Filgotinib_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Filgotinib perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Filgotinib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRB10 growth factor receptor-bound protein 10 0.110247
FAM13A family with sequence similarity 13, member A 0.108591
PTMA prothymosin, alpha 0.0867419
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0865767
MACF1 microtubule-actin crosslinking factor 1 0.0831647
LIMCH1 LIM and calponin homology domains 1 0.0797195
DSCAM Down syndrome cell adhesion molecule 0.0755825
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0743461
FN1 fibronectin 1 0.0645301
TMSB10 thymosin beta 10 0.0630848
BACE2 beta-site APP-cleaving enzyme 2 0.0621094
ASPH aspartate beta-hydroxylase 0.0613379
ZBTB20 zinc finger and BTB domain containing 20 0.0580708
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0546208
TXNRD1 thioredoxin reductase 1 0.054257
PTPRM protein tyrosine phosphatase, receptor type, M 0.053035
GPC6 glypican 6 0.0518833
LAMC2 laminin, gamma 2 0.0511572
KDM5B lysine (K)-specific demethylase 5B 0.0508252
MAML3 mastermind-like 3 (Drosophila) 0.0499652
AKAP9 A kinase (PRKA) anchor protein 9 0.0489059
PDE10A phosphodiesterase 10A 0.0486414
ARHGAP21 Rho GTPase activating protein 21 0.0473405
AKAP13 A kinase (PRKA) anchor protein 13 0.0450145
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0449541
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0446556
PDE8A phosphodiesterase 8A 0.0440886
PUM2 pumilio RNA-binding family member 2 0.0440316
TPR translocated promoter region, nuclear basket protein 0.0431761
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0431043
SQSTM1 sequestosome 1 0.0424728
PRELID2 PRELI domain containing 2 0.0422525
LAMB3 laminin, beta 3 0.0420007
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0412845
SYNGAP1 synaptic Ras GTPase activating protein 1 0.040847
PSD3 pleckstrin and Sec7 domain containing 3 0.0398508
CTNND1 catenin (cadherin-associated protein), delta 1 0.0396656
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0395496
RICTOR RPTOR independent companion of MTOR, complex 2 0.0393358
USP53 ubiquitin specific peptidase 53 0.0385433
FMNL2 formin-like 2 0.0385275
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0383954
MBNL1 muscleblind-like splicing regulator 1 0.0381303
BAIAP2L1 BAI1-associated protein 2-like 1 0.0379378
GRAMD1B GRAM domain containing 1B 0.0365557
SVIL supervillin 0.0363159
DDIT4 DNA-damage-inducible transcript 4 0.0361892
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0360276
RNF145 ring finger protein 145 0.0358574
KDM7A lysine (K)-specific demethylase 7A 0.0358274
ZSWIM6 zinc finger, SWIM-type containing 6 0.034728
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.0344724
EPS8 epidermal growth factor receptor pathway substrate 8 0.0341439
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0339969
CNKSR3 CNKSR family member 3 0.0338978
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0337484
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0337274
UBC ubiquitin C 0.0335539
NBEAL1 neurobeachin-like 1 0.0335445
EGFR epidermal growth factor receptor 0.0334972
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0324744
RASAL2 RAS protein activator like 2 0.032105
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0320543
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.032033
FOXO3 forkhead box O3 0.0318175
XPO1 exportin 1 0.0308463
MYOF myoferlin 0.0308405
ANKHD1 ankyrin repeat and KH domain containing 1 0.0303845
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0299194
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 0.029793
FNIP1 folliculin interacting protein 1 0.0295458
BZW1 basic leucine zipper and W2 domains 1 0.0292224
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0292195
JMJD1C jumonji domain containing 1C 0.0283508
RCOR1 REST corepressor 1 0.0281735
GOLGA4 golgin A4 0.0278937
KMT2C lysine (K)-specific methyltransferase 2C 0.0271934
PDIA3 protein disulfide isomerase family A, member 3 0.027088
RPL9 ribosomal protein L9 0.0267773
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0266905
CDK13 cyclin-dependent kinase 13 0.026676
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0266088
CTSB cathepsin B 0.0264815
PTK2 protein tyrosine kinase 2 0.0264745
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0264202
TNRC6B trinucleotide repeat containing 6B 0.0259539
ITPRID2 ITPR interacting domain containing 2 0.0257851
ZFP36L1 ZFP36 ring finger protein-like 1 0.0257706
IRS2 insulin receptor substrate 2 0.0257461
FNDC3B fibronectin type III domain containing 3B 0.0257187
ZNF638 zinc finger protein 638 0.0256287
MCL1 myeloid cell leukemia 1 0.0255633
TOP1 topoisomerase (DNA) I 0.0255559
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0255543
SMAD3 SMAD family member 3 0.0252675
CD109 CD109 molecule 0.0250545
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0245347
ATP11A ATPase, class VI, type 11A 0.0244717
TTC3 tetratricopeptide repeat domain 3 0.0242556
COG5 component of oligomeric golgi complex 5 0.0241429

decreased expression

Symbol Name Standardized Value
