Filgotinib_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Filgotinib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Filgotinib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.141037
PSD3 pleckstrin and Sec7 domain containing 3 0.131611
DST dystonin 0.130495
CD44 CD44 molecule (Indian blood group) 0.128973
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0988225
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0933401
TP63 tumor protein p63 0.0862546
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0797607
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0790751
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0770582
DLG1 discs, large homolog 1 (Drosophila) 0.0770143
EHBP1 EH domain binding protein 1 0.076193
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0719248
RUNX1 runt-related transcription factor 1 0.0717614
RAD51B RAD51 paralog B 0.0700969
TSC22D1 TSC22 domain family, member 1 0.0696167
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0692343
DPYD dihydropyrimidine dehydrogenase 0.0688854
VCL vinculin 0.0652556
LDHA lactate dehydrogenase A 0.0626886
BCAR3 breast cancer anti-estrogen resistance 3 0.0613365
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0585834
EXOC4 exocyst complex component 4 0.0584482
ADGRG6 adhesion G protein-coupled receptor G6 0.0576064
RIGI RNA sensor RIG-I 0.0559166
AHNAK AHNAK nucleoprotein 0.0555238
ZDHHC14 zinc finger, DHHC-type containing 14 0.054212
CADM2 cell adhesion molecule 2 0.0537642
SMYD3 SET and MYND domain containing 3 0.0521502
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0505856
PLK2 polo-like kinase 2 0.0501627
LPP LIM domain containing preferred translocation partner in lipoma 0.0488033
ENO1 enolase 1, (alpha) 0.0484301
APP amyloid beta (A4) precursor protein 0.0481313
RNF213 ring finger protein 213 0.0478803
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0460931
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0455025
SP100 SP100 nuclear antigen 0.0443408
EPHA4 EPH receptor A4 0.0437429
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0433463
AHNAK2 AHNAK nucleoprotein 2 0.0431483
TNS3 tensin 3 0.0406275
DOCK11 dedicator of cytokinesis 11 0.0405653
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0402792
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0399676
IFI6 interferon, alpha-inducible protein 6 0.0399613
MACF1 microtubule-actin crosslinking factor 1 0.0397012
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0396775
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0388532
NPAS2 neuronal PAS domain protein 2 0.0386928
PODXL podocalyxin-like 0.0384935
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0379057
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0376995
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0372308
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.0365125
PTK2 protein tyrosine kinase 2 0.0355697
WARS1 tryptophanyl-tRNA synthetase 1 0.0353391
FNIP1 folliculin interacting protein 1 0.0352349
TTC28 tetratricopeptide repeat domain 28 0.0351995
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0350455
FMNL2 formin-like 2 0.0346638
TXNIP thioredoxin interacting protein 0.0346336
EFNA5 ephrin-A5 0.0345586
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0338696
CDK6 cyclin-dependent kinase 6 0.033747
TBC1D5 TBC1 domain family, member 5 0.0332833
PRELID2 PRELI domain containing 2 0.0331319
MBD5 methyl-CpG binding domain protein 5 0.0331317
HDAC9 histone deacetylase 9 0.0326703
RAB27B RAB27B, member RAS oncogene family 0.0323886
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0322096
TRIP12 thyroid hormone receptor interactor 12 0.0318992
MBNL2 muscleblind-like splicing regulator 2 0.0315742
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0315685
GCLM glutamate-cysteine ligase, modifier subunit 0.0311102
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0306548
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0301665
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0300789
NCEH1 neutral cholesterol ester hydrolase 1 0.0300789
DNER delta/notch-like EGF repeat containing 0.0300732
ITGB4 integrin, beta 4 0.0299128
BABAM2 BRISC and BRCA1 A complex member 2 0.0298837
BCAS3 breast carcinoma amplified sequence 3 0.0293312
AKAP9 A kinase (PRKA) anchor protein 9 0.0292785
ADAM10 ADAM metallopeptidase domain 10 0.0292205
CANX calnexin 0.0291671
PGK1 phosphoglycerate kinase 1 0.0287246
RGS4 regulator of G-protein signaling 4 0.0285597
ARHGAP5 Rho GTPase activating protein 5 0.0285297
SDCCAG8 serologically defined colon cancer antigen 8 0.0284327
H1-0 H1.0 linker histone 0.0284078
ANKRD12 ankyrin repeat domain 12 0.0282921
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.027898
ADAR adenosine deaminase, RNA-specific 0.0278212
