| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Filgotinib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Filgotinib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.350267 |
| EGFR | epidermal growth factor receptor | 0.211964 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.166039 |
| ASPH | aspartate beta-hydroxylase | 0.156257 |
| LMO7 | LIM domain 7 | 0.126729 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.107433 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.104815 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.101618 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0975987 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0964114 |
| MCL1 | myeloid cell leukemia 1 | 0.0960389 |
| PKM | pyruvate kinase, muscle | 0.088348 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0867952 |
| LDHA | lactate dehydrogenase A | 0.0843642 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0774557 |
| GRAMD1B | GRAM domain containing 1B | 0.072843 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0720963 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.068801 |
| CPE | carboxypeptidase E | 0.0674396 |
| MYOF | myoferlin | 0.0664198 |
| VCL | vinculin | 0.0661415 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0651752 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0644201 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0629311 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0618543 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0614459 |
| SCEL | sciellin | 0.0599197 |
| LAMA4 | laminin, alpha 4 | 0.0573447 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0559179 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0551788 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0551164 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0550893 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0546301 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0546167 |
| INTS6 | integrator complex subunit 6 | 0.0542522 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0530775 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0529008 |
| ANXA2 | annexin A2 | 0.0519449 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0515565 |
| JMJD1C | jumonji domain containing 1C | 0.0506796 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0493298 |
| NABP1 | nucleic acid binding protein 1 | 0.0484604 |
| DSPP | dentin sialophosphoprotein | 0.0481919 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0477666 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.047699 |
| ENO1 | enolase 1, (alpha) | 0.0448917 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0440437 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0432865 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.043228 |
| VMP1 | vacuole membrane protein 1 | 0.0424549 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0423982 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0422181 |
| SMYD3 | SET and MYND domain containing 3 | 0.0419324 |
| EGR1 | early growth response 1 | 0.0409854 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.04088 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.039851 |
| LAMC2 | laminin, gamma 2 | 0.0388543 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0387458 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0380501 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0378903 |
| TJP1 | tight junction protein 1 | 0.0377394 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0376015 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0363416 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0361224 |
| ACTG1 | actin gamma 1 | 0.0360433 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0360074 |
| FOXP1 | forkhead box P1 | 0.0359315 |
| MYO1E | myosin IE | 0.0349812 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0347005 |
| SLTM | SAFB-like, transcription modulator | 0.034495 |
| PLS3 | plastin 3 | 0.0344042 |
| NTN4 | netrin 4 | 0.0336371 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0330024 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0328731 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.03238 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0318278 |
| KRT18 | keratin 18, type I | 0.0317556 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0315928 |
| S100A10 | S100 calcium binding protein A10 | 0.0315817 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0309394 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0309084 |
| CD163L1 | CD163 molecule-like 1 | 0.0307313 |
| MSN | moesin | 0.0306846 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0305785 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0304144 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0299419 |
| PRKCA | protein kinase C, alpha | 0.0298036 |
| AREG | amphiregulin | 0.0296453 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0295649 |
| EFNA5 | ephrin-A5 | 0.0292477 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0291437 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0288554 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.0288227 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0286766 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0286417 |
| TES | testin LIM domain protein | 0.0286085 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.028556 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.028201 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0280624 |
| CTBP2 | C-terminal binding protein 2 | 0.0280539 |
| Symbol | Name | Standardized Value |
|---|---|---|
