Filgotinib_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Filgotinib perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Filgotinib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.189598
THSD4 thrombospondin, type I, domain containing 4 0.138953
PDE4D phosphodiesterase 4D, cAMP-specific 0.135808
DOCK4 dedicator of cytokinesis 4 0.0968297
CMIP c-Maf inducing protein 0.0967087
UBASH3B ubiquitin associated and SH3 domain containing B 0.0827116
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0787316
FMNL2 formin-like 2 0.074091
PM20D1 peptidase M20 domain containing 1 0.0718466
SAMD4A sterile alpha motif domain containing 4A 0.0683123
TRIO trio Rho guanine nucleotide exchange factor 0.0638412
SMOC1 SPARC related modular calcium binding 1 0.0636523
MAML3 mastermind-like 3 (Drosophila) 0.0611035
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0605135
FNDC3B fibronectin type III domain containing 3B 0.0584262
MCL1 myeloid cell leukemia 1 0.0577707
IGFBP3 insulin-like growth factor binding protein 3 0.055193
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0547152
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0546559
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0542604
SVIL supervillin 0.0522214
ERBIN erbb2 interacting protein 0.0505617
UTRN utrophin 0.0491055
PTPRM protein tyrosine phosphatase, receptor type, M 0.0489704
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0486055
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0475207
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.047125
LPP LIM domain containing preferred translocation partner in lipoma 0.0467957
BASP1 brain abundant, membrane attached signal protein 1 0.0463996
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0457576
RAD51B RAD51 paralog B 0.0456225
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0450357
COPA coatomer protein complex, subunit alpha 0.0443583
KYNU kynureninase 0.0442728
DOCK5 dedicator of cytokinesis 5 0.0429085
BICC1 BicC family RNA binding protein 1 0.0426539
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0424291
EXT1 exostosin glycosyltransferase 1 0.0424215
FLNB filamin B, beta 0.0421426
BIRC6 baculoviral IAP repeat containing 6 0.0418342
DST dystonin 0.0413733
LDHA lactate dehydrogenase A 0.0412777
ARHGAP26 Rho GTPase activating protein 26 0.0411886
GLIS3 GLIS family zinc finger 3 0.040978
PARD3 par-3 family cell polarity regulator 0.0409395
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0404022
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0398447
EFNA5 ephrin-A5 0.0396074
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0389727
EGFR epidermal growth factor receptor 0.0385708
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0373528
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0370231
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0361967
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0359921
USP34 ubiquitin specific peptidase 34 0.0350764
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.035055
NF1 neurofibromin 1 0.0349179
TTC28 tetratricopeptide repeat domain 28 0.0343156
NEGR1 neuronal growth regulator 1 0.0341945
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.034103
AKAP12 A kinase (PRKA) anchor protein 12 0.033309
PTK2 protein tyrosine kinase 2 0.0331873
NEBL nebulette 0.0328255
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0325066
PDLIM5 PDZ and LIM domain 5 0.0322192
FAM107B family with sequence similarity 107, member B 0.0320061
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0317963
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0316999
JMJD1C jumonji domain containing 1C 0.0316268
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0310502
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0307676
VCL vinculin 0.0304022
SBF2 SET binding factor 2 0.0303076
STRN3 striatin, calmodulin binding protein 3 0.0297966
PRR16 proline rich 16 0.0294681
CFDP1 craniofacial development protein 1 0.0290751
ANKRD11 ankyrin repeat domain 11 0.0290231
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0289525
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0284368
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.028286
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0280468
CUX1 cut-like homeobox 1 0.0279817
CTBP2 C-terminal binding protein 2 0.0277988
PLS3 plastin 3 0.0277573
AKAP13 A kinase (PRKA) anchor protein 13 0.0275066
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0275023
PUM2 pumilio RNA-binding family member 2 0.0274695
PYGL phosphorylase, glycogen, liver 0.0273827
PTPRG protein tyrosine phosphatase, receptor type, G 0.0269138
MBNL1 muscleblind-like splicing regulator 1 0.0268644
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0268638
APP amyloid beta (A4) precursor protein 0.02683
HDAC9 histone deacetylase 9 0.026694
