| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Filgotinib perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Filgotinib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.208578 |
| NRG1 | neuregulin 1 | 0.130526 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.129173 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.123167 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.118821 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.111233 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.103117 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0875747 |
| MEIS2 | Meis homeobox 2 | 0.0857465 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.085605 |
| DPH6 | diphthamine biosynthesis 6 | 0.083585 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0783445 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0778597 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | 0.077132 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0766311 |
| BPTF | bromodomain PHD finger transcription factor | 0.0764334 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0749501 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0741437 |
| MEF2A | myocyte enhancer factor 2A | 0.073634 |
| LSAMP | limbic system-associated membrane protein | 0.0724614 |
| CRH | corticotropin releasing hormone | 0.0700249 |
| SLITRK6 | SLIT and NTRK-like family, member 6 | 0.0682195 |
| ATRNL1 | attractin-like 1 | 0.0675767 |
| PCDH9 | protocadherin 9 | 0.0673134 |
| FNBP1 | formin binding protein 1 | 0.0647083 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0646468 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0638817 |
| PLAT | plasminogen activator, tissue | 0.0611282 |
| ST6GALNAC3 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 | 0.0611015 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0593849 |
| IGF2 | insulin-like growth factor 2 | 0.0582357 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | 0.0575981 |
| MAP1B | microtubule-associated protein 1B | 0.0575315 |
| UNC5C | unc-5 homolog C (C. elegans) | 0.0541675 |
| NDRG1 | N-myc downstream regulated 1 | 0.05375 |
| SYT1 | synaptotagmin I | 0.0532875 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0532188 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0531361 |
| CADM2 | cell adhesion molecule 2 | 0.0527545 |
| DST | dystonin | 0.052331 |
| SMYD3 | SET and MYND domain containing 3 | 0.052002 |
| ANGPT1 | angiopoietin 1 | 0.0514814 |
| PRKCA | protein kinase C, alpha | 0.0513671 |
| ASPH | aspartate beta-hydroxylase | 0.0510683 |
| RAD51B | RAD51 paralog B | 0.0500049 |
| CENPF | centromere protein F, 350/400kDa | 0.0489597 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0475178 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | 0.0472083 |
| EXOC4 | exocyst complex component 4 | 0.0459854 |
| PCBP2 | poly(rC) binding protein 2 | 0.0454916 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0452153 |
| ZNF292 | zinc finger protein 292 | 0.0449741 |
| KCNIP4 | Kv channel interacting protein 4 | 0.0442422 |
| NREP | neuronal regeneration related protein | 0.0432316 |
| FAM13A | family with sequence similarity 13, member A | 0.0429228 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0427904 |
| DIAPH2 | diaphanous-related formin 2 | 0.0418452 |
| HMGA2 | high mobility group AT-hook 2 | 0.0417095 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0416556 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0414604 |
| ATXN1 | ataxin 1 | 0.0410588 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0408272 |
| TOX | thymocyte selection-associated high mobility group box | 0.0402771 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0398126 |
| ZNF638 | zinc finger protein 638 | 0.0395292 |
| RALYL | RALY RNA binding protein-like | 0.039307 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0388878 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0386274 |
| MSI2 | musashi RNA-binding protein 2 | 0.0384538 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0384371 |
| NBEA | neurobeachin | 0.0378494 |
| MBTD1 | mbt domain containing 1 | 0.0372868 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0364672 |
| MCL1 | myeloid cell leukemia 1 | 0.0364358 |
| MAPK10 | mitogen-activated protein kinase 10 | 0.036431 |
| SEPTIN9 | septin 9 | 0.0359608 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0358528 |
| CDH13 | cadherin 13 | 0.0355096 |
| ENO1 | enolase 1, (alpha) | 0.0353633 |
| DACH2 | dachshund family transcription factor 2 | 0.0352676 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.0350677 |
| TCF12 | transcription factor 12 | 0.0345294 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0344474 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | 0.0344426 |
| SCG2 | secretogranin II | 0.0342377 |
| SPAG16 | sperm associated antigen 16 | 0.0338539 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.03376 |
| ATM | ATM serine/threonine kinase | 0.0337555 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0337413 |
| VEGFA | vascular endothelial growth factor A | 0.03362 |
| AHR | aryl hydrocarbon receptor | 0.0334553 |
| C1ORF21 | chromosome 1 open reading frame 21 | 0.0334098 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0331134 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0331028 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.0330909 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0330341 |
| PGK1 | phosphoglycerate kinase 1 | 0.0328313 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0326646 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0322999 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0322322 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EXT1 | exostosin glycosyltransferase 1 | -0.0741627 |
