Filgotinib_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Filgotinib perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Filgotinib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.155573
COL8A1 collagen, type VIII, alpha 1 0.129921
CDH13 cadherin 13 0.11245
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.103747
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0943702
TRIO trio Rho guanine nucleotide exchange factor 0.0888044
NAV1 neuron navigator 1 0.0854996
DST dystonin 0.0808511
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0807328
AHNAK AHNAK nucleoprotein 0.0751288
SLC39A11 solute carrier family 39, member 11 0.0740187
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0663211
COL5A1 collagen, type V, alpha 1 0.0637061
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0599647
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0592714
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0540882
MAP1B microtubule-associated protein 1B 0.0538496
MACF1 microtubule-actin crosslinking factor 1 0.051853
EGFR epidermal growth factor receptor 0.0500255
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0488319
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0471366
FNDC3B fibronectin type III domain containing 3B 0.0465894
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0462084
ABI3BP ABI family, member 3 (NESH) binding protein 0.0459546
POTEF POTE ankyrin domain family, member F 0.0440248
MYOF myoferlin 0.042694
HDAC9 histone deacetylase 9 0.040082
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0396857
IGFBP3 insulin-like growth factor binding protein 3 0.0395334
PDE4D phosphodiesterase 4D, cAMP-specific 0.0394379
VCL vinculin 0.0391563
PBX3 pre-B-cell leukemia homeobox 3 0.0384647
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0383379
MYH9 myosin, heavy chain 9, non-muscle 0.0373784
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0371415
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0368695
SP3 Sp3 transcription factor 0.0366544
DCLK2 doublecortin-like kinase 2 0.0366443
EFNA5 ephrin-A5 0.0365762
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0362361
PRELID2 PRELI domain containing 2 0.0358874
ASPH aspartate beta-hydroxylase 0.0351359
TENM3 teneurin transmembrane protein 3 0.0348601
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0338417
MSN moesin 0.0337011
ADAM9 ADAM metallopeptidase domain 9 0.0334179
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0333664
RUNX1 runt-related transcription factor 1 0.0324532
MCL1 myeloid cell leukemia 1 0.0317933
FN1 fibronectin 1 0.0313684
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0309567
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0302292
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0296875
PKM pyruvate kinase, muscle 0.0291244
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0288967
ITPRID2 ITPR interacting domain containing 2 0.0278697
FLNA filamin A, alpha 0.0276316
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0269956
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0269462
RTN4 reticulon 4 0.0265809
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0264139
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0262366
CANX calnexin 0.0259954
SORBS2 sorbin and SH3 domain containing 2 0.0252498
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0251078
CENPF centromere protein F, 350/400kDa 0.0247208
ANKRD11 ankyrin repeat domain 11 0.0245868
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0237824
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0236021
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0235946
NEK7 NIMA-related kinase 7 0.0235862
LIMCH1 LIM and calponin homology domains 1 0.0231085
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0225577
GLS2 glutaminase 2 (liver, mitochondrial) 0.0222986
DLG1 discs, large homolog 1 (Drosophila) 0.0221513
DSPP dentin sialophosphoprotein 0.021726
ZMIZ1 zinc finger, MIZ-type containing 1 0.0216328
ERRFI1 ERBB receptor feedback inhibitor 1 0.0211126
CYTH3 cytohesin 3 0.0210413
FNDC3A fibronectin type III domain containing 3A 0.0208739
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0208606
LHFPL6 LHFPL tetraspan subfamily member 6 0.0206089
ADARB1 adenosine deaminase, RNA-specific, B1 0.0205648
LDHA lactate dehydrogenase A 0.0200549
SPDL1 spindle apparatus coiled-coil protein 1 0.019982
TPM3 tropomyosin 3 0.0197751
SDK1 sidekick cell adhesion molecule 1 0.0196869
CDK6 cyclin-dependent kinase 6 0.0195617
NCOR2 nuclear receptor corepressor 2 0.0194932
IPO9 importin 9 0.0193459
MED13L mediator complex subunit 13-like 0.0193019
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0192825
COPA coatomer protein complex, subunit alpha 0.019199
CUX1 cut-like homeobox 1 0.0189778
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0189566
