Ferulic acid_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ferulic acid perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ferulic acid_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.159581
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.140979
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.121465
NDRG1 N-myc downstream regulated 1 0.109841
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.101026
DSCAM Down syndrome cell adhesion molecule 0.0926439
LMO7 LIM domain 7 0.0896338
TNPO1 transportin 1 0.0853942
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0847477
BAIAP2L1 BAI1-associated protein 2-like 1 0.0845448
WAC WW domain containing adaptor with coiled-coil 0.083224
FNIP1 folliculin interacting protein 1 0.083032
NAP1L4 nucleosome assembly protein 1-like 4 0.0816935
CCNY cyclin Y 0.0778802
PARD3 par-3 family cell polarity regulator 0.0770418
ERBIN erbb2 interacting protein 0.075092
PRELID2 PRELI domain containing 2 0.0749264
USP9X ubiquitin specific peptidase 9, X-linked 0.0745761
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.0720677
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0716953
FN1 fibronectin 1 0.0703529
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0699739
BIRC6 baculoviral IAP repeat containing 6 0.0683879
THOC2 THO complex 2 0.0668991
PTK2 protein tyrosine kinase 2 0.0658806
PICALM phosphatidylinositol binding clathrin assembly protein 0.0656168
RAB22A RAB22A, member RAS oncogene family 0.064731
HLA-E major histocompatibility complex, class I, E 0.0645484
FMN1 formin 1 0.0639479
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0637153
RSRC2 arginine/serine-rich coiled-coil 2 0.0599463
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0585399
ANKRD11 ankyrin repeat domain 11 0.0572633
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0568626
ADAM17 ADAM metallopeptidase domain 17 0.0564548
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0549275
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0547722
USP53 ubiquitin specific peptidase 53 0.0543552
BTBD9 BTB (POZ) domain containing 9 0.0536477
ITGA6 integrin, alpha 6 0.0536299
YAP1 Yes-associated protein 1 0.0514429
COPA coatomer protein complex, subunit alpha 0.051069
KIDINS220 kinase D-interacting substrate, 220kDa 0.0495353
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0487769
RNF149 ring finger protein 149 0.0486859
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0479826
MACF1 microtubule-actin crosslinking factor 1 0.0476239
LIMS1 LIM and senescent cell antigen-like domains 1 0.0468434
VEGFA vascular endothelial growth factor A 0.0461376
ARRDC3 arrestin domain containing 3 0.0447795
TPM3 tropomyosin 3 0.0444045
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0428855
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0424393
RAB7A RAB7A, member RAS oncogene family 0.0422154
PIAS1 protein inhibitor of activated STAT, 1 0.0418735
FNBP4 formin binding protein 4 0.0416
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0413476
PRRC2C proline-rich coiled-coil 2C 0.0413202
ACTN4 actinin, alpha 4 0.0413134
PNISR PNN-interacting serine/arginine-rich protein 0.0401472
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0398859
KLF6 Kruppel-like factor 6 0.0398128
SHB Src homology 2 domain containing adaptor protein B 0.0394497
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0390669
ATXN1 ataxin 1 0.0386199
TRA2B transformer 2 beta homolog (Drosophila) 0.0376216
CDK8 cyclin-dependent kinase 8 0.0374864
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.034977
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0340708
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0332235
RBM26 RNA binding motif protein 26 0.0328947
SVIL supervillin 0.032828
DENND4A DENN/MADD domain containing 4A 0.0320853
USP47 ubiquitin specific peptidase 47 0.0319454
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0317702
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0314877
NCOA3 nuclear receptor coactivator 3 0.0313636
SND1 staphylococcal nuclease and tudor domain containing 1 0.0309282
RPS3 ribosomal protein S3 0.0298699
PNPLA8 patatin-like phospholipase domain containing 8 0.0294292
TJP2 tight junction protein 2 0.0288364
NAP1L1 nucleosome assembly protein 1-like 1 0.0284703
SENP5 SUMO1/sentrin specific peptidase 5 0.0270439
CEMIP2 cell migration inducing hyaluronidase 2 0.0266704
CUX1 cut-like homeobox 1 0.0266599
ZNF292 zinc finger protein 292 0.0265841
EIF4B eukaryotic translation initiation factor 4B 0.0265758
CERT1 ceramide transporter 1 0.0257705
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0255228
MCTP1 multiple C2 domains, transmembrane 1 0.0249926
KMT2C lysine (K)-specific methyltransferase 2C 0.024656
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0240133
SMAD3 SMAD family member 3 0.023735
ARHGAP32 Rho GTPase activating protein 32 0.0231969
PIBF1 progesterone immunomodulatory binding factor 1 0.0231563
APP amyloid beta (A4) precursor protein 0.0230765
