Ferulic acid_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ferulic acid perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ferulic acid_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.265207
MYH9 myosin, heavy chain 9, non-muscle 0.206169
NDRG1 N-myc downstream regulated 1 0.199932
VEGFA vascular endothelial growth factor A 0.136583
STC1 stanniocalcin 1 0.12078
PGK1 phosphoglycerate kinase 1 0.103346
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0861226
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0809985
CD109 CD109 molecule 0.0790357
BHLHE40 basic helix-loop-helix family, member e40 0.0773622
FNDC3B fibronectin type III domain containing 3B 0.0764612
EEF2 eukaryotic translation elongation factor 2 0.0753899
NAV2 neuron navigator 2 0.0710472
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0688507
FLNB filamin B, beta 0.0680573
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0618146
ZNF292 zinc finger protein 292 0.0598914
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0584896
PLEC plectin 0.0579778
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0543463
GOLGA4 golgin A4 0.0536637
MSN moesin 0.0533953
PKM pyruvate kinase, muscle 0.0527334
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0525609
CEMIP cell migration inducing protein, hyaluronan binding 0.0520685
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0502629
DDIT4 DNA-damage-inducible transcript 4 0.0498603
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0496012
CALR calreticulin 0.0488176
TRIO trio Rho guanine nucleotide exchange factor 0.0486689
MCTP2 multiple C2 domains, transmembrane 2 0.047724
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0476072
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0475735
ARRDC3 arrestin domain containing 3 0.0469678
UBA6 ubiquitin-like modifier activating enzyme 6 0.046668
ESYT2 extended synaptotagmin-like protein 2 0.0464089
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0434469
FAM13A family with sequence similarity 13, member A 0.0426068
MKI67 marker of proliferation Ki-67 0.0421449
FMNL2 formin-like 2 0.0409359
CENPF centromere protein F, 350/400kDa 0.0399321
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0396993
TNIP1 TNFAIP3 interacting protein 1 0.0394291
NONO non-POU domain containing, octamer-binding 0.0390651
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0388021
TPM3 tropomyosin 3 0.0382929
HOOK2 hook microtubule-tethering protein 2 0.0379016
ELL2 elongation factor, RNA polymerase II, 2 0.0376477
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0371364
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0370622
COPA coatomer protein complex, subunit alpha 0.0368157
TFG TRK-fused gene 0.0367936
COL5A1 collagen, type V, alpha 1 0.0358082
TRAM2 translocation associated membrane protein 2 0.0354661
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0353947
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0353812
FLNA filamin A, alpha 0.0353476
MEF2A myocyte enhancer factor 2A 0.03533
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0351401
SNAP25 synaptosomal-associated protein, 25kDa 0.0348872
HELZ helicase with zinc finger 0.0347377
RBM39 RNA binding motif protein 39 0.0346977
PTPRF protein tyrosine phosphatase, receptor type, F 0.0346656
RAD23B RAD23 homolog B (S. cerevisiae) 0.0346433
CEP250 centrosomal protein 250kDa 0.0342059
PSD3 pleckstrin and Sec7 domain containing 3 0.0340043
MACF1 microtubule-actin crosslinking factor 1 0.0338786
ATP13A3 ATPase type 13A3 0.0335735
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0326148
FAM20C family with sequence similarity 20, member C 0.0325899
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0325628
ANXA2 annexin A2 0.032558
SOD2 superoxide dismutase 2, mitochondrial 0.0323997
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0323536
YEATS2 YEATS domain containing 2 0.0321161
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0320273
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0317501
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0315795
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0311914
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0311651
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0310604
ZEB2 zinc finger E-box binding homeobox 2 0.0307827
ICAM1 intercellular adhesion molecule 1 0.0307206
OGA O-GlcNAcase 0.0302513
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0293378
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0293345
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0293242
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0291551
GRB10 growth factor receptor-bound protein 10 0.0290408
FNIP1 folliculin interacting protein 1 0.0288414
MMP12 matrix metallopeptidase 12 0.0284919
INHBA inhibin, beta A 0.0282684
COL7A1 collagen, type VII, alpha 1 0.0281241
AFAP1 actin filament associated protein 1 0.0280228
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0278845
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0277668
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 0.0277475
