa 0.0257565
COL8A1 collagen, type VIII, alpha 1 0.0257468
ZEB2 zinc finger E-box binding homeobox 2 0.0256785
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0255042
PLEC plectin 0.0253888
DNER delta/notch-like EGF repeat containing 0.0250114
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0250046
AKAP13 A kinase (PRKA) anchor protein 13 0.0248418
NCAM1 neural cell adhesion molecule 1 0.0246166
GPC6 glypican 6 0.024494
ZNF292 zinc finger protein 292 0.0244683
BIRC6 baculoviral IAP repeat containing 6 0.0244609
ATP13A3 ATPase type 13A3 0.0244107
SDK1 sidekick cell adhesion molecule 1 0.0242457
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0240628
GRB10 growth factor receptor-bound protein 10 0.0238891
CD109 CD109 molecule 0.0238741
WDFY2 WD repeat and FYVE domain containing 2 0.0238193
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0237019
NUP58 nucleoporin 58 0.023684
TGFBR1 transforming growth factor, beta receptor 1 0.023595
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0232986
ELL2 elongation factor, RNA polymerase II, 2 0.0232596

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.176479
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0993211
VIM vimentin -0.0929775
TMSB10 thymosin beta 10 -0.089055
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0859094
TPT1 tumor protein, translationally-controlled 1 -0.0671652
RPS6 ribosomal protein S6 -0.0635772
PTMA prothymosin, alpha -0.0615183
RPLP1 ribosomal protein, large, P1 -0.0607722
FTL ferritin, light polypeptide -0.0586052
RPS24 ribosomal protein S24 -0.0550545
MT2A metallothionein 2A -0.0492228
RPL31 ribosomal protein L31 -0.0489872
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0431841
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0423849
RPL35A ribosomal protein L35a -0.0420124
RPL12 ribosomal protein L12 -0.0417643
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0407418
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0406668
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0403406
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.040284
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0382143
S100A6 S100 calcium binding protein A6 -0.0378789
RPS8 ribosomal protein S8 -0.0370901
RPS19 ribosomal protein S19 -0.0368464
RPS23 ribosomal protein S23 -0.0356884
RPL34 ribosomal protein L34 -0.0339819
RPLP2 ribosomal protein, large, P2 -0.0333511
RPL19 ribosomal protein L19 -0.0331396
RPL26 ribosomal protein L26 -0.0299736
RPS29 ribosomal protein S29 -0.0299448
SRGN serglycin -0.029278
RPL23 ribosomal protein L23 -0.0286239
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0271932
RPS14 ribosomal protein S14 -0.0259857
RPS21 ribosomal protein S21 -0.0256242
RPL7A ribosomal protein L7a -0.025228
RPL9 ribosomal protein L9 -0.025185
RPL37A ribosomal protein L37a -0.0247344
RPS25 ribosomal protein S25 -0.0246771
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0243303
SMYD3 SET and MYND domain containing 3 -0.0241606
S100A10 S100 calcium binding protein A10 -0.0240808
TFPI2 tissue factor pathway inhibitor 2 -0.0238772
RPL32 ribosomal protein L32 -0.0236755
RPS27A ribosomal protein S27a -0.0234814
GNAS GNAS complex locus -0.0234794
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.023463
RPL36A ribosomal protein L36a -0.0233027
EIF1 eukaryotic translation initiation factor 1 -0.0231111
SOX4 SRY (sex determining region Y)-box 4 -0.0227161
RPS13 ribosomal protein S13 -0.0224049
KIAA0825 KIAA0825 -0.0221953
RPS16 ribosomal protein S16 -0.0221694
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0217193
RPS3 ribosomal protein S3 -0.021606
RPL36 ribosomal protein L36 -0.0214793
VDAC1 voltage-dependent anion channel 1 -0.0210824
TM4SF1 transmembrane 4 L six family member 1 -0.0204829
RPL37 ribosomal protein L37 -0.0202457
NCKAP5 NCK-associated protein 5 -0.020155
RPLP0 ribosomal protein, large, P0 -0.0196745
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0194428
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0177724
RPL28 ribosomal protein L28 -0.0176221
ATP5F1E ATP synthase F1 subunit epsilon -0.0168875
FN1 fibronectin 1 -0.0168312
RGS2 regulator of G-protein signaling 2 -0.0167247
SCN3A sodium channel, voltage gated, type III alpha subunit -0.0166164
B2M beta-2-microglobulin -0.01655
CADM2 cell adhesion molecule 2 -0.016542
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0164662
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0164218
S100A11 S100 calcium binding protein A11 -0.016208
RPL5 ribosomal protein L5 -0.0161882
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0159226
NCOA7 nuclear receptor coactivator 7 -0.0158443
BASP1 brain abundant, membrane attached signal protein 1 -0.0156273
RPL11 ribosomal protein L11 -0.0156154
RPS28 ribosomal protein S28 -0.0155975
RPL27A ribosomal protein L27a -0.0154588
WSB1 WD repeat and SOCS box containing 1 -0.0154165
BPTF bromodomain PHD finger transcription factor -0.0152808
RPS15 ribosomal protein S15 -0.0151344
RPS27 ribosomal protein S27 -0.0150739
SLC38A2 solute carrier family 38, member 2 -0.0150452
RPL35 ribosomal protein L35 -0.0148888
RPL13A ribosomal protein L13a -0.0148797
FOXC1 forkhead box C1 -0.0146706
EIF5B eukaryotic translation initiation factor 5B -0.0146115
S100A9 S100 calcium binding protein A9 -0.0145209
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0144889
HLA-B major histocompatibility complex, class I, B -0.0143352
RANBP17 RAN binding protein 17 -0.0143085
ADGRB3 adhesion G protein-coupled receptor B3 -0.014225
ASTN2 astrotactin 2 -0.0141596
TBCA tubulin folding cofactor A -0.0140772
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0140741
CCNI cyclin I -0.0139533
HLA-A major histocompatibility complex, class I, A -0.0138883