| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Filgotinib perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Filgotinib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.119592 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.119107 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.102939 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0975207 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0937486 |
| JMJD1C | jumonji domain containing 1C | 0.0926104 |
| MMP12 | matrix metallopeptidase 12 | 0.0859906 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0849094 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0845236 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0833942 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.080257 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0795749 |
| GPC6 | glypican 6 | 0.0780689 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0779834 |
| NRG1 | neuregulin 1 | 0.0719254 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0713844 |
| APP | amyloid beta (A4) precursor protein | 0.0705866 |
| PRELID2 | PRELI domain containing 2 | 0.068675 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0659779 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0639488 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0635347 |
| RBM39 | RNA binding motif protein 39 | 0.0632297 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.061125 |
| HDAC8 | histone deacetylase 8 | 0.060187 |
| DST | dystonin | 0.0598837 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0596956 |
| PTMA | prothymosin, alpha | 0.0562987 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0561826 |
| VMP1 | vacuole membrane protein 1 | 0.054115 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0522857 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0501756 |
| RPL35A | ribosomal protein L35a | 0.0481268 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.046042 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.043778 |
| RAD51B | RAD51 paralog B | 0.0433628 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0423122 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | 0.0422078 |
| DSCAM | Down syndrome cell adhesion molecule | 0.042056 |
| FN1 | fibronectin 1 | 0.0419047 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0413811 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0405966 |
| TMEM165 | transmembrane protein 165 | 0.0399146 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0393168 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.038363 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.038258 |
| ATXN1 | ataxin 1 | 0.0378374 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0376312 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0372086 |
| SQSTM1 | sequestosome 1 | 0.0369617 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.035894 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0351697 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0351174 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.032302 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.031972 |
| FNIP1 | folliculin interacting protein 1 | 0.0312858 |
| SCFD1 | sec1 family domain containing 1 | 0.030178 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0288885 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0283996 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0280049 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0255364 |
| RPL11 | ribosomal protein L11 | 0.025179 |
| MCL1 | myeloid cell leukemia 1 | 0.0243828 |
| H3-3B | H3.3 histone B | 0.0238449 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0231903 |
| FTL | ferritin, light polypeptide | 0.0221994 |
| HLA-B | major histocompatibility complex, class I, B | 0.0219022 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0217036 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0216517 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0214104 |
| EGFR | epidermal growth factor receptor | 0.0213337 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0206502 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0202743 |
| GNAS | GNAS complex locus | 0.0201848 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0186571 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.018646 |
| NF1 | neurofibromin 1 | 0.0182858 |
| GOLGB1 | golgin B1 | 0.018051 |
| TMSB4X | thymosin beta 4, X-linked | 0.0177798 |
| RPL19 | ribosomal protein L19 | 0.0176155 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0164164 |
| ERBIN | erbb2 interacting protein | 0.0161481 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0160532 |
| NDRG1 | N-myc downstream regulated 1 | 0.0150125 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0143831 |
| GOLGA4 | golgin A4 | 0.0137265 |
| RPS6 | ribosomal protein S6 | 0.013322 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0130478 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0124301 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0117102 |
| TPR | translocated promoter region, nuclear basket protein | 0.0105255 |
| USP34 | ubiquitin specific peptidase 34 | 0.0103986 |
| QKI | QKI, KH domain containing, RNA binding | 0.00960165 |
| MYO1E | myosin IE | 0.00944283 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.00860946 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.00844673 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.00792919 |
| CCNI | cyclin I | 0.00732514 |
| COL5A2 | collagen, type V, alpha 2 | 0.00692841 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.00681172 |
| BBX | bobby sox homolog (Drosophila) | 0.00678697 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FLNB | filamin B, beta | -0.107187 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.101893 |
| VGF | VGF nerve growth factor inducible | -0.0909625 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0847804 |
| DTNA | dystrobrevin, alpha | -0.0700197 |
| INHBA | inhibin, beta A | -0.0698573 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0685541 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0678224 |
| FOXP1 | forkhead box P1 | -0.0668637 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0645524 |
| TBC1D5 | TBC1 domain family, member 5 | -0.064392 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0640442 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0627493 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0624702 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0621569 |
| PDE10A | phosphodiesterase 10A | -0.0602612 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0595002 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0572139 |
| CALU | calumenin | -0.0557442 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0557321 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0549446 |
| PKM | pyruvate kinase, muscle | -0.0546903 |
| RPS19 | ribosomal protein S19 | -0.0546768 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0529339 |
| NGLY1 | N-glycanase 1 | -0.0500354 |
| FAM13A | family with sequence similarity 13, member A | -0.0484263 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0468609 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0465965 |
| PDCD6IP | programmed cell death 6 interacting protein | -0.0460818 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | -0.0448636 |
| ACTG1 | actin gamma 1 | -0.0446834 |
| MATR3 | matrin 3 | -0.0443007 |
| RNF145 | ring finger protein 145 | -0.0442349 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0442065 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0441777 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0438733 |
| S100A6 | S100 calcium binding protein A6 | -0.0436408 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0421554 |
| PTK2 | protein tyrosine kinase 2 | -0.0419823 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.041828 |
| AHNAK | AHNAK nucleoprotein | -0.0413132 |
| S100A10 | S100 calcium binding protein A10 | -0.0408912 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0389244 |
| SMYD3 | SET and MYND domain containing 3 | -0.0386105 |
| YBX1 | Y box binding protein 1 | -0.0380434 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.036455 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.0363733 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.0361085 |
| CD44 | CD44 molecule (Indian blood group) | -0.0350809 |
| PRKCA | protein kinase C, alpha | -0.034665 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0345852 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0338823 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0333327 |
| MEIS2 | Meis homeobox 2 | -0.0330394 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0323287 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0322755 |
| CDCP1 | CUB domain containing protein 1 | -0.0322026 |
| POTEF | POTE ankyrin domain family, member F | -0.0319812 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0317598 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0315544 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0315236 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0309524 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0304867 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.030265 |
| HELZ | helicase with zinc finger | -0.0297586 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.029755 |
| OGA | O-GlcNAcase | -0.0295402 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0291597 |
| TMSB10 | thymosin beta 10 | -0.0289185 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0284786 |
| PDE8A | phosphodiesterase 8A | -0.028109 |
| PUM1 | pumilio RNA-binding family member 1 | -0.027957 |
| KPNB1 | karyopherin (importin) beta 1 | -0.027456 |
| CEP170 | centrosomal protein 170kDa | -0.0270281 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0268043 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0267131 |
| NAV1 | neuron navigator 1 | -0.0263902 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0263711 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0260259 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0251098 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0248628 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0247055 |
| RPL32 | ribosomal protein L32 | -0.0245787 |
| ZNF292 | zinc finger protein 292 | -0.0242565 |
| PARD3 | par-3 family cell polarity regulator | -0.0242237 |
| HMGA2 | high mobility group AT-hook 2 | -0.024135 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0231395 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0231088 |
| MED13 | mediator complex subunit 13 | -0.0230635 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.023056 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0228767 |
| RASA3 | RAS p21 protein activator 3 | -0.0225835 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0221429 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0218652 |
| MAP4 | microtubule-associated protein 4 | -0.0210248 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0209505 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.020677 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0206765 |
| FNDC3B | fibronectin type III domain containing 3B | -0.019729 |
| RPS8 | ribosomal protein S8 | -0.0193493 |
