Filgotinib_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Filgotinib perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Filgotinib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.121155
ERRFI1 ERBB receptor feedback inhibitor 1 0.11693
PTPRM protein tyrosine phosphatase, receptor type, M 0.114391
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.113107
RERE arginine-glutamic acid dipeptide (RE) repeats 0.103868
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0936924
FN1 fibronectin 1 0.0861782
SORBS1 sorbin and SH3 domain containing 1 0.0799973
EEF2 eukaryotic translation elongation factor 2 0.0779623
AKAP12 A kinase (PRKA) anchor protein 12 0.0732237
PLIN2 perilipin 2 0.0724169
APOB apolipoprotein B 0.0712583
FMNL2 formin-like 2 0.0692248
EPS8 epidermal growth factor receptor pathway substrate 8 0.0646098
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.064367
AHSG alpha-2-HS-glycoprotein 0.0638235
FBF1 Fas (TNFRSF6) binding factor 1 0.0633305
PDLIM5 PDZ and LIM domain 5 0.061762
FAT1 FAT atypical cadherin 1 0.0617558
EML4 echinoderm microtubule associated protein like 4 0.0614997
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0611136
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0609575
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.05958
LCOR ligand dependent nuclear receptor corepressor 0.0585604
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0577216
MACF1 microtubule-actin crosslinking factor 1 0.0569925
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 0.0567887
DSPP dentin sialophosphoprotein 0.0550843
SAMD4A sterile alpha motif domain containing 4A 0.0541123
VEGFA vascular endothelial growth factor A 0.0526484
MCL1 myeloid cell leukemia 1 0.0525374
TF transferrin 0.0514529
VCL vinculin 0.0505121
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0493955
RPS6 ribosomal protein S6 0.0486617
ADGRG6 adhesion G protein-coupled receptor G6 0.0476973
RPL5 ribosomal protein L5 0.0465315
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0462743
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0451098
C3 complement component 3 0.0441413
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0440195
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0439476
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.043405
APOA2 apolipoprotein A-II 0.043356
A2M alpha-2-macroglobulin 0.0426804
VMP1 vacuole membrane protein 1 0.0418907
ITGAV integrin, alpha V 0.0413753
LDHA lactate dehydrogenase A 0.0413384
DTNA dystrobrevin, alpha 0.0412789
BCL2L1 BCL2-like 1 0.0407066
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.039543
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0392125
MAML2 mastermind-like 2 (Drosophila) 0.0384813
PEG10 paternally expressed 10 0.0376808
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0374036
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0371751
RBM25 RNA binding motif protein 25 0.0369465
FLNB filamin B, beta 0.0364095
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0364039
DLC1 DLC1 Rho GTPase activating protein 0.0363721
APLP2 amyloid beta (A4) precursor-like protein 2 0.0363466
ARHGAP26 Rho GTPase activating protein 26 0.036305
CNKSR3 CNKSR family member 3 0.036214
KIF1B kinesin family member 1B 0.0360798
AFDN afadin, adherens junction formation factor 0.0357627
PCBP2 poly(rC) binding protein 2 0.035539
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0353954
SRRM2 serine/arginine repetitive matrix 2 0.0346935
KRT8 keratin 8, type II 0.0345197
RPS8 ribosomal protein S8 0.03444
RPL37A ribosomal protein L37a 0.0339697
ITGB5 integrin, beta 5 0.0335005
INTS6 integrator complex subunit 6 0.0332686
CPE carboxypeptidase E 0.0332574
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0331976
FOXO1 forkhead box O1 0.0331625
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0328823
RPS13 ribosomal protein S13 0.0325034
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0323163
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0322647
ZHX2 zinc fingers and homeoboxes 2 0.0321148
WDFY2 WD repeat and FYVE domain containing 2 0.0319449
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0316286
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0315717
EIF4B eukaryotic translation initiation factor 4B 0.0315577
FOXN3 forkhead box N3 0.0312624
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0312497
UTRN utrophin 0.0310445
LMO7 LIM domain 7 0.0307858
RPL3 ribosomal protein L3 0.0297087
GPC3 glypican 3 0.0296889
PTBP3 polypyrimidine tract binding protein 3 0.0296669
MBNL1 muscleblind-like splicing regulator 1 0.0295461
MED13L mediator complex subunit 13-like 0.0288032
MBNL2 muscleblind-like splicing regulator 2 0.0286514
TRIM26 tripartite motif containing 26 0.0284991
GDI2 GDP dissociation inhibitor 2 0.0283407
BRD2 bromodomain containing 2 0.0282592
CDK6 cyclin-dependent kinase 6 0.0282056
SERTAD2 SERTA domain containing 2 0.0280482

decreased expression

Symbol Name Standardized Value
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.147329
