Ferulic acid_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ferulic acid perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ferulic acid_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KRT8 keratin 8, type II 0.135027
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0846203
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.082592
PABPC1 poly(A) binding protein, cytoplasmic 1 0.082279
PLEC plectin 0.0801555
KRT18 keratin 18, type I 0.0727977
H1-0 H1.0 linker histone 0.0648953
EEF2 eukaryotic translation elongation factor 2 0.0601248
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0597322
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0594842
FLNA filamin A, alpha 0.0569678
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0568904
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0541034
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0529337
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0522465
MYH9 myosin, heavy chain 9, non-muscle 0.0512809
ACTN4 actinin, alpha 4 0.0505177
BHLHE40 basic helix-loop-helix family, member e40 0.0494702
KMT2E lysine (K)-specific methyltransferase 2E 0.0464953
MATR3 matrin 3 0.0441785
SNX9 sorting nexin 9 0.0441123
EPS8 epidermal growth factor receptor pathway substrate 8 0.0437996
FXR1 fragile X mental retardation, autosomal homolog 1 0.042768
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.04243
NCKAP1 NCK-associated protein 1 0.0421354
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0418875
LMTK2 lemur tyrosine kinase 2 0.0417385
MYO5B myosin VB 0.0410362
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.040678
LENG8 leukocyte receptor cluster (LRC) member 8 0.0403741
KMT2C lysine (K)-specific methyltransferase 2C 0.0401115
AFDN afadin, adherens junction formation factor 0.0399587
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.039608
TFG TRK-fused gene 0.0394784
VMP1 vacuole membrane protein 1 0.0383714
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0377152
RAD23B RAD23 homolog B (S. cerevisiae) 0.0376519
EWSR1 EWS RNA-binding protein 1 0.0371737
CCNL1 cyclin L1 0.0366197
USP3 ubiquitin specific peptidase 3 0.0362855
VEGFA vascular endothelial growth factor A 0.0357996
MED13L mediator complex subunit 13-like 0.0354249
ZNF292 zinc finger protein 292 0.0353338
NONO non-POU domain containing, octamer-binding 0.033622
ANXA11 annexin A11 0.0334654
TRA2A transformer 2 alpha homolog (Drosophila) 0.0332246
TRA2B transformer 2 beta homolog (Drosophila) 0.0321789
MKI67 marker of proliferation Ki-67 0.0319931
FAR1 fatty acyl CoA reductase 1 0.0315982
TNIP1 TNFAIP3 interacting protein 1 0.0315281
ADAM17 ADAM metallopeptidase domain 17 0.0312574
RPL3 ribosomal protein L3 0.0311226
RAB1A RAB1A, member RAS oncogene family 0.030971
RAD21 RAD21 homolog (S. pombe) 0.0307707
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0304614
RBM39 RNA binding motif protein 39 0.0299489
CST3 cystatin C 0.0298008
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0296869
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0296041
PTMA prothymosin, alpha 0.0292234
NAMPT nicotinamide phosphoribosyltransferase 0.0291367
ARRDC3 arrestin domain containing 3 0.0286833
MEF2A myocyte enhancer factor 2A 0.0285744
KDM6A lysine (K)-specific demethylase 6A 0.0284974
NUMA1 nuclear mitotic apparatus protein 1 0.0284951
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0284772
MTMR3 myotubularin related protein 3 0.0283985
YBX1 Y box binding protein 1 0.028375
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0280732
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0279616
MED15 mediator complex subunit 15 0.027958
XPO1 exportin 1 0.0278743
FMR1 fragile X mental retardation 1 0.0277644
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0277374
PNN pinin, desmosome associated protein 0.0273199
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0269763
UBA6 ubiquitin-like modifier activating enzyme 6 0.0268147
ARHGAP26 Rho GTPase activating protein 26 0.0265659
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0263519
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.026339
TSC22D2 TSC22 domain family, member 2 0.0262861
RYBP RING1 and YY1 binding protein 0.0262318
MACF1 microtubule-actin crosslinking factor 1 0.0260676
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0259802
CTNND1 catenin (cadherin-associated protein), delta 1 0.0257917
USP9X ubiquitin specific peptidase 9, X-linked 0.0257149
NPTN neuroplastin 0.0255234
UGCG UDP-glucose ceramide glucosyltransferase 0.0254558
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0252994
DSPP dentin sialophosphoprotein 0.0252173
ANXA2 annexin A2 0.0251749
RPL23 ribosomal protein L23 0.0251651
HSPA8 heat shock 70kDa protein 8 0.0250371
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0248375
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0247642
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0244782
TUFT1 tuftelin 1 0.0244049
TPM3 tropomyosin 3 0.0243373
ARGLU1 arginine and glutamate rich 1 0.0243046
RBM33 RNA binding motif protein 33 0.024197