ENO2 enolase 2 (gamma, neuronal) 0.0277832
PLSCR1 phospholipid scramblase 1 0.0277638
CFAP299 cilia and flagella associated protein 299 0.0275988
ERRFI1 ERBB receptor feedback inhibitor 1 0.0274826
EPB41 erythrocyte membrane protein band 4.1 0.0268347
IFITM1 interferon induced transmembrane protein 1 0.0262885

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.13815
MT2A metallothionein 2A -0.129001
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.102185
PTMA prothymosin, alpha -0.0889404
TXNRD1 thioredoxin reductase 1 -0.0832208
TMSB10 thymosin beta 10 -0.0808306
RPS8 ribosomal protein S8 -0.0706092
TPT1 tumor protein, translationally-controlled 1 -0.0685182
RPS6 ribosomal protein S6 -0.0624299
KMT2E lysine (K)-specific methyltransferase 2E -0.0613444
RPL37A ribosomal protein L37a -0.0542946
RPL26 ribosomal protein L26 -0.054065
SPAG9 sperm associated antigen 9 -0.052504
RPS2 ribosomal protein S2 -0.0501351
RPL35A ribosomal protein L35a -0.0485537
RPS19 ribosomal protein S19 -0.0465884
FTL ferritin, light polypeptide -0.0462512
NUP58 nucleoporin 58 -0.0454007
RPL23 ribosomal protein L23 -0.0444548
TM4SF1 transmembrane 4 L six family member 1 -0.0434326
GARS1 glycyl-tRNA synthetase 1 -0.0433105
EIF1 eukaryotic translation initiation factor 1 -0.0414071
RPS12 ribosomal protein S12 -0.0407992
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0406542
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0403844
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.040116
NAMPT nicotinamide phosphoribosyltransferase -0.0400587
RPS3 ribosomal protein S3 -0.0398875
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0395838
RPL5 ribosomal protein L5 -0.0384713
WSB1 WD repeat and SOCS box containing 1 -0.0375299
RPL36 ribosomal protein L36 -0.0373565
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0372764
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0371927
TMEM41B transmembrane protein 41B -0.0365391
RPS23 ribosomal protein S23 -0.0359229
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0342639
RPL38 ribosomal protein L38 -0.034015
RBM39 RNA binding motif protein 39 -0.033834
RPLP2 ribosomal protein, large, P2 -0.0332897
MT1X metallothionein 1X -0.032746
RPLP1 ribosomal protein, large, P1 -0.0318072
KDM3A lysine (K)-specific demethylase 3A -0.0309378
RPS27A ribosomal protein S27a -0.0305616
MATR3 matrin 3 -0.0297906
RPL31 ribosomal protein L31 -0.0293234
RPS29 ribosomal protein S29 -0.0291124
ANXA1 annexin A1 -0.0290222
RPL9 ribosomal protein L9 -0.0290002
NAP1L1 nucleosome assembly protein 1-like 1 -0.0289594
RPL19 ribosomal protein L19 -0.0278262
RPS10 ribosomal protein S10 -0.027085
RPL28 ribosomal protein L28 -0.0269062
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0267803
RPL18 ribosomal protein L18 -0.0267316
ZEB1 zinc finger E-box binding homeobox 1 -0.0265217
YBX3 Y box binding protein 3 -0.0264314
TFRC transferrin receptor -0.0263988
RPL37 ribosomal protein L37 -0.0262405
RPL7A ribosomal protein L7a -0.0259094
RPS25 ribosomal protein S25 -0.025696
SRGN serglycin -0.0256654
PRRC2C proline-rich coiled-coil 2C -0.0256582
USP34 ubiquitin specific peptidase 34 -0.0255373
ZFAND3 zinc finger, AN1-type domain 3 -0.0252797
NOP58 NOP58 ribonucleoprotein -0.0252501
RPS21 ribosomal protein S21 -0.0251465
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.024537
RPL11 ribosomal protein L11 -0.0244934
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0242372
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0240358
RPS24 ribosomal protein S24 -0.0239778
RPL12 ribosomal protein L12 -0.0238437
RPS13 ribosomal protein S13 -0.0238016
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0234435
RPL32 ribosomal protein L32 -0.023411
ADAM17 ADAM metallopeptidase domain 17 -0.0233067
EREG epiregulin -0.0232779
PNISR PNN-interacting serine/arginine-rich protein -0.022966
RPL13A ribosomal protein L13a -0.0226294
RPL7 ribosomal protein L7 -0.0225436
RPL34 ribosomal protein L34 -0.0224654
RPS16 ribosomal protein S16 -0.0224564
WDR45B WD repeat domain 45B -0.0222759
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0220632
RPS27 ribosomal protein S27 -0.0218653
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.021796
HMGA1 high mobility group AT-hook 1 -0.0217823
RPL36A ribosomal protein L36a -0.0217571
RPL27 ribosomal protein L27 -0.0212348
RPS5 ribosomal protein S5 -0.0211573
YBX1 Y box binding protein 1 -0.0205243
RTN4 reticulon 4 -0.0205069
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0204691
RPS17 ribosomal protein S17 -0.0202516
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.020028
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.019827
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0195281
OLA1 Obg-like ATPase 1 -0.0194934
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.019434