Ferulic acid_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ferulic acid perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ferulic acid_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A 0.112787
NDRG1 N-myc downstream regulated 1 0.11221
VEGFA vascular endothelial growth factor A 0.0702465
GRB10 growth factor receptor-bound protein 10 0.0678968
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0637613
TRIO trio Rho guanine nucleotide exchange factor 0.0624507
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0610991
MYH9 myosin, heavy chain 9, non-muscle 0.0600342
VGF VGF nerve growth factor inducible 0.0588342
CHD7 chromodomain helicase DNA binding protein 7 0.0565948
SMOC1 SPARC related modular calcium binding 1 0.0545114
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0532953
NUMA1 nuclear mitotic apparatus protein 1 0.0473476
DTNA dystrobrevin, alpha 0.0471171
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0460638
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.0455118
FAM13A family with sequence similarity 13, member A 0.0449757
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0421053
GPC6 glypican 6 0.0418303
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0410977
MBNL2 muscleblind-like splicing regulator 2 0.040745
EEF2 eukaryotic translation elongation factor 2 0.0404326
MACF1 microtubule-actin crosslinking factor 1 0.0399606
MPRIP myosin phosphatase Rho interacting protein 0.039755
FAT1 FAT atypical cadherin 1 0.0396869
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0387619
RORA RAR-related orphan receptor A 0.0378956
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0370116
SMC1A structural maintenance of chromosomes 1A 0.0347917
CA8 carbonic anhydrase VIII 0.034782
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0343576
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0337748
AFF1 AF4/FMR2 family, member 1 0.0334168
ESRRG estrogen-related receptor gamma 0.0330753
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0330197
BHLHE40 basic helix-loop-helix family, member e40 0.0328607
IQSEC1 IQ motif and Sec7 domain 1 0.0322399
ERRFI1 ERBB receptor feedback inhibitor 1 0.0314139
DENND1A DENN/MADD domain containing 1A 0.0301671
TENM1 teneurin transmembrane protein 1 0.0297748
MSI2 musashi RNA-binding protein 2 0.0295688
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.029549
CCNY cyclin Y 0.0293821
CADM1 cell adhesion molecule 1 0.0292399
RPL3 ribosomal protein L3 0.0284935
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0283057
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0281164
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0280387
SRRM2 serine/arginine repetitive matrix 2 0.0278951
SREBF2 sterol regulatory element binding transcription factor 2 0.0278767
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 0.0277242
ZNF292 zinc finger protein 292 0.0276394
APP amyloid beta (A4) precursor protein 0.0273371
SPAG5 sperm associated antigen 5 0.0270569
NUP58 nucleoporin 58 0.0265952
PDE4B phosphodiesterase 4B, cAMP-specific 0.0264931
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0258236
TPM3 tropomyosin 3 0.0258104
MED13L mediator complex subunit 13-like 0.0257527
TSPYL2 TSPY-like 2 0.025225
NCOR2 nuclear receptor corepressor 2 0.024807
IQGAP3 IQ motif containing GTPase activating protein 3 0.0247631
NONO non-POU domain containing, octamer-binding 0.0245156
JAM3 junctional adhesion molecule 3 0.0244233
PSD3 pleckstrin and Sec7 domain containing 3 0.0238812
RAD51B RAD51 paralog B 0.0237879
EYA2 EYA transcriptional coactivator and phosphatase 2 0.0236919
RPTOR regulatory associated protein of MTOR, complex 1 0.0236795
PRPF8 pre-mRNA processing factor 8 0.0236709
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0234874
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0231303
NCKAP5 NCK-associated protein 5 0.0230426
COPA coatomer protein complex, subunit alpha 0.0226725
RPH3AL rabphilin 3A-like (without C2 domains) 0.0226667
NBAS neuroblastoma amplified sequence 0.0225193
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0223126
SERGEF secretion regulating guanine nucleotide exchange factor 0.0222928
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0222058
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0221508
MSN moesin 0.0219554
GSE1 Gse1 coiled-coil protein 0.021639
ELL2 elongation factor, RNA polymerase II, 2 0.0216177
MKI67 marker of proliferation Ki-67 0.0209412
AHDC1 AT hook, DNA binding motif, containing 1 0.0206634
RIMBP2 RIMS binding protein 2 0.0206518
FNDC3B fibronectin type III domain containing 3B 0.0206053
MRPS6 mitochondrial ribosomal protein S6 0.0205317
ZNF407 zinc finger protein 407 0.0204825
MYO1B myosin IB 0.0204546
PIAS2 protein inhibitor of activated STAT, 2 0.020189
PDIA6 protein disulfide isomerase family A, member 6 0.0201692
RAD23B RAD23 homolog B (S. cerevisiae) 0.0199502
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0198939
RERE arginine-glutamic acid dipeptide (RE) repeats 0.019783
