| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Filgotinib perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Filgotinib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.261889 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.239979 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.234619 |
| FN1 | fibronectin 1 | 0.229113 |
| PM20D1 | peptidase M20 domain containing 1 | 0.17336 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.170667 |
| DST | dystonin | 0.105835 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.104312 |
| MCL1 | myeloid cell leukemia 1 | 0.10249 |
| PDE10A | phosphodiesterase 10A | 0.100727 |
| PDLIM5 | PDZ and LIM domain 5 | 0.089838 |
| MYOF | myoferlin | 0.0897182 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0883442 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.088199 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0861668 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0833595 |
| GDA | guanine deaminase | 0.0791906 |
| KYNU | kynureninase | 0.0788015 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0743336 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0726448 |
| EFNA5 | ephrin-A5 | 0.0692045 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0685655 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0671795 |
| ASPH | aspartate beta-hydroxylase | 0.0636825 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0631137 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0623855 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0603309 |
| COL5A2 | collagen, type V, alpha 2 | 0.0594617 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0584232 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0572555 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.057088 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0569377 |
| LDHA | lactate dehydrogenase A | 0.0565197 |
| VCL | vinculin | 0.0562926 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0553618 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.054434 |
| VIM | vimentin | 0.053251 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.053245 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0519247 |
| CANX | calnexin | 0.0509143 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0503814 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0501306 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.049593 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0478767 |
| CD109 | CD109 molecule | 0.046427 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0461287 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0456502 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0451035 |
| EPHA4 | EPH receptor A4 | 0.0450538 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0446658 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0440936 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | 0.0436779 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0436627 |
| STC1 | stanniocalcin 1 | 0.0420532 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0418798 |
| PCBP3 | poly(rC) binding protein 3 | 0.0416584 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0413684 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0412856 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0409731 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0404641 |
| SMAD2 | SMAD family member 2 | 0.0392231 |
| EGR1 | early growth response 1 | 0.0391109 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0388968 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0388389 |
| COPA | coatomer protein complex, subunit alpha | 0.0386169 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0383644 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0380204 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0379603 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0379416 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0365439 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0362751 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0361039 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0360048 |
| EZR | ezrin | 0.0359658 |
| COL4A6 | collagen, type IV, alpha 6 | 0.0356304 |
| PYGL | phosphorylase, glycogen, liver | 0.0355879 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0344858 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.0339791 |
| MAP7 | microtubule-associated protein 7 | 0.0334695 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0331383 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0328797 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0324284 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0323291 |
| PKM | pyruvate kinase, muscle | 0.0322368 |
| B2M | beta-2-microglobulin | 0.0321408 |
| CHL1 | cell adhesion molecule L1-like | 0.0320991 |
| RGS2 | regulator of G-protein signaling 2 | 0.0319781 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0317278 |
| ANXA2 | annexin A2 | 0.0316479 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0315081 |
| FLNB | filamin B, beta | 0.0313993 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.031172 |
| PCBP2 | poly(rC) binding protein 2 | 0.0311356 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0309643 |
| HLA-A | major histocompatibility complex, class I, A | 0.0301147 |
| FMNL2 | formin-like 2 | 0.030108 |
| UBC | ubiquitin C | 0.0298089 |
| GRAMD1B | GRAM domain containing 1B | 0.0296598 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0296496 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0294397 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0444987 |
