Ferulic acid_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ferulic acid perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ferulic acid_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.249222
FN1 fibronectin 1 0.216578
MYH9 myosin, heavy chain 9, non-muscle 0.176039
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.13832
MMP1 matrix metallopeptidase 1 0.126244
ATP13A3 ATPase type 13A3 0.0704686
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0618159
JARID2 jumonji, AT rich interactive domain 2 0.0616457
VEGFA vascular endothelial growth factor A 0.0567213
EEF2 eukaryotic translation elongation factor 2 0.0554084
MYO10 myosin X 0.0535418
TRIO trio Rho guanine nucleotide exchange factor 0.0533157
DST dystonin 0.0495908
FNDC3B fibronectin type III domain containing 3B 0.0444745
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0443732
NAV1 neuron navigator 1 0.0441991
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0423037
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0421355
NDRG1 N-myc downstream regulated 1 0.0417504
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0407321
FMNL2 formin-like 2 0.0399411
MSN moesin 0.0376812
SPAG9 sperm associated antigen 9 0.0363266
SEPTIN9 septin 9 0.033671
INHBA inhibin, beta A 0.0329484
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0327573
FAM13A family with sequence similarity 13, member A 0.0325098
COL6A2 collagen, type VI, alpha 2 0.0324415
UBA6 ubiquitin-like modifier activating enzyme 6 0.03233
PDE8A phosphodiesterase 8A 0.0318361
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0309732
ARHGAP21 Rho GTPase activating protein 21 0.0304488
PLEC plectin 0.0297395
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.029113
FLNA filamin A, alpha 0.0289786
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0288751
ELL2 elongation factor, RNA polymerase II, 2 0.0287656
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0286001
CALD1 caldesmon 1 0.0282616
MACF1 microtubule-actin crosslinking factor 1 0.0270713
CCL5 chemokine (C-C motif) ligand 5 0.0269512
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0266302
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.02602
RPL3 ribosomal protein L3 0.0258508
RUNX1 runt-related transcription factor 1 0.0254204
BHLHE40 basic helix-loop-helix family, member e40 0.0254013
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0253642
TNS1 tensin 1 0.0250567
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0248202
FAT1 FAT atypical cadherin 1 0.0235267
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0232774
HMGA2 high mobility group AT-hook 2 0.0230194
MYO1B myosin IB 0.0226975
PICALM phosphatidylinositol binding clathrin assembly protein 0.0226653
SOD2 superoxide dismutase 2, mitochondrial 0.0224625
HIPK2 homeodomain interacting protein kinase 2 0.0223715
SMTN smoothelin 0.022313
APP amyloid beta (A4) precursor protein 0.0220902
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0217773
COL6A1 collagen, type VI, alpha 1 0.0216749
MMP12 matrix metallopeptidase 12 0.0215096
CDK19 cyclin-dependent kinase 19 0.021479
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0214773
LOC112694756 uncharaterized LOC112694756 0.0212009
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0211238
LTBP1 latent transforming growth factor beta binding protein 1 0.021094
FNDC3A fibronectin type III domain containing 3A 0.0209858
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0208965
MED13L mediator complex subunit 13-like 0.0208391
COL5A2 collagen, type V, alpha 2 0.020692
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0206745
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0206013
COL1A2 collagen, type I, alpha 2 0.0205907
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.0205371
TNIP1 TNFAIP3 interacting protein 1 0.0203834
SETD5 SET domain containing 5 0.0202671
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 0.0201734
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.020153
RICTOR RPTOR independent companion of MTOR, complex 2 0.019959
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0197603
COL5A1 collagen, type V, alpha 1 0.0196523
DUSP10 dual specificity phosphatase 10 0.019525
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0194129
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0191219
ACTN1 actinin, alpha 1 0.0190364
TTC28 tetratricopeptide repeat domain 28 0.0189617
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0188272
GREM1 gremlin 1, DAN family BMP antagonist 0.0186113
CDH13 cadherin 13 0.0185218
NFE2L1 nuclear factor, erythroid 2-like 1 0.0184929
COL4A1 collagen, type IV, alpha 1 0.0184641
CTBP2 C-terminal binding protein 2 0.018424
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0184093
COPA coatomer protein complex, subunit alpha 0.018269
OXR1 oxidation resistance 1 0.018269
