| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Filgotinib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Filgotinib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.327767 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.271095 |
| COL6A3 | collagen, type VI, alpha 3 | 0.111434 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.100223 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0831671 |
| CD44 | CD44 molecule (Indian blood group) | 0.0768289 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0732359 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0711465 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0612086 |
| COL1A2 | collagen, type I, alpha 2 | 0.0588606 |
| LDHA | lactate dehydrogenase A | 0.0560748 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0546974 |
| LOXL2 | lysyl oxidase-like 2 | 0.0511524 |
| ASPH | aspartate beta-hydroxylase | 0.0478848 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.044045 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0400944 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0396859 |
| MAP1B | microtubule-associated protein 1B | 0.0392344 |
| VCAN | versican | 0.0390008 |
| VEGFA | vascular endothelial growth factor A | 0.0387093 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0383813 |
| TPM4 | tropomyosin 4 | 0.0376111 |
| VIM | vimentin | 0.0368658 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.036622 |
| HMGA2 | high mobility group AT-hook 2 | 0.0361721 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0353455 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.032777 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0313172 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0312037 |
| SDC2 | syndecan 2 | 0.0307266 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0294921 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0289328 |
| VCL | vinculin | 0.0285739 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0280414 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0279941 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0270963 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.026528 |
| NRP1 | neuropilin 1 | 0.025757 |
| TMEM165 | transmembrane protein 165 | 0.0245426 |
| ARRDC3 | arrestin domain containing 3 | 0.0240176 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0237396 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0231262 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.022723 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0219593 |
| CALU | calumenin | 0.0212565 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0212241 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0209468 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0207882 |
| AXL | AXL receptor tyrosine kinase | 0.0207441 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.020617 |
| TMF1 | TATA element modulatory factor 1 | 0.0190726 |
| SVIL | supervillin | 0.0185918 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0185172 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0184956 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.018408 |
| ENO1 | enolase 1, (alpha) | 0.0182064 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.018194 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0176886 |
| POSTN | periostin, osteoblast specific factor | 0.0171573 |
| NKTR | natural killer cell triggering receptor | 0.0171316 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0166792 |
| EGR1 | early growth response 1 | 0.0166461 |
| LOX | lysyl oxidase | 0.0165174 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0165124 |
| SYNJ2 | synaptojanin 2 | 0.0162078 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0161852 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0160856 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0159914 |
| ATP13A3 | ATPase type 13A3 | 0.015851 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0156464 |
| ITGAV | integrin, alpha V | 0.0154172 |
| MSN | moesin | 0.0149678 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0149488 |
| COL1A1 | collagen, type I, alpha 1 | 0.0148933 |
| PKM | pyruvate kinase, muscle | 0.014681 |
| CTSB | cathepsin B | 0.014117 |
| PALLD | palladin, cytoskeletal associated protein | 0.0140534 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.014046 |
| SERINC3 | serine incorporator 3 | 0.0139214 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0138158 |
| ITGA11 | integrin, alpha 11 | 0.013786 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0135946 |
| FAT1 | FAT atypical cadherin 1 | 0.0134019 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0133273 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0132768 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0132752 |
| CPQ | carboxypeptidase Q | 0.0130666 |
| CD109 | CD109 molecule | 0.0129738 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | 0.0126468 |
| ECE1 | endothelin converting enzyme 1 | 0.012482 |
| NAV1 | neuron navigator 1 | 0.0124233 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0123001 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0122405 |
| PDE10A | phosphodiesterase 10A | 0.0120797 |
| ABLIM3 | actin binding LIM protein family, member 3 | 0.0120131 |
| PRELID2 | PRELI domain containing 2 | 0.0120068 |
| HLA-A | major histocompatibility complex, class I, A | 0.0119078 |