APLP2 amyloid beta (A4) precursor-like protein 2 0.0227047
APAF1 apoptotic peptidase activating factor 1 0.022174
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0221334
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0213124

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.28649
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.164928
CANX calnexin -0.13318
VIM vimentin -0.126684
FTL ferritin, light polypeptide -0.113149
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.112596
ASPH aspartate beta-hydroxylase -0.108101
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.10243
NAMPT nicotinamide phosphoribosyltransferase -0.0988527
TMSB10 thymosin beta 10 -0.0914929
PKM pyruvate kinase, muscle -0.0874391
GPC6 glypican 6 -0.0860196
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0854337
CCNI cyclin I -0.0823004
RPS8 ribosomal protein S8 -0.0779949
AHNAK AHNAK nucleoprotein -0.0752045
GOLGA4 golgin A4 -0.0735895
LDHA lactate dehydrogenase A -0.0723549
EIF1 eukaryotic translation initiation factor 1 -0.0713026
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0701875
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0698667
NF1 neurofibromin 1 -0.0697534
LOC112694756 uncharaterized LOC112694756 -0.0690424
B2M beta-2-microglobulin -0.0689399
PTMA prothymosin, alpha -0.0686964
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0664188
S100A9 S100 calcium binding protein A9 -0.0650307
TOR1AIP2 torsin A interacting protein 2 -0.0635096
UBC ubiquitin C -0.062391
MT2A metallothionein 2A -0.0616826
AKAP12 A kinase (PRKA) anchor protein 12 -0.0585802
TPT1 tumor protein, translationally-controlled 1 -0.0578388
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0568774
EXT1 exostosin glycosyltransferase 1 -0.0542241
ADAM10 ADAM metallopeptidase domain 10 -0.0527841
EFNA5 ephrin-A5 -0.0515672
OSMR oncostatin M receptor -0.0508654
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0508151
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.050704
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0505269
IGFBP3 insulin-like growth factor binding protein 3 -0.0497853
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0471848
SLC38A2 solute carrier family 38, member 2 -0.0470075
SLC38A1 solute carrier family 38, member 1 -0.0462622
ACTG1 actin gamma 1 -0.0457779
LOXL2 lysyl oxidase-like 2 -0.0456141
TNRC6B trinucleotide repeat containing 6B -0.0446222
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.044221
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0436746
WSB1 WD repeat and SOCS box containing 1 -0.0403673
HLA-B major histocompatibility complex, class I, B -0.0394256
SAMD4A sterile alpha motif domain containing 4A -0.0376059
SMYD3 SET and MYND domain containing 3 -0.0375217
SETD5 SET domain containing 5 -0.037274
MAP1B microtubule-associated protein 1B -0.036841
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0367518
MAP4 microtubule-associated protein 4 -0.0361173
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0353332
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0352044
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0342555
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0339925
DST dystonin -0.0335765
SON SON DNA binding protein -0.0308856
GRB10 growth factor receptor-bound protein 10 -0.0308345
RPL34 ribosomal protein L34 -0.0307378
GSK3B glycogen synthase kinase 3 beta -0.0300266
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0299415
USP37 ubiquitin specific peptidase 37 -0.0291888
ZFHX3 zinc finger homeobox 3 -0.0281585
FTH1 ferritin, heavy polypeptide 1 -0.0265469
SOD2 superoxide dismutase 2, mitochondrial -0.0261008
FBXO11 F-box protein 11 -0.0258179
KTN1 kinectin 1 (kinesin receptor) -0.0255444
TJP1 tight junction protein 1 -0.0254687
RAP1B RAP1B, member of RAS oncogene family -0.0254014
CD46 CD46 molecule, complement regulatory protein -0.0247449
RPS12 ribosomal protein S12 -0.0246229
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0242016
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0227757
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0225474
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0223618
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0221172
VCL vinculin -0.020451
ZNF395 zinc finger protein 395 -0.0204188
GMDS GDP-mannose 4,6-dehydratase -0.02031
TNPO3 transportin 3 -0.0200102
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0196693
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0185479
ZFAND3 zinc finger, AN1-type domain 3 -0.0178118
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0172426
NKD1 naked cuticle homolog 1 (Drosophila) -0.0163469
NAV1 neuron navigator 1 -0.0157386
BPTF bromodomain PHD finger transcription factor -0.015723
STC1 stanniocalcin 1 -0.0150434
OGA O-GlcNAcase -0.0148395
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0146564
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.014492
PGK1 phosphoglycerate kinase 1 -0.0123984
ZNF148 zinc finger protein 148 -0.0121723
INTS6 integrator complex subunit 6 -0.0118234