Filgotinib_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Filgotinib perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Filgotinib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.147754
CEMIP cell migration inducing protein, hyaluronan binding 0.142494
GPHN gephyrin 0.115723
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.103908
FAT1 FAT atypical cadherin 1 0.0899836
VCL vinculin 0.0864649
SPTBN1 spectrin, beta, non-erythrocytic 1 0.085611
GMDS GDP-mannose 4,6-dehydratase 0.0825432
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0804936
NALF1 NALCN channel auxiliary factor 1 0.0703774
ITGA6 integrin, alpha 6 0.0701171
TRIM2 tripartite motif containing 2 0.0650024
RNF43 ring finger protein 43 0.0597055
DSCAM Down syndrome cell adhesion molecule 0.0552441
TNS4 tensin 4 0.0485259
CADPS Ca++-dependent secretion activator 0.0478832
PDLIM5 PDZ and LIM domain 5 0.0474752
ANKRD17 ankyrin repeat domain 17 0.0463064
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0456521
PKP2 plakophilin 2 0.0450436
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0434147
MYO1E myosin IE 0.0432098
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0424185
MYH9 myosin, heavy chain 9, non-muscle 0.0415025
EREG epiregulin 0.041439
RAB10 RAB10, member RAS oncogene family 0.0408258
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0403895
ARHGAP32 Rho GTPase activating protein 32 0.0403574
MED13L mediator complex subunit 13-like 0.0402804
PUM2 pumilio RNA-binding family member 2 0.0402109
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0400854
VMP1 vacuole membrane protein 1 0.0399964
CD46 CD46 molecule, complement regulatory protein 0.0399711
CTBP2 C-terminal binding protein 2 0.0394521
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0391401
ZFAND3 zinc finger, AN1-type domain 3 0.0369129
DSPP dentin sialophosphoprotein 0.0365961
MACF1 microtubule-actin crosslinking factor 1 0.0365244
ETNK1 ethanolamine kinase 1 0.0349605
GSK3B glycogen synthase kinase 3 beta 0.0346293
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0343875
ANKRD11 ankyrin repeat domain 11 0.033738
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0333106
EPS8 epidermal growth factor receptor pathway substrate 8 0.0333052
ANXA2 annexin A2 0.033137
SHROOM3 shroom family member 3 0.0323646
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0322626
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0322487
MBD5 methyl-CpG binding domain protein 5 0.0319778
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0314696
OGA O-GlcNAcase 0.0313928
NFIA nuclear factor I/A 0.0307585
RBM39 RNA binding motif protein 39 0.0306456
PTBP3 polypyrimidine tract binding protein 3 0.0306269
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0304592
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0303103
SMYD3 SET and MYND domain containing 3 0.0302962
NRXN3 neurexin 3 0.0299928
ARHGAP26 Rho GTPase activating protein 26 0.0297081
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0293499
COG5 component of oligomeric golgi complex 5 0.0290048
NCOR1 nuclear receptor corepressor 1 0.0288524
SETD5 SET domain containing 5 0.0286565
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0284022
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0283343
MSI2 musashi RNA-binding protein 2 0.0282439
FOXO1 forkhead box O1 0.0281939
NF1 neurofibromin 1 0.0281775
UBE2H ubiquitin-conjugating enzyme E2H 0.0279613
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0276926
TBC1D5 TBC1 domain family, member 5 0.0274398
WDR43 WD repeat domain 43 0.0273944
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0270327
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0268972
ARL15 ADP-ribosylation factor-like 15 0.0267183
LMO7 LIM domain 7 0.0266603
NCEH1 neutral cholesterol ester hydrolase 1 0.0266208
PIGR polymeric immunoglobulin receptor 0.0265562
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0264142
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0264006
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0263135
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0262756
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.026272
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0261382
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0261227
BIRC6 baculoviral IAP repeat containing 6 0.0260444
GOLGA4 golgin A4 0.0260054
CDK6 cyclin-dependent kinase 6 0.0259723
ABHD2 abhydrolase domain containing 2 0.0259659
MECOM MDS1 and EVI1 complex locus 0.025814
PRSS3 protease, serine, 3 0.0256884
CTNND1 catenin (cadherin-associated protein), delta 1 0.0256688
CD44 CD44 molecule (Indian blood group) 0.0254163
CEMIP2 cell migration inducing hyaluronidase 2 0.0253719
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0253343
