Ferulic acid_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ferulic acid perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ferulic acid_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.102265
MYH9 myosin, heavy chain 9, non-muscle 0.100436
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.090971
ZNF292 zinc finger protein 292 0.0904443
EEF2 eukaryotic translation elongation factor 2 0.0874572
DST dystonin 0.0844857
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0840927
KMT2C lysine (K)-specific methyltransferase 2C 0.0804846
TRIO trio Rho guanine nucleotide exchange factor 0.0776372
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0717887
FUS FUS RNA binding protein 0.0712353
MB21D2 Mab-21 domain containing 2 0.0671898
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0660998
TMSB4X thymosin beta 4, X-linked 0.0659049
SPAG9 sperm associated antigen 9 0.0634843
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0615366
ZEB2 zinc finger E-box binding homeobox 2 0.0610053
ITGAV integrin, alpha V 0.0600761
MYO10 myosin X 0.0591589
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0579687
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.056369
ANKRD33B ankyrin repeat domain 33B 0.0561429
UPP1 uridine phosphorylase 1 0.0550122
YBX1 Y box binding protein 1 0.0541954
NONO non-POU domain containing, octamer-binding 0.0540968
TSC22D2 TSC22 domain family, member 2 0.0532003
SRP54 signal recognition particle 54kDa 0.0527292
THBS1 thrombospondin 1 0.052406
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0519218
APP amyloid beta (A4) precursor protein 0.0507951
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.050785
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0488629
RPL3 ribosomal protein L3 0.0481823
MACF1 microtubule-actin crosslinking factor 1 0.0479831
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0466282
YAP1 Yes-associated protein 1 0.0461638
KDM6A lysine (K)-specific demethylase 6A 0.0437987
FIP1L1 factor interacting with PAPOLA and CPSF1 0.0437918
PICALM phosphatidylinositol binding clathrin assembly protein 0.0437575
BHLHE40 basic helix-loop-helix family, member e40 0.0437227
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0426358
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0421805
ZFAND3 zinc finger, AN1-type domain 3 0.0421207
HDAC9 histone deacetylase 9 0.0419844
RPL5 ribosomal protein L5 0.0413933
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0412302
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0407556
APLP2 amyloid beta (A4) precursor-like protein 2 0.0400442
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0399964
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.0393427
RAD23B RAD23 homolog B (S. cerevisiae) 0.0392477
ADGRL2 adhesion G protein-coupled receptor L2 0.038999
NCKAP1 NCK-associated protein 1 0.03898
RBM20 RNA binding motif protein 20 0.0387893
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0386204
MMP1 matrix metallopeptidase 1 0.0377669
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0376988
CORO1C coronin, actin binding protein, 1C 0.0371292
ANXA5 annexin A5 0.0370635
WDR43 WD repeat domain 43 0.0370205
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.036908
CANX calnexin 0.0366243
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0364734
SAMD4A sterile alpha motif domain containing 4A 0.0359457
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0356161
PHIP pleckstrin homology domain interacting protein 0.0354723
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0351438
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.034979
FEM1C fem-1 homolog c (C. elegans) 0.0345672
SET SET nuclear proto-oncogene 0.0344222
TPM3 tropomyosin 3 0.0339715
RBM33 RNA binding motif protein 33 0.0337092
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0335623
GASK1B golgi associated kinase 1B 0.0333055
TENM2 teneurin transmembrane protein 2 0.0330257
CALR calreticulin 0.0326352
C1QBP complement component 1, q subcomponent binding protein 0.0322341
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0322169
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 0.0320619
ANXA1 annexin A1 0.031772
FAM168A family with sequence similarity 168, member A 0.0317203
COL5A2 collagen, type V, alpha 2 0.0314146
QKI QKI, KH domain containing, RNA binding 0.0312213
RPS12 ribosomal protein S12 0.031014
SFPQ splicing factor proline/glutamine-rich 0.0307251
ZBTB35 zinc finger and BTB domain containing 35 0.030614
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0305466
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0302843
TTC28 tetratricopeptide repeat domain 28 0.0302162
PDGFC platelet derived growth factor C 0.0301557
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0301482
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0300284
LOC112694756 uncharaterized LOC112694756 0.0298917
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 0.0292752
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0292556
HSPA8 heat shock 70kDa protein 8 0.0284431