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.131643
GPC6 glypican 6 -0.11783
LRMDA leucine rich melanocyte differentiation associated -0.117071
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0984118
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0927196
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0773463
RNF213 ring finger protein 213 -0.075217
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0746031
NPAS2 neuronal PAS domain protein 2 -0.0720602
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0703427
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0659015
GK glycerol kinase -0.0595209
OSMR oncostatin M receptor -0.0562777
ELL2 elongation factor, RNA polymerase II, 2 -0.054315
CP ceruloplasmin (ferroxidase) -0.0538781
CFB complement factor B -0.0530548
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0485458
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0465247
EHBP1 EH domain binding protein 1 -0.044409
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0420804
PTPRF protein tyrosine phosphatase, receptor type, F -0.0416869
ZMYND8 zinc finger, MYND-type containing 8 -0.0413721
SOX5 SRY (sex determining region Y)-box 5 -0.0410136
KRT23 keratin 23, type I -0.040517
IGFBP1 insulin-like growth factor binding protein 1 -0.0403129
KDM3A lysine (K)-specific demethylase 3A -0.039943
MT2A metallothionein 2A -0.0396319
FAM135A family with sequence similarity 135, member A -0.0394897
EGR1 early growth response 1 -0.0384753
CCL20 chemokine (C-C motif) ligand 20 -0.0366675
EPAS1 endothelial PAS domain protein 1 -0.0364658
RIGI RNA sensor RIG-I -0.0363071
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.034381
KYNU kynureninase -0.0332687
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0329083
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0324332
DNAH17 dynein, axonemal, heavy chain 17 -0.031781
RNASET2 ribonuclease T2 -0.0308804
EXT1 exostosin glycosyltransferase 1 -0.0303311
LAMA4 laminin, alpha 4 -0.0292971
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.028753
LCN2 lipocalin 2 -0.0284767
DNAH5 dynein, axonemal, heavy chain 5 -0.0282675
APOC1 apolipoprotein C-I -0.0281685
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0277507
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0274581
NCOA7 nuclear receptor coactivator 7 -0.0264661
IFITM1 interferon induced transmembrane protein 1 -0.0263802
TPT1 tumor protein, translationally-controlled 1 -0.0260751
KLF6 Kruppel-like factor 6 -0.0258709
ITGA1 integrin, alpha 1 -0.0256993
PLAC8 placenta-specific 8 -0.0254019
PLSCR1 phospholipid scramblase 1 -0.0251705
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0251259
MX2 MX dynamin-like GTPase 2 -0.0246906
SYN3 synapsin III -0.0246883
MALRD1 MAM and LDL receptor class A domain containing 1 -0.0246824
FERMT1 fermitin family member 1 -0.0241363
ATP11A ATPase, class VI, type 11A -0.0236079
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0235997
SCAF11 SR-related CTD-associated factor 11 -0.023292
SRPK1 SRSF protein kinase 1 -0.0230726
ENKUR enkurin, TRPC channel interacting protein -0.02291
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0227534
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0224661
DUSP16 dual specificity phosphatase 16 -0.0220807
IFI6 interferon, alpha-inducible protein 6 -0.021693
HLA-E major histocompatibility complex, class I, E -0.0215922
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0214715
IL1RAP interleukin 1 receptor accessory protein -0.0212187
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0210354
GLIPR1 GLI pathogenesis-related 1 -0.0206841
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0205378
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.0202432
SH3GLB1 SH3-domain GRB2-like endophilin B1 -0.0200817
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0200255
ARHGAP21 Rho GTPase activating protein 21 -0.0199186
B2M beta-2-microglobulin -0.0197033
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0196947
BABAM2 BRISC and BRCA1 A complex member 2 -0.0196647
PHF21A PHD finger protein 21A -0.0194915
IFIH1 interferon induced with helicase C domain 1 -0.0192107
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0189163
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0188889
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0188046
TGFBI transforming growth factor, beta-induced, 68kDa -0.0187268
ATXN1 ataxin 1 -0.0186863
IFITM3 interferon induced transmembrane protein 3 -0.0185478
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0183022
ENAH enabled homolog (Drosophila) -0.0181041
CCDC146 coiled-coil domain containing 146 -0.0178972
FHIT fragile histidine triad -0.0178883
PALLD palladin, cytoskeletal associated protein -0.017721
H1-0 H1.0 linker histone -0.0176604
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 -0.0174473
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0174349
APOL1 apolipoprotein L, 1 -0.0172949
RAI14 retinoic acid induced 14 -0.0172462
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0172189