Filgotinib_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Filgotinib perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Filgotinib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 0.173255
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0838173
MGAT4C MGAT4 family, member C 0.0814822
PDE4D phosphodiesterase 4D, cAMP-specific 0.0805762
BCHE butyrylcholinesterase 0.0700985
TENM3 teneurin transmembrane protein 3 0.0664528
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0660504
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0646377
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0629681
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0560534
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0529295
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0523441
TBC1D5 TBC1 domain family, member 5 0.0487624
NEBL nebulette 0.0487216
CELF2 CUGBP, Elav-like family member 2 0.0482549
MED13L mediator complex subunit 13-like 0.048081
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0467944
ERRFI1 ERBB receptor feedback inhibitor 1 0.042868
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.042518
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0385949
VCL vinculin 0.0357291
EIF4B eukaryotic translation initiation factor 4B 0.0353268
MACF1 microtubule-actin crosslinking factor 1 0.0349753
SMYD3 SET and MYND domain containing 3 0.0333783
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0332094
PDGFC platelet derived growth factor C 0.0331285
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0327125
NHSL1 NHS-like 1 0.0325111
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0313262
SPATS2 spermatogenesis associated, serine-rich 2 0.0309562
WWOX WW domain containing oxidoreductase 0.0299384
RRM2 ribonucleotide reductase M2 0.0298822
ZNF292 zinc finger protein 292 0.0296537
EPHA6 EPH receptor A6 0.0296188
LMO7 LIM domain 7 0.0290281
MMP12 matrix metallopeptidase 12 0.0289949
RAD51B RAD51 paralog B 0.0288689
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0282105
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0282014
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0265558
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0265007
ANKRD12 ankyrin repeat domain 12 0.0260982
ANXA1 annexin A1 0.0260935
PRELID2 PRELI domain containing 2 0.0258675
TAS2R14 taste receptor, type 2, member 14 0.0256173
AXIN2 axin 2 0.0247222
EHBP1 EH domain binding protein 1 0.0245796
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0243537
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0242938
DPYD dihydropyrimidine dehydrogenase 0.0240666
ZMYM2 zinc finger, MYM-type 2 0.0239164
AHNAK AHNAK nucleoprotein 0.0235701
CCSER1 coiled-coil serine-rich protein 1 0.0235612
MTAP methylthioadenosine phosphorylase 0.0234529
EXOC6B exocyst complex component 6B 0.0234363
IL6ST interleukin 6 signal transducer 0.0234324
SRSF1 serine/arginine-rich splicing factor 1 0.0231561
EXOC4 exocyst complex component 4 0.0224659
MBNL1 muscleblind-like splicing regulator 1 0.0221854
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0219924
XPO1 exportin 1 0.0219155
THSD7A thrombospondin, type I, domain containing 7A 0.02175
ADGRG6 adhesion G protein-coupled receptor G6 0.0216835
DTNA dystrobrevin, alpha 0.0216179
MSH6 mutS homolog 6 0.0214383
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0210275
FSTL5 follistatin-like 5 0.0209591
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0209569
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.020912
TPM3 tropomyosin 3 0.0207371
HELB helicase (DNA) B 0.0206346
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.0205212
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0205121
MECOM MDS1 and EVI1 complex locus 0.0201126
AKAP13 A kinase (PRKA) anchor protein 13 0.0200776
TRA2B transformer 2 beta homolog (Drosophila) 0.0200664
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0199457
TMEM106B transmembrane protein 106B 0.0198675
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0198402
YEATS2 YEATS domain containing 2 0.0198264
ENO1 enolase 1, (alpha) 0.0197278
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0196596
GASK1B golgi associated kinase 1B 0.0194083
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0192354
LDHA lactate dehydrogenase A 0.019201
SP3 Sp3 transcription factor 0.0191235
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0190963
ZDHHC2 zinc finger, DHHC-type containing 2 0.0190797
LRMDA leucine rich melanocyte differentiation associated 0.0189937
CEP192 centrosomal protein 192kDa 0.0188645
EDARADD EDAR-associated death domain 0.0188111
TPI1 triosephosphate isomerase 1 0.0186187
FGF14 fibroblast growth factor 14 0.0186004
LCLAT1 lysocardiolipin acyltransferase 1 0.0183313
NFIA nuclear factor I/A 0.0181496