decreased expression

Symbol Name Standardized Value
MAML2 mastermind-like 2 (Drosophila) -0.133393
EHBP1 EH domain binding protein 1 -0.0828193
ZBTB20 zinc finger and BTB domain containing 20 -0.0784303
ZMYND8 zinc finger, MYND-type containing 8 -0.0767593
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0665822
TPT1 tumor protein, translationally-controlled 1 -0.0624886
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0566347
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0546644
FTL ferritin, light polypeptide -0.0506233
MACC1 metastasis associated in colon cancer 1 -0.0504932
NKD1 naked cuticle homolog 1 (Drosophila) -0.0460473
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0454233
NCEH1 neutral cholesterol ester hydrolase 1 -0.045229
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0447136
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0444895
GCC2 GRIP and coiled-coil domain containing 2 -0.0430101
SDK1 sidekick cell adhesion molecule 1 -0.0427019
CDK13 cyclin-dependent kinase 13 -0.0417508
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0414259
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0411549
CUX1 cut-like homeobox 1 -0.039653
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0395474
DLG1 discs, large homolog 1 (Drosophila) -0.0390508
TMEM123 transmembrane protein 123 -0.0388089
SLC38A1 solute carrier family 38, member 1 -0.0387557
RPS6 ribosomal protein S6 -0.0386943
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0355587
NEBL nebulette -0.0349163
PATJ PATJ crumbs cell polarity complex component -0.0346715
PTPRK protein tyrosine phosphatase, receptor type, K -0.0344119
MX2 MX dynamin-like GTPase 2 -0.033817
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0337856
ZBTB38 zinc finger and BTB domain containing 38 -0.0335017
STAU1 staufen double-stranded RNA binding protein 1 -0.0334774
CADPS Ca++-dependent secretion activator -0.0328932
PLSCR1 phospholipid scramblase 1 -0.0320704
CEMIP cell migration inducing protein, hyaluronan binding -0.0314794
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.031397
USP34 ubiquitin specific peptidase 34 -0.0308181
RPL35A ribosomal protein L35a -0.0307594
EXOC4 exocyst complex component 4 -0.0304763
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0304443
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0303891
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0301892
LOC102724023 ES1 protein homolog, mitochondrial -0.0300462
BPTF bromodomain PHD finger transcription factor -0.0295324
GMDS GDP-mannose 4,6-dehydratase -0.0294819
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0293219
GNAS GNAS complex locus -0.0289196
SP100 SP100 nuclear antigen -0.0285928
LARS1 leucyl-tRNA synthetase 1 -0.0284522
CCND1 cyclin D1 -0.0281963
EPCAM epithelial cell adhesion molecule -0.028008
HM13 histocompatibility (minor) 13 -0.0279116
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0278312
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.0274656
LAMA4 laminin, alpha 4 -0.0272564
PKP4 plakophilin 4 -0.0270599
IER3 immediate early response 3 -0.0268605
CD2AP CD2-associated protein -0.0268537
SOX4 SRY (sex determining region Y)-box 4 -0.0268019
NFIA nuclear factor I/A -0.0267902
ETV6 ets variant 6 -0.0265064
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0264987
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0264977
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0263943
RIGI RNA sensor RIG-I -0.0263942
DACH1 dachshund family transcription factor 1 -0.0260931
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0260113
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0257602
ZNFX1 zinc finger, NFX1-type containing 1 -0.025721
SVIL supervillin -0.0257166
NRP1 neuropilin 1 -0.0254946
PHF14 PHD finger protein 14 -0.0253861
MYO1E myosin IE -0.0249921
IARS1 isoleucyl-tRNA synthetase 1 -0.0248736
TAS2R14 taste receptor, type 2, member 14 -0.0247508
FTH1 ferritin, heavy polypeptide 1 -0.024732
GTF2IRD1 GTF2I repeat domain containing 1 -0.0247168
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0245543
TPM4 tropomyosin 4 -0.0244713
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0240643
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.023693
RPLP1 ribosomal protein, large, P1 -0.0236705
SERINC5 serine incorporator 5 -0.0236491
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0235649
CTSD cathepsin D -0.0231235
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0231097
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0227451
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.022737
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0227322
RAD51B RAD51 paralog B -0.0225915
AHNAK AHNAK nucleoprotein -0.0225495
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 -0.0223824
MAP4 microtubule-associated protein 4 -0.022365
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0223588
ARHGAP5 Rho GTPase activating protein 5 -0.0220948
KPNB1 karyopherin (importin) beta 1 -0.0220837
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0219993
LDHA lactate dehydrogenase A -0.0219387