Fetal Alcohol Syndrome Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A fetal alcohol spectrum disorder that results in severe mental and physical defects which can develop in a child when the mother drinks alcohol during pregnancy. The presenting features include craniofacial dysmorphology (microcephaly, smooth philtrum, thin upper lip, small eye openings), pre- and postnatal growth deficiency, and central nervous system dysfunction. (Human Disease Ontology, DOID_0050665)
External Link https://www.disgenet.org/browser/0/1/0/C0015923
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Genes

88 genes associated with the disease Fetal Alcohol Syndrome in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ACTB actin, beta
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADNP activity-dependent neuroprotector homeobox
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase)
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AVP arginine vasopressin
BCL2 B-cell CLL/lymphoma 2
BCL6 B-cell CLL/lymphoma 6
BCR breakpoint cluster region
BDNF brain-derived neurotrophic factor
BPIFA1 BPI fold containing family A, member 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAT catalase
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD28 CD28 molecule
CFLAR CASP8 and FADD-like apoptosis regulator
CHL1 cell adhesion molecule L1-like
CNOT3 CCR4-NOT transcription complex, subunit 3
CNR1 cannabinoid receptor 1 (brain)
COL11A2 collagen, type XI, alpha 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNNBL1 catenin, beta like 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCR3 chemokine (C-X-C motif) receptor 3
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DAPK1 death-associated protein kinase 1
DTNBP1 dystrobrevin binding protein 1
ELOVL6 ELOVL fatty acid elongase 6
ERCC6L excision repair cross-complementation group 6-like
FANCE Fanconi anemia, complementation group E
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FLG filaggrin
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GRAP2 GRB2-related adaptor protein 2
GSK3B glycogen synthase kinase 3 beta
HOXA9 homeobox A9
IL10 interleukin 10
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL6 interleukin 6
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4
KMT2A lysine (K)-specific methyltransferase 2A
L1CAM L1 cell adhesion molecule
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MECP2 methyl CpG binding protein 2
MEIS1 Meis homeobox 1
NLGN4X neuroligin 4, X-linked
NOS1 nitric oxide synthase 1 (neuronal)
OTX2 orthodenticle homeobox 2
PARP1 poly (ADP-ribose) polymerase 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PFAS phosphoribosylformylglycinamidine synthase
PGF placental growth factor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLG plasminogen
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POMC proopiomelanocortin
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
REST RE1-silencing transcription factor
RHOA ras homolog family member A
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SHARPIN SHANK-associated RH domain interactor
SHH sonic hedgehog
SIRT1 sirtuin 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLITRK2 SLIT and NTRK-like family, member 2
SRF serum response factor (c-fos serum response element-binding transcription factor)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFB1 transforming growth factor, beta 1
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TP53 tumor protein p53
TYMS thymidylate synthetase
VIP vasoactive intestinal peptide
WIPF2 WAS/WASL interacting protein family, member 2