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0179548
ARFGEF3 ARFGEF family member 3 0.0179014
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0178611
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0178442
PGK1 phosphoglycerate kinase 1 0.0178132

decreased expression

Symbol Name Standardized Value
AREG amphiregulin -0.225417
VIM vimentin -0.169296
TMSB10 thymosin beta 10 -0.12748
FTL ferritin, light polypeptide -0.0983138
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0947398
EIF1 eukaryotic translation initiation factor 1 -0.0670318
RPS12 ribosomal protein S12 -0.0653837
RPS8 ribosomal protein S8 -0.0596201
RPL23 ribosomal protein L23 -0.0534639
PTMA prothymosin, alpha -0.0531572
RPS6 ribosomal protein S6 -0.0530541
RPS3 ribosomal protein S3 -0.0509527
RPL36 ribosomal protein L36 -0.0497064
RPL37A ribosomal protein L37a -0.0491265
RPLP2 ribosomal protein, large, P2 -0.0446457
RPS19 ribosomal protein S19 -0.0441452
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0435313
RPL35A ribosomal protein L35a -0.0435143
RPS23 ribosomal protein S23 -0.0434933
TPT1 tumor protein, translationally-controlled 1 -0.0414347
RPL26 ribosomal protein L26 -0.0407994
RPL19 ribosomal protein L19 -0.0407593
RPL34 ribosomal protein L34 -0.0404514
BIRC3 baculoviral IAP repeat containing 3 -0.0403607
SLC38A2 solute carrier family 38, member 2 -0.0388679
RPL31 ribosomal protein L31 -0.038081
RPS29 ribosomal protein S29 -0.0364489
RPLP1 ribosomal protein, large, P1 -0.0363188
RPS27A ribosomal protein S27a -0.0361922
CNRIP1 cannabinoid receptor interacting protein 1 -0.0358244
RPS14 ribosomal protein S14 -0.0357888
ACTG1 actin gamma 1 -0.0345239
SLC38A1 solute carrier family 38, member 1 -0.0317751
RPL37 ribosomal protein L37 -0.0317323
RPS25 ribosomal protein S25 -0.0314839
RPL28 ribosomal protein L28 -0.0309665
RPS27 ribosomal protein S27 -0.0306538
RPL12 ribosomal protein L12 -0.0305088
NAP1L1 nucleosome assembly protein 1-like 1 -0.030091
MYL12B myosin, light chain 12B, regulatory -0.0300256
RPL8 ribosomal protein L8 -0.0286552
RPS13 ribosomal protein S13 -0.0286238
RPS2 ribosomal protein S2 -0.0282795
RPS16 ribosomal protein S16 -0.0277494
HSPB1 heat shock 27kDa protein 1 -0.0268533
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0265912
KLF6 Kruppel-like factor 6 -0.0263818
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0261761
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0259658
S100A6 S100 calcium binding protein A6 -0.0253349
RPS21 ribosomal protein S21 -0.0250722
ERBIN erbb2 interacting protein -0.0248243
EDN1 endothelin 1 -0.0246431
RPL11 ribosomal protein L11 -0.0245382
EGR1 early growth response 1 -0.0244935
SQSTM1 sequestosome 1 -0.0243125
RPL18 ribosomal protein L18 -0.0238608
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0238445
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0235714
RPS20 ribosomal protein S20 -0.0234491
PFN1 profilin 1 -0.0230343
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0228851
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0226948
LOC102724023 ES1 protein homolog, mitochondrial -0.022581
TBCA tubulin folding cofactor A -0.0222301
RPL36A ribosomal protein L36a -0.0217756
ZNF804A zinc finger protein 804A -0.0211084
HLA-A major histocompatibility complex, class I, A -0.020823
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0208197
RPS10 ribosomal protein S10 -0.0204001
RPS11 ribosomal protein S11 -0.0203846
OSBPL8 oxysterol binding protein-like 8 -0.0203659
RPLP0 ribosomal protein, large, P0 -0.0202551
ATP5F1E ATP synthase F1 subunit epsilon -0.0201701
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.01992
CSNK1A1 casein kinase 1, alpha 1 -0.0197592
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0197452
GNAS GNAS complex locus -0.0197176
RPL35 ribosomal protein L35 -0.0195859
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.019571
RPL9 ribosomal protein L9 -0.0195447
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0193707
RPL32 ribosomal protein L32 -0.0193072
YBX1 Y box binding protein 1 -0.0192742
YBX3 Y box binding protein 3 -0.0191818
RPL38 ribosomal protein L38 -0.0188633
MRPL51 mitochondrial ribosomal protein L51 -0.0180173
SEC62 SEC62 homolog (S. cerevisiae) -0.017835
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0177789
RAB7A RAB7A, member RAS oncogene family -0.0177407
S100A11 S100 calcium binding protein A11 -0.0175815
RPL10A ribosomal protein L10a -0.0174464
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0174016
RBM39 RNA binding motif protein 39 -0.0172271
RPL27A ribosomal protein L27a -0.0172111
DUSP6 dual specificity phosphatase 6 -0.0171798
RASAL2 RAS protein activator like 2 -0.0171618
RPS15 ribosomal protein S15 -0.0171316
ATP5F1B ATP synthase F1 subunit beta -0.0170948
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0170606