Ferulic acid_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ferulic acid perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ferulic acid_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.155641
EEF2 eukaryotic translation elongation factor 2 0.130607
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.093915
RPL3 ribosomal protein L3 0.0814918
MYH9 myosin, heavy chain 9, non-muscle 0.0759352
NAV2 neuron navigator 2 0.0719972
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0670538
UPP1 uridine phosphorylase 1 0.0652295
FLNA filamin A, alpha 0.0626797
BHLHE40 basic helix-loop-helix family, member e40 0.0618765
LOC112694756 uncharaterized LOC112694756 0.0587937
PRRC2B proline-rich coiled-coil 2B 0.0577858
TXNRD1 thioredoxin reductase 1 0.054872
NUP58 nucleoporin 58 0.0546724
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0539828
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0536814
SMTN smoothelin 0.0535485
STC1 stanniocalcin 1 0.0505417
MCL1 myeloid cell leukemia 1 0.048602
ACTG1 actin gamma 1 0.0484219
CORO1C coronin, actin binding protein, 1C 0.0484043
MAST4 microtubule associated serine/threonine kinase family member 4 0.0475978
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.047356
NCKAP1 NCK-associated protein 1 0.0455382
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0449296
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0438169
ZFAND3 zinc finger, AN1-type domain 3 0.0433468
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0430772
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0421162
KMT2C lysine (K)-specific methyltransferase 2C 0.0418727
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0411738
USP9X ubiquitin specific peptidase 9, X-linked 0.0407706
SRRM2 serine/arginine repetitive matrix 2 0.0397405
ZEB1 zinc finger E-box binding homeobox 1 0.0395211
FOSL1 FOS-like antigen 1 0.0379783
ADAM17 ADAM metallopeptidase domain 17 0.0377794
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.037272
MKI67 marker of proliferation Ki-67 0.0372224
ATP13A3 ATPase type 13A3 0.0372162
PKM pyruvate kinase, muscle 0.0369617
APP amyloid beta (A4) precursor protein 0.0363454
PUM1 pumilio RNA-binding family member 1 0.0356199
RAD21 RAD21 homolog (S. pombe) 0.035098
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0350644
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0348985
ACTN1 actinin, alpha 1 0.0343992
SMYD3 SET and MYND domain containing 3 0.033948
RBM33 RNA binding motif protein 33 0.0336669
PRPF8 pre-mRNA processing factor 8 0.0333912
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0332475
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0330719
PTK2 protein tyrosine kinase 2 0.0330351
USP3 ubiquitin specific peptidase 3 0.0327816
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0326731
PRRC2A proline-rich coiled-coil 2A 0.0323854
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0323287
YBX1 Y box binding protein 1 0.0322914
NONO non-POU domain containing, octamer-binding 0.0322474
ARGLU1 arginine and glutamate rich 1 0.0316903
EIF4A1 eukaryotic translation initiation factor 4A1 0.0314613
ECPAS Ecm29 proteasome adaptor and scaffold 0.0313717
FAR1 fatty acyl CoA reductase 1 0.0312399
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0307715
FOXJ3 forkhead box J3 0.0305446
ZNF292 zinc finger protein 292 0.0303162
CAMTA1 calmodulin binding transcription activator 1 0.0301358
WAC WW domain containing adaptor with coiled-coil 0.0300107
KDM6A lysine (K)-specific demethylase 6A 0.0297519
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.029734
KAT6A K(lysine) acetyltransferase 6A 0.0296749
RAD23B RAD23 homolog B (S. cerevisiae) 0.0292954
TOMM34 translocase of outer mitochondrial membrane 34 0.0290841
RBM39 RNA binding motif protein 39 0.029076
OGA O-GlcNAcase 0.0289436
HELZ helicase with zinc finger 0.0286197
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0285731
CSNK2A2 casein kinase 2, alpha prime polypeptide 0.0285239
CAPRIN2 caprin family member 2 0.028342
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0282557
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0279522
MED27 mediator complex subunit 27 0.0278807
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0277856
ABI1 abl-interactor 1 0.0275765
UBA1 ubiquitin-like modifier activating enzyme 1 0.027525
EXT1 exostosin glycosyltransferase 1 0.0274656
KMT2D lysine (K)-specific methyltransferase 2D 0.0271499
CCNY cyclin Y 0.0267974
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0267496
KDM3A lysine (K)-specific demethylase 3A 0.0266595
TPM3 tropomyosin 3 0.0262011
EIF4B eukaryotic translation initiation factor 4B 0.0261453
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0259891
UBA6 ubiquitin-like modifier activating enzyme 6 0.0258915
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0258068
FHL2 four and a half LIM domains 2 0.0257086
