| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Filgotinib perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Filgotinib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.232622 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.168014 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.15525 |
| MCL1 | myeloid cell leukemia 1 | 0.151769 |
| RAD51B | RAD51 paralog B | 0.135083 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0936903 |
| GRAMD1B | GRAM domain containing 1B | 0.0841382 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0827589 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0791799 |
| TPM3 | tropomyosin 3 | 0.077298 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0699789 |
| DENND5B | DENN/MADD domain containing 5B | 0.068817 |
| EXOC4 | exocyst complex component 4 | 0.0672015 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0637844 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0626754 |
| ENO1 | enolase 1, (alpha) | 0.0603577 |
| ATXN1 | ataxin 1 | 0.0595366 |
| PRELID2 | PRELI domain containing 2 | 0.0584647 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0551205 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0531204 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0525379 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0515872 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0503568 |
| POTEF | POTE ankyrin domain family, member F | 0.0499595 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0498991 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0491776 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.049035 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0486008 |
| WWOX | WW domain containing oxidoreductase | 0.0473374 |
| PKM | pyruvate kinase, muscle | 0.0448381 |
| PHF21A | PHD finger protein 21A | 0.0446687 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0426159 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0421569 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0421206 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0419776 |
| SBF2 | SET binding factor 2 | 0.0406056 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0402055 |
| PCBP2 | poly(rC) binding protein 2 | 0.0395716 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0394369 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0393781 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.038902 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0384092 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0377453 |
| ZNF148 | zinc finger protein 148 | 0.0372279 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0371494 |
| PHF20 | PHD finger protein 20 | 0.037037 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0370089 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0364671 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0360985 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0354548 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0352085 |
| LDHA | lactate dehydrogenase A | 0.035208 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0348765 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0344577 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0342414 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0341569 |
| MSH6 | mutS homolog 6 | 0.0335856 |
| TXNRD1 | thioredoxin reductase 1 | 0.0334217 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0324195 |
| SMYD3 | SET and MYND domain containing 3 | 0.0321804 |
| PFKP | phosphofructokinase, platelet | 0.0320195 |
| SET | SET nuclear proto-oncogene | 0.0318632 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0310153 |
| DSPP | dentin sialophosphoprotein | 0.0306082 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0304786 |
| PGK1 | phosphoglycerate kinase 1 | 0.0299631 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0299614 |
| SRSF1 | serine/arginine-rich splicing factor 1 | 0.0299023 |
| FAM168A | family with sequence similarity 168, member A | 0.0298878 |
| TMEM14B | transmembrane protein 14B | 0.0297805 |
| ZNF292 | zinc finger protein 292 | 0.0296372 |
| TPI1 | triosephosphate isomerase 1 | 0.0292487 |
| CBX5 | chromobox homolog 5 | 0.0291334 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | 0.0290869 |
| PRKCE | protein kinase C, epsilon | 0.0288946 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0288636 |
| RRM2 | ribonucleotide reductase M2 | 0.0285412 |
| RNF145 | ring finger protein 145 | 0.0280639 |
| PYGL | phosphorylase, glycogen, liver | 0.0279094 |
| CEP250 | centrosomal protein 250kDa | 0.0275724 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0275306 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0274907 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0274559 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0274327 |
| ADAR | adenosine deaminase, RNA-specific | 0.0272204 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0268913 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0267416 |
| CEP192 | centrosomal protein 192kDa | 0.0267286 |
| CENPF | centromere protein F, 350/400kDa | 0.0267139 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0260908 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0256703 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0256567 |
| TPM4 | tropomyosin 4 | 0.025648 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0254626 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0252176 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0252131 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0252096 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.0251258 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0250528 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.025024 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TFPI2 | tissue factor pathway inhibitor 2 | -0.108572 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0853653 |