| RPS24 | ribosomal protein S24 | -0.0331896 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0327858 |
| PTMA | prothymosin, alpha | -0.0324381 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0260252 |
| TXNRD1 | thioredoxin reductase 1 | -0.0255191 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0234275 |
| RPL23 | ribosomal protein L23 | -0.0217971 |
| RPL37A | ribosomal protein L37a | -0.0206639 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0205917 |
| RPL26 | ribosomal protein L26 | -0.0197667 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0191 |
| RPL34 | ribosomal protein L34 | -0.0180527 |
| RPL38 | ribosomal protein L38 | -0.0170501 |
| RPL9 | ribosomal protein L9 | -0.0158105 |
| WDR43 | WD repeat domain 43 | -0.015441 |
| TNPO1 | transportin 1 | -0.0151108 |
| RPLP2 | ribosomal protein, large, P2 | -0.0151026 |
| RPL12 | ribosomal protein L12 | -0.0144875 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0144343 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0142295 |
| RPL35A | ribosomal protein L35a | -0.0126909 |
| NOP58 | NOP58 ribonucleoprotein | -0.0125425 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0120666 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0119978 |
| RPS25 | ribosomal protein S25 | -0.0118474 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0117997 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0110028 |
| HMGB1 | high mobility group box 1 | -0.0105987 |
| UCK2 | uridine-cytidine kinase 2 | -0.010291 |
| RPS27A | ribosomal protein S27a | -0.0102775 |
| TCERG1 | transcription elongation regulator 1 | -0.0100512 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0100259 |
| WRN | Werner syndrome, RecQ helicase-like | -0.00986351 |
| RPL31 | ribosomal protein L31 | -0.00966832 |
| RPS16 | ribosomal protein S16 | -0.00962099 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.00933272 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | -0.00913977 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.00908777 |
| TMSB10 | thymosin beta 10 | -0.00889517 |
| ANKRD10 | ankyrin repeat domain 10 | -0.00883291 |
| RPS21 | ribosomal protein S21 | -0.00880127 |
| RPL36A | ribosomal protein L36a | -0.0086838 |
| USP3 | ubiquitin specific peptidase 3 | -0.00865654 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -0.008638 |
| RPL35 | ribosomal protein L35 | -0.00856877 |
| WDR36 | WD repeat domain 36 | -0.00856414 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.00853486 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.00850708 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | -0.00848337 |
| NCKAP1 | NCK-associated protein 1 | -0.00841731 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | -0.00840692 |
| KLF6 | Kruppel-like factor 6 | -0.00835855 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.00828375 |
| MDN1 | MDN1, midasin homolog (yeast) | -0.00828303 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.00827368 |
| RPS8 | ribosomal protein S8 | -0.00827247 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.00825515 |
| FAR1 | fatty acyl CoA reductase 1 | -0.00822383 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.00814023 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.00810826 |
| NPR2 | natriuretic peptide receptor 2 | -0.00805084 |
| RPS13 | ribosomal protein S13 | -0.00804617 |
| RPL5 | ribosomal protein L5 | -0.00800336 |
| RPL6 | ribosomal protein L6 | -0.00799267 |
| NUP153 | nucleoporin 153kDa | -0.00799101 |
| RPS29 | ribosomal protein S29 | -0.00797682 |
| PLCB4 | phospholipase C, beta 4 | -0.00795303 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.00784846 |
| RTN4 | reticulon 4 | -0.00776723 |
| DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56 | -0.00772607 |
| RPL13A | ribosomal protein L13a | -0.00767066 |
| ANLN | anillin, actin binding protein | -0.00766679 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | -0.00763962 |
| AHCTF1 | AT hook containing transcription factor 1 | -0.00762122 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.00761898 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.00753957 |
| HYCC2 | hyccin PI4KA lipid kinase complex subunit 2 | -0.00753332 |
| RPLP1 | ribosomal protein, large, P1 | -0.00743806 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.00740877 |
| CEP85L | centrosomal protein 85kDa-like | -0.00735613 |
| DKC1 | dyskeratosis congenita 1, dyskerin | -0.00734278 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.00731219 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.00730411 |
| DNAJC2 | DnaJ (Hsp40) homolog, subfamily C, member 2 | -0.00725086 |
| NEMF | nuclear export mediator factor | -0.00721829 |
| SNAPC1 | small nuclear RNA activating complex, polypeptide 1, 43kDa | -0.00715494 |
| CPSF6 | cleavage and polyadenylation specific factor 6, 68kDa | -0.00714615 |
| RPS15 | ribosomal protein S15 | -0.00714169 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.00708898 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.00705203 |
| NOP56 | NOP56 ribonucleoprotein | -0.00698473 |
| TIAL1 | TIA1 cytotoxic granule-associated RNA binding protein-like 1 | -0.00692695 |
| XPR1 | xenotropic and polytropic retrovirus receptor 1 | -0.00691415 |
| RPS3 | ribosomal protein S3 | -0.00689146 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.00686124 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.00685151 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | -0.00684915 |
| FAM133B | family with sequence similarity 133, member B | -0.00683164 |
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | -0.00681197 |