| RNF213 | ring finger protein 213 | -0.0714373 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0642223 |
| PTMA | prothymosin, alpha | -0.0616576 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0591986 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0590296 |
| RIGI | RNA sensor RIG-I | -0.0577128 |
| SP100 | SP100 nuclear antigen | -0.0559751 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0557401 |
| RPL23 | ribosomal protein L23 | -0.0511271 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.04939 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0479083 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0443753 |
| RPS6 | ribosomal protein S6 | -0.0424216 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0399371 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.039129 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0384085 |
| COL3A1 | collagen, type III, alpha 1 | -0.037315 |
| WAC | WW domain containing adaptor with coiled-coil | -0.03689 |
| RPL38 | ribosomal protein L38 | -0.0368664 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | -0.0365891 |
| HMGB2 | high mobility group box 2 | -0.0353533 |
| LPIN1 | lipin 1 | -0.0346442 |
| LMNA | lamin A/C | -0.0337989 |
| RPS24 | ribosomal protein S24 | -0.0333218 |
| PDE10A | phosphodiesterase 10A | -0.0326191 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0325112 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.032481 |
| MX2 | MX dynamin-like GTPase 2 | -0.0323474 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.0318945 |
| RPLP1 | ribosomal protein, large, P1 | -0.0314733 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0300694 |
| COL1A1 | collagen, type I, alpha 1 | -0.0295536 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0287376 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.02838 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0271462 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0269015 |
| SLMAP | sarcolemma associated protein | -0.0262484 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0261443 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | -0.0259065 |
| GLCCI1 | glucocorticoid induced 1 | -0.0258364 |
| OLA1 | Obg-like ATPase 1 | -0.0257928 |
| FRMD4A | FERM domain containing 4A | -0.0255066 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.0254852 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0253758 |
| WDR43 | WD repeat domain 43 | -0.0253322 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0247033 |
| MX1 | MX dynamin-like GTPase 1 | -0.0246472 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0244409 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0242479 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0240514 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.0240235 |
| PCNX1 | pecanex 1 | -0.0240131 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0233769 |
| GPC5 | glypican 5 | -0.0232406 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0231504 |
| ANXA2 | annexin A2 | -0.0231382 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.023086 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0229054 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0227137 |
| NEK7 | NIMA-related kinase 7 | -0.0218704 |
| CCND1 | cyclin D1 | -0.0217781 |
| ARF1 | ADP-ribosylation factor 1 | -0.0217555 |
| RPL26 | ribosomal protein L26 | -0.0216861 |
| TMSB10 | thymosin beta 10 | -0.0216691 |
| RPL19 | ribosomal protein L19 | -0.0215761 |
| YME1L1 | YME1-like 1 ATPase | -0.0214422 |
| HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | -0.0211729 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.021152 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0210941 |
| H3-3B | H3.3 histone B | -0.0210592 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | -0.0209337 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0209212 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0208827 |
| RAB21 | RAB21, member RAS oncogene family | -0.0206538 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0205137 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.020463 |
| SQSTM1 | sequestosome 1 | -0.0201498 |
| TJP1 | tight junction protein 1 | -0.0199507 |
| RPS2 | ribosomal protein S2 | -0.019882 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0196191 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.019532 |
| NAA50 | N(alpha)-acetyltransferase 50, NatE catalytic subunit | -0.0193533 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | -0.0193215 |
| ACTG1 | actin gamma 1 | -0.0193081 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0193046 |
| PAXBP1 | PAX3 and PAX7 binding protein 1 | -0.0192589 |
| QKI | QKI, KH domain containing, RNA binding | -0.019219 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0190514 |
| IFI44 | interferon-induced protein 44 | -0.0189795 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0188216 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | -0.0186845 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0186517 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.01865 |
| TRIM56 | tripartite motif containing 56 | -0.0185727 |
| NPLOC4 | nuclear protein localization 4 homolog (S. cerevisiae) | -0.0185314 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | -0.0184895 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | -0.0184505 |
| COLEC11 | collectin sub-family member 11 | -0.0183355 |
| TRIM37 | tripartite motif containing 37 | -0.0183332 |