CTNND1 catenin (cadherin-associated protein), delta 1 0.0256065
CEP250 centrosomal protein 250kDa 0.0252305
STK4 serine/threonine kinase 4 0.0251998
SET SET nuclear proto-oncogene 0.0249623
WDR43 WD repeat domain 43 0.0249588

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.14185
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.134775
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.116689
RPS6 ribosomal protein S6 -0.111131
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0964163
DLC1 DLC1 Rho GTPase activating protein -0.095354
TPT1 tumor protein, translationally-controlled 1 -0.0931167
FRMD4A FERM domain containing 4A -0.0913646
HDAC9 histone deacetylase 9 -0.0828807
IFI16 interferon, gamma-inducible protein 16 -0.0808302
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.079312
FTL ferritin, light polypeptide -0.0750242
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0746464
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0701076
RPL35A ribosomal protein L35a -0.0683124
ZNF438 zinc finger protein 438 -0.0672169
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0625404
IARS1 isoleucyl-tRNA synthetase 1 -0.0563517
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0533455
RPLP1 ribosomal protein, large, P1 -0.051935
NABP1 nucleic acid binding protein 1 -0.0503051
BNC2 basonuclin 2 -0.0471128
NAP1L1 nucleosome assembly protein 1-like 1 -0.0467427
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0462293
TTR transthyretin -0.0455471
NAV3 neuron navigator 3 -0.0455083
RPS24 ribosomal protein S24 -0.0449702
PCNX4 pecanex 4 -0.0440042
RPLP2 ribosomal protein, large, P2 -0.0433238
FRMD6 FERM domain containing 6 -0.0428813
PTMA prothymosin, alpha -0.0409504
RPL7A ribosomal protein L7a -0.0393956
TMSB10 thymosin beta 10 -0.0391758
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0385207
ZBTB20 zinc finger and BTB domain containing 20 -0.0380032
SP100 SP100 nuclear antigen -0.0378375
HMGA2 high mobility group AT-hook 2 -0.0376007
RPL34 ribosomal protein L34 -0.0375542
MTDH metadherin -0.0371757
RRBP1 ribosome binding protein 1 -0.0371165
TPM4 tropomyosin 4 -0.0370007
RPL9 ribosomal protein L9 -0.0369666
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.036871
RPS21 ribosomal protein S21 -0.036432
RSL1D1 ribosomal L1 domain containing 1 -0.0355612
LARS1 leucyl-tRNA synthetase 1 -0.035479
RPL31 ribosomal protein L31 -0.0350829
RPS19 ribosomal protein S19 -0.0338287
RPL12 ribosomal protein L12 -0.0335092
PBX3 pre-B-cell leukemia homeobox 3 -0.0330845
RAB7A RAB7A, member RAS oncogene family -0.03264
PDIA3 protein disulfide isomerase family A, member 3 -0.0324384
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0322426
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0322353
KTN1 kinectin 1 (kinesin receptor) -0.0322118
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0321563
RPS8 ribosomal protein S8 -0.0321214
RPS20 ribosomal protein S20 -0.0320892
OSBPL8 oxysterol binding protein-like 8 -0.0319326
ALCAM activated leukocyte cell adhesion molecule -0.0312674
RPS29 ribosomal protein S29 -0.0306413
GOLGA4 golgin A4 -0.0304576
CUX1 cut-like homeobox 1 -0.0301014
TM4SF1 transmembrane 4 L six family member 1 -0.0298637
RPL37 ribosomal protein L37 -0.0296902
RPL8 ribosomal protein L8 -0.0291152
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0289207
RPL35 ribosomal protein L35 -0.0287605
RPS27A ribosomal protein S27a -0.0283255
MT1X metallothionein 1X -0.0279857
RPS25 ribosomal protein S25 -0.0277428
JMJD1C jumonji domain containing 1C -0.0272267
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0270497
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0262509
RPL4 ribosomal protein L4 -0.0261285
RPS2 ribosomal protein S2 -0.0260097
RPL19 ribosomal protein L19 -0.0255633
RASAL2 RAS protein activator like 2 -0.0254109
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0253569
RPS16 ribosomal protein S16 -0.0249864
RBM25 RNA binding motif protein 25 -0.0244858
RPL28 ribosomal protein L28 -0.024368
KPNB1 karyopherin (importin) beta 1 -0.0243371
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0242819
SLC38A2 solute carrier family 38, member 2 -0.024275
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0237937
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0237552
RPS14 ribosomal protein S14 -0.0236685
FNIP1 folliculin interacting protein 1 -0.0236009
EIF1 eukaryotic translation initiation factor 1 -0.0234958
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0233178
RPL36A ribosomal protein L36a -0.0232835
DEK DEK proto-oncogene -0.0231989
RPL30 ribosomal protein L30 -0.022862
AKAP12 A kinase (PRKA) anchor protein 12 -0.0226377
AKAP9 A kinase (PRKA) anchor protein 9 -0.0224526
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.0220102
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0219991
TTC3 tetratricopeptide repeat domain 3 -0.0215785
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0214992