PTK2 protein tyrosine kinase 2 0.018165
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0180551
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0180411
TGFBI transforming growth factor, beta-induced, 68kDa 0.0180186
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0179228

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.274345
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.223972
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.144297
TPT1 tumor protein, translationally-controlled 1 -0.0931304
MT2A metallothionein 2A -0.0821704
FTL ferritin, light polypeptide -0.0728794
TMSB10 thymosin beta 10 -0.0654809
RPLP1 ribosomal protein, large, P1 -0.0633691
EIF1 eukaryotic translation initiation factor 1 -0.057227
RPL35A ribosomal protein L35a -0.0471256
RPS6 ribosomal protein S6 -0.0451688
RPS24 ribosomal protein S24 -0.042334
PTMA prothymosin, alpha -0.0390811
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0382398
IER3 immediate early response 3 -0.0379529
RPS8 ribosomal protein S8 -0.0375045
RPL34 ribosomal protein L34 -0.0372974
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0372592
HLA-B major histocompatibility complex, class I, B -0.0372521
RPS19 ribosomal protein S19 -0.0360135
ACTG1 actin gamma 1 -0.0349584
RPL12 ribosomal protein L12 -0.0346057
RPLP2 ribosomal protein, large, P2 -0.0344549
TM4SF1 transmembrane 4 L six family member 1 -0.0340043
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0323377
RPL11 ribosomal protein L11 -0.0294333
SRGN serglycin -0.0280738
RPL32 ribosomal protein L32 -0.0273157
RPL23 ribosomal protein L23 -0.0269346
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0268932
RPS13 ribosomal protein S13 -0.0266814
CAVIN1 caveolae associated protein 1 -0.0254494
S100A6 S100 calcium binding protein A6 -0.0250849
RBM25 RNA binding motif protein 25 -0.0246468
RPS20 ribosomal protein S20 -0.0238143
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0237763
RPS16 ribosomal protein S16 -0.0236965
COL1A1 collagen, type I, alpha 1 -0.0232746
ALCAM activated leukocyte cell adhesion molecule -0.0224143
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0219524
S100A9 S100 calcium binding protein A9 -0.0218216
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0217869
RPL7A ribosomal protein L7a -0.0216998
RPS21 ribosomal protein S21 -0.0207919
UBC ubiquitin C -0.020774
RPS25 ribosomal protein S25 -0.0206037
RPL37A ribosomal protein L37a -0.0203019
BTG1 B-cell translocation gene 1, anti-proliferative -0.0197019
RPS23 ribosomal protein S23 -0.0194405
RPL9 ribosomal protein L9 -0.019141
RPL27A ribosomal protein L27a -0.019016
RPS29 ribosomal protein S29 -0.0189185
RPS15 ribosomal protein S15 -0.0188144
RPS14 ribosomal protein S14 -0.0186122
RPL8 ribosomal protein L8 -0.0185424
RPL35 ribosomal protein L35 -0.018372
RPLP0 ribosomal protein, large, P0 -0.0179279
NAP1L1 nucleosome assembly protein 1-like 1 -0.0179216
ZBTB20 zinc finger and BTB domain containing 20 -0.0178842
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0177166
VDAC1 voltage-dependent anion channel 1 -0.0172673
RPL26 ribosomal protein L26 -0.0172459
CANX calnexin -0.0171238
RPL13A ribosomal protein L13a -0.0167279
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0166758
RPL27 ribosomal protein L27 -0.0165641
RPL28 ribosomal protein L28 -0.0162803
SP100 SP100 nuclear antigen -0.0160815
H3-3B H3.3 histone B -0.0160171
GCC2 GRIP and coiled-coil domain containing 2 -0.0158052
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0157447
SLC38A1 solute carrier family 38, member 1 -0.0156337
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0155367
HLA-E major histocompatibility complex, class I, E -0.0152997
MYL12B myosin, light chain 12B, regulatory -0.0152858
RPL37 ribosomal protein L37 -0.0152841
RPL10A ribosomal protein L10a -0.0152005
IFITM3 interferon induced transmembrane protein 3 -0.0151355
MORF4L2 mortality factor 4 like 2 -0.0147322
RPL38 ribosomal protein L38 -0.0147222
RPS11 ribosomal protein S11 -0.0146536
RPS27A ribosomal protein S27a -0.0143901
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0143204
RPL31 ribosomal protein L31 -0.0142502
TXNIP thioredoxin interacting protein -0.0142059
RPL36 ribosomal protein L36 -0.0141256
ARF1 ADP-ribosylation factor 1 -0.0140622
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0139983
RPS5 ribosomal protein S5 -0.0138937
RPL5 ribosomal protein L5 -0.0138253
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0137841
RRBP1 ribosome binding protein 1 -0.0137021
RPL36A ribosomal protein L36a -0.0134372
RTN4 reticulon 4 -0.0134001
HMGB1 high mobility group box 1 -0.0133341
RPL7 ribosomal protein L7 -0.0129361
RPS3 ribosomal protein S3 -0.0128707
ATP5F1E ATP synthase F1 subunit epsilon -0.0128275
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0127472
SQSTM1 sequestosome 1 -0.0127429