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0281596
SUB1 SUB1 homolog (S. cerevisiae) 0.0281526
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0281057
ENAH enabled homolog (Drosophila) 0.0279661

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.116023
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0920609
VIM vimentin -0.0756611
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0749426
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0673747
TOP2A topoisomerase (DNA) II alpha 170kDa -0.065713
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0641724
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0621698
CADM2 cell adhesion molecule 2 -0.060782
GNAS GNAS complex locus -0.0601741
PEG10 paternally expressed 10 -0.0569053
RPS16 ribosomal protein S16 -0.0552059
PCDH9 protocadherin 9 -0.0495384
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0487905
RPS24 ribosomal protein S24 -0.0476284
LOC102724023 ES1 protein homolog, mitochondrial -0.0467459
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0461281
RPLP1 ribosomal protein, large, P1 -0.0459035
MYL12B myosin, light chain 12B, regulatory -0.0452233
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0446476
TPT1 tumor protein, translationally-controlled 1 -0.0439862
PCLO piccolo presynaptic cytomatrix protein -0.0429738
RBM25 RNA binding motif protein 25 -0.04245
CDH19 cadherin 19, type 2 -0.0422243
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0419702
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0417933
RTN3 reticulon 3 -0.0417869
FOXP2 forkhead box P2 -0.0407744
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0397982
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0390916
MEIS2 Meis homeobox 2 -0.0389308
SNX6 sorting nexin 6 -0.0386051
MRPS30 mitochondrial ribosomal protein S30 -0.0382282
RPS8 ribosomal protein S8 -0.0376013
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0358081
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0355466
GARS1 glycyl-tRNA synthetase 1 -0.0355256
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0354525
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0345794
TNRC6B trinucleotide repeat containing 6B -0.0345339
RTN4 reticulon 4 -0.034432
WASF2 WAS protein family, member 2 -0.0324595
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0323785
COL3A1 collagen, type III, alpha 1 -0.0317738
VCL vinculin -0.0309279
LDHA lactate dehydrogenase A -0.03047
SLC30A8 solute carrier family 30 (zinc transporter), member 8 -0.0301807
BSG basigin (Ok blood group) -0.0296358
SMC4 structural maintenance of chromosomes 4 -0.0290504
GPC3 glypican 3 -0.0290256
SGO2 shugoshin 2 -0.0288416
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0286004
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0281906
COL1A2 collagen, type I, alpha 2 -0.0280126
HSPB1 heat shock 27kDa protein 1 -0.0276754
AK1 adenylate kinase 1 -0.0276636
ACTN4 actinin, alpha 4 -0.0273922
DEK DEK proto-oncogene -0.0273853
UBB ubiquitin B -0.0270351
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.027013
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0269324
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0267324
TPR translocated promoter region, nuclear basket protein -0.026686
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0266803
FTL ferritin, light polypeptide -0.0266047
ADNP activity-dependent neuroprotector homeobox -0.0265414
PARD3B par-3 family cell polarity regulator beta -0.026541
NALF1 NALCN channel auxiliary factor 1 -0.0263232
HMGB1 high mobility group box 1 -0.0263084
GOLGA4 golgin A4 -0.0262736
PRTG protogenin -0.0262182
CDK12 cyclin-dependent kinase 12 -0.0260158
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0260047
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0258323
BTBD3 BTB (POZ) domain containing 3 -0.0256208
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0250584
CNRIP1 cannabinoid receptor interacting protein 1 -0.0246725
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0246672
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0245375
HOOK3 hook microtubule-tethering protein 3 -0.0242745
EIF1 eukaryotic translation initiation factor 1 -0.0239618
NDFIP1 Nedd4 family interacting protein 1 -0.0238246
RPL12 ribosomal protein L12 -0.0237793
RLF rearranged L-myc fusion -0.0236937
RPL28 ribosomal protein L28 -0.0235882
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0235054
MIS18BP1 MIS18 binding protein 1 -0.023455
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0234413
RPS19 ribosomal protein S19 -0.0232973
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0230559
INTS6 integrator complex subunit 6 -0.0230317
TOP1 topoisomerase (DNA) I -0.0229631
KNL1 kinetochore scaffold 1 -0.0225045
BPTF bromodomain PHD finger transcription factor -0.0223326
FBXO17 F-box protein 17 -0.0222579
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0220141
KIF4A kinesin family member 4A -0.0220088
TUBA1B tubulin, alpha 1b -0.0219974
TJP1 tight junction protein 1 -0.021975
PATJ PATJ crumbs cell polarity complex component -0.0217598