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0185099
MSI2 musashi RNA-binding protein 2 0.0185036
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0184883
L1CAM L1 cell adhesion molecule 0.0182864
FSTL1 follistatin-like 1 0.0182692

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.198426
MT2A metallothionein 2A -0.143287
VIM vimentin -0.141567
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.114462
HLA-B major histocompatibility complex, class I, B -0.0917878
NDRG1 N-myc downstream regulated 1 -0.0660519
B2M beta-2-microglobulin -0.0646198
PTMA prothymosin, alpha -0.0623086
S100A6 S100 calcium binding protein A6 -0.0564543
LOX lysyl oxidase -0.0561782
IFITM3 interferon induced transmembrane protein 3 -0.0549792
CSTB cystatin B (stefin B) -0.0525568
PLAT plasminogen activator, tissue -0.0522919
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0502391
IFITM1 interferon induced transmembrane protein 1 -0.0492806
HLA-C major histocompatibility complex, class I, C -0.0451836
EIF1 eukaryotic translation initiation factor 1 -0.041828
HLA-E major histocompatibility complex, class I, E -0.0411107
FTH1 ferritin, heavy polypeptide 1 -0.0388682
S100A10 S100 calcium binding protein A10 -0.0370345
UBC ubiquitin C -0.0367899
TPT1 tumor protein, translationally-controlled 1 -0.0349668
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0333642
MX2 MX dynamin-like GTPase 2 -0.0328166
CD99 CD99 molecule -0.0327822
THBS2 thrombospondin 2 -0.0306141
SQSTM1 sequestosome 1 -0.0305181
NAP1L1 nucleosome assembly protein 1-like 1 -0.0297381
MT1X metallothionein 1X -0.029393
GPC6 glypican 6 -0.0281331
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.028004
FTL ferritin, light polypeptide -0.0276548
RPL12 ribosomal protein L12 -0.0270519
TMSB4X thymosin beta 4, X-linked -0.0269024
FBXL7 F-box and leucine-rich repeat protein 7 -0.0259546
IFI6 interferon, alpha-inducible protein 6 -0.0256392
RPS19 ribosomal protein S19 -0.0250166
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0249069
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0244376
STC1 stanniocalcin 1 -0.0242707
LMNA lamin A/C -0.0241491
TM4SF1 transmembrane 4 L six family member 1 -0.0241264
RPS24 ribosomal protein S24 -0.024085
RPL28 ribosomal protein L28 -0.0240796
RPS3 ribosomal protein S3 -0.024077
RPL23 ribosomal protein L23 -0.0238281
HLA-A major histocompatibility complex, class I, A -0.0237113
CAVIN1 caveolae associated protein 1 -0.0235535
RPLP2 ribosomal protein, large, P2 -0.0231876
LOC112694756 uncharaterized LOC112694756 -0.0215353
RPL35A ribosomal protein L35a -0.0215194
COL3A1 collagen, type III, alpha 1 -0.0207904
SLC38A1 solute carrier family 38, member 1 -0.0206349
RPL34 ribosomal protein L34 -0.0203588
COL1A2 collagen, type I, alpha 2 -0.0203235
RPL36 ribosomal protein L36 -0.0203041
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0202361
HIP1 huntingtin interacting protein 1 -0.0196299
GNAS GNAS complex locus -0.0195357
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0191286
RPL26 ribosomal protein L26 -0.0190526
RPL37A ribosomal protein L37a -0.0188931
RPS8 ribosomal protein S8 -0.0188046
RPS27A ribosomal protein S27a -0.0187773
RPS6 ribosomal protein S6 -0.0187634
HSPB1 heat shock 27kDa protein 1 -0.0182324
MTSS1 metastasis suppressor 1 -0.0179551
H3-3B H3.3 histone B -0.0176348
RHOBTB3 Rho-related BTB domain containing 3 -0.0176033
WDFY1 WD repeat and FYVE domain containing 1 -0.0175592
IFI16 interferon, gamma-inducible protein 16 -0.0175139
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0172975
TMOD1 tropomodulin 1 -0.0172568
RPL19 ribosomal protein L19 -0.0171945
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0170277
SEC61G Sec61 gamma subunit -0.0169309
S100A11 S100 calcium binding protein A11 -0.0166499
SP100 SP100 nuclear antigen -0.0165891
GOLGA4 golgin A4 -0.0163334
RPL32 ribosomal protein L32 -0.016319
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.0163148
RACK1 receptor for activated C kinase 1 -0.0161321
PLSCR1 phospholipid scramblase 1 -0.016052
RPS15 ribosomal protein S15 -0.0158232
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0156283
MPZL1 myelin protein zero-like 1 -0.015561
RPL35 ribosomal protein L35 -0.0154651
S100A9 S100 calcium binding protein A9 -0.0153381
EPAS1 endothelial PAS domain protein 1 -0.0152287
RPS12 ribosomal protein S12 -0.0150217
ZEB1 zinc finger E-box binding homeobox 1 -0.0150093
BSG basigin (Ok blood group) -0.0147853
NPEPPS aminopeptidase puromycin sensitive -0.0147231
RPS11 ribosomal protein S11 -0.0145943
RPLP1 ribosomal protein, large, P1 -0.0142548
WSB1 WD repeat and SOCS box containing 1 -0.014142
S100A4 S100 calcium binding protein A4 -0.0141196
RPL7A ribosomal protein L7a -0.0140646
RPS27 ribosomal protein S27 -0.0140539
BHLHE40 basic helix-loop-helix family, member e40 -0.0140174