Ferulic acid_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ferulic acid perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ferulic acid_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.30945
EEF2 eukaryotic translation elongation factor 2 0.141739
FLNA filamin A, alpha 0.121875
LSAMP limbic system-associated membrane protein 0.121067
SREBF2 sterol regulatory element binding transcription factor 2 0.117045
MSI2 musashi RNA-binding protein 2 0.113199
FNDC3B fibronectin type III domain containing 3B 0.10081
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0989797
PLEC plectin 0.0959357
SLC39A11 solute carrier family 39, member 11 0.0836328
NLGN1 neuroligin 1 0.083599
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0821361
BHLHE40 basic helix-loop-helix family, member e40 0.0801032
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.076088
FLNB filamin B, beta 0.0748697
RPS3 ribosomal protein S3 0.0712011
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.066755
SEPTIN9 septin 9 0.0662183
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0649487
MYH9 myosin, heavy chain 9, non-muscle 0.064731
NAV2 neuron navigator 2 0.0627802
ANKRD11 ankyrin repeat domain 11 0.0622316
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0620241
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0606574
LOC112694756 uncharaterized LOC112694756 0.0593696
RACK1 receptor for activated C kinase 1 0.0591198
FMNL2 formin-like 2 0.0591096
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0583324
RPL23 ribosomal protein L23 0.0581448
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.056945
TCOF1 Treacher Collins-Franceschetti syndrome 1 0.056941
CEP250 centrosomal protein 250kDa 0.0544513
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.0511273
BACE2 beta-site APP-cleaving enzyme 2 0.0510404
HPCAL1 hippocalcin-like 1 0.0509596
VEGFA vascular endothelial growth factor A 0.0501783
NONO non-POU domain containing, octamer-binding 0.0489111
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0487197
SFTPA2 surfactant protein A2 0.0471825
IGF1R insulin-like growth factor 1 receptor 0.0471771
CTTN cortactin 0.0464561
RAD51B RAD51 paralog B 0.045804
PRRC2B proline-rich coiled-coil 2B 0.0456873
INPP5F inositol polyphosphate-5-phosphatase F 0.0452255
ZMIZ1 zinc finger, MIZ-type containing 1 0.0449821
IL1RAP interleukin 1 receptor accessory protein 0.0448224
RPL3 ribosomal protein L3 0.0445564
NRG3 neuregulin 3 0.0444888
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0440789
PGK1 phosphoglycerate kinase 1 0.0432605
PRELID2 PRELI domain containing 2 0.0425239
EP300 E1A binding protein p300 0.0424563
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0423837
SOX10 SRY (sex determining region Y)-box 10 0.0410959
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0408195
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0401392
TNNC1 troponin C type 1 (slow) 0.039054
ACTN1 actinin, alpha 1 0.0390519
PMEL premelanosome protein 0.0388241
FUS FUS RNA binding protein 0.038717
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0385887
CSDE1 cold shock domain containing E1, RNA-binding 0.0382154
PTMA prothymosin, alpha 0.0380762
LINGO2 leucine rich repeat and Ig domain containing 2 0.0380359
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0380255
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0379551
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0378635
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0374012
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0368114
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.0364398
NDRG1 N-myc downstream regulated 1 0.0362565
TCF20 transcription factor 20 (AR1) 0.035799
NFE2L1 nuclear factor, erythroid 2-like 1 0.0353296
DENND1A DENN/MADD domain containing 1A 0.0349058
FHIT fragile histidine triad 0.034723
KAZN kazrin, periplakin interacting protein 0.0346435
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0345895
CTBP2 C-terminal binding protein 2 0.0343617
RPL35A ribosomal protein L35a 0.0343571
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0340464
AKAP12 A kinase (PRKA) anchor protein 12 0.0339224
TNIP1 TNFAIP3 interacting protein 1 0.0339026
SRRM2 serine/arginine repetitive matrix 2 0.033832
RPS10 ribosomal protein S10 0.033671
CD109 CD109 molecule 0.0333111
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0331676
COPA coatomer protein complex, subunit alpha 0.0331067
IGFBP3 insulin-like growth factor binding protein 3 0.032637
MKI67 marker of proliferation Ki-67 0.0324877
LRMDA leucine rich melanocyte differentiation associated 0.032207
CALR calreticulin 0.0318982
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0315294
TMEM51 transmembrane protein 51 0.0315162
ANGPTL4 angiopoietin-like 4 0.031456
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0313041
RAD23B RAD23 homolog B (S. cerevisiae) 0.0312757
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.0310923
PTPRF protein tyrosine phosphatase, receptor type, F 0.030589
LEF1 lymphoid enhancer-binding factor 1 0.0302776
CADM1 cell adhesion molecule 1 0.0298164

decreased expression

