| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Filgotinib perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Filgotinib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CD44 | CD44 molecule (Indian blood group) | 0.0958262 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0728579 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0684796 |
| RAD51B | RAD51 paralog B | 0.0654546 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0620833 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0559449 |
| HMGA2 | high mobility group AT-hook 2 | 0.0531388 |
| VCL | vinculin | 0.0526349 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0492598 |
| PRELID2 | PRELI domain containing 2 | 0.0484444 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0484407 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0479142 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0453262 |
| ASPH | aspartate beta-hydroxylase | 0.0431278 |
| NTN4 | netrin 4 | 0.0405798 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0395582 |
| DST | dystonin | 0.0393808 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0354869 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0348047 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0339402 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0331546 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0322113 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0320293 |
| MCL1 | myeloid cell leukemia 1 | 0.0316009 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | 0.0306686 |
| MAP1B | microtubule-associated protein 1B | 0.0305367 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0301091 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0289154 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0284534 |
| ADD3 | adducin 3 (gamma) | 0.0276925 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0276572 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0270162 |
| GLCCI1 | glucocorticoid induced 1 | 0.026617 |
| KSR1 | kinase suppressor of ras 1 | 0.0261575 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0256296 |
| VMP1 | vacuole membrane protein 1 | 0.0253722 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0248148 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0246111 |
| FN1 | fibronectin 1 | 0.0245911 |
| FAM107B | family with sequence similarity 107, member B | 0.0244487 |
| SVIL | supervillin | 0.0244288 |
| JMJD1C | jumonji domain containing 1C | 0.0241721 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0233176 |
| GPC6 | glypican 6 | 0.0232735 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0232581 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0220935 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0215065 |
| MYO10 | myosin X | 0.0214543 |
| ACTN4 | actinin, alpha 4 | 0.0211749 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0211504 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0209767 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0207092 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0206988 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0203645 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.0200941 |
| TBC1D5 | TBC1 domain family, member 5 | 0.019988 |
| WLS | wntless Wnt ligand secretion mediator | 0.0199722 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0195689 |
| PHF3 | PHD finger protein 3 | 0.0195345 |
| HEG1 | heart development protein with EGF-like domains 1 | 0.0191937 |
| SYNJ2 | synaptojanin 2 | 0.0191568 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.019128 |
| METTL15 | methyltransferase like 15 | 0.0188474 |
| ATXN1 | ataxin 1 | 0.0186425 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0186231 |
| EGFR | epidermal growth factor receptor | 0.0185939 |
| ZNF804A | zinc finger protein 804A | 0.0184371 |
| CAB39 | calcium binding protein 39 | 0.018239 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.01797 |
| EPHA4 | EPH receptor A4 | 0.0179404 |
| STK38L | serine/threonine kinase 38 like | 0.0178782 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0177193 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0176884 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0174889 |
| MYOF | myoferlin | 0.0173409 |
| GALNT1 | polypeptide N-acetylgalactosaminyltransferase 1 | 0.0172445 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0172438 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0171926 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0171623 |
| UTRN | utrophin | 0.0167531 |
| AHNAK | AHNAK nucleoprotein | 0.016379 |
| GRAMD1B | GRAM domain containing 1B | 0.0162182 |
| MSN | moesin | 0.0157958 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0157879 |
| GLIPR1 | GLI pathogenesis-related 1 | 0.015755 |
| SMYD3 | SET and MYND domain containing 3 | 0.0157249 |
| HDAC9 | histone deacetylase 9 | 0.0154318 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0153859 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0153176 |
| ATXN10 | ataxin 10 | 0.0149043 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0148099 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.014753 |
| MEIS1 | Meis homeobox 1 | 0.0146778 |
| FRMD5 | FERM domain containing 5 | 0.0146398 |
| IL6ST | interleukin 6 signal transducer | 0.0146142 |
| CAPRIN2 | caprin family member 2 | 0.0141783 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0140961 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0140296 |