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0792585 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0752347 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0751834 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0605776 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0538735 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.051884 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0403457 |
| RPS24 | ribosomal protein S24 | -0.0399595 |
| RNF213 | ring finger protein 213 | -0.0380244 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0362831 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0357419 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0348313 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0320189 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0317263 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0284866 |
| MT2A | metallothionein 2A | -0.0279998 |
| H1-0 | H1.0 linker histone | -0.0271645 |
| RPL34 | ribosomal protein L34 | -0.0265581 |
| B2M | beta-2-microglobulin | -0.0264023 |
| HLA-B | major histocompatibility complex, class I, B | -0.0244718 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | -0.0243596 |
| RPL35A | ribosomal protein L35a | -0.0239065 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0230126 |
| GM2A | GM2 ganglioside activator | -0.0227942 |
| TRIM56 | tripartite motif containing 56 | -0.0224619 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0224472 |
| NDE1 | nudE neurodevelopment protein 1 | -0.0224284 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0221878 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0217997 |
| SP100 | SP100 nuclear antigen | -0.0214676 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0213617 |
| LAMB3 | laminin, beta 3 | -0.0212643 |
| ADAR | adenosine deaminase, RNA-specific | -0.0208416 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.020755 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0207438 |
| SEPTIN2 | septin 2 | -0.0199442 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0198257 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0193285 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0189372 |
| SQSTM1 | sequestosome 1 | -0.0188191 |
| WDR45B | WD repeat domain 45B | -0.0187972 |
| SMAD3 | SMAD family member 3 | -0.0186791 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0184285 |
| NGLY1 | N-glycanase 1 | -0.0183782 |
| ABLIM1 | actin binding LIM protein 1 | -0.0175881 |
| MX1 | MX dynamin-like GTPase 1 | -0.0171325 |
| RPS21 | ribosomal protein S21 | -0.0169916 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0169621 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0168296 |
| MAP3K4 | mitogen-activated protein kinase kinase kinase 4 | -0.0166101 |
| ZFR | zinc finger RNA binding protein | -0.0165574 |
| IER3 | immediate early response 3 | -0.0162956 |
| UBE2O | ubiquitin-conjugating enzyme E2O | -0.0161814 |
| RPL37A | ribosomal protein L37a | -0.016086 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.015942 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0159377 |
| RIGI | RNA sensor RIG-I | -0.0156882 |
| IFNAR2 | interferon (alpha, beta and omega) receptor 2 | -0.0155443 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0154989 |
| RNF169 | ring finger protein 169 | -0.0154744 |
| RPS8 | ribosomal protein S8 | -0.0151257 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0150888 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0150391 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0149443 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0148907 |
| ARF1 | ADP-ribosylation factor 1 | -0.0148538 |
| KIAA1217 | KIAA1217 | -0.0147423 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | -0.0147031 |
| PMP22 | peripheral myelin protein 22 | -0.014574 |
| IFNGR2 | interferon gamma receptor 2 (interferon gamma transducer 1) | -0.0143392 |
| TPTEP2-CSNK1E | TPTEP2-CSNK1E readthrough | -0.0143221 |
| ZNF217 | zinc finger protein 217 | -0.0142993 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | -0.0142933 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0142718 |
| TKT | transketolase | -0.0142488 |
| MSMO1 | methylsterol monooxygenase 1 | -0.0141782 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0141058 |
| KLRD1 | killer cell lectin-like receptor subfamily D, member 1 | -0.0139979 |
| ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | -0.013962 |
| OGA | O-GlcNAcase | -0.013938 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0138191 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0138107 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0137788 |
| DENND4A | DENN/MADD domain containing 4A | -0.013735 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0136901 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0134526 |
| RPS27A | ribosomal protein S27a | -0.0133662 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.0133397 |
| PLSCR1 | phospholipid scramblase 1 | -0.0131467 |
| RPL26 | ribosomal protein L26 | -0.0130436 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0129942 |
| IFI44L | interferon-induced protein 44-like | -0.0128871 |
| CNNM2 | cyclin and CBS domain divalent metal cation transport mediator 2 | -0.0127581 |
| TMSB10 | thymosin beta 10 | -0.0127075 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0123493 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0122688 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0122531 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0120867 |
| ATG14 | autophagy related 14 | -0.0120691 |
| PGK1 | phosphoglycerate kinase 1 | -0.0119464 |