UBA6 ubiquitin-like modifier activating enzyme 6 0.0196459
SET SET nuclear proto-oncogene 0.0196291
CAMTA1 calmodulin binding transcription activator 1 0.0195214
FKBP9 FK506 binding protein 9, 63 kDa 0.0194703
CHGB chromogranin B 0.0192684
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0191656

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.129091
MT2A metallothionein 2A -0.126372
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.106908
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.105232
FTL ferritin, light polypeptide -0.103258
RPS21 ribosomal protein S21 -0.0797422
CALCA calcitonin-related polypeptide alpha -0.0758337
RPLP1 ribosomal protein, large, P1 -0.0658945
RPS6 ribosomal protein S6 -0.058607
RPL26 ribosomal protein L26 -0.0580414
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.057171
IFI6 interferon, alpha-inducible protein 6 -0.0548414
RIMS2 regulating synaptic membrane exocytosis 2 -0.052712
RPS16 ribosomal protein S16 -0.051361
S100A9 S100 calcium binding protein A9 -0.0508448
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0484576
RPL37 ribosomal protein L37 -0.0484129
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0470593
ATP5F1E ATP synthase F1 subunit epsilon -0.0461826
RPS8 ribosomal protein S8 -0.0453376
RPS19 ribosomal protein S19 -0.042994
ISG15 ISG15 ubiquitin-like modifier -0.0413931
GNAS GNAS complex locus -0.041356
RPL8 ribosomal protein L8 -0.0410862
TMSB10 thymosin beta 10 -0.0408165
RPL32 ribosomal protein L32 -0.0405556
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0403466
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0391565
RPL12 ribosomal protein L12 -0.0376638
SNTG1 syntrophin, gamma 1 -0.0376287
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0374078
RPS3 ribosomal protein S3 -0.0373086
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0366914
UBB ubiquitin B -0.0366895
TPT1 tumor protein, translationally-controlled 1 -0.0366153
RPL35 ribosomal protein L35 -0.0350781
RPL34 ribosomal protein L34 -0.0348526
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.0347567
RBM25 RNA binding motif protein 25 -0.0343409
RPS25 ribosomal protein S25 -0.0331349
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0326806
DEK DEK proto-oncogene -0.0323824
RPS5 ribosomal protein S5 -0.0320917
RPL36AL ribosomal protein L36a-like -0.0320469
RPL36 ribosomal protein L36 -0.0315366
KPNB1 karyopherin (importin) beta 1 -0.0315112
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0315025
RPL23 ribosomal protein L23 -0.0314606
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0312012
RPL38 ribosomal protein L38 -0.0311674
RPLP2 ribosomal protein, large, P2 -0.0307052
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0305392
RPL31 ribosomal protein L31 -0.0303673
RPL19 ribosomal protein L19 -0.0297375
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0295864
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0294971
RPS24 ribosomal protein S24 -0.0294404
PTCHD4 patched domain containing 4 -0.0292077
RPS29 ribosomal protein S29 -0.0291397
STC1 stanniocalcin 1 -0.0287771
RPL5 ribosomal protein L5 -0.0285898
RPL35A ribosomal protein L35a -0.0285558
RPS11 ribosomal protein S11 -0.0283872
PDE4D phosphodiesterase 4D, cAMP-specific -0.0283831
ACTG1 actin gamma 1 -0.0282977
RPS27A ribosomal protein S27a -0.0282058
TXNRD1 thioredoxin reductase 1 -0.0282009
HMGB1 high mobility group box 1 -0.0280593
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0279517
RPL7A ribosomal protein L7a -0.0273217
NDUFA4 NDUFA4, mitochondrial complex associated -0.0272781
RPLP0 ribosomal protein, large, P0 -0.0272435
EIF1 eukaryotic translation initiation factor 1 -0.0271424
MT1X metallothionein 1X -0.0271111
INHBA inhibin, beta A -0.0268361
NAP1L1 nucleosome assembly protein 1-like 1 -0.0264158
TUBA1B tubulin, alpha 1b -0.0262988
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0262822
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -0.0262314
RPL37A ribosomal protein L37a -0.0260262
PNISR PNN-interacting serine/arginine-rich protein -0.025586
SOX4 SRY (sex determining region Y)-box 4 -0.0254646
TRIM9 tripartite motif containing 9 -0.0252671
EIF5B eukaryotic translation initiation factor 5B -0.0250988
CHGA chromogranin A -0.025078
RPL11 ribosomal protein L11 -0.0250594
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0247372
RPL36A ribosomal protein L36a -0.0244891
NOVA1 neuro-oncological ventral antigen 1 -0.0242598
RPS23 ribosomal protein S23 -0.0242457
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0239377
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0237014
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.02319
NSD3 nuclear receptor binding SET domain protein 3 -0.0229671
RPL7 ribosomal protein L7 -0.0228715
RPL28 ribosomal protein L28 -0.0228326
PHF14 PHD finger protein 14 -0.0226426
RPS27 ribosomal protein S27 -0.0224857
RPS20 ribosomal protein S20 -0.0224836
STXBP5L syntaxin binding protein 5-like -0.022304