MAST4 microtubule associated serine/threonine kinase family member 4 -0.119208
PDE4D phosphodiesterase 4D, cAMP-specific -0.113842
IGF2 insulin-like growth factor 2 -0.0957262
NDRG1 N-myc downstream regulated 1 -0.0906669
EXT1 exostosin glycosyltransferase 1 -0.0895246
ELL2 elongation factor, RNA polymerase II, 2 -0.0888491
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0824506
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0672477
PLAUR plasminogen activator, urokinase receptor -0.0656244
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0626416
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0625625
MXD1 MAX dimerization protein 1 -0.0616029
KYNU kynureninase -0.060786
NAP1L1 nucleosome assembly protein 1-like 1 -0.0607405
RIGI RNA sensor RIG-I -0.0607104
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0552009
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0549869
KLF5 Kruppel-like factor 5 (intestinal) -0.0549839
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0543939
MCTP1 multiple C2 domains, transmembrane 1 -0.0516018
DGKD diacylglycerol kinase, delta 130kDa -0.0501751
SPAG9 sperm associated antigen 9 -0.0500603
MCTP2 multiple C2 domains, transmembrane 2 -0.0479476
DOCK4 dedicator of cytokinesis 4 -0.0464323
ABI1 abl-interactor 1 -0.0451415
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0446044
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0440577
VCL vinculin -0.0438942
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0437929
RPS24 ribosomal protein S24 -0.0434562
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0432073
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.042468
BTG1 B-cell translocation gene 1, anti-proliferative -0.0423123
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0420571
EIF1 eukaryotic translation initiation factor 1 -0.0415928
NRIP1 nuclear receptor interacting protein 1 -0.0410288
CXCL8 chemokine (C-X-C motif) ligand 8 -0.040998
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0409331
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0408918
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0398644
OSMR oncostatin M receptor -0.0398403
NKD1 naked cuticle homolog 1 (Drosophila) -0.038995
NPTN neuroplastin -0.0387411
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0386868
KIF5B kinesin family member 5B -0.0383002
MON2 MON2 homolog (S. cerevisiae) -0.0373356
IFIH1 interferon induced with helicase C domain 1 -0.0371816
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0371763
ZNF207 zinc finger protein 207 -0.0371013
MBD5 methyl-CpG binding domain protein 5 -0.036524
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.036163
RTN4 reticulon 4 -0.0358089
SOS2 son of sevenless homolog 2 (Drosophila) -0.0353916
TPM4 tropomyosin 4 -0.0353415
OASL 2'-5'-oligoadenylate synthetase-like -0.0333424
COPA coatomer protein complex, subunit alpha -0.0331938
DSPP dentin sialophosphoprotein -0.0321939
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0320852
SETX senataxin -0.0317291
MORF4L2 mortality factor 4 like 2 -0.0315441
TRIO trio Rho guanine nucleotide exchange factor -0.031283
RPL23 ribosomal protein L23 -0.0312563
COPB1 coatomer protein complex, subunit beta 1 -0.0312515
NAMPT nicotinamide phosphoribosyltransferase -0.0312073
RPS12 ribosomal protein S12 -0.0310862
BPTF bromodomain PHD finger transcription factor -0.0308461
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0301887
TPT1 tumor protein, translationally-controlled 1 -0.0301735
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0296212
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0296106
TSC22D2 TSC22 domain family, member 2 -0.0295536
MAML2 mastermind-like 2 (Drosophila) -0.0295525
HSPA8 heat shock 70kDa protein 8 -0.0294212
GPBP1 GC-rich promoter binding protein 1 -0.0286341
ANO6 anoctamin 6 -0.0285465
NBAS neuroblastoma amplified sequence -0.027808
RNF149 ring finger protein 149 -0.027411
FAM107B family with sequence similarity 107, member B -0.0271579
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0270173
HMBOX1 homeobox containing 1 -0.0268164
KIF13B kinesin family member 13B -0.026722
DENND4A DENN/MADD domain containing 4A -0.0266425
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha -0.0261361
FBXO11 F-box protein 11 -0.0259381
TM9SF3 transmembrane 9 superfamily member 3 -0.0258106
MACC1 metastasis associated in colon cancer 1 -0.0257878
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0257626
CSNK1A1 casein kinase 1, alpha 1 -0.0255313
SYT1 synaptotagmin I -0.0255037
HLA-B major histocompatibility complex, class I, B -0.0253863
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0252676
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0252179
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0248642
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0247245
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0247195
ETNK1 ethanolamine kinase 1 -0.0246877
RPL37A ribosomal protein L37a -0.0244492
PAPOLA poly(A) polymerase alpha -0.0243819
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0242485
ABHD2 abhydrolase domain containing 2 -0.0240279