PDPK1 3-phosphoinositide dependent protein kinase 1 0.027713
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0275182
GYS1 glycogen synthase 1 (muscle) 0.027436

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.130525
VIM vimentin -0.117565
MT2A metallothionein 2A -0.104604
HLA-B major histocompatibility complex, class I, B -0.100653
COL1A2 collagen, type I, alpha 2 -0.0836681
COL1A1 collagen, type I, alpha 1 -0.0819083
FTL ferritin, light polypeptide -0.0752371
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0641637
TMSB10 thymosin beta 10 -0.0604772
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0601129
FRMD4A FERM domain containing 4A -0.0560077
B2M beta-2-microglobulin -0.0554729
RPLP1 ribosomal protein, large, P1 -0.0518552
IFI6 interferon, alpha-inducible protein 6 -0.0502158
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0480643
TPT1 tumor protein, translationally-controlled 1 -0.0459897
SP100 SP100 nuclear antigen -0.0436366
IFIH1 interferon induced with helicase C domain 1 -0.0432725
STAT1 signal transducer and activator of transcription 1, 91kDa -0.041493
TIMP1 TIMP metallopeptidase inhibitor 1 -0.039578
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0384535
TFPI2 tissue factor pathway inhibitor 2 -0.0380019
ZBTB20 zinc finger and BTB domain containing 20 -0.0378074
NRP1 neuropilin 1 -0.0367138
IFITM3 interferon induced transmembrane protein 3 -0.0356964
IER3 immediate early response 3 -0.0356681
ZEB1 zinc finger E-box binding homeobox 1 -0.0351425
HLA-A major histocompatibility complex, class I, A -0.0351325
VCL vinculin -0.0338835
RPS6 ribosomal protein S6 -0.0335483
RPL35A ribosomal protein L35a -0.0334035
RPLP2 ribosomal protein, large, P2 -0.0327889
XAF1 XIAP associated factor 1 -0.029525
COL5A3 collagen, type V, alpha 3 -0.0294754
RPL28 ribosomal protein L28 -0.0293429
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0282586
CDH13 cadherin 13 -0.0280956
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0279869
PMP22 peripheral myelin protein 22 -0.0277052
STAU1 staufen double-stranded RNA binding protein 1 -0.0274929
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0272098
EXT1 exostosin glycosyltransferase 1 -0.0268553
IFI16 interferon, gamma-inducible protein 16 -0.0268418
RPL31 ribosomal protein L31 -0.0259504
S100A6 S100 calcium binding protein A6 -0.0258655
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0257725
RPS16 ribosomal protein S16 -0.0255017
RIGI RNA sensor RIG-I -0.0251058
SVIL supervillin -0.0250638
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0243098
RPS24 ribosomal protein S24 -0.0239331
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0235469
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0235285
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0234689
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0227888
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0227485
HLA-C major histocompatibility complex, class I, C -0.0226687
NAV1 neuron navigator 1 -0.0224359
IFITM1 interferon induced transmembrane protein 1 -0.0222473
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0222318
RPS19 ribosomal protein S19 -0.0222223
AGO3 argonaute RISC catalytic component 3 -0.0220114
LOC102724023 ES1 protein homolog, mitochondrial -0.021884
FHIT fragile histidine triad -0.0217779
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0215354
CDK13 cyclin-dependent kinase 13 -0.021285
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0212756
EIF1 eukaryotic translation initiation factor 1 -0.0212203
TNS3 tensin 3 -0.0208879
IL1B interleukin 1, beta -0.0208588
APCDD1L adenomatosis polyposis coli down-regulated 1-like -0.0207328
S100A9 S100 calcium binding protein A9 -0.0204375
TNNC1 troponin C type 1 (slow) -0.020256
ZNF609 zinc finger protein 609 -0.0201774
RPS21 ribosomal protein S21 -0.0201602
EPSTI1 epithelial stromal interaction 1 (breast) -0.020125
SAMD9 sterile alpha motif domain containing 9 -0.0200008
PARD3 par-3 family cell polarity regulator -0.0199462
RRBP1 ribosome binding protein 1 -0.0199388
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0197702
OSMR oncostatin M receptor -0.019717
PHF14 PHD finger protein 14 -0.0195035
SAMHD1 SAM domain and HD domain 1 -0.0192274
SAMD9L sterile alpha motif domain containing 9-like -0.0191259
BSG basigin (Ok blood group) -0.019013
RPL34 ribosomal protein L34 -0.018984
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0189364
ATM ATM serine/threonine kinase -0.0189226
RPL37 ribosomal protein L37 -0.0187854
GLIS3 GLIS family zinc finger 3 -0.0187125
POTEF POTE ankyrin domain family, member F -0.0187059
NCOA7 nuclear receptor coactivator 7 -0.0186862
MX2 MX dynamin-like GTPase 2 -0.0186705
RBM25 RNA binding motif protein 25 -0.0185016
ZBTB38 zinc finger and BTB domain containing 38 -0.0182728
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0182061
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.018186
SHISA5 shisa family member 5 -0.0181534
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0180527
MBD5 methyl-CpG binding domain protein 5 -0.0179852