Symbol Name Standardized Value
FMN1 formin 1 -0.0523611
TENM1 teneurin transmembrane protein 1 -0.0515481
CCND1 cyclin D1 -0.0485788
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0476693
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0463786
ALCAM activated leukocyte cell adhesion molecule -0.0384385
FRMD5 FERM domain containing 5 -0.0355075
TP63 tumor protein p63 -0.0349245
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0338663
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0337915
ERBIN erbb2 interacting protein -0.0328548
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0324734
RPS2 ribosomal protein S2 -0.0320334
TFPI2 tissue factor pathway inhibitor 2 -0.0318479
SQSTM1 sequestosome 1 -0.0315708
TXNRD1 thioredoxin reductase 1 -0.0308522
GOLGB1 golgin B1 -0.0305517
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0291898
CD44 CD44 molecule (Indian blood group) -0.0288845
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0282368
MT2A metallothionein 2A -0.0278066
RHOBTB3 Rho-related BTB domain containing 3 -0.0277718
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0272642
EMP1 epithelial membrane protein 1 -0.0270593
BPTF bromodomain PHD finger transcription factor -0.0261335
FBXL17 F-box and leucine-rich repeat protein 17 -0.0257874
UBC ubiquitin C -0.024141
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0234126
CENPF centromere protein F, 350/400kDa -0.0233762
TUSC3 tumor suppressor candidate 3 -0.0229256
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0224637
PCNX4 pecanex 4 -0.0222011
RASAL2 RAS protein activator like 2 -0.0218539
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0210261
FBXO32 F-box protein 32 -0.020723
TMF1 TATA element modulatory factor 1 -0.0207127
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0205136
MAP4 microtubule-associated protein 4 -0.0203721
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0203506
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0198874
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0197142
MYO9A myosin IXA -0.0196867
FAM3C family with sequence similarity 3, member C -0.0196797
RUNX1 runt-related transcription factor 1 -0.0195936
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0193261
KTN1 kinectin 1 (kinesin receptor) -0.0191339
MAPK8 mitogen-activated protein kinase 8 -0.0190033
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0188531
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0184544
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0184259
NRIP1 nuclear receptor interacting protein 1 -0.018321
TPX2 TPX2, microtubule-associated -0.0180955
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0175906
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0174652
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0171865
DSTN destrin (actin depolymerizing factor) -0.0166954
SOS1 son of sevenless homolog 1 (Drosophila) -0.0165241
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0165214
DUSP6 dual specificity phosphatase 6 -0.0164014
RPLP1 ribosomal protein, large, P1 -0.0162584
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -0.0161846
TPST1 tyrosylprotein sulfotransferase 1 -0.0160912
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0160856
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0160573
EXT1 exostosin glycosyltransferase 1 -0.0160267
GSPT1 G1 to S phase transition 1 -0.0160012
MBNL1 muscleblind-like splicing regulator 1 -0.0159757
AKAP9 A kinase (PRKA) anchor protein 9 -0.0159585
TASOR2 transcription activation suppressor family member 2 -0.0157552
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0156333
NEK1 NIMA-related kinase 1 -0.0155869
BLZF1 basic leucine zipper nuclear factor 1 -0.0155152
PHACTR4 phosphatase and actin regulator 4 -0.0154553
U2SURP U2 snRNP-associated SURP domain containing -0.0153957
FER fer (fps/fes related) tyrosine kinase -0.0153598
EXOC6B exocyst complex component 6B -0.0153325
AGO3 argonaute RISC catalytic component 3 -0.0153044
WWTR1 WW domain containing transcription regulator 1 -0.0152959
PCBP2 poly(rC) binding protein 2 -0.0152269
USP47 ubiquitin specific peptidase 47 -0.0152178
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0152005
CEP128 centrosomal protein 128kDa -0.0151029
DPYD dihydropyrimidine dehydrogenase -0.0150162
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0149819
SECISBP2L SECIS binding protein 2-like -0.0149817
RPL4 ribosomal protein L4 -0.0148954
NT5C2 5'-nucleotidase, cytosolic II -0.0147978
PAPOLA poly(A) polymerase alpha -0.0147772
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.0147323
USP53 ubiquitin specific peptidase 53 -0.0146986
BICD1 bicaudal D homolog 1 (Drosophila) -0.0146722
PBX3 pre-B-cell leukemia homeobox 3 -0.0144797
GPATCH8 G patch domain containing 8 -0.0144114
SLC38A1 solute carrier family 38, member 1 -0.0143831
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0142844
SNX24 sorting nexin 24 -0.0141552
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0141452
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0141409
RB1 retinoblastoma 1 -0.014059
ZNF638 zinc finger protein 638 -0.0140551