| THBS1 | thrombospondin 1 | 0.0139748 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0139413 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.140841 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.139835 |
| VIM | vimentin | -0.120871 |
| FTL | ferritin, light polypeptide | -0.080571 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0690648 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0658749 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0581775 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.055782 |
| RPLP1 | ribosomal protein, large, P1 | -0.055671 |
| RPS19 | ribosomal protein S19 | -0.0540608 |
| PTMA | prothymosin, alpha | -0.0536544 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0532268 |
| MT2A | metallothionein 2A | -0.0518745 |
| B2M | beta-2-microglobulin | -0.0517103 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0505922 |
| LOX | lysyl oxidase | -0.0489508 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0478023 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.046026 |
| MTSS1 | metastasis suppressor 1 | -0.0456042 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0446546 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0435478 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0424732 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0418142 |
| RPL36 | ribosomal protein L36 | -0.0389881 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0388065 |
| RPL35A | ribosomal protein L35a | -0.0373991 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0372428 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0369312 |
| RPS21 | ribosomal protein S21 | -0.0366942 |
| PTK2 | protein tyrosine kinase 2 | -0.0362924 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0362457 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0356952 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0354322 |
| RPL31 | ribosomal protein L31 | -0.0354092 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0352254 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0349259 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0347134 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0344795 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0342471 |
| STC1 | stanniocalcin 1 | -0.0341444 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0337784 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0335996 |
| RPLP2 | ribosomal protein, large, P2 | -0.0330368 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0326372 |
| S100A6 | S100 calcium binding protein A6 | -0.0319995 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0313207 |
| IFI44L | interferon-induced protein 44-like | -0.0303046 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0302347 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0297073 |
| USP34 | ubiquitin specific peptidase 34 | -0.0296443 |
| RPS29 | ribosomal protein S29 | -0.0295589 |
| RPL23 | ribosomal protein L23 | -0.0295092 |
| NUMB | numb homolog (Drosophila) | -0.0294987 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0293001 |
| SP100 | SP100 nuclear antigen | -0.0292472 |
| RPL34 | ribosomal protein L34 | -0.0291707 |
| RIOK3 | RIO kinase 3 | -0.0291035 |
| RPS6 | ribosomal protein S6 | -0.0289273 |
| CLMP | CXADR-like membrane protein | -0.0288248 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0288043 |
| RPL28 | ribosomal protein L28 | -0.0287871 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0282333 |
| RPS8 | ribosomal protein S8 | -0.0280029 |
| RPL37A | ribosomal protein L37a | -0.0279234 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0274112 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0271937 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0260182 |
| RPS27 | ribosomal protein S27 | -0.0259745 |
| RPL32 | ribosomal protein L32 | -0.0258909 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0256636 |
| HLA-B | major histocompatibility complex, class I, B | -0.0253558 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0253314 |
| RPS13 | ribosomal protein S13 | -0.0252729 |
| RPS12 | ribosomal protein S12 | -0.0248072 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0247868 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0247818 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0247691 |
| S100A10 | S100 calcium binding protein A10 | -0.0245584 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0243843 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0243805 |
| VRK2 | vaccinia related kinase 2 | -0.0242955 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0242116 |
| RPL12 | ribosomal protein L12 | -0.0241256 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0239074 |
| FAM20C | family with sequence similarity 20, member C | -0.0236905 |
| RPL11 | ribosomal protein L11 | -0.0234783 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0233772 |
| USP3 | ubiquitin specific peptidase 3 | -0.0233291 |
| MX2 | MX dynamin-like GTPase 2 | -0.0232304 |
| CTNNBL1 | catenin, beta like 1 | -0.0231224 |
| DNER | delta/notch-like EGF repeat containing | -0.0230796 |
| WDR45B | WD repeat domain 45B | -0.0230443 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0227408 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0227301 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | -0.022659 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0225914 |
| BMERB1 | bMERB domain containing 1 | -0.0223168 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0222988 |
| PARD3 | par-3 family cell polarity regulator | -0.0222483 |
| S100A9 | S100 calcium binding protein A9 | -0.0222066 |