| OSMR | oncostatin M receptor | -0.0762937 |
| TMSB10 | thymosin beta 10 | -0.0585728 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0502317 |
| RPL12 | ribosomal protein L12 | -0.0473794 |
| RPL23 | ribosomal protein L23 | -0.0468174 |
| PTMA | prothymosin, alpha | -0.0462406 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0456317 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0448425 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0446863 |
| RPS21 | ribosomal protein S21 | -0.043545 |
| RPS8 | ribosomal protein S8 | -0.0433032 |
| RPL26 | ribosomal protein L26 | -0.0431484 |
| RPL35A | ribosomal protein L35a | -0.0424522 |
| CAVIN1 | caveolae associated protein 1 | -0.0410862 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0403916 |
| KLF6 | Kruppel-like factor 6 | -0.0391875 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0381044 |
| RPL32 | ribosomal protein L32 | -0.0370523 |
| RPL37A | ribosomal protein L37a | -0.0362194 |
| EGR1 | early growth response 1 | -0.0358718 |
| SPAG9 | sperm associated antigen 9 | -0.0333974 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0317398 |
| PLSCR1 | phospholipid scramblase 1 | -0.0316551 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0312478 |
| ATF6 | activating transcription factor 6 | -0.0303519 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.030177 |
| RPS19 | ribosomal protein S19 | -0.0296786 |
| RIGI | RNA sensor RIG-I | -0.0292635 |
| RPLP1 | ribosomal protein, large, P1 | -0.0283785 |
| GOLGA4 | golgin A4 | -0.028295 |
| RPS15 | ribosomal protein S15 | -0.028215 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0280057 |
| IER3 | immediate early response 3 | -0.0273294 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0272898 |
| RPL36 | ribosomal protein L36 | -0.0270562 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0267124 |
| RPL35 | ribosomal protein L35 | -0.026138 |
| MORF4L2 | mortality factor 4 like 2 | -0.0253366 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0250684 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0250017 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0248825 |
| RPS27A | ribosomal protein S27a | -0.0248725 |
| RPS3 | ribosomal protein S3 | -0.0247712 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0245551 |
| FUS | FUS RNA binding protein | -0.0244622 |
| RPL19 | ribosomal protein L19 | -0.0233094 |
| RPL38 | ribosomal protein L38 | -0.023114 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0230551 |
| PMP22 | peripheral myelin protein 22 | -0.0225942 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0223844 |
| RPL34 | ribosomal protein L34 | -0.0222629 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0221875 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0219669 |
| RPS24 | ribosomal protein S24 | -0.021948 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0218763 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0216879 |
| ZFR | zinc finger RNA binding protein | -0.0215505 |
| FSCN1 | fascin actin-bundling protein 1 | -0.0213843 |
| RPL36A | ribosomal protein L36a | -0.0208949 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0204468 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0201953 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0200803 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0200588 |
| EIF2S1 | eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa | -0.0199828 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0199093 |
| CDK17 | cyclin-dependent kinase 17 | -0.0199033 |
| RPL28 | ribosomal protein L28 | -0.0197756 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0195852 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0195536 |
| RPLP2 | ribosomal protein, large, P2 | -0.019327 |
| GON4L | gon-4-like (C. elegans) | -0.0192498 |
| RPS29 | ribosomal protein S29 | -0.0192456 |
| TRIM56 | tripartite motif containing 56 | -0.0191626 |
| RPS27 | ribosomal protein S27 | -0.0191082 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0188973 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.0187257 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0186696 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0186639 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0186548 |
| FTL | ferritin, light polypeptide | -0.0185115 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0183151 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0182466 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0181217 |
| RPL8 | ribosomal protein L8 | -0.0180906 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0180657 |
| RPS23 | ribosomal protein S23 | -0.0180593 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0180177 |
| MAP4 | microtubule-associated protein 4 | -0.017933 |
| EIF3J | eukaryotic translation initiation factor 3, subunit J | -0.0178255 |
| GOLT1B | golgi transport 1B | -0.0177933 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0177611 |
| MASTL | microtubule associated serine/threonine kinase-like | -0.0175437 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0174876 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0174292 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0173642 |
| CDC27 | cell division cycle 27 | -0.0173522 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.017106 |
| UPF2 | UPF2 regulator of nonsense transcripts homolog (yeast) | -0.0170042 |