| CENPF | centromere protein F, 350/400kDa | 0.0117864 |
| SP3 | Sp3 transcription factor | 0.0117362 |
| HAS2 | hyaluronan synthase 2 | 0.0116169 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.193978 |
| MT2A | metallothionein 2A | -0.113144 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0637925 |
| TMSB10 | thymosin beta 10 | -0.0598697 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0582247 |
| RPS8 | ribosomal protein S8 | -0.0559269 |
| PTMA | prothymosin, alpha | -0.0514935 |
| IER3 | immediate early response 3 | -0.0481538 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.045977 |
| RPS6 | ribosomal protein S6 | -0.0409873 |
| FTL | ferritin, light polypeptide | -0.0365281 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0357723 |
| CADM1 | cell adhesion molecule 1 | -0.0349734 |
| CDH13 | cadherin 13 | -0.0344309 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0327012 |
| RPL35A | ribosomal protein L35a | -0.0326906 |
| ACTG1 | actin gamma 1 | -0.032308 |
| RPS19 | ribosomal protein S19 | -0.0318515 |
| RPS3 | ribosomal protein S3 | -0.0307954 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0300895 |
| RPLP2 | ribosomal protein, large, P2 | -0.0294443 |
| RPL12 | ribosomal protein L12 | -0.0290497 |
| RPL19 | ribosomal protein L19 | -0.028882 |
| RPL11 | ribosomal protein L11 | -0.0284101 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.028307 |
| RPL36 | ribosomal protein L36 | -0.0280728 |
| RPL23 | ribosomal protein L23 | -0.0279481 |
| RPL34 | ribosomal protein L34 | -0.0263522 |
| RPLP1 | ribosomal protein, large, P1 | -0.0259915 |
| RPL28 | ribosomal protein L28 | -0.0255507 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0254826 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0253326 |
| S100A9 | S100 calcium binding protein A9 | -0.0252612 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0252292 |
| RPL8 | ribosomal protein L8 | -0.0251012 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.025081 |
| COL5A1 | collagen, type V, alpha 1 | -0.0250105 |
| RPL32 | ribosomal protein L32 | -0.0249738 |
| RPL7 | ribosomal protein L7 | -0.0248155 |
| RPL26 | ribosomal protein L26 | -0.0245404 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0240049 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0220311 |
| RPL37A | ribosomal protein L37a | -0.0218195 |
| RPL31 | ribosomal protein L31 | -0.0214864 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0214091 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0213037 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0209991 |
| TMSB4X | thymosin beta 4, X-linked | -0.0205336 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0199299 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0198216 |
| RPS13 | ribosomal protein S13 | -0.0196023 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0192827 |
| RPL5 | ribosomal protein L5 | -0.0191863 |
| SQSTM1 | sequestosome 1 | -0.0189728 |
| RIGI | RNA sensor RIG-I | -0.0188956 |
| RPS12 | ribosomal protein S12 | -0.0187901 |
| RPS23 | ribosomal protein S23 | -0.0187191 |
| RPL18 | ribosomal protein L18 | -0.0184875 |
| RPS27A | ribosomal protein S27a | -0.0183029 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0182941 |
| RPL9 | ribosomal protein L9 | -0.0181048 |
| TSC22D2 | TSC22 domain family, member 2 | -0.018073 |
| RPS15 | ribosomal protein S15 | -0.0177451 |
| QKI | QKI, KH domain containing, RNA binding | -0.0176083 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0175753 |
| RPL13A | ribosomal protein L13a | -0.0175393 |
| RPS21 | ribosomal protein S21 | -0.0174762 |
| SRGN | serglycin | -0.0174525 |
| RPS5 | ribosomal protein S5 | -0.0173384 |
| RPS16 | ribosomal protein S16 | -0.0172667 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0171655 |
| PPP3CC | protein phosphatase 3, catalytic subunit, gamma isozyme | -0.0169316 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0166787 |
| RPS20 | ribosomal protein S20 | -0.0166113 |
| RPS11 | ribosomal protein S11 | -0.0162944 |
| RACK1 | receptor for activated C kinase 1 | -0.0162729 |
| USP3 | ubiquitin specific peptidase 3 | -0.0162474 |
| FOXP1 | forkhead box P1 | -0.0162193 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0158048 |
| RPS10 | ribosomal protein S10 | -0.0157433 |
| RPL35 | ribosomal protein L35 | -0.0156169 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0155666 |
| RLF | rearranged L-myc fusion | -0.0152862 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0152708 |
| RPS17 | ribosomal protein S17 | -0.0151951 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0151943 |
| ZNF292 | zinc finger protein 292 | -0.0151895 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0151773 |
| ADM | adrenomedullin | -0.0151505 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.014998 |
| RPS14 | ribosomal protein S14 | -0.0148523 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0148483 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0147467 |
| INTS6 | integrator complex subunit 6 | -0.0146795 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0144884 |
| RPL30 | ribosomal protein L30 | -0.0144067 |
| RND3 | Rho family GTPase 3 | -0.0139158 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0138422 |
| RPS25 | ribosomal protein S25 | -0.0137578 |
| MT1X | metallothionein 1X | -0.0136629 |