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0253025
SFPQ splicing factor proline/glutamine-rich 0.0251891
POF1B premature ovarian failure, 1B 0.0251467
RNF145 ring finger protein 145 0.0249398
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0249317

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.148138
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.122752
TPT1 tumor protein, translationally-controlled 1 -0.0998019
MUC6 mucin 6, oligomeric mucus/gel-forming -0.097013
PTMA prothymosin, alpha -0.0884313
RPS6 ribosomal protein S6 -0.0788917
FTL ferritin, light polypeptide -0.0726804
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0708649
NDRG1 N-myc downstream regulated 1 -0.0707843
MT2A metallothionein 2A -0.06519
RPL35A ribosomal protein L35a -0.0630837
RPS19 ribosomal protein S19 -0.0620526
RPS8 ribosomal protein S8 -0.0538315
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0529642
RPLP1 ribosomal protein, large, P1 -0.0478825
S100A6 S100 calcium binding protein A6 -0.0474968
RPL9 ribosomal protein L9 -0.0416892
RPL36 ribosomal protein L36 -0.0407129
RPL37A ribosomal protein L37a -0.0399437
ACTG1 actin gamma 1 -0.0349217
RPLP2 ribosomal protein, large, P2 -0.0346719
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0339739
RPL31 ribosomal protein L31 -0.0328739
RPS12 ribosomal protein S12 -0.0312987
S100A9 S100 calcium binding protein A9 -0.0308671
B2M beta-2-microglobulin -0.0303283
LMNA lamin A/C -0.0302778
POTEF POTE ankyrin domain family, member F -0.0294283
TFF1 trefoil factor 1 -0.0287329
RPL34 ribosomal protein L34 -0.0286063
MT1X metallothionein 1X -0.0277006
RPL23 ribosomal protein L23 -0.027622
RPS23 ribosomal protein S23 -0.0275304
RPL12 ribosomal protein L12 -0.0268696
HMGA1 high mobility group AT-hook 1 -0.0267744
RPS29 ribosomal protein S29 -0.0266373
RPS27 ribosomal protein S27 -0.0263574
S100A10 S100 calcium binding protein A10 -0.025648
MUC17 mucin 17, cell surface associated -0.0255119
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0247099
RPS27A ribosomal protein S27a -0.0244972
SOX4 SRY (sex determining region Y)-box 4 -0.0244026
TPM4 tropomyosin 4 -0.0238265
RPS21 ribosomal protein S21 -0.0234845
ESYT2 extended synaptotagmin-like protein 2 -0.0233867
RPS14 ribosomal protein S14 -0.0233245
RPS13 ribosomal protein S13 -0.0231291
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0223626
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0222786
ENO2 enolase 2 (gamma, neuronal) -0.0215241
RPS11 ribosomal protein S11 -0.0215081
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0214175
RPS25 ribosomal protein S25 -0.0213658
RPL37 ribosomal protein L37 -0.0212711
EIF1 eukaryotic translation initiation factor 1 -0.0211953
RPL28 ribosomal protein L28 -0.0211207
KRT19 keratin 19, type I -0.0210862
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0209472
RPLP0 ribosomal protein, large, P0 -0.0208497
RPL7A ribosomal protein L7a -0.0208378
RPL8 ribosomal protein L8 -0.02056
CSTB cystatin B (stefin B) -0.0202171
RPL30 ribosomal protein L30 -0.0199766
ISG15 ISG15 ubiquitin-like modifier -0.0196777
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0196572
FOSL1 FOS-like antigen 1 -0.0194007
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0192933
HILPDA hypoxia inducible lipid droplet-associated -0.0192813
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0192636
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0191341
S100P S100 calcium binding protein P -0.0189682
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0189163
RPL32 ribosomal protein L32 -0.0186261
IFI27 interferon, alpha-inducible protein 27 -0.018622
ANXA1 annexin A1 -0.0185397
RPL26 ribosomal protein L26 -0.0185178
LOC112694756 uncharaterized LOC112694756 -0.0184406
PRDX2 peroxiredoxin 2 -0.0181968
RPL27A ribosomal protein L27a -0.0181956
MT1E metallothionein 1E -0.0175876
RPL36A ribosomal protein L36a -0.0175615
HMGB1 high mobility group box 1 -0.0175189
KTN1 kinectin 1 (kinesin receptor) -0.0174623
RPS16 ribosomal protein S16 -0.0173423
VEGFA vascular endothelial growth factor A -0.0173092
RPS17 ribosomal protein S17 -0.0171278
RPL19 ribosomal protein L19 -0.0170924
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0168679
AGR2 anterior gradient 2 -0.0168375
RPL35 ribosomal protein L35 -0.0168295
RPL38 ribosomal protein L38 -0.0167666
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0165888
RPS3 ribosomal protein S3 -0.0163062
KLK10 kallikrein-related peptidase 10 -0.0160258
TFF3 trefoil factor 3 (intestinal) -0.0159942
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0157917
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.0157334
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0156791
ATF4 activating transcription factor 4 -0.0156041
EZR ezrin -0.0155318