ERRFI1 ERBB receptor feedback inhibitor 1 0.0263736
MYOF myoferlin 0.0262818
GLG1 golgi glycoprotein 1 0.0262665
ZBTB20 zinc finger and BTB domain containing 20 0.0262066
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0261317
MACF1 microtubule-actin crosslinking factor 1 0.0260712
AHNAK AHNAK nucleoprotein 0.025748

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.272254
FTL ferritin, light polypeptide -0.089786
EIF1 eukaryotic translation initiation factor 1 -0.0573373
PTMA prothymosin, alpha -0.0571898
RPS12 ribosomal protein S12 -0.0571374
TFPI2 tissue factor pathway inhibitor 2 -0.0565249
RPL23 ribosomal protein L23 -0.0560157
RPL19 ribosomal protein L19 -0.0549362
RPS2 ribosomal protein S2 -0.0485248
TM4SF1 transmembrane 4 L six family member 1 -0.0469988
TMSB10 thymosin beta 10 -0.0454375
RPLP1 ribosomal protein, large, P1 -0.0435193
NAMPT nicotinamide phosphoribosyltransferase -0.0430685
RPS21 ribosomal protein S21 -0.0416703
RPL7 ribosomal protein L7 -0.0382238
RPL37A ribosomal protein L37a -0.0373377
IER3 immediate early response 3 -0.0364199
RPS8 ribosomal protein S8 -0.0355507
RTN4 reticulon 4 -0.0354343
RPS27A ribosomal protein S27a -0.0350292
YBX3 Y box binding protein 3 -0.0321205
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0320631
RPS25 ribosomal protein S25 -0.0314751
PFDN2 prefoldin subunit 2 -0.0302381
RPS19 ribosomal protein S19 -0.0298094
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0297506
RPL26 ribosomal protein L26 -0.0289421
RPL36 ribosomal protein L36 -0.0289031
SLC38A1 solute carrier family 38, member 1 -0.0284242
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.027827
RPS6 ribosomal protein S6 -0.0278255
TPT1 tumor protein, translationally-controlled 1 -0.026711
C15ORF48 chromosome 15 open reading frame 48 -0.0260561
FGB fibrinogen beta chain -0.0259651
RPS29 ribosomal protein S29 -0.0253767
RPL5 ribosomal protein L5 -0.0249073
DENND4A DENN/MADD domain containing 4A -0.0236355
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0235609
RPL9 ribosomal protein L9 -0.0231303
RPS23 ribosomal protein S23 -0.022315
RPS20 ribosomal protein S20 -0.0223064
UPP1 uridine phosphorylase 1 -0.022293
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0220637
ATP5F1E ATP synthase F1 subunit epsilon -0.0219933
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0217787
HSPA8 heat shock 70kDa protein 8 -0.0217085
RPL12 ribosomal protein L12 -0.0216172
RPL37 ribosomal protein L37 -0.0213665
RPL35A ribosomal protein L35a -0.021351
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0211173
RPL30 ribosomal protein L30 -0.0208608
BHLHE40 basic helix-loop-helix family, member e40 -0.0208214
RPS17 ribosomal protein S17 -0.0206507
RPS3 ribosomal protein S3 -0.0205582
RPL38 ribosomal protein L38 -0.0201905
BIRC3 baculoviral IAP repeat containing 3 -0.0201316
RPL31 ribosomal protein L31 -0.0200925
NAP1L1 nucleosome assembly protein 1-like 1 -0.0199543
RPS24 ribosomal protein S24 -0.0192733
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0189193
RPLP2 ribosomal protein, large, P2 -0.0188906
RPS5 ribosomal protein S5 -0.0188081
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0187852
OLA1 Obg-like ATPase 1 -0.018311
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0179733
RAD21 RAD21 homolog (S. pombe) -0.0179192
BIRC2 baculoviral IAP repeat containing 2 -0.0178007
KLF6 Kruppel-like factor 6 -0.0177215
AREG amphiregulin -0.0173868
SRGN serglycin -0.0173615
USP3 ubiquitin specific peptidase 3 -0.0170742
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0170077
IGF2 insulin-like growth factor 2 -0.0169839
RPS16 ribosomal protein S16 -0.0169171
GOLT1B golgi transport 1B -0.0168664
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0168567
ZNF292 zinc finger protein 292 -0.0166368
YBX1 Y box binding protein 1 -0.0165336
RPL32 ribosomal protein L32 -0.0163294
RPL4 ribosomal protein L4 -0.0161791
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0160527
S100A9 S100 calcium binding protein A9 -0.0159501
JAK1 Janus kinase 1 -0.0159119
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0159056
RPL8 ribosomal protein L8 -0.0156805
RPL34 ribosomal protein L34 -0.0155029
RPL18 ribosomal protein L18 -0.0152997
B2M beta-2-microglobulin -0.0149941
RPL11 ribosomal protein L11 -0.0149192
LAPTM4A lysosomal protein transmembrane 4 alpha -0.0148948
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.014709
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.0146646
RBM8A RNA binding motif protein 8A -0.0146381
FXR1 fragile X mental retardation, autosomal homolog 1 -0.014606
LDHB lactate dehydrogenase B -0.0146023
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0145999
RPS11 ribosomal protein S11 -0.0145464
RPL36A ribosomal protein L36a -0.0144811
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0144475
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 -0.0142954