| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Filgotinib perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Filgotinib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0983226 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0740472 |
| TSC22D2 | TSC22 domain family, member 2 | 0.072372 |
| RPL35A | ribosomal protein L35a | 0.0649851 |
| VCL | vinculin | 0.0619302 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0585643 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0516031 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0497956 |
| LMO7 | LIM domain 7 | 0.0490414 |
| CTBP2 | C-terminal binding protein 2 | 0.0485846 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0458967 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0452467 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0449522 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0424775 |
| GOLGB1 | golgin B1 | 0.0417158 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0405447 |
| EFNA5 | ephrin-A5 | 0.0403215 |
| SCFD1 | sec1 family domain containing 1 | 0.0390577 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0373348 |
| FNIP1 | folliculin interacting protein 1 | 0.0373262 |
| RCOR1 | REST corepressor 1 | 0.0372388 |
| SETD5 | SET domain containing 5 | 0.036967 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0345478 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0343798 |
| RUNX1 | runt-related transcription factor 1 | 0.0343584 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.034338 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0325126 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0324995 |
| ERBIN | erbb2 interacting protein | 0.0310141 |
| CD109 | CD109 molecule | 0.0309583 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0308672 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0308207 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0300161 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.02974 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0296115 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0293258 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0290741 |
| UBAP1 | ubiquitin associated protein 1 | 0.0289955 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0279759 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0276926 |
| MYO1E | myosin IE | 0.0276621 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0276002 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0273716 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0272129 |
| MYO6 | myosin VI | 0.0271017 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0260007 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0259288 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0259032 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0258873 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0257684 |
| TJP1 | tight junction protein 1 | 0.0257183 |
| PRKCA | protein kinase C, alpha | 0.0254666 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0254666 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0253637 |
| PTK2 | protein tyrosine kinase 2 | 0.0252972 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0252142 |
| ATP11A | ATPase, class VI, type 11A | 0.0251248 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0251025 |
| RBM25 | RNA binding motif protein 25 | 0.0249421 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0247175 |
| MCL1 | myeloid cell leukemia 1 | 0.024682 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0246337 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0244672 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0241409 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0238002 |
| INTS6 | integrator complex subunit 6 | 0.0236419 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0235697 |
| PTGES2 | prostaglandin E synthase 2 | 0.0233992 |
| NKTR | natural killer cell triggering receptor | 0.0231507 |
| GOLGA4 | golgin A4 | 0.022835 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0227766 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0223168 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0219414 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0219014 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0218726 |
| TMEM263 | transmembrane protein 263 | 0.0213235 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0212448 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0212096 |
| RPL9 | ribosomal protein L9 | 0.021199 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 0.0210252 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0207912 |
| NUP98 | nucleoporin 98kDa | 0.0205818 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.020312 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0201899 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0201025 |
| NABP1 | nucleic acid binding protein 1 | 0.0200923 |
| GLCCI1 | glucocorticoid induced 1 | 0.0199292 |
| GPATCH8 | G patch domain containing 8 | 0.0199079 |
| FBXO34 | F-box protein 34 | 0.0198461 |
| RNF145 | ring finger protein 145 | 0.0198376 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0198049 |
| COPA | coatomer protein complex, subunit alpha | 0.0197403 |
| SP3 | Sp3 transcription factor | 0.0196887 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0196574 |
| FBXO11 | F-box protein 11 | 0.0195032 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.019444 |
| CCNY | cyclin Y | 0.0192902 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0191918 |
| PTEN | phosphatase and tensin homolog | 0.0191462 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0190708 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.19877 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.1699 |
| UBC | ubiquitin C | -0.151304 |
| TMSB10 | thymosin beta 10 | -0.122329 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.120464 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.112062 |
| POTEF | POTE ankyrin domain family, member F | -0.101301 |
| S100A6 | S100 calcium binding protein A6 | -0.0932292 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0911981 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0899731 |
| TMSB4X | thymosin beta 4, X-linked | -0.0882341 |
| FN1 | fibronectin 1 | -0.0855729 |
| LAMB3 | laminin, beta 3 | -0.0819931 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0814006 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0775884 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.07469 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0704342 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0656274 |
| G0S2 | G0/G1 switch 2 | -0.0652815 |
| CALR | calreticulin | -0.0650543 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0618606 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0590033 |
| KRT7 | keratin 7, type II | -0.0589093 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0585738 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0583539 |
| CANX | calnexin | -0.0566438 |
| MT2A | metallothionein 2A | -0.0565858 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0561313 |
| PGK1 | phosphoglycerate kinase 1 | -0.0556381 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0534156 |
| MAP1B | microtubule-associated protein 1B | -0.0529564 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0511065 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0487449 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0485088 |
| S100A10 | S100 calcium binding protein A10 | -0.048335 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0480339 |
| MX1 | MX dynamin-like GTPase 1 | -0.0476232 |
| FBXO32 | F-box protein 32 | -0.0472979 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0464651 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0459645 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0451984 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0446422 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0441641 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0435701 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0434059 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0425687 |
| LAMC2 | laminin, gamma 2 | -0.0417072 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0416944 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.040746 |
| ENO1 | enolase 1, (alpha) | -0.0404819 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | -0.0399178 |
| EPCAM | epithelial cell adhesion molecule | -0.0392838 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0390439 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.039039 |
| H1-0 | H1.0 linker histone | -0.0382261 |
| HMGA1 | high mobility group AT-hook 1 | -0.0378776 |
| FTL | ferritin, light polypeptide | -0.0375955 |
| RPL8 | ribosomal protein L8 | -0.037242 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0370463 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0366462 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0366075 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0358365 |
| ADAR | adenosine deaminase, RNA-specific | -0.0353117 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0349254 |
| TXNRD1 | thioredoxin reductase 1 | -0.0348083 |
| PLSCR1 | phospholipid scramblase 1 | -0.0348014 |
| LDHA | lactate dehydrogenase A | -0.0347086 |
| IRF6 | interferon regulatory factor 6 | -0.0346557 |
| HMGB2 | high mobility group box 2 | -0.0344013 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0343094 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.034286 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0341884 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.034023 |
| TPI1 | triosephosphate isomerase 1 | -0.0339784 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.033773 |
| FAM162A | family with sequence similarity 162, member A | -0.0335889 |
| TMEM123 | transmembrane protein 123 | -0.0331078 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0330989 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0329111 |
| CSTB | cystatin B (stefin B) | -0.0324806 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0324359 |
| RNF213 | ring finger protein 213 | -0.0321618 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.031783 |
| DSG2 | desmoglein 2 | -0.0313234 |
| RPL32 | ribosomal protein L32 | -0.0312198 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.031137 |
| GPX4 | glutathione peroxidase 4 | -0.0311173 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0307996 |
| SP100 | SP100 nuclear antigen | -0.0304449 |
| SQSTM1 | sequestosome 1 | -0.0297785 |
| TPM3 | tropomyosin 3 | -0.0296723 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0295737 |
| TPM4 | tropomyosin 4 | -0.0290974 |
| CD47 | CD47 molecule | -0.0288792 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0288675 |
| HLA-E | major histocompatibility complex, class I, E | -0.0285735 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0281959 |
| AHNAK | AHNAK nucleoprotein | -0.0279773 |
| PCBP2 | poly(rC) binding protein 2 | -0.0277748 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0273456 |
